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Fluorene-d<sub>8</sub>

" in MedChemExpress (MCE) Product Catalog:

3729

Inhibitors & Agonists

10

Biochemical Assay Reagents

6

Peptides

1

Inhibitory Antibodies

11

Natural
Products

11

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3651

Isotope-Labeled Compounds

4

Antibodies

16

Click Chemistry

1

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W026772S
    Fluorene-d10

    		Fluorescent Dye Isotope-Labeled Compounds Others
    Fluorene-d10 is the deuterium labeled Fluorene. Fluorene, a polycyclic aromatic hydrocarbon (PAH), is a precursor to other fluorene compounds. Fluorene and its derivative can be used as a precursor to fluorene-based dyes[1].
    Fluorene-d10
  • HY-17037S1
    Pirenzepine-d8 dihydrochloride

    LS 519-d<sub>8sub> dihydrochloride; Pirenzepin-d<sub>8sub> dihydrochloride; Gastrozepin-d<sub>8sub> dihydrochloride

    		 Isotope-Labeled Compounds mAChR Cancer
    Pirenzepine-d8 (LS 519-d8; Pirenzepin-d8) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .
    Pirenzepine-d8 dihydrochloride
  • HY-W014340S
    2-Nitro-9H-fluorene-d9

    		Isotope-Labeled Compounds Others
    2-Nitro-9H-fluorene-d9 is the deuterium labeled 2-Nitro-9H-fluorene[1].
    2-Nitro-9H-fluorene-d9
  • HY-W026772S1
    Fluorene-d8

    		Isotope-Labeled Compounds Fluorescent Dye Reactive Oxygen Species TNF Receptor Interleukin Related SOD Inflammation/Immunology
    Fluorene-d8 is the deuterium labeled Fluorene (HY-W026772). Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .
    Fluorene-d8
  • HY-146227
    DNA topoisomerase II inhibitor 1

    		Topoisomerase Apoptosis Cancer
    DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .
    DNA topoisomerase II inhibitor 1
  • HY-RS13999
    SUB1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SUB1 Human Pre-designed siRNA Set A
    SUB1 Human Pre-designed siRNA Set A
  • HY-B1804S1
    Tricaprilin-d50

    Trioctanoin-d<sub>50sub>; Glyceryl trioctanoate-d<sub>50sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Neurological Disease Inflammation/Immunology
    Tricaprilin-d50 (Trioctanoin-d50 is the deuterium labeled Tricaprilin (HY-B1804). Tricaprilin is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT) .
    Tricaprilin-d50
  • HY-B1804S2
    Tricaprilin-d15

    Trioctanoin-d<sub>15sub>; Glyceryl trioctanoate-d<sub>15sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Neurological Disease Inflammation/Immunology
    Tricaprilin-d15 (Trioctanoin-d15 is the deuterium labeled Tricaprilin (HY-B1804). Tricaprilin is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT) .
    Tricaprilin-d15
  • HY-10844S1
    Pretomanid-d5

    PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>

    		 Antibiotic Bacterial Isotope-Labeled Compounds Infection Cancer
    Pretomanid-d5 is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.
    Pretomanid-d5
  • HY-P10215
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2

    		Parasite Infection
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2
  • HY-G0021S
    N-Desmethylclozapine-d8

    Norclozapine-d<sub>8sub>; Desmethylclozapine-d<sub>8sub>; Normethylclozapine-d<sub>8sub>

    		 mAChR Opioid Receptor Drug Metabolite Virus Protease Infection
    N-Desmethylclozapine-d8 is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].
    N-Desmethylclozapine-d8
  • HY-G0021S1
    N-Desmethylclozapine-d8 hydrochloride

    Norclozapine-d<sub>8sub> hydrochloride; Desmethylclozapine-d<sub>8sub> hydrochloride; Normethylclozapine-d<sub>8sub> hydrochloride

    		 mAChR Opioid Receptor Drug Metabolite Virus Protease Infection
    N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].
    N-Desmethylclozapine-d8 hydrochloride
  • HY-B0615AS
    Moricizine-d8(Hydrochloride)

    EN 313-d<sub>8sub>; Ethmozin-d<sub>8sub>; Moracizine-d<sub>8sub>

    		 Isotope-Labeled Compounds Cardiovascular Disease
    Moricizine-d8 (Hydrochloride) is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period[1][2].
    Moricizine-d8(Hydrochloride)
  • HY-14740S
    Elvitegravir-d8

    GS-9137-d<sub>8sub>; JTK-303-d<sub>8sub>; D06677-d<sub>8sub>

    		 Isotope-Labeled Compounds HIV Integrase HIV Infection
    Elvitegravir-d8 is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
    Elvitegravir-d8
  • HY-17037S
    Pirenzepine-d8

    LS 519-d<sub>8sub> free base; Pirenzepin-d<sub>8sub>; Gastrozepin-d<sub>8sub>

    		 Isotope-Labeled Compounds mAChR Neurological Disease Inflammation/Immunology
    Pirenzepine-d8 is the deuterium labeled Pirenzepine dihydrochloride. Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.
    Pirenzepine-d8
  • HY-50896S3
    Erlotinib-d8

    CP-358774-d<sub>8sub>; NSC 718781-d<sub>8sub>; OSI-774-d<sub>8sub>

    		 Isotope-Labeled Compounds Cancer
    Erlotinib-d8 (CP-358774-d8) is deuterium labeled Erlotinib. Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer . Erlotinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Erlotinib-d8
  • HY-10227S
    Bortezomib-d8

    PS-341-d<sub>8sub>; LDP-341-d<sub>8sub>; NSC 681239-d<sub>8sub>

    		 Proteasome NF-κB Apoptosis Autophagy Cancer
    Bortezomib-d8 is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity[1][2].
    Bortezomib-d8
  • HY-10570S2
    Nevirapine-d8

    BI-RG 587-d<sub>8sub>; NSC 641530-d<sub>8sub>; NVP-d<sub>8sub>

    		 Isotope-Labeled Compounds Reverse Transcriptase Parasite HIV Infection Cancer
    Nevirapine-d8 (BI-RG 587-d8) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM .
    Nevirapine-d8
  • HY-15531S
    Venetoclax-d8

    ABT-199-d<sub>8sub>; GDC-0199-d<sub>8sub>; RG7601-d<sub>8sub>

    		 Bcl-2 Family Autophagy Cancer
    Venetoclax-d8 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].
    Venetoclax-d8
  • HY-13463BS
    Avatrombopag-d8 hydrochloride

    AKR-501-d<sub>8sub> hydrochloride; E5501-d<sub>8sub> hydrochloride; YM477-d<sub>8sub> hydrochloride

    		 Isotope-Labeled Compounds Thrombopoietin Receptor Cardiovascular Disease
    Avatrombopag-d8 (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A[1][2][3].
    Avatrombopag-d8 hydrochloride
  • HY-13011S
    Alectinib-d8

    CH5424802-d<sub>8sub>; RO5424802-d<sub>8sub>; AF802-d<sub>8sub>

    		 Anaplastic lymphoma kinase (ALK) Cancer
    Alectinib-d8 is the deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].
    Alectinib-d8
  • HY-15581S
    MMAD-d8

    Demethyldolastatin 10-d<sub>8sub>; Monomethylauristatin D-d<sub>8sub>; Monomethyl Dolastatin 10-d<sub>8sub>

    		 ADC Cytotoxin Microtubule/Tubulin Cancer
    MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.
    MMAD-d8
  • HY-Y1309S
    1-Naphthol-d8

    Furro ER-d<sub>8sub>; NSC 9586-d<sub>8sub>; Nako TRB-d<sub>8sub>

    		 Endogenous Metabolite Others
    1-Naphthol-d8 is the deuterium labeled 1-Naphthol[1]. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe[2].
    1-Naphthol-d8
  • HY-N0623S5
    L-Tryptophan-d8

    Tryptophan-d<sub>8sub>; Tryptophane-d<sub>8sub>

    		 Endogenous Metabolite Metabolic Disease
    L-Tryptophan-d8 is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
    L-Tryptophan-d8
  • HY-B0272S1
    Rifampicin-d8

    Rifampin-d<sub>8sub>; Rifamycin AMP-d<sub>8sub>

    		 Bacterial Influenza Virus Antibiotic Infection
    Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.
    Rifampicin-d8
  • HY-N0378S
    D-Mannitol-d8

    Mannitol-d<sub>8sub>; Mannite-d<sub>8sub>

    		 Endogenous Metabolite Apoptosis Metabolic Disease
    D-Mannitol-d8 is the deuterium labeled D-Mannitol. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.
    D-Mannitol-d8
  • HY-N0007S
    Bisdemethoxycurcumin-d8

    Curcumin III-d<sub>8sub>; Didemethoxycurcumin-d<sub>8sub>

    		 Apoptosis Autophagy Cancer
    Bisdemethoxycurcumin-d8 is the deuterium labeled Bisdemethoxycurcumin. Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.
    Bisdemethoxycurcumin-d8
  • HY-B0104S2
    Glimepiride-d8

    Glimperide-d<sub>8sub>; HOE-490-d<sub>8sub>

    		 Amyloid-β Isotope-Labeled Compounds Metabolic Disease
    Glimepiride-d8 (Glimperide-d8; HOE-490-d8) is deuterium-labeled Glimepiride (HY-B0104) .
    Glimepiride-d8
  • HY-13502AS
    Mitoxantrone-d8 dihydrochloride

    Mitozantrone-d<sub>8sub>(dihydrochloride); NSC 301739-d<sub>8sub> dihydrochloride

    		 Endogenous Metabolite PKC Apoptosis Topoisomerase Orthopoxvirus Isotope-Labeled Compounds Infection Cancer
    Mitoxantrone-d8 dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
    Mitoxantrone-d8 dihydrochloride
  • HY-B0246S2
    Carbamazepine-d8

    CBZ-d<sub>8sub>; NSC 169864-d<sub>8sub>

    		 Isotope-Labeled Compounds Sodium Channel Autophagy Mitophagy Neurological Disease Cancer
    Carbamazepine-d8 is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent, with an IC50 of 131 μM .
    Carbamazepine-d8
  • HY-13502AS1
    Mitoxantrone-d8 hydrochloride

    Mitozantrone-d<sub>8sub> hydrochloride; NSC 301739-d<sub>8sub> hydrochloride

    		 Isotope-Labeled Compounds Endogenous Metabolite Apoptosis Orthopoxvirus PKC Topoisomerase Infection Cancer
    Mitoxantrone-d8 (hydrochloride) (Mitozantrone-d8 (hydrochloride)) is deuterium labeled Mitoxantrone (dihydrochloride). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
    Mitoxantrone-d8 hydrochloride
  • HY-90001S2
    Ritonavir-d8

    ABT 538-d<sub>8sub>; RTV-d<sub>8sub>

    		 Apoptosis HIV Protease SARS-CoV HIV Isotope-Labeled Compounds Infection Cancer
    Ritonavir-d8 is deuterated labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.61 μM.
    Ritonavir-d8
  • HY-13502S
    Mitoxantrone-d8

    Mitozantrone-d<sub>8sub>; NSC 301739-d<sub>8sub>

    		 Isotope-Labeled Compounds Topoisomerase PKC Cancer
    Mitoxantrone-d8 (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM[1][2].
    Mitoxantrone-d8
  • HY-W700392
    IMPDH-IN-2

    		IMPDH Cancer
    IMPDH-IN-2 (compound 2) is an inhibitor of inosine monophosphate dehydrogenase (IMPDH) with IC50 for IMPDH I and IMPDH II >Values are 0.15 and 0.17 μM, respectively. IMPDH-IN-2 has antitumor activity .
    IMPDH-IN-2
  • HY-B1955S
    4',4-Dibromobiphenyl-d8

    NSC 2098-d<sub>8sub>; PBB 15-d<sub>8sub>; p,p'-Dibromobiphenyl-d<sub>8sub>

    		 Isotope-Labeled Compounds Others
    4',4-Dibromobiphenyl-d8 is the deuterium labeled 4',4-Dibromobiphenyl[1].
    4',4-Dibromobiphenyl-d8
  • HY-34444S
    1,1-Dioxothiolan-d8

    Bondelane A-d<sub>8sub>; Cyclic tetramethylene sulfone-d<sub>8sub>; Cyclotetramethylene sulfone-d<sub>8sub>

    		 Isotope-Labeled Compounds Others
    1,1-Dioxothiolan-d8 is the deuterium labeled 1,1-Dioxothiolan[1].
    1,1-Dioxothiolan-d8
  • HY-107434S
    Molindone-d8

    (±)-Molindone-d<sub>8sub>; SPN-810M-d<sub>8sub>

    		 Isotope-Labeled Compounds Dopamine Receptor Neurological Disease
    Molindone-d8 is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses[1][2].
    Molindone-d8
  • HY-B1895S
    Levodropropizine-d8

    (S)-(-)-Dropropizine-d<sub>8sub>; DF-526-d<sub>8sub>

    		 Isotope-Labeled Compounds Histamine Receptor Inflammation/Immunology Endocrinology
    Levodropropizine-d8 is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.
    Levodropropizine-d8
  • HY-17507S2
    Pantoprazole-d8

    BY1023-d<sub>8sub>; SKF96022-d<sub>8sub>

    		 Isotope-Labeled Compounds Bacterial Autophagy Apoptosis Proton Pump Inflammation/Immunology Cancer
    Pantoprazole-d8 (BY1023-d8) is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole-d8
  • HY-13593S
    Chlorambucil-d8

    CB-1348-d<sub>8sub>; WR-139013-d<sub>8sub>

    		 Isotope-Labeled Compounds DNA Alkylator/Crosslinker Cancer
    Chlorambucil-d8 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].
    Chlorambucil-d8
  • HY-B0400S
    D-Sorbitol-d8

    Sorbitol-d<sub>8sub>; D-Glucitol-d<sub>8sub>

    		 Endogenous Metabolite Others
    D-Sorbitol-d8 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[1].
    D-Sorbitol-d8
  • HY-100665S
    Dehydroaripiprazole-d8

    OPC-14857-d<sub>8sub>; DM-14857-d<sub>8sub>

    		 Isotope-Labeled Compounds 5-HT Receptor Neurological Disease
    Dehydroaripiprazole-d8 is deuterium labeled Dehydroaripiprazole. Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole[1][2][3].
    Dehydroaripiprazole-d8
  • HY-G0016S2
    N-Acetyl dapsone-d8

    MADDS-d<sub>8sub>; Monoacetyldapsone-d<sub>8sub>

    		 Isotope-Labeled Compounds Others
    N-Acetyl Dapsone-d8 is the deuterium labeled N-Acetyl Dapsone[1].
    N-Acetyl dapsone-d8
  • HY-10617AS
    Rucaparib-d8

    AG014699-d<sub>8sub> ; PF-01367338-d<sub>8sub>

    		 Isotope-Labeled Compounds PARP Cancer
    Rucaparib-d8 (AG014699-d8 ) is deuterium labeled Rucaparib. Rucaparib (AG014699) is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP1. Rucaparib is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib has the potential for castration-resistant prostate cancer (CRPC) research .
    Rucaparib-d8
  • HY-10162S1
    Olaparib-d8

    AZD2281-d<sub>8sub>; KU0059436-d<sub>8sub>

    		 Isotope-Labeled Compounds PARP Autophagy Mitophagy Cancer
    Olaparib-d8 (AZD2281-d8) is the deuterium labeled Olaparib (HY-10162). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator .
    Olaparib-d8
  • HY-14667S
    Lomitapide-d8

    AEGR-733-d<sub>8sub>; BMS-201038-d<sub>8sub>

    		 Isotope-Labeled Compounds Cardiovascular Disease
    Lomitapide-d8 is deuterium labeled Lomitapide. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
    Lomitapide-d8
  • HY-17401S
    Ranolazine-d8 dihydrochloride

    CVT 303-dd<sub>8sub> dihydrochloride; RS 43285-d<sub>8sub>

    		 Calcium Channel Sodium Channel Autophagy Cardiovascular Disease Cancer
    Ranolazine-d8 (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor[3].
    Ranolazine-d8 dihydrochloride
  • HY-13001S
    Quizartinib-d8

    AC220-d<sub>8sub>; AC708-d<sub>8sub>

    		 Isotope-Labeled Compounds Ligands for Target Protein for PROTAC Apoptosis FLT3 Cancer
    Quizartinib-d8 (AC220-d8) is deuterium labeled Quizartinib. Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis .
    Quizartinib-d8
  • HY-132386S
    Imatinib-d8 mesylate

    STI571-d<sub>8sub> mesylate; CGP-57148B-d<sub>8sub> mesylate

    		 Isotope-Labeled Compounds Others
    Imatinib-d8 (mesylate) is the deuterium labeled Imatinib mesylate[1].
    Imatinib-d8 mesylate
  • HY-W013376S
    Norcyclizine-d8

    1-(Diphenylmethyl)piperazine-d<sub>8sub>; 1-Benzhydrylpiperazine-d<sub>8sub>

    		 Isotope-Labeled Compounds Cancer
    Norcyclizine-d8 is the deuterium labeled Norcyclizine .
    Norcyclizine-d8

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