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Diethyl butylmalonate-d<sub>9</sub>

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Click Chemistry:	PROTAC Synthesis (1) Azide (2) Alkynes (15)
Oligonucleotides:	Nucleosides and their Analogs (1) Pre-designed siRNA Sets (1) siRNAs (1)

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Isotope-Labeled Compounds

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Targets Recommended: P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-44178

**Diethyl butylmalonate**	Bacterial	Infection
Diethyl butylmalonate exhibits toxicity to T. pyriformis, with a log(IGC50 ^-1) of 0.557 .

HY-Y0836S

Diethyl succinate-13C4 1,4-Diethyl butanedioate-1,2,3,4-¹³C<sub>4sub>	Isotope-Labeled Compounds	Metabolic Disease
Diethyl succinate- ¹³C₄ is the ¹³C labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].

HY-W025062

Diethyl pyridine-2,4-dicarboxylate	Others	Others
Diethyl pyridine-2,4-dicarb is a potent prolyl 4-hydroxylase-directed proinhibitor. Diethyl pyridine-2,4-dicarb inhibits prolyl hydroxylation and procollagen processing in chick-embryo calvaria .

HY-44178S

Diethyl butylmalonate-D9	Bacterial	Infection
Diethyl butylmalonate-d₉ is the deuterium labeled Diethyl butylmalonate[1]. Diethyl butylmalonate exhibits toxicity to T. pyriformis, with a log(IGC50-1) of 0.557[2].

HY-Y0836S1

Diethyl succinate-d4 Diethyl Butanedioate-d<sub>4sub>	Isotope-Labeled Compounds	Metabolic Disease
Diethyl succinate-d₄ is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].

HY-101417S1

Diethyl phosphate-d10-1 Diethyl phosphoric acid-d<sub>10sub>	Endogenous Metabolite	Others
Diethyl phosphate-d₁₀-1 is the deuterium labeled Diethyl phosphate[1]. Diethylphosphate (DEP) is product of metabolism and of environmental degradation of a commonly used insecticide Chlorpyrifos.

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-W015604S1

*2,3-Diethyl-5-methylpyrazine-d7* Pyrazine, 2,3-Diethyl-5-methyl-d<sub>7sub>	Isotope-Labeled Compounds	Others
2,3-Diethyl-5-methylpyrazine-d₇ is deuterated labeled 2,4-Dimethylthiazole.

HY-W150644S

*Benzaldehyde diethyl* acetal-d10** α,α-Diethoxytoluene-d<sub>10sub>	Isotope-Labeled Compounds	Others
Benzaldehyde diethyl acetal-d10 is a deuterated labeled Benzaldehyde diethyl acetal .

HY-W015604S

*2,3-Diethyl-5-methylpyrazine-13C2* Pyrazine, 2,3-Diethyl-5-methyl-¹³C<sub>2sub>	Isotope-Labeled Compounds	Others
2,3-Diethyl-5-methylpyrazine- ¹³C₂ is ¹³C labeled 4-Hydroxy-5-methylfuran-3(2H)-one.

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-W010056

Diethyl fumarate	Others	Inflammation/Immunology
Diethyl fumarate is a decomposition product of Malathion (an insecticide). Diethyl fumarate is a reputed skin irritant. Diethyl fumarate can causes non-immunologic contact urticaria on skin .

HY-Y0836

Diethyl succinate 1 Publications Verification Diethyl Butanedioate	Biochemical Assay Reagents Reactive Oxygen Species	Metabolic Disease Inflammation/Immunology
Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings .

HY-D0846

Diethyl pyrocarbonate	Biochemical Assay Reagents	Neurological Disease
Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling .

HY-Y1147

Diethyl maleate Maleic acid Diethyl ester	Biochemical Assay Reagents	Others
Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells .

HY-W111830

Diethyl terephthalate Terephthalic acid, Diethyl ester	Others	Others
Diethyl terephthalate (Terephthalic acid) is a monomer in the synthesis of polyethylene terephthalate (PET) material. Diethyl terephthalate is usually used as a substrate for isolating PET-degrading strains .

HY-130506

*Glutamic acid diethyl* ester**	Others	Others
Glutamic acid diethyl ester is a glutamate antagonist with potential biological activity. Glutamic acid diethyl ester is used in biochemical research to explore the mechanism of action of glutamate. Glutamic acid diethyl ester can also be used as a precursor for the synthesis of other compounds and has certain industrial application value. Glutamic acid diethyl ester shows certain application potential in compound development .

HY-Y1361

Diethyl D-(-)-tartrate D-(-)-Tartaric acid Diethyl ester	Biochemical Assay Reagents	Others
Diethyl D-(-)-tartrate (D-(-)-Tartaric acid diethyl ester) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-136376R

*Mefenpyr-diethyl* (Standard)**	Others	Others
Mefenpyr-diethyl (Standard) is the analytical standard of Mefenpyr-diethyl. This product is intended for research and analytical applications. Mefenpyr-diethyl is an herbicide safener, which protects crops against herbicide injury .

HY-Y0836R

Diethyl succinate (Standard)	Biochemical Assay Reagents Reactive Oxygen Species	Metabolic Disease Inflammation/Immunology
Diethyl succinate (Standard) is the analytical standard of Diethyl succinate. This product is intended for research and analytical applications. Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings .

HY-Y0284

Diethyl phthalate	Others	Endocrinology
Diethyl phthalate is an endocrine disruptor that has the activity of affecting the apoptosis system of PC12 cells. Diethyl phthalate is widely used in a variety of plastics and personal care products. Diethyl phthalate has shown the potential to induce male reproductive toxicity unrelated to androgens in animal experiments .

HY-Y0484S

1-Indanamine-d9 hydrochloride 1-Aminoindan-d<sub>9sub> hydrochloride; 1-Aminoindane-d<sub>9sub> hydrochloride; NSC 186227-d<sub>9sub> hydrochloride; 1-Aminoindane-d<sub>9sub> hydrochloride	Isotope-Labeled Compounds	Others
1-Indanamine-d₉ (1-Aminoindan-d₉; 1-Aminoindane-d₉; NSC 186227-d₉; 1-Aminoindane-d₉) hydrochloride is deuterium-labeled 1-Indanamine hydrochloride (HY-Y0484) .

HY-W703021

Diethyl chloromaleate	Biochemical Assay Reagents	Others
Diethyl chloromaleate is a biochemical reagent.

HY-167706

Diethyl-Lodoxamide	Others	Inflammation/Immunology
Diethyl-Lodoxamide is a highly potent GPR35 agonist with potential to inhibit inflammatory bowel disease. Diethyl-Lodoxamide activates GPR35 in humans, mice and rats, showing similar EC₅₀ values. Diethyl-Lodoxamide can alleviate the clinical symptoms of DSS-induced inflammatory bowel disease in mouse models, and the effect is better than the traditional drug 5-ASA. The pharmaceutical properties of Diethyl-Lodoxamide have been optimized to better meet the requirements of drug design .

HY-Y0284S

Diethyl phthalate-d4	Isotope-Labeled Compounds	Others
Diethyl phthalate-d₄ is the deuterium labeled Diethyl phthalate[1].

HY-Y0284S1

Diethyl phthalate-d10	Isotope-Labeled Compounds	Others
Diethyl phthalate-d₁₀ is the deuterium labeled Diethyl phthalate[1].

HY-Y0284S2

Diethyl phthalate-d14	Isotope-Labeled Compounds	Others
Diethyl phthalate-d₁₄ is the deuterium labeled Diethyl phthalate[1].

HY-17020S

Miglustat-d9 N-Butyldeoxynojirimycin-d<sub>9sub>; NB-DNJ-d<sub>9sub>; OGT 918-d<sub>9sub>	Isotope-Labeled Compounds Glucosylceramide Synthase (GCS)	Neurological Disease
Miglustat-d9 is the deuterium labeled Miglustat. Miglustat (N-Butyldeoxynojirimycin) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1) .

HY-110363

Miglustat-d9 hydrochloride N-Butyldeoxynojirimycin-d<sub>9sub> hydrochloride; NB-DNJ-d<sub>9sub> hydrochloride; OGT 918-d<sub>9sub> hydrochloride	Isotope-Labeled Compounds Glucosylceramide Synthase (GCS)	Neurological Disease
Miglustat-d₉ (hydrochloride) is the deuterium labeled Miglustat (hydrochloride). Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1)[1][2].

HY-B1260S3

Cetrimonium-d9(bromide) CTAB-d<sub>9sub>; Cetyltrimethylammonium-d<sub>9sub> bromide; Hexadecyltrimethylammonium-d<sub>9sub> bromide	Isotope-Labeled Compounds	Others
Cetrimonium-d₉ (bromide) is the deuterium labeled Cetrimonium bromide[1]. Cetrimonium bromide (CTAB) is an amine based cationic quaternary surfactant, is one of the components of the topical antiseptic Cetrimide.

HY-W015778S

2-Methoxy-5-methylphenol-d3 Isocreosole-d<sub>3sub>	Isotope-Labeled Compounds	Others
2-Methoxy-5-methylphenol-d₃ is deuterated labeled 2,3-Diethyl-5-methylpyrazine.

HY-B1290S1

2-Phenylethanol-d9 Phenylethyl alcohol-d<sub>9sub>; Phenethyl alcohol-d<sub>9sub>; Benzyl carbinol-d<sub>9sub>	Bacterial Virus Protease Antibiotic	Infection
2-Phenylethanol-d₉ is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.

HY-B1431S2

Butylparaben-d9 Butyl parahydroxybenzoate-d<sub>9sub>; Butyl paraben-d<sub>9sub>; Butyl 4-hydroxybenzoate-d<sub>9sub>	Isotope-Labeled Compounds	Infection
Butylparaben-d₉ (Butyl parahydroxybenzoate-d₉; Butyl paraben-d₉) is a deuterium labeled Butylparaben (HY-B1431).

HY-116790BS

(±)-Penbutolol-d9 (Rac)-Penbutolol-d<sub>9sub>; (±)-Isopenbutolol-d<sub>9sub>	5-HT Receptor Adrenergic Receptor Isotope-Labeled Compounds	Others
(±)-Penbutolol-d₉ is the deuterium labeled (±)-Penbutolol[1].

HY-17501S

Bambuterol-d9 hydrochloride (±)-Bambuterol-d<sub>9sub> hydrochloride; KWD-2183-d<sub>9sub> hydrochloride	Adrenergic Receptor	Endocrinology
Bambuterol-d₉ (hydrochloride) is the deuterium labeled Bambuterol. Bambuterol ((±)-Bambuterol) hydrochloride is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline.

HY-116790BSA

(±)-Penbutolol-d9 hydrochloride (Rac)-Penbutolol-d<sub>9sub> hydrochloride; (±)-Isopenbutolol-d<sub>9sub> hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology
(±)-Penbutolol-d₉ (hydrochloride) is a deuterium labeled (±)-Penbutolol hydrochloride. (+)-Penbutolol hydrochloride is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1].

HY-B1037S2

Salbutamol-d9 Albuterol-d<sub>9sub>; AH-3365-d<sub>9sub>	Isotope-Labeled Compounds Adrenergic Receptor	Neurological Disease Endocrinology
Salbutamol-d₉ is the deuterium labeled Salbutamol. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).

HY-B0269S

Rifapentine-d9 DL 473-d<sub>9sub>; Cyclopentylrifampicin-d<sub>9sub>	Bacterial Antibiotic	Infection
Rifapentine-d₉ is the deuterium labeled Rifapentine. Rifapentine (DL 473) is an antibiotic compound used in the treatment of tuberculosis.

HY-B1037S3

Salbutamol-d9 acetate Albuterol-d<sub>9sub> acetate; AH-3365-d<sub>9sub> acetate	Adrenergic Receptor	Endocrinology
Salbutamol-d₉ (acetate) is the deuterium labeled Salbutamol[1]. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).

HY-14865S

Omadacycline-d9 PTK 0796-d<sub>9sub>; Amadacycline-d<sub>9sub>	Bacterial Isotope-Labeled Compounds	Others
Omadacycline-d9 (PTK 0796-d9; Amadacycline-d9) is the deuterium labeled Omadacycline (HY-14865) that can be used as the internal standard for the analysis of Omadacycline .

HY-111935

*3,3'-Diethyl-9-methylthiacarbocyanine iodide*	Microtubule/Tubulin	Neurological Disease
3,3'-Diethyl-9-methylthiacarbocyanine iodide is a cyanine dye, also a tau aggregation inhibitor, with an IC₅₀ value of 0.28 μM for tau. 3,3'-Diethyl-9-methylthiacarbocyanine iodide can cause misfunction of the microtubule cytoskeleton. 3,3'-Diethyl-9-methylthiacarbocyanine iodide can be used for researching Alzheimer’s disease .

HY-15459S1

Cabazitaxel-d9 XRP6258-d<sub>9sub>; RPR-116258A-d<sub>9sub>; taxoid XRP6258-d<sub>9sub>	Isotope-Labeled Compounds Microtubule/Tubulin Autophagy	Cancer
Cabazitaxel-d₉ is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

HY-I1162

Diethyl acetamidomalonate Diethyl 2-acetamidomalonate	Biochemical Assay Reagents	Others
Diethyl 2-acetamidomalonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-120546S

Ulixacaltamide-d9 hydrochloride Z944-d<sub>9sub> hydrochloride; PRAX-944-d<sub>9sub> hydrochloride	Calcium Channel Isotope-Labeled Compounds	Others
Ulixacaltamide-d₉ (hydrochloride) salt is the deuterium labeled Ulixacaltamide hydrochloride[1].

HY-10237S

Boceprevir-d9 EBP 520-d<sub>9sub>; SCH 503034-d<sub>9sub>	Isotope-Labeled Compounds HCV Protease HCV SARS-CoV	Infection
Boceprevir-d₉ is the deuterium labeled Boceprevir. Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay[1][2][3][4][5]. Boceprevir inhibits SARS-CoV-2 3CLpro activity[6].

HY-113270AS

Actinine-d9 chloride γ-Butyrobetaine-d<sub>9sub> hydrochloride; Deoxycarnitine-d<sub>9sub> hydrochloride	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Actinine-d₉ chloride is the deuterium labeled Actinine chloride. Actinine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat[1][2].

HY-B0399S

L-Carnitine-d9 1 Publications Verification (R)-Carnitine-d<sub>9sub>; Levocarnitine-d<sub>9sub>	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease Metabolic Disease
L-Carnitine-d₉ is the deuterium labeled L-Carnitine. L-Carnitine (Levocarnitine) is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2].

HY-B2246S

L-Carnitine-d9 chloride (R)-Carnitine-d<sub>9sub> chloride; Levocarnitine-d<sub>9sub> chloride	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Carnitine-d₉ (chloride)e is the deuterium labeled L-Carnitine chloride. L-Carnitine chloride, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine chloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine chloride is an antioxidant. L-Carnitine chloride can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].

HY-17369BS

Tirofiban-d9 L700462-d<sub>9sub>; MK383-d<sub>9sub>	Isotope-Labeled Compounds Integrin	Cardiovascular Disease
Tirofiban-d₉ is deuterium labeled Tirofiban.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W010056

Diethyl fumarate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Others
Diethyl fumarate is a decomposition product of Malathion (an insecticide). Diethyl fumarate is a reputed skin irritant. Diethyl fumarate can causes non-immunologic contact urticaria on skin .

HY-Y0836

Diethyl succinate 1 Publications Verification Diethyl Butanedioate	Structural Classification Natural Products Microorganisms other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Biochemical Assay Reagents Reactive Oxygen Species
Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings .

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-P5069A

*Glutathione diethyl* ester TFA**	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glutathione diethyl ester (TFA) is a delivery agent for glutathione monoester, and thus for glutathione, in human cells and therefore could serve to decrease oxidative stress and toxicity .

HY-128720

Diethyl oxalpropionate	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-Y0836R

Diethyl succinate (Standard)	Structural Classification Natural Products Microorganisms other families Source classification Plants	Biochemical Assay Reagents Reactive Oxygen Species
Diethyl succinate (Standard) is the analytical standard of Diethyl succinate. This product is intended for research and analytical applications. Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-P99294

Ganitumab AMG 479; Human Anti-IGF1R Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	IGF-1R
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (K_D=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .

HY-N0662R

Amentoflavone (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-101417

Diethyl phosphate Diethyl phosphoric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Diethylphosphate (DEP) is product of metabolism and of environmental degradation of a commonly used insecticide Chlorpyrifos .

HY-W751835

Baloxavir-d4 Maximum Cited Publications 30 Publications Verification Baloxavir acid-d<sub>4sub>; S-033447-d<sub>4sub>	Classification of Application Fields Disease Research Fields Cancer	Isotope-Labeled Compounds
Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-B0504S

Creatinine-d3 3 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-133668

Monoethyl phthalate	Other disease Disease markers Endogenous metabolite	Drug Metabolite
Monoethyl phthalate is a metabolite of diethyl phthalate. Monoethyl phthalate acts as a urinary biomarker of phthalates exposure indicating the risks of thyroid cancer and benign nodule .

Cat. No.	Product Name	Chemical Structure

HY-Y0836S

Diethyl succinate-13C4
Diethyl succinate- ¹³C₄ is the ¹³C labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].

HY-Y0284S

Diethyl phthalate-d4
Diethyl phthalate-d₄ is the deuterium labeled Diethyl phthalate[1].

HY-44178S

Diethyl butylmalonate-D9
Diethyl butylmalonate-d₉ is the deuterium labeled Diethyl butylmalonate[1]. Diethyl butylmalonate exhibits toxicity to T. pyriformis, with a log(IGC50-1) of 0.557[2].

HY-Y0836S1

Diethyl succinate-d4
Diethyl succinate-d₄ is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].

HY-101417S1

Diethyl phosphate-d10-1
Diethyl phosphate-d₁₀-1 is the deuterium labeled Diethyl phosphate[1]. Diethylphosphate (DEP) is product of metabolism and of environmental degradation of a commonly used insecticide Chlorpyrifos.

HY-W015604S1

*2,3-Diethyl-5-methylpyrazine-d7*
2,3-Diethyl-5-methylpyrazine-d₇ is deuterated labeled 2,4-Dimethylthiazole.

HY-W150644S

*Benzaldehyde diethyl* acetal-d10**
Benzaldehyde diethyl acetal-d10 is a deuterated labeled Benzaldehyde diethyl acetal .

HY-W015604S

*2,3-Diethyl-5-methylpyrazine-13C2*
2,3-Diethyl-5-methylpyrazine- ¹³C₂ is ¹³C labeled 4-Hydroxy-5-methylfuran-3(2H)-one.

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-Y0484S

1-Indanamine-d9 hydrochloride
1-Indanamine-d₉ (1-Aminoindan-d₉; 1-Aminoindane-d₉; NSC 186227-d₉; 1-Aminoindane-d₉) hydrochloride is deuterium-labeled 1-Indanamine hydrochloride (HY-Y0484) .

HY-Y0284S1

Diethyl phthalate-d10
Diethyl phthalate-d₁₀ is the deuterium labeled Diethyl phthalate[1].

HY-Y0284S2

Diethyl phthalate-d14
Diethyl phthalate-d₁₄ is the deuterium labeled Diethyl phthalate[1].

HY-17020S

Miglustat-d9
Miglustat-d9 is the deuterium labeled Miglustat. Miglustat (N-Butyldeoxynojirimycin) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1) .

HY-110363

Miglustat-d9 hydrochloride
Miglustat-d₉ (hydrochloride) is the deuterium labeled Miglustat (hydrochloride). Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1)[1][2].

HY-B1260S3

Cetrimonium-d9(bromide)
Cetrimonium-d₉ (bromide) is the deuterium labeled Cetrimonium bromide[1]. Cetrimonium bromide (CTAB) is an amine based cationic quaternary surfactant, is one of the components of the topical antiseptic Cetrimide.

HY-W015778S

2-Methoxy-5-methylphenol-d3
2-Methoxy-5-methylphenol-d₃ is deuterated labeled 2,3-Diethyl-5-methylpyrazine.

HY-B1290S1

2-Phenylethanol-d9

2-Phenylethanol-d₉ is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.

HY-B1431S2

Butylparaben-d9
Butylparaben-d₉ (Butyl parahydroxybenzoate-d₉; Butyl paraben-d₉) is a deuterium labeled Butylparaben (HY-B1431).

HY-116790BS

(±)-Penbutolol-d9
(±)-Penbutolol-d₉ is the deuterium labeled (±)-Penbutolol[1].

HY-17501S

Bambuterol-d9 hydrochloride
Bambuterol-d₉ (hydrochloride) is the deuterium labeled Bambuterol. Bambuterol ((±)-Bambuterol) hydrochloride is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline.

HY-116790BSA

(±)-Penbutolol-d9 hydrochloride
(±)-Penbutolol-d₉ (hydrochloride) is a deuterium labeled (±)-Penbutolol hydrochloride. (+)-Penbutolol hydrochloride is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1].

HY-B1037S2

Salbutamol-d9
Salbutamol-d₉ is the deuterium labeled Salbutamol. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).

HY-B0269S

Rifapentine-d9
Rifapentine-d₉ is the deuterium labeled Rifapentine. Rifapentine (DL 473) is an antibiotic compound used in the treatment of tuberculosis.

HY-B1037S3

Salbutamol-d9 acetate
Salbutamol-d₉ (acetate) is the deuterium labeled Salbutamol[1]. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).

HY-14865S

Omadacycline-d9
Omadacycline-d9 (PTK 0796-d9; Amadacycline-d9) is the deuterium labeled Omadacycline (HY-14865) that can be used as the internal standard for the analysis of Omadacycline .

HY-15459S1

Cabazitaxel-d9
Cabazitaxel-d₉ is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

HY-120546S

Ulixacaltamide-d9 hydrochloride
Ulixacaltamide-d₉ (hydrochloride) salt is the deuterium labeled Ulixacaltamide hydrochloride[1].

HY-10237S

Boceprevir-d9
Boceprevir-d₉ is the deuterium labeled Boceprevir. Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay[1][2][3][4][5]. Boceprevir inhibits SARS-CoV-2 3CLpro activity[6].

HY-113270AS

Actinine-d9 chloride
Actinine-d₉ chloride is the deuterium labeled Actinine chloride. Actinine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat[1][2].

HY-B0399S

L-Carnitine-d9

1 Publications Verification

L-Carnitine-d₉ is the deuterium labeled L-Carnitine. L-Carnitine (Levocarnitine) is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2].

HY-B2246S

L-Carnitine-d9 chloride

L-Carnitine-d₉ (chloride)e is the deuterium labeled L-Carnitine chloride. L-Carnitine chloride, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine chloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine chloride is an antioxidant. L-Carnitine chloride can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].

HY-17369BS

Tirofiban-d9
Tirofiban-d₉ is deuterium labeled Tirofiban.

HY-B0228S14

Adenosine-d9
Adenosine-d₉ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio .

HY-W015855S

2-Methoxy-3-methylpyrazine-d3
2-Methoxy-3-methylpyrazine-d₃ is deuterated labeled 2,3-Diethyl-5-methylpyrazine.

HY-B0739AS

Citicoline-d9 sodium
Citicoline-d₉ (sodium) is the deuterium labeled Citicoline sodium. Citicoline sodium salt is an intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes and also exerts neuroprotective effects.

HY-Y0453S

4-Carboethoxypiperidine-d9
4-Carboethoxypiperidine-d₉ is the deuterium labeled 4-Carboethoxypiperidine[1].

HY-N1446S5

Oleic acid-d9
Oleic acid-d₉ is deuterium labeled Oleic acid. Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator[1][2].

HY-14660S

Dabrafenib-d9
Dabrafenib-d₉ is the deuterium labeled Dabrafenib. Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively[4].

HY-101952S1

Prostaglandin E2-d9
Prostaglandin E2-d₉ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-B0131S2

Prostaglandin E1-d9
Prostaglandin E1-d₉ is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

HY-17552S

sn-Glycero-3-phosphocholine-d9

sn-Glycero-3-phosphocholine-d₉ is the deuterium labeled sn-Glycero-3-phosphocholine. sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia[1][2].

HY-Y1088S2

Hydrocinnamic acid-d9
Hydrocinnamic acid-d₉ is the deuterium labeled Hydrocinnamic acid[1]. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activitie[2]s.

HY-N0111S2

Coenzyme Q10-d9
Coenzyme Q10-d₉ is the deuterium labeled Coenzyme Q10. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

HY-B0896S2

Triacetin-d9
Glyceryl Triacetate-d₉ is the deuterium labeled Triacetin[1]. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.

HY-Y0012S1

4-Butylaniline-d9
4-Butylaniline-d₉ is the deuterium labeled 4-Butylaniline[1].

HY-W062703S

(Rac)-Ruxolitinib-d9
(Rac)-Ruxolitinib D9 ((Rac)-INCB18424 D9) is the deuterium labeled (Rac)-Ruxolitinib. (Rac)-Ruxolitinib is a JAK2 inhibitor .

HY-W423245S

*2,5-Diethyl-3-methylpyrazine-d3*
2,5-Diethyl-3-methylpyrazine-d₃ is deuterated labeled Sec-butyl butyrate.

HY-W778140

Diethyl phosphate-13C4 sodium
Diethyl phosphate- ¹³C4 (sodium) is the ¹³C labeled isotope of Diethyl phosphate- ¹³C4 (sodium)(HY-101417).Diethylphosphate (DEP) is product of metabolism and of environmental degradation of a commonly used insecticide Chlorpyrifos .

HY-12956S1

Dinoprost-d9
Dinoprost-d₉ is the deuterium labeled Dinoprost. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].

HY-Y0017S

L-Norleucine-d9
L-Norleucine-d₉ is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

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