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C16 Ceramide-d<sub>7</sub> (d16:1,C16:0)

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By Research Areas:	Cancer (775) Cardiovascular Disease (224) Endocrinology (191) Infection (395) Inflammation/Immunology (336) Metabolic Disease (402) Neurological Disease (411)
Click Chemistry:	PROTAC Synthesis (3) Azide (4) Alkynes (15)
Oligonucleotides:	Pegylated Lipids (3) Pre-designed siRNA Sets (2) Phospholipids (2) siRNAs (2)

3161

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Peptides

Inhibitory Antibodies

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Recombinant Proteins

2934

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116258S

C16 Ceramide-d7 (d16:1,C16:0)	Isotope-Labeled Compounds	Others
C16 Ceramide-d7 (d16:1,C16:0) is the deuterium labeled C16 Ceramide (d16:1,C16:0)[1].

HY-100354S4

C16-Ceramide-d31	Endogenous Metabolite	Others
C16-Ceramide-d₃₁ is deuterium labeled C16-Ceramide.

HY-N10634

D-Glucosyl-β-1,1′-N-palmitoylsphingosine C16 Glucosyl(β) Ceramide (d18:1/16:0)	Others	Inflammation/Immunology
D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity .

HY-144005

**C16 PEG2000 Ceramide** C16 PEG Ceramide (MW 2000)	Liposome Autophagy	Cancer
C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide. C16 PEG2000 Ceramide can be used for lipid carrier to delivery. C16 PEG2000 Ceramide induces autophagy. C16 PEG2000 Ceramide can be used for cancer research .

HY-144005A

**C16 PEG750 Ceramide** C16 PEG Ceramide (MW 750)	Biochemical Assay Reagents Liposome	Others
C16 PEG750 Ceramide (C16 PEG Ceramide (MW 750)) is a PEG lipid for the preparation of liposomes and can be used in drug delivery studies .

HY-144005B

**C16 PEG5000 Ceramide** C16 PEG Ceramide (MW 5000)	Biochemical Assay Reagents Liposome	Others
C16 PEG5000 Ceramide (C16 PEG Ceramide (MW 5000)) is a PEG lipid for the preparation of liposomes and can be used in drug delivery studies .

HY-100354S3

C16-Ceramide-d9	Isotope-Labeled Compounds Endogenous Metabolite	Others
C16-Ceramide-d₉ is deuterium labeled C16-Ceramide.

HY-146936S

C16:1 Ceramide-d7	Isotope-Labeled Compounds	Others
C16:1 Ceramide-d₇ is deuterium labeled C16:1 Ceramide.

HY-165031

C16 (2'(S)-Hydroxy) ceramide (d18:1/16:0) 16:0 (2S-OH)-Ceramide; 2'-Hydroxy C16-Ceramide; 2'(S)-Hydroxy cer(d18:1/16:0)	Biochemical Assay Reagents	Others
C16 (2'(S)-Hydroxy) ceramide (d18:1/16:0) 是一种生化试剂。

HY-145467

C16 Ceramide-1-phosphate (d18:1/16:0) (ammonium) C16 Ceramide-1-phosphate ammonium; Ceramide-1-phosphate (d18:1/16:0) (ammonium); CerP(d18:1/16:0) ammonium	Others	Metabolic Disease
C16 Ceramide-1-phosphate (d18:1/16:0) (ammonium) (C16 Ceramide-1-phosphate (ammonium); Ceramide-1-phosphate (d18:1/16:0) (ammonium)) is an ester product.

HY-108635

C16-PAF 10+ Cited Publications PAF (C16)	p38 MAPK MEK ERK Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability .

HY-141570

Lyso-PAF C-16	Others	Others
Lyso-PAF C-16 is a substrate of lysoplasmalogen (LysoPls)-specific phospholipase D (LysoPLD). Lyso-PAF C-16 selective acetylates with arachidonic acid .

HY-141612

Pyrrolidino PAF C-16	Others	Cardiovascular Disease
Pyrrolidino PAF C-16 is a platelet activating factor ( PAF ) analogue that has hypohematic effects .

HY-134101

2-O-Ethyl PAF C-16	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
2-O-Ethyl PAF C-16 is a homolog of PAF and a competitive ligand for PAF receptor (Platelet-activating Factor Receptor (PAFR)). 2-O-Ethyl PAF C-16 inhibits the binding of the PAF antagonist WEB 2086 (HY-108634) to the PAF receptor with an IC₅₀ of 21 nM .

HY-141839

GLP-1R modulator C16	GCGR	Metabolic Disease
GLP-1R modulator C16 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC₅₀ 8.43 ± 3.82 μM).

HY-100354S

C16-Ceramide-13C16	Apoptosis Endogenous Metabolite MDM-2/p53 Isotope-Labeled Compounds	Others
C16-Ceramide- ¹³C₁₆ is a ¹³C-labeled Glycine ethyl ester monohydrochloride[1].

HY-139282

C16 1-Deoxyceramide (m18:1/16:0) C16:0 1-DeoxyCeramide; C16:0 Ceramide (m18:1/16:0); Cer(m18:1/16:0)	Endogenous Metabolite	Metabolic Disease
C16 1-Deoxyceramide (m18:1/16:0) (C16:0 1-Deoxyceramide) is a lipid molecule, which is composed of a long-chain fatty acid (16:0) and a 1-deoxysphingoid backbone. Deoxyceramide accumulates under the conditions of obesity and type 2 diabetes (T2D). Deoxyceramide is unable to be further metabolized to more complex sphingolipid, and is toxic when accumulates in the body. Deoxyceramide increases in differentiated adipocytes in vitro .

HY-100354

**C16-Ceramide** 1 Publications Verification	MDM-2/p53 Apoptosis Endogenous Metabolite	Cancer
C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding .

HY-132190

Hexanolamino PAF C-16 1-O-Hexa-decyl-2-acetyl-sn-glycero-3-phospho(N,N,N-trimethyl)-hexanolamine	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Hexanolamino PAF C-16 (1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho (N,N,N trimethyl) hexanolamine) is a Platelet-activating Factor Receptor (PAFR) Modulator with partial agonist activity. Hexanolamino PAF C-16 induces platelet aggregation and macrophage production but fails to increase [Ca2+]i in platelets, suggesting that PAF receptors may interact with PAF receptors through Ca ²⁺-dependent and -independent pathways. Related to platelet aggregation .

HY-13977A

PKR-IN-C16 5 Publications Verification	Apoptosis	Neurological Disease
PKR-IN-C16 (Compound C16) is a specific double-stranded RNA-dependent protein kinase (PKR) inhibitor. PKR-IN-C16 shows promising neuroprotective properties and can rescue acute brain lesions .

HY-147755

C16-K-cBB1	Bacterial	Infection
C16-K-cBB1 is a potent and selective antimicrobial agent for MRSA (Methicillin resistant Staphylococcus aureus), with a MIC of 1 µg/mL. C16-K-cBB1 has very good selectivity, as it has weak hemolytic activity. C16-K-cBB1 is able to kill MRSA cells in a matter of 120 min at a concentration of 12.5 μg/mL .

HY-148292

C16-Sphingosine-1-phosphate	LPL Receptor	Cardiovascular Disease Inflammation/Immunology
C16-Sphingosine-1-phosphate is a derivative of Sphingosine-1-phosphate and also an endogenous ligand for the EDG/S1P receptor. C16-Sphingosine-1-phosphate can be used in the research of angiogenesis, inflammation, and cardiovascular diseases .

HY-167549

*N-C16-Deoxysphinganine*	Biochemical Assay Reagents	Others
N-C16-Deoxysphinganine is a biochemical reagent.

HY-141578S

*C18:1-Ceramide-13C18*	Isotope-Labeled Compounds	Others
C18:1-Ceramide- ¹³C₁₈ is a ¹³C-labeled C16-Ceramide[1].

HY-W045598

*Boc-C16-COOH*	ADC Linker PROTAC Linkers	Cancer
Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

HY-W590669

C16-Dihydroceramide N-Palmitoyl sphinganine; (2S,3R)-2-N-Palmitoyloctadecasphinganine	Others	Metabolic Disease
C16-Dihydroceramide (N-Palmitoyl sphinganine) is an ester product.

HY-118040

*3-Oxo-C16:1*	Others	Metabolic Disease
3-Oxo-C16:1 could induce changes in root protein production in the model legume Medicago truncatula. 3-Oxo-C16:1 is an unsaturated 16-carbon AHL utilized by species such as S. meliloti and Agrobacterium vitus .

HY-140342

*Boc-C16-NHS ester*	PROTAC Linkers	Cancer
Boc-C16-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-154831

C22-Ceramide N-Behenoyl-D-erythro-sphingosine; Cer d18:1/22:0	Liposome	Metabolic Disease
C22-Ceramide (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes .

HY-D1736

BODIPY FL-C16	Fluorescent Dye	Others
BODIPY FL-C16 is a fluorescent probe that combines BODIPY FL dye and a sixteen-carbon fatty acid chain, and it can be used for lipid metabolism-related research .

HY-140188

*Amino-PEG6-amido-C16-COOH* 17-(Amino-PEG6-ethylcarbamoyl)heptadecanoic acid	PROTAC Linkers	Cancer
Amino-PEG6-amido-C16-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-19542S1

*C6 Ceramide-d11* C6-Cer-d<sub>11sub>; N-Hexanoylsphingosine-d<sub>11sub>	Apoptosis Isotope-Labeled Compounds	Cancer
C6 Ceramide-d₁₁ is deuterated labeled C6 Ceramide (HY-19542). C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .

HY-140201

*Amino-PEG6-amido-C16-Boc* 17-(Amino-PEG6-ethylcarbamoyl)heptadecanoic t-butyl ester	PROTAC Linkers	Cancer
Amino-PEG6-amido-C16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140202

*Amino-PEG9-amido-C16-Boc* 17-(Amino-PEG9-ethylcarbamoyl)heptadecanoic t-butyl ester	PROTAC Linkers	Cancer
Amino-PEG9-amido-C16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-141631

Dihomo-γ-Linolenoyl PAF C-16 L-α-Phosphatidylcholine	Biochemical Assay Reagents	Others
Dihomo-γ-Linolenoyl PAF C-16is a PAFanalogue, it is in sn-2location contains dihomo-γ-linolenoate, instead of PAF C-16The acetate part in .

HY-W040304

Alkynyl Palmitic Acid 1 Publications Verification Alk-C16	PROTAC Linkers	Cancer
Alkynyl Palmitic Acid (Alk-C16) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Alkynyl Palmitic Acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-140787

*Azide-PEG6-amido-C16-Boc* 17-(Azide-PEG6-ethylcarbamoyl)heptadecanoic t-butyl ester	PROTAC Linkers	Cancer
Azide-PEG6-amido-C16-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Azide-PEG6-amido-C16-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140791

*Azide-PEG9-amido-C16-Boc* 17-(Azide-PEG9-ethylcarbamoyl)heptadecanoic t-butyl ester	PROTAC Linkers	Cancer
Azide-PEG9-amido-C16-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Azide-PEG9-amido-C16-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-100355S1

*C18-Ceramide-d7*	Isotope-Labeled Compounds Endogenous Metabolite	Others
C18-Ceramide-d₇ is deuterium labeled C18-Ceramide.

HY-139062

C6 Urea Ceramide C6 Ceramide (d18:1/6:0) Urea; Cer(d18:1/6:0) Urea; D-erythro-Urea-C6-Ceramide	Others	Cancer
C6 Urea Ceramide (C6 Ceramide (d18:1/6:0) Urea; Cer(d18:1/6:0) Urea) is an inhibitor of neutral ceramidase. It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and HT-29 colon cancer cells, but not in MEFs lacking neutral ceramidase. At concentrations of 5 and 10 μM, it inhibits proliferation of HT-29 cells and induces apoptosis and autophagy, but not in noncancerous RIE-1 cells. C6 Urea Ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the 20S proteasome in HT-29 and HCT116 cells, but not in RIE-1 cells. When administered at doses of 1.25, 2.5, and 5 mg/kg for five days, it reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissues in the HT-29 mouse xenograft model.

HY-100355S

*C18-Ceramide-d3*	Isotope-Labeled Compounds	Others
C18-Ceramide-d₃ is the deuterium labeled C18-Ceramide[1].

HY-134508S

*C24-Ceramide-d7*	Isotope-Labeled Compounds	Others
C24-Ceramide-d₇ is the deuterium labeled C24-Ceramide[1].

HY-134508A

*C24-Ceramide (d18:1/24:0)*	Others	Others
C24-Ceramide (d18:1/24:0) is a sphingolipid that can be used for the lipid membranes composed. C24-Ceramide (d18:1/24:0) induces time-dependent changes in membrane properties. C24-Ceramide (d18:1/24:0) induces membrane reorganization .

HY-141578S1

*C18:1 Ceramide-d7*	Isotope-Labeled Compounds Endogenous Metabolite	Others
C18:1 Ceramide-d₇ is deuterium labeled C18:1 Ceramide.

HY-146934S

*C22:1 Ceramide-d7*	Isotope-Labeled Compounds	Others
C22:1 Ceramide-d₇ is deuterium labeled C22:1 Ceramide.

HY-146935S

*C20:1 Ceramide-d7*	Isotope-Labeled Compounds	Others
C20:1 Ceramide-d₇ is deuterium labeled C20:1 Ceramide.

HY-134575S

*C24:1-Ceramide-d7*	Isotope-Labeled Compounds	Others
C24:1-Ceramide-d₇ is the deuterium labeled C24:1-Ceramide[1].

HY-146760S

*C15 Glucosyl(β) ceramide-d7*	Isotope-Labeled Compounds	Others
C15 Glucosyl(β) ceramide-d₇ is deuterium labeled C15 Glucosyl(β) ceramide.

HY-146906S

*C18 Glucosyl(ß) ceramide-d5*	Isotope-Labeled Compounds	Others
C18 Glucosyl(ß) ceramide-d₅ is deuterium labeled C18 Glucosyl(ß) ceramide.

HY-146907S

*C18:1 Glucosyl ceramide-d5*	Isotope-Labeled Compounds	Others
C18:1 Glucosyl ceramide-d₅ is deuterium labeled C18:1 Glucosyl ceramide.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10634

D-Glucosyl-β-1,1′-N-palmitoylsphingosine C16 Glucosyl(β) Ceramide (d18:1/16:0)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Others
D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity .

HY-108635

C16-PAF 10+ Cited Publications PAF (C16)	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	p38 MAPK MEK ERK Endogenous Metabolite
C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability .

HY-141570

Lyso-PAF C-16	Microorganisms Source classification	Others
Lyso-PAF C-16 is a substrate of lysoplasmalogen (LysoPls)-specific phospholipase D (LysoPLD). Lyso-PAF C-16 selective acetylates with arachidonic acid .

HY-100354

**C16-Ceramide** 1 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	MDM-2/p53 Apoptosis Endogenous Metabolite
C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding .

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-117081

*C30(ω-hydroxy) Ceramide (d18:1/30:0)*	Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Others
C30(ω-hydroxy) Ceramide (d18:1/30:0), a sphingolipid, is an epidermis-specifically vital component of the water barrier in mammalian skin. C30(ω-hydroxy) Ceramide (d18:1/30:0) is expressed in epidermal keratinocytes and male germ cells during their differentiation and maturation. C30(ω-hydroxy) Ceramide (d18:1/30:0) deficiency in the epiderm of Elovl4 deletion or mutation mice .

HY-145520

*(±)-2'-hydroxy Ceramide (d18:0/18:0)* (±)-2'-hydroxy Cer(d18:0/18:0)	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(±)-2'-hydroxy Ceramide (d18:0/18:0) is a sphingomyelin that can be isolated from mammalian platelets stimulation by ADP .

HY-W747104

(9E)-Tetradecen-1-ol	Structural Classification Natural Products Animals Source classification	Others
(9E)-Tetradecen-1-ol is a pheromone that has no significant sexual attraction when used alone and can be secreted from the abdomen of the female Bertha armyworm moth (Mamestra configurata (Walker)). Isolate in tip extract to get in isolate. Another pheromone (Z)-11-hexadecen-1-ol was also isolated at the same time. Only when the two pheromones are mixed do they show male attraction (the ratio of C16:C14 in the mixture is about 19:1). optimal) .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-P99294

Ganitumab AMG 479; Human Anti-IGF1R Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	IGF-1R
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (K_D=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .

HY-N0662R

Amentoflavone (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-141578

C18:1-Ceramide	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
C18:1-Ceramide is a ceramide subspecies. C18:1-Ceramide can be used in the study of type 2 diabetes

HY-W751835

Baloxavir-d4 Maximum Cited Publications 30 Publications Verification Baloxavir acid-d<sub>4sub>; S-033447-d<sub>4sub>	Classification of Application Fields Disease Research Fields Cancer	Isotope-Labeled Compounds
Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-100355

C18-Ceramide	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
C18-Ceramide can promote exocytosis of glutamate from damaged neurons. C18-Ceramide promotes cell death in glioma cells. Ceramides is involved in diverse cellular functions, such as differentiation, cell cycle progression, cell-cell adhesion, senescence, and apoptosis .

HY-112016

C20 Ceramide N-Arachidoyl-D-sphingosine	Structural Classification Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
C20 Ceramide is a natural 20:0 ceramide that is abundant in the brain .

HY-B0504S

Creatinine-d3 3 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-129099

N-Desmethyltamoxifen	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-129099A

N-Desmethyltamoxifen hydrochloride	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-133823

11-Hexadecenoic acid C16:1 (cis-11/trans-11) Fatty acid	Microorganisms Source classification	Endogenous Metabolite
11-Hexadecenoic acid is a monounsaturated fatty acid. 11-cis-Hexadecenoic acid and 11-trans-hexadecenoic acid have been found in ewe milk fat, and levels of each increase with dietary lipid supplementation of linseed, sunflower, olive, or fish oils. 11-trans-Hexadecenoic acid has also been found in intramuscular fat samples isolated from male and female foals. This product is a mixture of 11-cis- and 11-trans-hexadecenoic acids.

HY-N6723

Fumonisin B2	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Endogenous metabolite Disease Research Fields Other Antibiotics	Acyltransferase
Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of *sphingosine N-acyltransferase (ceramide* synthase)** and disrupts de novo sphingolipid biosynthesis .

HY-P1975

Aureobasidin A 2 Publications Verification Basifungin	Infection Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields Other Antibiotics	Fungal Parasite
Aureobasidin A (Basifungin) is a cyclic peptide antibiotic with oral activity. Aureobasidin A is an inhibitor of inositol phosphorylated ceramide synthetase AUR1. Aureobasidin A has antifungal and antiparasitic activity .

HY-13626

Spisulosine ES-285	Alkaloids Classification of Application Fields Animals Source classification Marine natural products Other marine organisms Disease Research Fields Cancer	PKC
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation .

HY-N6730

Hydrolyzed Fumonisin B1 Aminopentol	Natural Products Microorganisms Source classification	Apoptosis
Hydrolyzed Fumonisin B1 (Aminopentol) is the backbone and main hydrolysis product of the mycotoxin Fumonisin B1 (HY-N6719). Hydrolyzed Fumonisin B1 can weakly inhibit ceramide synthase .

HY-N6719

Fumonisin B1 5 Publications Verification	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Endogenous metabolite Disease Research Fields Other Antibiotics	Acyltransferase
Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of *sphingosine N-acyltransferase (ceramide* synthase)** and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .

Cat. No.	Product Name	Chemical Structure

HY-116258S

C16 Ceramide-d7 (d16:1,C16:0)
C16 Ceramide-d7 (d16:1,C16:0) is the deuterium labeled C16 Ceramide (d16:1,C16:0)[1].

HY-100354S4

C16-Ceramide-d31
C16-Ceramide-d₃₁ is deuterium labeled C16-Ceramide.

HY-141578S

*C18:1-Ceramide-13C18*
C18:1-Ceramide- ¹³C₁₈ is a ¹³C-labeled C16-Ceramide[1].

HY-100354S3

C16-Ceramide-d9
C16-Ceramide-d₉ is deuterium labeled C16-Ceramide.

HY-146936S

C16:1 Ceramide-d7
C16:1 Ceramide-d₇ is deuterium labeled C16:1 Ceramide.

HY-100354S

C16-Ceramide-13C16
C16-Ceramide- ¹³C₁₆ is a ¹³C-labeled Glycine ethyl ester monohydrochloride[1].

HY-19542S1

*C6 Ceramide-d11*
C6 Ceramide-d₁₁ is deuterated labeled C6 Ceramide (HY-19542). C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .

HY-100355S1

*C18-Ceramide-d7*
C18-Ceramide-d₇ is deuterium labeled C18-Ceramide.

HY-100355S

*C18-Ceramide-d3*
C18-Ceramide-d₃ is the deuterium labeled C18-Ceramide[1].

HY-134508S

*C24-Ceramide-d7*
C24-Ceramide-d₇ is the deuterium labeled C24-Ceramide[1].

HY-141578S1

*C18:1 Ceramide-d7*
C18:1 Ceramide-d₇ is deuterium labeled C18:1 Ceramide.

HY-146934S

*C22:1 Ceramide-d7*
C22:1 Ceramide-d₇ is deuterium labeled C22:1 Ceramide.

HY-146935S

*C20:1 Ceramide-d7*
C20:1 Ceramide-d₇ is deuterium labeled C20:1 Ceramide.

HY-134575S

*C24:1-Ceramide-d7*
C24:1-Ceramide-d₇ is the deuterium labeled C24:1-Ceramide[1].

HY-146760S

*C15 Glucosyl(β) ceramide-d7*
C15 Glucosyl(β) ceramide-d₇ is deuterium labeled C15 Glucosyl(β) ceramide.

HY-146906S

*C18 Glucosyl(ß) ceramide-d5*
C18 Glucosyl(ß) ceramide-d₅ is deuterium labeled C18 Glucosyl(ß) ceramide.

HY-146907S

*C18:1 Glucosyl ceramide-d5*
C18:1 Glucosyl ceramide-d₅ is deuterium labeled C18:1 Glucosyl ceramide.

HY-141570S

*Lyso-PAF C-16-d4*
Lyso-PAF C-16-d₄ is the deuterium labeled Lyso-PAF C-16[1].

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-107327S

Carazolol-d7
Carazolol-d₇ is the deuterium labeled Carazolol[1].

HY-N0006S

Demethoxycurcumin-d7
Demethoxycurcumin-d₇ is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin(Curcumin II), a major active curcuminoid, possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.

HY-66005S2

Acetaminophen-d7
Acetaminophen-d₇ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-B0389S6

D-Glucose-d7
D-Glucose-d₇7 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].

HY-107352S

Fosfenopril-d7
Fosfenopril-d₇ is deuterium labeled Fosfenopril.

HY-D0711S2

Indocyanine green-d7
Indocyanine green-d7 (Foxgreen-d7) is the deuterium labeled Indocyanine green (HY-D0711). Indocyanine green is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography .

HY-12057S1

Vemurafenib-d7
Vemurafenib-d₇ is deuterium labeled Vemurafenib. Vemurafenib (PLX4032) is a first-in-class, selective, potent inhibitor of B-RAF kinase, with IC50s of 31 and 48 nM for RAFV600E and c-RAF-1, respectively[1][4]. Vemurafenib induces cell autophagy[5].

HY-Y0376S

DMPA-d7
DMPA-d₇ is the deuterium labeled DMPA[1].

HY-Y1309S1

1-Naphthol-d7
1-Naphthol-d7 is the deuterium labeled Naphthol .

HY-135328S

Norverapamil-d7
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-17025S

Rifabutin-d7
Rifabutin-d₇ is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-107855S

DL-Mevalonolactone-d7
DL-Mevalonolactone-d₇ is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

HY-41700S3

D-Alanine-d7
D-Alanine-d₇ is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.

HY-146944S

12-PAHSA-13C16
12-PAHSA- ¹³C₁₆ is ¹³C₁₆ labeled 12-PAHSA.

HY-N0650S11

L-Serine-d7
L-Serine-d₇ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-B0679S

Lubiprostone-d7
Lubiprostone-d₇ (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (RU0211) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation[1][2].

HY-50898S1

Lapatinib-d7 dihydrochloride
Lapatinib-d₇ (dihydrochloride) is the deuterium labeled Lapatinib dihydrochloride. Lapatinib (GW572016) dihydrochloride is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].

HY-12296S

Navtemadlin-d7
Navtemadlin-d₇ is the deuterium labeled Navtemadlin. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].

HY-13720AS

Pergolide-d7 mesylate
Pergolide-d₇ (mesylate) is the deuterium labeled Pergolide mesylate. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research[1][2].

HY-N2334AS

Glycochenodeoxycholic acid-d7 sodium

Glycochenodeoxycholic acid-d₇ (sodium) is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].

HY-12785S1

Albendazole sulfoxide-d7
Albendazole sulfoxide-d₇ is the deuterium labeled Albendazole sulfoxide. Albendazole sulfoxide (Ricobendazole), the main active metabolite of Albendazole, exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1].

HY-14268S1

Febuxostat-d7
Febuxostat-d₇ is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a Ki of 0.6 nM[1].

HY-B1674S4

(±)-Leucine-d7
(±)-Leucine-d₇ is the deuterium labeled (±)-Leucine. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08%[1].

HY-N7745S

Glucosylsphingosine-d7
Glucosylsphingosine-d₇ is deuterium labeled Glucosylsphingosine.

HY-135853S

Molnupiravir-d7

Molnupiravir-d₇ is the deuterium labeled Molnupiravir. Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza[1][2].

HY-14275S1

Verapamil-d7
Verapamil-d₇ is the deuterium labeled Verapamil (HY-14275). Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .

HY-B0202S3

Irbesartan-d7
Irbesartan-d₇ is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0202AS

Irbesartan-d7 hydrochloride

Irbesartan-d₇ hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-30237S

(R)-Roscovitine-d7
(R)-Roscovitine-d₇ (Seliciclib-d₇; CYC202-d₇) is deuterium-labeled (R)-Roscovitine (HY-30237) .

HY-B0161AS1

Duloxetine-d7 hydrochloride
Duloxetine-d7 hydrochloride ((S)-Duloxetine-d7 hydrochloride) is the deuterium labeled Duloxetine hydrochloride (HY-B0161A). Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-101047S

D-erythro-Sphingosine-d7
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

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