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5-Methyluridine-d<sub>4</sub>

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (732) Cardiovascular Disease (212) Endocrinology (185) Infection (387) Inflammation/Immunology (321) Metabolic Disease (352) Neurological Disease (385)
Click Chemistry:	Azide (2) Alkynes (14)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

2967

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
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Recombinant Proteins

2898

Isotope-Labeled Compounds

Antibodies

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Oligonucleotides

Targets Recommended: P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-66005S

Acetaminophen-d4 Paracetamol-d<sub>4sub>; 4-Acetamidophenol-d<sub>4sub>; 4'-Hydroxyacetanilide-d<sub>4sub>	COX Histone Acetyltransferase Endogenous Metabolite	Inflammation/Immunology
Acetaminophen-d₄ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

HY-Y1042S

4-Cyanophenol-d4 4-Hydroxybenzonitrile-d<sub>4sub>; 4-Hydroxycyanobenzene-d<sub>4sub>; NSC 400524-d<sub>4sub>	Isotope-Labeled Compounds	Others
4-Cyanophenol-d₄ is the deuterium labeled 4-Cyanophenol[1].

HY-B1008S

4-Aminobenzoic acid-d4 PABA-d<sub>4sub>; Vitamin Bx-d<sub>4sub>; Vitamin H1-d<sub>4sub>; p-Aminobenzoic acid-d<sub>4sub>	Isotope-Labeled Compounds Endogenous Metabolite	Others
4-Aminobenzoic acid-d₄ is the deuterium labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.

HY-N0006S1

Demethoxycurcumin-d4 Curcumin II-d<sub>4sub>; Desmethoxycurcumin-d<sub>4sub>; Monodemethoxycurcumin-d<sub>4sub>	Apoptosis Autophagy Bacterial	Cancer
Demethoxycurcumin-d₄ is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin (Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties[1].

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-W009444S

5-Methyluridine-d4	Endogenous Metabolite	Others
5-Methyluridine-d₄ is the deuterium labeled 5-Methyluridine[1]. 5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids[2].

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-41680S

4-Aminobenzonitrile-d4 4-Aminobenzonitrile-d<sub>4sub>; 4-Cyanoaniline-d<sub>4sub>; 4-Cyanobenzenamine-d<sub>4sub>	Isotope-Labeled Compounds	Others
4-Aminobenzonitrile-d₄ is the deuterium labeled 4-Aminobenzonitrile[1].

HY-17413S2

Zidovudine-d4 Azidothymidine-d<sub>4sub>; AZT-d<sub>4sub>; ZDV-d<sub>4sub>	CRISPR/Cas9 HIV Isotope-Labeled Compounds	Infection Cancer
Zidovudine-d₄ is deuterated labeled Zidovudine (HY-17413). Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.

HY-B0329S

Isoniazid-d4 INH-d<sub>4sub>; Isonicotinic acid hydrazide-d<sub>4sub>; Isonicotinic hydrazide-d<sub>4sub>	Bacterial Autophagy Mitophagy Antibiotic	Infection
Isoniazid-d₄ is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].

HY-100048S

Acetylisoniazid-d4 Acetylisoniazide-d<sub>4sub>; N-Monoacetylisoniazid-d<sub>4sub>; NSC 36084-d<sub>4sub>	Isotope-Labeled Compounds	Others
Acetylisoniazid-d₄ is the deuterium labeled Acetylisoniazid[1].

HY-118861S

Enclomiphene-d4 hydrochloride (E)-Clomiphene-d<sub>4sub> hydrochloride; trans-Clomiphene-d<sub>4sub> hydrochloride; Enclomifene-d<sub>4sub> hydrochloride	Isotope-Labeled Compounds Estrogen Receptor/ERR	Inflammation/Immunology
Enclomiphene-d₄ (hydrochloride) is a deuterium labeled Enclomiphene. Enclomiphene-d₄ (hydrochloride) is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property[1].

HY-109015S

Tucidinostat-d4 Chidamide-d<sub>4sub>; HBI-8000-d<sub>4sub>; CS 055-d<sub>4sub>	Isotope-Labeled Compounds HDAC	Cancer
Tucidinostat-d₄ is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively[1].

HY-19696AS

Tauroursodeoxycholate-d4 sodium Tauroursodeoxycholic acid-d<sub>4sub> sodium; TUDCA-d<sub>4sub> sodium; UR 906-d<sub>4sub> sodium	Isotope-Labeled Compounds ERK Caspase Apoptosis Endogenous Metabolite	Cancer
Tauroursodeoxycholate-d₄ (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S1

Tauroursodeoxycholate-d4 Tauroursodeoxycholic acid-d<sub>4sub>; TUDCA-d<sub>4sub>; UR 906-d<sub>4sub>	Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-B0389S24

D-Glucose-d4 Glucose-d<sub>4sub>; D-(+)-Glucose-d<sub>4sub>; Dextrose-d<sub>4sub>	Endogenous Metabolite	Metabolic Disease Cancer
D-Glucose-d₄ is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec

HY-B0696AS

Tiagabine-d4 hydrochloride NO050328-dd<sub>4sub> hydrochloride; NO328-d<sub>4sub> hydrochloride; TGB-d<sub>4sub> hydrochloride	GABA Receptor Isotope-Labeled Compounds	Neurological Disease
Tiagabine-d₄ hydrochloride is deuterated labeled Tiagabine hydrochloride (HY-B0696A). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC₅₀s of 67, 446 and 182 nM for [ ³H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .

HY-13273S

Ostarine-d4 MK-2866-d<sub>4sub>; GTX-024-d<sub>4sub>; Enobosarm-d<sub>4sub>	Isotope-Labeled Compounds Androgen Receptor	Cancer
Ostarine-d4 is a deuterated labeled Ostarine .

HY-34498S

4-Chloro-2-methylphenol-d4 4-Chloro-o-cresol-d<sub>4sub>; 4-Chlorocresol-d<sub>4sub>; 5-Chloro-2-hydroxytoluene-d<sub>4sub>	Isotope-Labeled Compounds	Others
4-Chloro-2-methylphenol-d₄ is the deuterium labeled 4-Chloro-2-methylphenol[1].

HY-N5034S

Phosphorylethanolamine-d4 Monoaminoethyl phosphate-d<sub>4sub>; NSC 254167-d<sub>4sub>; O-Phosphoethanolamine-d<sub>4sub>	Isotope-Labeled Compounds	Metabolic Disease
Phosphorylethanolamine-d₄ (Monoaminoethyl phosphate-d₄; NSC 254167-d₄) is a deuterium labeled Phosphorylethanolamine (HY-N5034). Phosphorylethanolamine is an endogenous metabolite.

HY-107542S

Oleoylethanolamide-d4 N-Oleoylethanolamide-d<sub>4sub>; Oleamide MEA-d<sub>4sub>; Oleic acid monoethanolamide-d<sub>4sub>	Isotope-Labeled Compounds Endogenous Metabolite PPAR	Cardiovascular Disease Metabolic Disease
Oleoylethanolamide-d₄ is the deuterium labeled Oleoylethanolamide. Oleoylethanolamide is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis.

HY-B0017S

Telbivudine-d4 Epavudine-d<sub>4sub>; L-Thymidine-d<sub>4sub>; NV 02B-d<sub>4sub>	Isotope-Labeled Compounds HBV	Infection
Telbivudine-d₄ is deuterium labeled Telbivudine. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication[1].

HY-B0579S

Cyclosporin A-d4 Cyclosporine A-d<sub>4sub>; Ciclosporin A-d<sub>4sub>; CsA-d<sub>4sub>	Antibiotic Complement System Phosphatase	Inflammation/Immunology Cancer
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-16582AS

Sonidegib-d4 Erismodegib-d<sub>4sub>; LDE225-d<sub>4sub>; NVP-LDE225-d<sub>4sub>	Isotope-Labeled Compounds	Others
Sonidegib-d4 is a isotope of Sonidegib. Sonidegib is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively .

HY-10581AS1

Gatifloxacin-d4 hydrochloride AM-1155-d<sub>4sub> hydrochloride; BMS-206584-d<sub>4sub> hydrochloride; PD135432-d<sub>4sub> hydrochloride	Antibiotic Bacterial Topoisomerase Isotope-Labeled Compounds	Infection
Gatifloxacin-d₄ (AM-1155-d₄; BMS-206584-d₄; PD135432-d₄) hydrochloride is deuterium-labeled Gatifloxacin (hydrochloride) (HY-10581A) .

HY-W700069

Gatifloxacin-d4 AM-1155-d<sub>4sub>; BMS-206584-d<sub>4sub>; PD135432-d<sub>4sub>	Isotope-Labeled Compounds	Others
Gatifloxacin-d4 is the deuterium labeled Gatifloxacin .

HY-78004S1

1,2-Diphenylethane-d4 Dibenzil-d<sub>4sub>; s-Diphenylethane-d<sub>4sub>; Bibenzyl-d<sub>4sub>	Isotope-Labeled Compounds	Others
1,2-Diphenylethane-d4 (Dibenzil-d4; s-Diphenylethane-d4; Bibenzyl-d4) is the deuterium labeled Bibenzyl (HY-78004) .

HY-17422S1

Acyclovir-d4 Aciclovir-d<sub>4sub>; Acycloguanosine-d<sub>4sub>	Isotope-Labeled Compounds HSV Bacterial Apoptosis Antibiotic	Infection Cancer
Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1][2][3]. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[4].

HY-B0548AS1

Hydroxyzine-d4' dihydrochloride Vistaril-d<sub>4sub>' dihydrochloride; Atarax-dd<sub>4sub>' dihydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine-d₄ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2].

HY-B0035S

Sulfamethazine-d4 Sulfadimidine-d<sub>4sub>; Sulfadimerazine-d<sub>4sub>	Bacterial	Infection
Sulfamethazine-d₄ is a deuterium labeled Sulfamethazine (Sulfadimidine). Sulfamethazine is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections)[1][2].

HY-B1217S

Bronopol-d4 BNPD-d<sub>4sub>; BNPK-d<sub>4sub>	Isotope-Labeled Compounds Bacterial	Infection
Bronopol-d₄ is deuterium labeled Bronopol.

HY-W014839S1

Cyclamic acid-d4 sodium Cyclohexylsulfamic acid-sub>d<sub>4sub> sodium; Sodium cyclamate-sub>d<sub>4sub>	Isotope-Labeled Compounds	Others
Cyclamic acid-d4 (sodium) is the deuterium labeled Cyclamic acid (sodium) .

HY-15455S

Roflumilast-d4 APTA-2217-d<sub>4sub>; BYK 20869-d<sub>4sub>; B9302-107-d<sub>4sub>	Isotope-Labeled Compounds Phosphodiesterase (PDE) RSV	Inflammation/Immunology
Roflumilast-d₄ is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells[1][2].

HY-B1431S

Butylparaben-d4 Butyl parahydroxybenzoate-d<sub>4sub>; Butyl paraben-d<sub>4sub>; Butyl 4-hydroxybenzoate-d<sub>4sub>	Isotope-Labeled Compounds Bacterial Endogenous Metabolite	Infection
Butylparaben-d₄ is the deuterium labeled Butylparaben. Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.

HY-N0570S

Hydroxytyrosol-d4 DOPET-d<sub>4sub>; 3,4-Dihydroxyphenethyl alcohol-d<sub>4sub>; 3-Hydroxytyrosol-d<sub>4sub>	Isotope-Labeled Compounds Endogenous Metabolite Bacterial Fungal	Infection Inflammation/Immunology Cancer
Hydroxytyrosol-d₄ is the deuterium labeled Hydroxytyrosol. Hydroxytyrosol (DOPET) is a phenolic compound drawn from the olive tree and its leaves with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].

HY-B1290S

2-Phenylethanol-d4 Phenylethyl alcohol-d<sub>4sub>; Phenethyl alcohol-d<sub>4sub>; Benzyl carbinol-d<sub>4sub>	Bacterial Virus Protease Antibiotic	Infection
2-Phenylethanol-d₄ is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.

HY-Y1630S

NSC 10281-d4 Para-fluoronitrobenzene-d<sub>4sub>; p-Fluoronitrobenzene-d<sub>4sub>; p-Nitrofluorobenzene-d<sub>4sub>	Isotope-Labeled Compounds	Others
NSC 10281-d₄ is the deuterium labeled NSC 10281[1].

HY-157075S

(Z)-Rilpivirine-d4 R278474-d<sub>4sub>; TMC278-d<sub>4sub>; DB08864-d<sub>4sub>	Isotope-Labeled Compounds	Others
(Z)-Rilpivirine-d₄ (R278474-d₄; TMC278-d₄; DB08864-d₄) is deuterium-labeled (Z)-Rilpivirine .

HY-B0213S

Sulfameter-d4 Sulfametoxydiazine-d<sub>4sub>; 5-Methoxysulfadiazine-d<sub>4sub>	Isotope-Labeled Compounds	Others
Sulfameter-d₄ (Sulfametoxydiazine-d₄; 5-Methoxysulfadiazine-d₄)is the deuterium labeledSulfameter(HY-B0213) . Sulfameter (Sulfametoxydiazine; 5-Methoxysulfadiazine) is an effective long-acting sulfonamide antibiotic with antibacterial activities. Sulfameter can be used for the research of urinary tract infections and lepriasis .

HY-B0217S

Nitazoxanide-d4 NTZ-d<sub>4sub>; NSC-697855-d<sub>4sub>	Influenza Virus	Others
Nitazoxanide-d₄ is the deuterium labeled Nitazoxanide, which is an antiprotozoal agent.

HY-N1150S1

Thymidine-d4 DThyd-d<sub>4sub>; NSC 21548-d<sub>4sub>	DNA/RNA Synthesis Endogenous Metabolite	Others
Thymidine-d₄ is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3].

HY-14744S

Levamlodipine-d4 (S)-Amlodipine-d<sub>4sub>; Levoamlodipine-d<sub>4sub>	Isotope-Labeled Compounds Calcium Channel	Others
Levamlodipine-d₄ is the deuterium labeled Levamlodipine. Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina[1].

HY-17043S

Loratadine-d4 Loratidine-d<sub>4sub>; SCH 29851-d<sub>4sub>	Isotope-Labeled Compounds Histamine Receptor	Infection Inflammation/Immunology Endocrinology
Loratadine-d₄ is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-118901S

Opipramol-d4 Ensidon-d<sub>4sub>; G-33040-d<sub>4sub>	Sigma Receptor Isotope-Labeled Compounds	Others
Opipramol-d₄ is the deuterium labeled Opipramol[1].

HY-B1826S2

Adefovir-d4 GS-0393-d<sub>4sub>; PMEA-d<sub>4sub>	HBV Reverse Transcriptase	Infection
Adefovir-d₄ is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].

HY-B0105S1

Ketoconazole-d4 Ketoconazol-d<sub>4sub>; R 41400-d<sub>4sub>	Fungal Cytochrome P450 Ras	Infection Cancer
Ketoconazole-d₄ is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

HY-B0272S2

Rifampicin-d4 Rifampin-d<sub>4sub>; Rifamycin AMP-d<sub>4sub>	Bacterial Influenza Virus Antibiotic	Infection
Rifampicin-d₄ is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-14654S1

Aspirin-d4 Acetylsalicylic Acid-d<sub>4sub>; ASA-d<sub>4sub>	COX Autophagy Mitophagy Virus Protease	Inflammation/Immunology Cancer
Aspirin-d₄ is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL[1][2].

HY-B0150S

Nicotinamide-d4 1 Publications Verification Niacinamide-d<sub>4sub>; Nicotinic acid amide-d<sub>4sub>	Sirtuin Endogenous Metabolite	Neurological Disease Cancer
Nicotinamide-d₄ is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

Cat. No.	Product Name	Type

HY-W127572

Glycerol-d8 1,2,3-Propanetriol-d<sub>8sub>; Glycerin-d<sub>8sub>	Biochemical Assay Reagents
Glycerol-d₈ is the deuterium labeled Glycerol[1].

HY-109541S2

1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d9 DMPC-d<sub>9sub>	Drug Delivery
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d₉ is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine

HY-109541S1

1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d4 DMPC-d<sub>4sub>	Drug Delivery
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d₄ is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine

HY-W127840

Ethylene-d4-diamine 1,1,2,2-tetradeuterioethane-1,2-diamine-d<sub>4sub>	Biochemical Assay Reagents
Ethylene-d₄-diamine is the deuterium labeled Ethylene-diamine[1].

HY-W034392

Stewart-Grubbs catalyst

Biochemical Assay Reagents

Stewart-Grubbs catalyst is an effective catalyst for the cross-metathesis of olefins with a large number of allylic substituents. In addition, ChemBeads are chemically coated glass beads that improve flowability and chemical homogeneity, making them ideal for automated solid dispensing and high-throughput experiments. Notably, the manufacture of ChemBeads does not require additional chemicals or surfactants, allowing for precise dispensing of sub-milligram amounts of catalyst.

HY-109541S

1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d58 DMPC-d<sub>58sub>	Drug Delivery
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d₅₈ is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine

HY-109541S3

1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d13 DMPC-d<sub>13sub>	Drug Delivery
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d₁₃ is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine

HY-109541S4

1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d63 DMPC-d<sub>63sub>	Drug Delivery
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d₆₃ is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine

HY-109541S5

1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d67 DMPC-d<sub>67sub>	Drug Delivery
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d₆₇ is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine

HY-109541S6

(Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d72 (Rac)-DMPC-d<sub>72sub>	Drug Delivery
(Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d₇₂ is deuterium labeled (Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-ph

Cat. No.	Product Name	Target	Research Area

HY-P2274

Argifin	Parasite	Infection
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-N2466

Melanotan I 1 Publications Verification MT-I; [Nle4,D-Phe7]-α-MSH	Melanocortin Receptor	Neurological Disease Cancer
Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction ^[4].

HY-P1108A

Astressin 2B TFA	CFTR	Others
Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2-mediated inhibition of gastric emptying .

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Peptides	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent **Plasmodium subtilisin-like protease 1 (SUB1)** inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .

HY-P3426

BACE1-IN-10	Beta-secretase	Cancer
BACE1-IN-10 is a potent BACE1 Inhibitor. BACE1-IN-10 shows sub-micromolar activity against recombinant BACE1 (rBACE1) .

HY-P4756

*N-(2-Carbamoyl-ethyl)-Val-Leu-anilide*	Peptides	Others
N-(2-Carbamoyl-ethyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P1108

Astressin 2B	CFTR	Others
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying .

HY-P2592

Ro 23-7014	Peptides	Others
Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7) .

HY-P4521

*Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt*	MMP	Others
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate, and can be used to detect MMP12 enzyme activity .

HY-125628

Kahalalide A	Peptides	Infection
Kahalalide A is an anti-mycobacterial compound with antimicrobial activity. Kahalalide A is derived from the marine mollusk Elysia rufescens. Kahalalide A has attracted extensive attention in natural product research due to its potential medicinal value .

HY-P10272

Rusfertide PTG-300	Ferroportin	Others
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

Cat. No.	Product Name	Target	Research Area

HY-P99294

Ganitumab AMG 479; Human Anti-IGF1R Recombinant Antibody	IGF-1R	Cancer
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (K_D=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[4].

HY-W751835

Baloxavir-d4 Maximum Cited Publications 30 Publications Verification Baloxavir acid-d<sub>4sub>; S-033447-d<sub>4sub>	Classification of Application Fields Disease Research Fields Cancer	Isotope-Labeled Compounds
Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[4].

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[4].

HY-P99294

Ganitumab AMG 479; Human Anti-IGF1R Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	IGF-1R
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (K_D=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[3][4].

HY-N0662R

Amentoflavone (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[4].

HY-B0504S

Creatinine-d3 3 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

Species:	Human (13)
Tag:	GFP (3) His (12) Strep (5) Trx (1) Flag (7)
Source:	HEK293 (10) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P74650

	*PC4/SUB1 Protein, Human (His)* Activated RNA polymerase II transcriptional coactivator p15; PC4; p14; sub1; RPO2TC1	Human	E. coli
	The PC4/SUB1 protein acts as a multifunctional coactivator that cooperates with TAF to promote functional interactions between upstream activators and the general transcription machinery. Its role extends to the potential stability of multiprotein transcription complexes. PC4/SUB1 Protein, Human (His) is the recombinant human-derived PC4/SUB1 protein, expressed by E. coli , with N-His labeled tag. The total length of PC4/SUB1 Protein, Human (His) is 127 a.a., with molecular weight of ~19 kDa.

HY-P703334

	ABCF3 Protein, Human (HEK293, His, Strep, Flag) ATP-binding cassette sub-family F member 3; ABCF3; Homo sapiens; Human	Human	HEK293
	ABCF3 Protein, Human (HEK293, His, Strep, Flag) is the recombinant human-derived ABCF3, expressed by HEK293 , with Strep, His, Flag labeled tag. The total length of ABCF3 Protein, Human (HEK293, His, Strep, Flag) is 708 a.a.,

HY-P7621

	ABCB5 Protein, Human (Trx) rHuABCB5, N-Trx; ATP-binding cassette sub-family B member 5; P-glycoprotein ABCB5; ABCB5	Human	E. coli
	ABCB5, N-Trx Protein, Human is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.

HY-P703309

	ABCA6 Protein, Human (HEK293, His, Strep, Flag) ATP-binding cassette sub-family A member 6; ABCA6; Homo sapiens; Human; Translocase	Human	HEK293
	ABCA6 Protein, Human (HEK293, His, Strep, Flag) is the recombinant human-derived ABCA6, expressed by HEK293 , with Strep, His, Flag labeled tag. The total length of ABCA6 Protein, Human (HEK293, His, Strep, Flag) is 1616 a.a.,

HY-P72069

	ABCC1 Protein, Human (His) ABC 29; ABC29; ABCC 1; ABCC; Abcc1; ATP binding cassette sub family C CFTR/MRP; member 1; ATP binding cassette sub-family C member 1; ATP binding cassette subfamily C member 1; ATP binding cassette transporter variant ABCC1delta ex13; ATP binding cassette transporter variant ABCC1delta ex13&14; ATP binding cassette transporter variant ABCC1delta ex25; ATP binding cassette transporter variant ABCC1delta ex25&26; ATP binding cassette, sub-family C CFTR/MRP; , member 1; ATP-binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C4; transporter; LTC4 transporter; MRP 1; MRP; MRP1; MRP1_HUMAN; Multidrug resistance associated protein 1; Multidrug resistance protein; Multidrug resistance-associated protein 1; Multiple drug resistance associated protein; Multiple drug resistance protein 1	Human	E. coli
	ABCC1, Human (His) is a multitasking ATP-binding cassette (ABC) transporter. ABCC1, Human plays a part in inflammatory and other immunological diseases, age-related macular degeneration, cardiovascular disease, and certain neurological disorders as well as tumor progression.

HY-P701354

	ABCC4 Protein, Human (HEK293, GFP, Strep, His) ABCC4; ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B; Multidrug resistance-associated protein 4	Human	HEK293
	ABCC4 Protein, an ATP-binding cassette (ABC) family member, actively transports endogenous compounds (cAMP, cGMP, bile acids) and xenobiotics from cells. Its versatility extends to glutathione conjugates (LTC4, LTB4) and drug metabolites, mediating cotransport of bile acids with reduced glutathione. ABCC4's function includes resistance to anticancer agents like methotrexate, highlighting its role in cellular communication and drug transport. ABCC4 Protein, Human (HEK293, GFP, Strep, His) is the recombinant human-derived ABCC4 protein, expressed by HEK293 , with C-10*His, C-GFP, C-Strep labeled tag. The total length of ABCC4 Protein, Human (HEK293, GFP, Strep, His) is 1325 a.a., .

HY-P701355

	bABCC1 Protein, Human (HEK293, GFP, Strep, His) ABCC1; Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter; LTC4 transporter	Human	HEK293
	The bABCC1 protein plays a key role in cellular physiology, mediating the ATP-dependent export of a variety of substrates, including drugs and organic anions. Notably, it confers resistance to anticancer drugs, actively reducing their intracellular accumulation. bABCC1 Protein, Human (HEK293, GFP, Strep, His) is the recombinant human-derived bABCC1 protein, expressed by HEK293 , with C-10*His, C-GFP, C-Strep labeled tag. The total length of bABCC1 Protein, Human (HEK293, GFP, Strep, His) is 1530 a.a., .

HY-P701356

	bABCC1 Protein, Human (HEK293, E1454Q, GFP, Strep, His) ABCC1; Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter; LTC4 transporter	Human	HEK293
	The bABCC1 protein plays a key role in cellular physiology, mediating the ATP-dependent export of a variety of substrates, including drugs and organic anions. Notably, it confers resistance to anticancer drugs, actively reducing their intracellular accumulation. bABCC1 Protein, Human (HEK293, E1454Q, GFP, Strep, His) is the recombinant human-derived bABCC1 protein, expressed by HEK293 , with C-10*His, C-GFP, C-Strep labeled tag and E1454Q, , , , mutation. The total length of bABCC1 Protein, Human (HEK293, E1454Q, GFP, Strep, His) is 1530 a.a., .

HY-P703304

	ABCB10 Protein, Human (HEK293, Flag, His, E659Q) ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2; ABCB10; Homo sapiens; Human; ABC transporter 10 protein	Human	HEK293
	ABCB10 Protein, Human (HEK293, Flag, His, E659Q) is the recombinant human-derived ABCB10, expressed by HEK293 , with His, Flag labeled tag. ,

HY-P703305

	ABCB10 Protein, Human (HEK293, Flag, His, N229A) ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2; ABCB10; Homo sapiens; Human; ABC transporter 10 protein	Human	HEK293
	ABCB10 Protein, Human (HEK293, Flag, His, N229A) is the recombinant human-derived ABCB10, expressed by HEK293 , with His, Flag labeled tag. ,

HY-P703306

	ABCB10 Protein, Human (HEK293, Flag, His, N407A) ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2; ABCB10; Homo sapiens; Human; ABC transporter 10 protein	Human	HEK293
	ABCB10 Protein, Human (HEK293, Flag, His, N407A) is the recombinant human-derived ABCB10, expressed by HEK293 , with His, Flag labeled tag. ,

HY-P703307

	ABCB10 Protein, Human (HEK293, Flag, His, N229A, F398A) ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2; ABCB10; Homo sapiens; Human; ABC transporter 10 protein	Human	HEK293
	ABCB10 Protein, Human (HEK293, Flag, His, N229A, F398A) is the recombinant human-derived ABCB10, expressed by HEK293 , with His, Flag labeled tag. ,

HY-P703308

	ABCB10 Protein, Human (HEK293, Flag, His, N229A, N407A) ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2; ABCB10; Homo sapiens; Human; ABC transporter 10 protein	Human	HEK293
	ABCB10 Protein, Human (HEK293, Flag, His, N229A, N407A) is the recombinant human-derived ABCB10, expressed by HEK293 , with His, Flag labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-66005S

Acetaminophen-d4
Acetaminophen-d₄ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

HY-Y1042S

4-Cyanophenol-d4
4-Cyanophenol-d₄ is the deuterium labeled 4-Cyanophenol[1].

HY-B1008S

4-Aminobenzoic acid-d4
4-Aminobenzoic acid-d₄ is the deuterium labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.

HY-N0006S1

Demethoxycurcumin-d4
Demethoxycurcumin-d₄ is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin (Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties[1].

HY-B0329S

Isoniazid-d4
Isoniazid-d₄ is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].

HY-W009444S

5-Methyluridine-d4
5-Methyluridine-d₄ is the deuterium labeled 5-Methyluridine[1]. 5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids[2].

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-41680S

4-Aminobenzonitrile-d4
4-Aminobenzonitrile-d₄ is the deuterium labeled 4-Aminobenzonitrile[1].

HY-17413S2

Zidovudine-d4
Zidovudine-d₄ is deuterated labeled Zidovudine (HY-17413). Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.

HY-100048S

Acetylisoniazid-d4
Acetylisoniazid-d₄ is the deuterium labeled Acetylisoniazid[1].

HY-118861S

Enclomiphene-d4 hydrochloride
Enclomiphene-d₄ (hydrochloride) is a deuterium labeled Enclomiphene. Enclomiphene-d₄ (hydrochloride) is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property[1].

HY-109015S

Tucidinostat-d4
Tucidinostat-d₄ is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively[1].

HY-19696AS

Tauroursodeoxycholate-d4 sodium
Tauroursodeoxycholate-d₄ (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S1

Tauroursodeoxycholate-d4
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-B0389S24

D-Glucose-d4
D-Glucose-d₄ is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec

HY-B0696AS

Tiagabine-d4 hydrochloride
Tiagabine-d₄ hydrochloride is deuterated labeled Tiagabine hydrochloride (HY-B0696A). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC₅₀s of 67, 446 and 182 nM for [ ³H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .

HY-13273S

Ostarine-d4
Ostarine-d4 is a deuterated labeled Ostarine .

HY-34498S

4-Chloro-2-methylphenol-d4
4-Chloro-2-methylphenol-d₄ is the deuterium labeled 4-Chloro-2-methylphenol[1].

HY-N5034S

Phosphorylethanolamine-d4
Phosphorylethanolamine-d₄ (Monoaminoethyl phosphate-d₄; NSC 254167-d₄) is a deuterium labeled Phosphorylethanolamine (HY-N5034). Phosphorylethanolamine is an endogenous metabolite.

HY-107542S

Oleoylethanolamide-d4
Oleoylethanolamide-d₄ is the deuterium labeled Oleoylethanolamide. Oleoylethanolamide is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis.

HY-B0017S

Telbivudine-d4
Telbivudine-d₄ is deuterium labeled Telbivudine. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication[1].

HY-B0579S

Cyclosporin A-d4
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-16582AS

Sonidegib-d4
Sonidegib-d4 is a isotope of Sonidegib. Sonidegib is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively .

HY-10581AS1

Gatifloxacin-d4 hydrochloride
Gatifloxacin-d₄ (AM-1155-d₄; BMS-206584-d₄; PD135432-d₄) hydrochloride is deuterium-labeled Gatifloxacin (hydrochloride) (HY-10581A) .

HY-W700069

Gatifloxacin-d4
Gatifloxacin-d4 is the deuterium labeled Gatifloxacin .

HY-78004S1

1,2-Diphenylethane-d4
1,2-Diphenylethane-d4 (Dibenzil-d4; s-Diphenylethane-d4; Bibenzyl-d4) is the deuterium labeled Bibenzyl (HY-78004) .

HY-17422S1

Acyclovir-d4

Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1][2][3]. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[4].

HY-B0548AS1

Hydroxyzine-d4' dihydrochloride
Hydroxyzine-d₄ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2].

HY-B0035S

Sulfamethazine-d4
Sulfamethazine-d₄ is a deuterium labeled Sulfamethazine (Sulfadimidine). Sulfamethazine is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections)[1][2].

HY-B1217S

Bronopol-d4
Bronopol-d₄ is deuterium labeled Bronopol.

HY-W014839S1

Cyclamic acid-d4 sodium
Cyclamic acid-d4 (sodium) is the deuterium labeled Cyclamic acid (sodium) .

HY-15455S

Roflumilast-d4
Roflumilast-d₄ is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells[1][2].

HY-B1431S

Butylparaben-d4
Butylparaben-d₄ is the deuterium labeled Butylparaben. Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.

HY-N0570S

Hydroxytyrosol-d4
Hydroxytyrosol-d₄ is the deuterium labeled Hydroxytyrosol. Hydroxytyrosol (DOPET) is a phenolic compound drawn from the olive tree and its leaves with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].

HY-B1290S

2-Phenylethanol-d4

2-Phenylethanol-d₄ is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.

HY-Y1630S

NSC 10281-d4
NSC 10281-d₄ is the deuterium labeled NSC 10281[1].

HY-157075S

(Z)-Rilpivirine-d4
(Z)-Rilpivirine-d₄ (R278474-d₄; TMC278-d₄; DB08864-d₄) is deuterium-labeled (Z)-Rilpivirine .

HY-B0213S

Sulfameter-d4
Sulfameter-d₄ (Sulfametoxydiazine-d₄; 5-Methoxysulfadiazine-d₄)is the deuterium labeledSulfameter(HY-B0213) . Sulfameter (Sulfametoxydiazine; 5-Methoxysulfadiazine) is an effective long-acting sulfonamide antibiotic with antibacterial activities. Sulfameter can be used for the research of urinary tract infections and lepriasis .

HY-B0217S

Nitazoxanide-d4
Nitazoxanide-d₄ is the deuterium labeled Nitazoxanide, which is an antiprotozoal agent.

HY-N1150S1

Thymidine-d4
Thymidine-d₄ is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3].

HY-14744S

Levamlodipine-d4
Levamlodipine-d₄ is the deuterium labeled Levamlodipine. Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina[1].

HY-17043S

Loratadine-d4
Loratadine-d₄ is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-118901S

Opipramol-d4
Opipramol-d₄ is the deuterium labeled Opipramol[1].

HY-B1826S2

Adefovir-d4
Adefovir-d₄ is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].

HY-B0105S1

Ketoconazole-d4
Ketoconazole-d₄ is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

HY-B0272S2

Rifampicin-d4
Rifampicin-d₄ is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-14654S1

Aspirin-d4
Aspirin-d₄ is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL[1][2].

HY-B0150S

Nicotinamide-d4 1 Publications Verification
Nicotinamide-d₄ is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-B0360S

Rebamipide-d4
Rebamipide-d₄ is deuterium labeled Rebamipide. Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner[1].

HY-120734S

Quinoxyfen-d4
Quinoxyfen-d₄ is the deuterium labeled Quinoxyfen[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80527

	ABCB5 Antibody (YA836) ABCB5 P-gp; ATP binding cassette sub family B (MDR/TAP) member 5; P glycoprotein ABCB5	WB, ICC/IF	Human
	ABCB5 Antibody (YA836) is a non-conjugated and Mouse origined monoclonal antibody about 139 kDa, targeting to ABCB5 (8D2). It can be used for WB,ICC/IF assays with tag free, in the background of Human.

HY-P80772

	P Glycoprotein Antibody p-pg; PGP; ABCB1; MDR1; PGY1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD antigen CD243	WB	Human
	P Glycoprotein Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 141 kDa, targeting to P Glycoprotein. It can be used for WB assays with tag free, in the background of Human.

HY-P81118

	MRP2 Antibody ABC30 antibody; abcC2 antibody; ATP binding cassette sub family C (CFTR/MRP) member 2 antibody; ATP binding cassette subfamily C member 2 antibody; ATP-binding cassette sub-family C member 2 antibody; Canalicular multidrug resistance protein antibody; Canalicular multispecific organic anion transporter 1 antibody; CMOAT antibody; CMOAT1 antibody; cMRP antibody; DJS antibody; KIAA1010 antibody; MRP 2 antibody; MRP2_HUMAN antibody; Multidrug resistance associated protein 2 antibody; Multidrug resistance-associated protein 2 antibody;	WB, ICC/IF, FC	Human
	MRP2/ABCC2 Antibody is an unconjugated, approximately 174 kDa, rabbit-derived, anti-MRP2/ABCC2 monoclonal antibody. MRP2/ABCC2 Antibody can be used for: WB, ICC/IF, FC expriments in human background without labeling.

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Cat. No.	Product Name		Classification

HY-B0216S

Ethynyl Estradiol-d4 17α-Ethynylestradiol-d<sub>4sub>; Ethynylestradiol-d<sub>4sub>		Alkynes
Ethynyl Estradiol-d₄ is the deuterium labeled Ethynyl Estradiol. Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills. Ethynyl Estradiol-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-12008S

Erlotinib-d6 hydrochloride CP-358774-d<sub>6sub> hydrochloride; NSC 718781-d<sub>6sub> hydrochloride; OSI-774-d<sub>6sub> hydrochloride		Alkynes
Erlotinib-d₆ (hydrochloride) a deuterium labeled Erlotinib Hydrochloride. Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM[1]. Erlotinib-d6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-G0018S

Norgestimate metabolite norelgestromin-d6 17-Deacetyl norgestimate-d<sub>6sub>; 17-Deacylnorgestimate-d<sub>6sub>		Alkynes
Norgestimate metabolite norelgestromin-d₆ is the deuterium labeled Norgestimate metabolite norelgestromin. Norelgestromin is a metabolite of Norgestimate, which is a progestin or synthetic progestogen. Norgestimate metabolite norelgestromin-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17413S

Zidovudine-d3 Azidothymidine-d<sub>3sub>; AZT-d<sub>3sub>; ZDV-d<sub>3sub>		Azide
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-144162S

(Rac)-Selegiline-d5 hydrochloride (Rac)-Deprenyl-d<sub>5sub> hydrochloride; (±)-Selegiline-d<sub>5sub> hydrochloride; (±)-Deprenyl-d<sub>5sub> hydrochloride		Alkynes
(Rac)-Selegiline-d₅ (hydrochloride) is the deuterium labeled (Rac)-Selegiline hydrochloride[1].

HY-50896S

Erlotinib-d6 CP-358774-d<sub>6sub>; NSC 718781-d<sub>6sub>; OSI-774-d<sub>6sub>		Alkynes
Erlotinib-d₆ (CP-358774 D6) is a deuterium labeled Erlotinib (CP-358774). Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR[1]. Erlotinib-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0110S

Gestodene-d6 SHB 331-d<sub>6sub>; WL 70-d<sub>6sub>		Alkynes
Gestodene-d₆is the deuterium labeled Gestodene. Gestodene(SHB 331) is a progestogen hormonal contraceptive[1][2]. Gestodene-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-50896S1

Erlotinib-13C6 CP-358774-¹³C<sub>6sub>; NSC 718781-¹³C<sub>6sub>; OSI-774-¹³C<sub>6sub>		Alkynes
Erlotinib- ¹³C₆ is a ¹³C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].

HY-12008S1

Erlotinib-13C6 hydrochloride CP-358774-¹³C<sub>6sub> hydrochloride; NSC 718781-¹³C<sub>6sub> hydrochloride; OSI-774-¹³C<sub>6sub> hydrochloride		Alkynes
Erlotinib- ¹³C₆ (hydrochloride) is the ¹³C labeled Erlotinib Hydrochloride[1]. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM[2]. Erlotinib-13C6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17413S1

Zidovudine-13C,d3 Azidothymidine-¹³C,d<sub>3sub>; AZT-¹³C,d<sub>3sub>; ZDV-¹³C,d<sub>3sub>		Azide
Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-B0257S

Levonorgestrel-d8 D-Norgestrel-d<sub>8sub>		Alkynes
Levonorgestrel-d₈ is the deuterium labeled Levonorgestrel. Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives[1][2]. Levonorgestrel-d8 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0216S2

Ethynyl Estradiol-13C2 17α-Ethynylestradiol-¹³C<sub>2sub>; Ethynylestradiol-¹³C<sub>2sub>		Alkynes
Ethynyl Estradiol- ¹³C₂ is the ¹³C-labeled Ethynyl Estradiol. Ethynyl Estradiol-13C2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605BS

Rasagiline-13C3 mesylate racemic AGN1135-¹³C<sub>3sub>; TVP1012-¹³C<sub>3sub> racemic		Alkynes
Rasagiline- ¹³C₃ (mesylate racemic) is a ¹³C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor[1]. Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B1710S

Norethindrone acetate-d8 19-Norethindrone acetate-d<sub>8sub>		Alkynes
Norethindrone acetate-d₈ is the deuterium labeled Norethindrone acetate. Norethindrone acetate is a female hormone used for the research of endometriosis[1]. Norethindrone acetate-d8 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-150544S

N-Desmethyl selegiline-d5 hydrochloride (-)-N-Desmethylselegiline-d<sub>5sub> hydrochloride		Alkynes
N-Desmethyl Selegiline-dd₅ hydrochloride is the deuterium labeled N-Desmethyl Selegiline hydrochloride[1]. N-Desmethyl Selegiline-d5 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-167690

MK-6186		Alkynes
MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with sub-nanomolar activity against wild-type viruses and the two most common NNRTI-resistant RT mutants (K103N and Y181C). MK-6186 exhibits excellent antiviral activity against K103N and Y181C mutant viruses. When MK-6186 targets 12 common NNRTI-associated mutant viruses, only two relatively rare mutants (Y188L and V106I/Y188L) show high resistance, with FC values exceeding 100, while the FC values of the remaining viruses are all below 10. In addition, when MK-6186 faces 96 clinical virus isolates carrying NNRTI-resistant mutations, most (70%) viruses show more than 10-fold resistance to efavirenz (EFV), while only 29% of mutant viruses show more than 10-fold resistance to MK-6186 .

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