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Results for "

Rara?/? male mice

" in MedChemExpress (MCE) Product Catalog:

1967

Inhibitors & Agonists

15

Fluorescent Dye

26

Biochemical Assay Reagents

164

Peptides

45

Inhibitory Antibodies

378

Natural
Products

2

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50

Isotope-Labeled Compounds

1

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10

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29

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-113415A
    Testosterone sulfate (pyridinium)
    1 Publications Verification

    		 Endogenous Metabolite Drug Metabolite Endocrinology
    Testosterone sulfate pyridinium is a Testosterone sulfate with a pyridinium. Testosterone sulfate is the metabolite of Testosterone. Testosterone is the main male sex hormone which determination is useful for assessment of androgen status .
    Testosterone sulfate (pyridinium)
  • HY-150621
    AS1134900

    		Others Cancer
    AS1134900 is a highly selective, allosteric and uncompetitive NADP +-dependent malic enzyme 1 (ME1) inhibitor .
    AS1134900
  • HY-155478
    Androgen receptor-IN-6

    		Androgen Receptor Cancer
    Androgen receptor-IN-6 (compound 16) is an orally available androgen receptor (Androgen Receptor) potent inhibitor (IC50=0.12 μM in vitro), targeting the disordered N-terminal domain (NTD). Androgen receptor-IN-6 has good Caco2 cell membrane permeability and has an oral activity (F/%) of 16% in male CD-1 mice .
    Androgen receptor-IN-6
  • HY-78035
    Citraconic anhydride

    Methylmaleic anhydride

    		 Biochemical Assay Reagents Others
    Citraconic anhydride (Methylmaleic anhydride) is a derivative of maleic anhydride. Citraconic anhydride is utilized to block the proteins amino groups reversibly, stabilizes certain enzymes and improves their catalytic performance, or to reverse the effects of formalin fixation in tissue sections. Citraconic anhydride is irritating for skin and eyes .
    Citraconic anhydride
  • HY-RS11669
    RARA Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    RARA Human Pre-designed siRNA Set A contains three designed siRNAs for RARA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RARA Human Pre-designed siRNA Set A
    RARA Human Pre-designed siRNA Set A
  • HY-RS11670
    Rara Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Rara Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rara gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Rara Mouse Pre-designed siRNA Set A
    Rara Mouse Pre-designed siRNA Set A
  • HY-RS11671
    Rara Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Rara Rat Pre-designed siRNA Set A contains three designed siRNAs for Rara gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Rara Rat Pre-designed siRNA Set A
    Rara Rat Pre-designed siRNA Set A
  • HY-N12920
    (Z)-3-Dodecenyl acetate

    Z3-12:Ac

    		 Others Endocrinology
    (Z)-3-Dodecenyl acetate (Z3-12:Ac) is a specific sex pheromone attracting females, isolated from pentane extracts of mature unmated male yellow mealworm beetles .
    (Z)-3-Dodecenyl acetate
  • HY-164535
    Maridebart cafraglutide

    AMG 133

    		 GLP Receptor Metabolic Disease
    Maridebart cafraglutide (AMG 133) is an antibody-peptide conjugate acting as a GLP-1 receptor agonist and an antagonist of the GIP receptor. Maridebart cafraglutide reduces body weight and improve metabolic markers in male obese mice and cynomolgus monkeys. Maridebart cafraglutide is promising for research of obesity .
    Maridebart cafraglutide
  • HY-W009688
    Dibutyl maleate

    		Others Inflammation/Immunology
    Dibutyl maleate, the diester of the Maleic Acid, can be used as an intermediate of pharmaceutical synthesis. Dibutyl maleate can enhance contact sensitization to Fluorescein isothiocyanate in mice .
    Dibutyl maleate
  • HY-117081
    C30(ω-hydroxy) Ceramide (d18:1/30:0)

    		Others Others
    C30(ω-hydroxy) Ceramide (d18:1/30:0), a sphingolipid, is an epidermis-specifically vital component of the water barrier in mammalian skin. C30(ω-hydroxy) Ceramide (d18:1/30:0) is expressed in epidermal keratinocytes and male germ cells during their differentiation and maturation. C30(ω-hydroxy) Ceramide (d18:1/30:0) deficiency in the epiderm of Elovl4 deletion or mutation mice .
    C30(ω-hydroxy) Ceramide (d18:1/30:0)
  • HY-P10472
    Azaline B

    		GnRH Receptor Endocrinology
    Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .
    Azaline B
  • HY-164032
    Dimethandrolone undecanoate

    7α,11β-Dimethyl-17β-hydroxyestr-4-en-3-one 17-undecanoate

    		 GnRH Receptor Endocrinology
    Dimethandrolone undecanoate (7α,11β-Dimethyl-17β-hydroxyestr-4-en-3-one 17-undecanoate) exhibits withrogens and progesterone activity. Dimethandrolone undecanoate inhibits production of gonadotropins, suppresses testosterone production, and thus inhibits sperm production. Dimethandrolone undecanoate is potent for development of male hormone contraceptives .
    Dimethandrolone undecanoate
  • HY-B0860
    Diuron

    		Others Cancer
    Diuron is a phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (2,500 ppm, dietary) increases the incidence of urinary bladder urothelial carcinomas in male and female mice by 73 and 27%, respectively.
    Diuron
  • HY-20558R
    D-(+)-Malic acid (Standard)

    		Endogenous Metabolite Metabolic Disease
    D-(+)-Malic acid (Standard) is the analytical standard of D-(+)-Malic acid. This product is intended for research and analytical applications. D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport .
    D-(+)-Malic acid (Standard)
  • HY-20558
    D-(+)-Malic acid

    D-Malic acid

    		 Endogenous Metabolite Metabolic Disease
    D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport .
    D-(+)-Malic acid
  • HY-P10110
    retro-inverso TAT-Beclin 1 (D-amino acid)

    		Autophagy Neurological Disease
    retro-inverso TAT-Beclin 1 D-amino acid is has higher activity and resistance to proteolytic degradation in vivo compared to L-amino acids peptide. TAT-Beclin 1 can induce autophagy in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice .
    retro-inverso TAT-Beclin 1 (D-amino acid)
  • HY-148163
    Polystyrene
    1 Publications Verification

    		 Others Others
    Polystyrene can form Polystyrene microplastics (PS-MPs), a hazardous material with potential toxicity. Polystyrene microplastics is harm to zebrafish heart and induces male reproductive toxicity in mice . MCE provides Polystyrene products in solution packaging.
    Polystyrene
  • HY-P5883
    TAT-M2NX

    tatM2NX

    		 TRP Channel Neurological Disease
    TAT-M2NX (tatM2NX) is a TRPM2 inhibitor with specific neuroprotective activity in male mice. TAT-M2NX can be used to study ischemic neuronal damage .
    TAT-M2NX
  • HY-115826
    AB-163

    		Others Cancer
    AB-163 is an alkylating agent with anti-tumor activity. AB-163 exerts LD50s of 198 (p.o.) and 159 (i.p.) mg/kg in ICR/Ha male mice and can be utilized in cancer research .
    AB-163
  • HY-152471
    Eleven-Nineteen-Leukemia Protein IN-3

    		Epigenetic Reader Domain Cancer
    Eleven-Nineteen-Leukemia Protein IN-3 is an orally active inhibitor of ENL YEATS domain with an IC50 value of 15.4 nM. Eleven-Nineteen-Leukemia Protein IN-3 down-regulates MYC expression through ENL in cells and can enhances the thermal stability of ENL protein in vitro .
    Eleven-Nineteen-Leukemia Protein IN-3
  • HY-101106
    AR7
    5+ Cited Publications

    		 RAR/RXR Neurological Disease Cancer
    AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy .
    AR7
  • HY-59354S
    Maleic hydrazide-d2

    		DNA/RNA Synthesis Cancer
    Maleic hydrazide-d2 is the deuterium labeled Maleic hydrazide[1]. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins[2][3].
    Maleic hydrazide-d2
  • HY-59354R
    Maleic hydrazide (Standard)

    		DNA/RNA Synthesis Cancer
    Maleic hydrazide (Standard) is the analytical standard of Maleic hydrazide. This product is intended for research and analytical applications. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .
    Maleic hydrazide (Standard)
  • HY-155659
    4A7C-301

    		Nuclear Hormone Receptor 4A/NR4A Neurological Disease
    4A7C-301 is a Nurr1 agonist with robust neuroprotective effects in vitro. 4A7C-301 significantly ameliorates neuropathological abnormalities and improves motor and olfactory dysfunctions in AAV2-mediated α-synuclein-overexpressing male mouse models. 4A7C-301 can be used for the research of Parkinson’s disease .
    4A7C-301
  • HY-Y0367S
    Maleic Acid-d2

    maleic-2,3-d2 acid

    		 Bacterial Endogenous Metabolite Infection
    Maleic Acid-d2 is the deuterium labeled Maleic Acid[1]. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes[2][3].
    Maleic Acid-d2
  • HY-B0860R
    Diuron (Standard)

    		Others Cancer
    Diuron (Standard) is the analytical standard of Diuron. This product is intended for research and analytical applications. Diuron is a phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (2,500 ppm, dietary) increases the incidence of urinary bladder urothelial carcinomas in male and female mice by 73 and 27%, respectively.
    Diuron (Standard)
  • HY-P1726A
    MSG606 TFA

    		Melanocortin Receptor Cancer
    MSG606 TFA is a potent human MC1 receptor antagonist (IC50=17 nM). MSG606 TFA also partial agonist at human MC3 and MC5 receptors (EC50 values are 59 and 1300 nM, respectively). MSG606 TFA exhibits binding affinity for A375 melanoma cells in vitro. MSG606 TFA reverses the induced hyperalgesia in female mice, with no effect in male mice.
    MSG606 TFA
  • HY-131708A
    FNDR-20123

    		HDAC Parasite Infection
    FNDR-20123 is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25/29/2/11/282 nM, respectively.) and inhibits Class III HDAC isoforms at nanomolar concentrations .
    FNDR-20123
  • HY-Y1311R
    Malic acid (Standard)

    		Endogenous Metabolite Others
    Malic acid (Standard) is the analytical standard of Malic acid. This product is intended for research and analytical applications. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods.
    Malic acid (Standard)
  • HY-Y1311S
    Malic acid-d3

    Hydroxybutanedioic acid-d3; E 296-d3

    		 Endogenous Metabolite Others
    Malic acid-d3 is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods[1][2].
    Malic acid-d3
  • HY-131708
    FNDR-20123 free base

    		HDAC Parasite Infection
    FNDR-20123 free base is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations .
    FNDR-20123 free base
  • HY-162866
    CXM102

    		Autophagy Metabolic Disease
    CXM102 is an autophagy activator. CXM102 can induce autophagy in aged BMSCs, leading to the rejuvenation of BMSCs and preferential differentiation into osteoblasts. CXM102 promotes the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. CXM102 can stimulate bone synthesis metabolism in middle-aged male mice, reduce bone marrow adipocytes, delay bone loss, lower serum inflammation levels, decrease organ fibrosis, and extend the lifespan of the mice .
    CXM102
  • HY-Y1069S3
    (S)-Malic acid-13C4

    (S)-Hydroxybutanedioic acid-13C4; (S)-E 296-13C4; L-Malic acid-13C4

    		 Isotope-Labeled Compounds Others
    (S)-Malic acid- 13C4 is the 13C labeled S-Malic acid (HY-Y1069)[1].
    (S)-Malic acid-13C4
  • HY-162565
    CDD-2807

    		STK33 CDK RET Endocrinology
    CDD-2807 is an inhibitor for serine/threonine kinase 33 (STK33) with IC50 of 9.2 nM. CDD-2807 exhibits no significant toxicity in mice and can cross the blood-testis barrier without accumulating in the brain. CDD-2807 induces a reversible contraceptive effect and has potential for the development of the male contraceptive .
    CDD-2807
  • HY-128900
    11-cis-Vaccenyl acetate

    		Endogenous Metabolite Others
    11-cis-Vaccenyl acetate is male-specific lipid that mediates aggregation behavior in both male and female flies, which activates a few dozen olfactory neurons located in T1 sensilla on the antenna of both male and female flies .
    11-cis-Vaccenyl acetate
  • HY-Y1069S
    (S)-Malic acid-d3

    (S)-Hydroxybutanedioic acid-d3; (S)-E 296-d3; L-Malic acid-d3

    		 Endogenous Metabolite Metabolic Disease
    (S)-Malic acid-d3 is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive[1][2].
    (S)-Malic acid-d3
  • HY-120872
    AJS1669 free acid

    		Others Metabolic Disease
    AJS1669 free acid is a potent and orally available glycogen synthase (GS) activator. AJS1669 improves glucose metabolism and reduces body fat mass in mice[1].
    AJS1669 free acid
  • HY-59354
    Maleic hydrazide

    		DNA/RNA Synthesis Cancer
    Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .
    Maleic hydrazide
  • HY-163345
    5-HT7R antagonist 2

    		5-HT Receptor Neurological Disease
    5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a Ki of 67 nM, the IC50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment .
    Pharmacokinetic Analysis ICR Male Mice

    药代动力学分析
    Plasma Intravenous Administration Intraperitoneal Administration
    Tmax (h) 0.08 0.25
    T1/2 (h) 0.77 1.06
    Cmax (ng/mL) 33.07 156.44
    AUClast (ng·h/mL) 28.31 143.27
    CL (L/h/kg) 41.61 -
    Vss (L/kg) 32.43 -
    MRT (h) 0.79 0.93
    F (%) 50.60
    5-HT7R antagonist 2
  • HY-W250303A
    Malic acid disodium hydrate
    1 Publications Verification

    Hydroxybutanedioic acid disodium hydrate; Disodium DL-malate hydrate; E 296 disodium hydrate

    		 Biochemical Assay Reagents Others
    Malic acid disodium hydrate is an organic compound that is commonly used as a food additive, buffering agent, and nutritional supplement. It contains sodium and malic acid. Malic acid disodium hydrate has a variety of properties that make it suitable for these applications, including the ability to enhance food flavor, improve texture, and regulate acidity. In addition, due to its potential health benefits, including improved energy production, reduced fatigue, and enhanced athletic performance, Malic acid disodium hydrate can be used as a dietary supplement .
    Malic acid disodium hydrate
  • HY-157429
    25N-N1-Nap

    		5-HT Receptor Neurological Disease
    25N-N1-Nap (compound 16) is a β-arrestin-biased 5-HT2A agonist. 25N-N1-Nap antagonizes phencyclidine induced hyperactivity in Male C57BL/6 J mice .
    25N-N1-Nap
  • HY-144372
    TRPV1 antagonist 3

    		TRP Channel Neurological Disease
    TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist with an IC50 of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant .
    TRPV1 antagonist 3
  • HY-Y0367R
    Maleic Acid (Standard)

    		Endogenous Metabolite Bacterial Infection
    Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes. IC50 & Target: GAD . In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .
    Maleic Acid (Standard)
  • HY-P5819
    xStAx-VHLL

    		Wnt APC PROTACs β-catenin Cancer
    xStAx-VHLL is a PROTAC β-catenin degrader that manifests strong inhibition of Wnt signaling and sustains degradation of β-catenin in cancer cells and the intestinal organoids derived from wild-type and APC –/– mice. xStAx-VHLL can be used as a promising anticancer agent .
    xStAx-VHLL
  • HY-113878
    12-OAHSA

    		Endogenous Metabolite Metabolic Disease
    12-OAHSA is a component of olive oil. 12-OAHSA has oral activity, and improves glucose homeostasis in insulin resistant obese mice .
    12-OAHSA
  • HY-124861
    Malic enzyme inhibitor ME1
    2 Publications Verification

    ME1

    		 Others Metabolic Disease Cancer
    Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM .
    Malic enzyme inhibitor ME1
  • HY-162396
    P-gp inhibitor 21

    		P-glycoprotein Cancer
    P-gp inhibitor 21 (Compound 56) is an inhibitor for P-glycoprotein (P-gp) transport, which reverses P-gp-mediated multidrug resistance (MDR) and exhibits antitumor efficacy in mice without significant cytotoxicity .
    P-gp inhibitor 21
  • HY-126426
    CBHcy

    		DNA Methyltransferase Cardiovascular Disease
    CBHcy is an inhibitor for betaine-homocysteine S-methyltransferase (BGMT), with an IC50 of 0.09 μM. CBHcy upregulates the plasma total homocysteine and causes transient hyperhomocysteinemia in mice model .
    CBHcy
  • HY-153617
    FOXO1-IN-3

    		FOXO Metabolic Disease
    FOXO1-IN-3 is a highly-selective and orally active FOXO1 inhibitor. FOXO1-IN-3 reduces hepatic glucose production in mice. FOXO1-IN-3 improves insulin sensitivity and glucose control in db/db mice without causing weight gain .
    FOXO1-IN-3

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