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Ammonium-<sup>15</sup>N,d<sub>4</sub>

" in MedChemExpress (MCE) Product Catalog:

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3580

Inhibitors & Agonists

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163

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3202

Isotope-Labeled Compounds

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Click Chemistry

Oligonucleotides

Targets Recommended: P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W727879

Upadacitinib-15N,d2 ABT-494-<sup>15sup>N,d<sub>2sub>	Isotope-Labeled Compounds	Others
Upadacitinib- ¹⁵N,d₂ (ABT-494- ¹⁵N,d₂) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib- ¹⁵N,d₂ (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC₅₀=43 nM). Upadacitinib- ¹⁵N,d₂ (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib- ¹⁵N,d₂ (ABT-494) can be used for several autoimmune disorders research .

HY-129242S

Tempone-15N,d16 4-Oxo-Tempo-<sup>15sup>N,d<sub>16sub>	Isotope-Labeled Compounds	Others
Tempone- ¹⁵N,d₁₆ is the deuterium and ¹⁵N labeled Tempone[1].

HY-16973S

Fluralaner-13C2,15N,d3 A1443-<sup>13sup>C<sub>2sub>,<sup>15sup>N,d<sub>3sub>; AH252723-<sup>13sup>C<sub>2sub>,<sup>15sup>N,d<sub>3sub>	Isotope-Labeled Compounds Parasite	Infection
Fluralaner- ¹³C₂, ¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.

HY-A0042S2

Rufinamide-15N,d2-1 CGP 33101-<sup>15sup>N,d<sub>2sub>-1; E 2080-<sup>15sup>N,d<sub>2sub>-1; RUF 331-<sup>15sup>N,d<sub>2sub>-1	Isotope-Labeled Compounds	Neurological Disease
Rufinamide- ¹⁵N,d₂-1 (CGP 33101- ¹⁵N,d₂-1; E 2080- ¹⁵N,d₂-1; RUF 331- ¹⁵N,d₂-1) is ¹⁵N- and deuterium-labeled Rufinamide (HY-A0042) .

HY-10981S2

Lenvatinib-15N,d4 E7080-<sup>15sup>N,d<sub>4sub>	VEGFR c-Kit FGFR RET PDGFR Isotope-Labeled Compounds	Cancer
Lenvatinib- ¹⁵N,d₄ is ¹⁵N and deuterated labeled Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, *FGFR1-4, PDGFR, KIT, and RET*, shows potent antitumor activities .

HY-A0042S1

Rufinamide-15N,d2 CGP 33101-<sup>15sup>N,d<sub>2sub>; E 2080-<sup>15sup>N,d<sub>2sub>; RUF 331-<sup>15sup>N,d<sub>2sub>	Isotope-Labeled Compounds	Neurological Disease
Rufinamide- ¹⁵N,d₂ is the deuterium and ¹⁵N labeled Rufinamide[1]. Rufinamide is a new antiepileptic agent that differs structurally from other antiepileptic agents and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS)[2][3].

HY-N0650S9

L-Serine-15N,d3 (-)-Serine-<sup>15sup>N,d<sub>3sub>; (S)-Serine-<sup>15sup>N,d<sub>3sub>	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
L-Serine- ¹⁵N,d₃ is the deuterium and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0229S14

L-Alanine-15N,d4 L-2-Aminopropionic acid-<sup>15sup>N,d<sub>4sub>	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease Metabolic Disease
L-Alanine- ¹⁵N,d₄ is the deuterium and ¹⁵N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

HY-B0084S4

Dienogest-13C,15N,d4 STS 557-<sup>13sup>C,<sup>15sup>N,d<sub>4sub>	Isotope-Labeled Compounds Progesterone Receptor	Endocrinology
Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-N0229S5

L-Alanine-13C3,15N,d4 L-2-Aminopropionic acid-<sup>13sup>C<sub>3sub>,<sup>15sup>N,d<sub>4sub>	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease Metabolic Disease
L-Alanine- ¹³C₃, ¹⁵N,d₄ is the deuterium, ¹³C-, and 15-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

HY-17427S

Emtricitabine-15N,d2 BW1592-<sup>15sup>N,d<sub>2sub>	HIV Reverse Transcriptase Endogenous Metabolite	Infection
Emtricitabine- ¹⁵N,d₂ is a ¹⁵N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-N0650S3

L-Serine-13C3,15N,d3 (-)-Serine-<sup>13sup>C<sub>3sub>,<sup>15sup>N,d<sub>3sub>; (S)-Serine-<sup>13sup>C<sub>3sub>,<sup>15sup>N,d<sub>3sub>	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
L-Serine- ¹³C₃, ¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-A0166S

Cilastatin-15N,d3 MK0791-<sup>15sup>N,d<sub>3sub>	Bacterial Antibiotic	Infection
Cilastatin- ¹⁵N,d₃ is a ¹⁵N-labeled and deuterium labeled Cilastatin. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin is an antibacterial adjunct[1][2][3].

HY-N0717S2

L-Valine-13C5,15N,d8 Valine-<sup>13sup>C<sub>5sub>,<sup>15sup>N,d<sub>8sub>	Isotope-Labeled Compounds Endogenous Metabolite	Others
L-Valine- ¹³C₅, ¹⁵N,d₈ is the deuterium, ¹³C-, and 15-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].

HY-N0717S3

L-Valine-13C5,15N,d2 Valine-<sup>13sup>C<sub>5sub>,<sup>15sup>N,d<sub>2sub>	Isotope-Labeled Compounds Endogenous Metabolite	Others
L-Valine- ¹³C₅, ¹⁵N,d₂ is the deuterium, ¹³C-, and 15-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].

HY-B0250S

Lamivudine-15N,d2 BCH-189-<sup>15sup>N,d<sub>2sub>	HBV HIV Reverse Transcriptase Isotope-Labeled Compounds	Infection Cancer
Lamivudine- ¹⁵N,d₂ is ¹⁵N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-147737S

Ammonium-15N,d4 chloride	Isotope-Labeled Compounds	Others
Ammonium- ¹⁵N,d₄ (chloride) is the deuterium and ¹⁵N labeled Ammonium chloride[1].

HY-N0215S14

L-Phenylalanine-15N,d8 (S)-2-Amino-3-phenylpropionic acid-<sup>15sup>N,d<sub>8sub>	Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite	Metabolic Disease
L-Phenylalanine- ¹⁵N,d₈ is the deuterium and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-13613S2

Dutasteride-13C,15N,d GG 745-<sup>13sup>C,<sup>15sup>N,d; GI 198745-<sup>13sup>C,<sup>15sup>N,d	5 alpha Reductase Apoptosis Isotope-Labeled Compounds	Cancer
Dutasteride- ¹³C, ¹⁵N,d is ¹⁵N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .

HY-N0215S9

L-Phenylalanine-13C9,15N,d8 (S)-2-Amino-3-phenylpropionic acid-<sup>13sup>C<sub>9sub>,<sup>15sup>N,d<sub>8sub>	Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite	Metabolic Disease
L-Phenylalanine- ¹³C₉, ¹⁵N,d₈ is the deuterium, ¹³C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-W653882

Carbamazepine-d2,15N CBZ-d<sub>2sub>,<sup>15sup>N; NSC 169864-d<sub>2sub>,<sup>15sup>N	Isotope-Labeled Compounds	Others
Carbamazepine-d2,15N is a deuterated labeled Carbamazepine-d2,15N .

HY-N0091S7

Hypoxanthine-15N4 1 Publications Verification Purin-6-ol-<sup>15sup>N<sub>4sub>; Sarcine-<sup>15sup>N<sub>4sub>	Endogenous Metabolite	Others
Hypoxanthine- ¹⁵N₄ is the ¹⁵N labeled Hypoxanthine[1]. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia[2].

HY-108213S1

Inosinic acid-15N4 dilithium 5'-IMP<sup>15sup>N<sub>4sub> dilithium; IMP-<sup>15sup>N<sub>4sub> dilithium; Inosine 5'-dihydrogen phosphate-<sup>15sup>N<sub>4sub> dilithium	Isotope-Labeled Compounds	Metabolic Disease
Inosinic acid- ¹⁵N₄ dilithium (5'-IMP-15N4 (dilithium); IMP-15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-15N4 (dilithium)) is ¹⁵N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .

HY-B0445S

NAD+-13C5 ammonium β-DPN-<sup>13sup>C<sub>5sub> Ammonium; β-NAD-<sup>13sup>C<sub>5sub> Ammonium; β-Nicotinamide Adenine Dinucleotide-<sup>13sup>C<sub>5sub> Ammonium	Isotope-Labeled Compounds	Metabolic Disease
NAD+-13C5 (ammonium) is the ¹³C labled NAD+ (HY-B0445), with an ammonium .

HY-108213S

Inosinic acid-13C10,15N4 dilithium 5'-IMP-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>4sub> dilithium; IMP-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>4sub> dilithium; Inosine 5'-dihydrogen phosphate-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>4sub> dilithium	Isotope-Labeled Compounds	Metabolic Disease
Inosinic acid- ¹³C₁₀, ¹⁵N₄ dilithium (5'-IMP-13C10,15N4 (dilithium); IMP-13C10,15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-13C10,15N4 (dilithium)) is ¹³C- and ¹⁵N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .

HY-N0091S

Hypoxanthine-13C5,15N4 Purin-6-ol-<sup>13sup>C<sub>5sub>,<sup>15sup>N<sub>4sub>; Sarcine-<sup>13sup>C<sub>5sub>,<sup>15sup>N<sub>4sub>	Endogenous Metabolite Isotope-Labeled Compounds	Others
Hypoxanthine- ¹³C₅, ¹⁵N₄ is a ¹⁵N-labeled and ¹³C-labled Dansyl chloride.

HY-B0456S

Riboflavin-13C4,15N2 Vitamin B2-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>; E101-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>	Isotope-Labeled Compounds Endogenous Metabolite	Others
Riboflavin- ¹³C₄, ¹⁵N₂is the ¹³C-labeled and ¹⁵N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-B0456S1

Riboflavin-5-Phosphate-13C4,15N2-1 Vitamin B2-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>-1; E101-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>-1	Isotope-Labeled Compounds Endogenous Metabolite	Others
Riboflavin-5-Phosphate- ¹³C₄, ¹⁵N₂-1 is the ¹³C-labeled and ¹⁵N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.

HY-N0455AS1

L-Arginine-15N4 hydrochloride (S)-(+)-Arginine-<sup>15sup>N<sub>4sub> hydrochloride	Isotope-Labeled Compounds NO Synthase Endogenous Metabolite	Others
L-Arginine- ¹⁵N₄ (hydrochloride) is the ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis[1].

HY-N0667S2

L-Asparagine-15N2 monohydrate (-)-Asparagine-<sup>15sup>N<sub>2sub> monohydrate; Asn-<sup>15sup>N<sub>2sub> monohydrate; Asparamide-<sup>15sup>N<sub>2sub> monohydrate	Endogenous Metabolite	Neurological Disease
L-Asparagine- ¹⁵N₂ (monohydrate) is the ¹⁵N-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-D0184S2

2'-Deoxycytidine-15N3 Deoxycytidine-<sup>15sup>N<sub>3sub>; Cytosine deoxyriboside-<sup>15sup>N<sub>3sub>; Deoxyribose cytidine-<sup>15sup>N<sub>3sub>	Endogenous Metabolite	Others
2'-Deoxycytidine- ¹⁵N₃ is the ¹⁵N labeled 2'-Deoxycytidine[1]. 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu)[2].

HY-Y0271S

Urea-15N2 Carbamide-<sup>15sup>N<sub>2sub>; Carbonyldiamide-<sup>15sup>N<sub>2sub>	Endogenous Metabolite	Cardiovascular Disease Cancer
Urea- ¹⁵N₂ is the ¹⁵N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

HY-N1150S9

Thymidine-15N2 DThyd-<sup>15sup>N<sub>2sub>; NSC-<sup>15sup>N<sub>2sub>	DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus	Cancer
Thymidine- ¹⁵N₂ is the ¹⁵N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].

HY-B0139AS

Flucytosine-15N3 hydrochloride 5-Fluorocytosine-<sup>15sup>N<sub>3sub> hydrochloride; NSC 103805-<sup>15sup>N<sub>3sub> hydrochloride; Ro 2-9915-<sup>15sup>N<sub>3sub> hydrochloride	Isotope-Labeled Compounds	Others
Flucytosine- ¹⁵N₃ hydrochloride is ¹⁵N labeled Flucytosine.

HY-15306S

Eltrombopag-13C4 1 Publications Verification SB-497115-<sup>13sup>C<sub>4sub>	Thrombopoietin Receptor Bacterial Apoptosis	Infection Cardiovascular Disease Cancer
Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells ^[4] .}

HY-B1654S

Flavin adenine dinucleotide-13C5 ammonium FAD-<sup>13sup>C<sub>5sub> Ammonium	Isotope-Labeled Compounds	Cardiovascular Disease
Flavin adenine dinucleotide- ¹³C5 (FAD- ¹³C5) ammonium is ¹³C labeled Flavin adenine dinucleotide (HY-B1654). Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

HY-119695AS1

Simvastatin acid-d9 ammonium Tenivastatin-d<sub>9sub> Ammonium	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species Isotope-Labeled Compounds	Cardiovascular Disease Inflammation/Immunology
Simvastatin acid-d₉ ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-N0543S

Allantoin-13C2,15N4 5-Ureidohydantoin-<sup>13sup>C<sub>2sub>,<sup>15sup>N<sub>4sub>	Imidazoline Receptor Endogenous Metabolite	Cancer
Allantoin- ¹³C₂, ¹⁵N₄ is the ¹³C and ¹⁵N labeled Allantoin[1]. Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth[2].

HY-N0623S8

L-Tryptophan-15N2 Tryptophan-<sup>15sup>N<sub>2sub>; Tryptophane-<sup>15sup>N<sub>2sub>	Endogenous Metabolite	Metabolic Disease
L-Tryptophan- ¹⁵N₂ is the ¹⁵N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0097S3

Guanosine-15N5 DL-Guanosine-<sup>15sup>N<sub>5sub>; Vernine-<sup>15sup>N<sub>5sub>	HSV Endogenous Metabolite	Infection
Guanosine- ¹⁵N₅ is the ¹⁵N labeled Guanosine[1]. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity[2].

HY-N0455AS9

L-Arginine-15N4,d7 hydrochloride (S)-(+)-Arginine-<sup>15sup>N<sub>4sub>,d<sub>7sub> hydrochloride	Isotope-Labeled Compounds NO Synthase Endogenous Metabolite	Others
L-Arginine- ¹⁵N₄,d₇ (hydrochloride) is the deuterium and ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-119695AS2

Simvastatin acid-d3 ammonium Tenivastatin-d<sub>3sub> Ammonium	Reactive Oxygen Species HMG-CoA Reductase (HMGCR) Isotope-Labeled Compounds	Inflammation/Immunology
Simvastatin acid-d₃ (Tenivastatin-d₃) ammonium is deuterium-labeled Simvastatin acid (ammonium) (HY-119695A) .

HY-N0455AS8

L-Arginine-13C6,15N4 hydrochloride (S)-(+)-Arginine-<sup>13sup>C<sub>6sub>,<sup>15sup>N<sub>4sub> hydrochloride	NO Synthase Endogenous Metabolite	Others
L-Arginine- ¹³C₆, ¹⁵N₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-90006S3

5-Fluorouracil-13C4,15N2 5-FU-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>	Apoptosis Nucleoside Antimetabolite/Analog HIV Endogenous Metabolite	Cancer
5-Fluorouracil- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].

HY-W012926S

Dihydrouracil-13C4,15N2 5,6-Dihydrouracil-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>	Endogenous Metabolite	Metabolic Disease
Dihydrouracil- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Dihydrouracil[1]. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].

HY-B0228S11

Adenosine-15N5 Adenine riboside-<sup>15sup>N<sub>5sub>; D-Adenosine-<sup>15sup>N<sub>5sub>	Isotope-Labeled Compounds	Cancer
Adenosine- ¹⁵N₅ (Adenine riboside- ¹⁵N₅; D-Adenosine- ¹⁵N₅) is the ¹⁵N labled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-17563S4

2'-Deoxyguanosine-15N5 Deoxyguanosine-<sup>15sup>N<sub>5sub>; Guanine deoxyriboside-<sup>15sup>N<sub>5sub>	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
2'-Deoxyguanosine- ¹⁵N₅ (Deoxyguanosine- ¹⁵N₅; Guanine deoxyriboside- ¹⁵N₅) is ¹⁵N labeled 2'-Deoxyguanosine (HY-17563). 2'-Deoxyguanosine (Deoxyguanosine) is deoxyguanosine.

HY-B1028S

Pantethine-15N2 D-Pantethine-<sup>15sup>N<sub>2sub>; LBF disulfide-<sup>15sup>N<sub>2sub>	Isotope-Labeled Compounds	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Pantethine- ¹⁵N₂ is the ¹⁵N₂ labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration ^[4] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7071A

Maduramicin ammonium Maduramycin Ammonium	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Bacterial Apoptosis Antibiotic
Maduramicin ammonium (Maduramycin ammonium) is isolated from the actinomycete Actinomadura rubra. Maduramicin ammonium (Maduramycin ammonium) is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection . Maduramicin ammonium (Maduramycin ammonium) induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways .

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[4].

HY-W751835

Baloxavir-d4 25+ Cited Publications Baloxavir acid-d<sub>4sub>; S-033447-d<sub>4sub>	Classification of Application Fields Disease Research Fields Cancer	Isotope-Labeled Compounds
Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-119695A

Simvastatin acid ammonium Tenivastatin Ammonium	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species
Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-B1645

Ammonium iron(III) citrate 20+ Cited Publications Ammonium ferric citrate; FAC	Ketones, Aldehydes, Acids Source classification Rutaceae Plants Disease Research Fields Citrus reticulata Blanco Cancer	Ferroptosis
Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis . Ammonium iron(III) citrate can enhance protein production .

HY-N7395A

Cyclic ADP-ribose ammonium cADPR Ammonium	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-113037C

Farnesyl Pyrophosphate ammonium Farnesyl diphosphate Ammonium	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	TRP Channel Endogenous Metabolite
Farnesyl Pyrophosphate ammonium salt, a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate ammonium salt is a TRPM2 (TRP Channel) agonist, and activates TRPM2 opening for ion influx. Farnesyl pyrophosphate ammonium salt is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis .

HY-Y0488A

Formic acid ammonium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Formic acid ammonium salt is an endogenous metabolite.

HY-Y0488AR

*Formic acid ammonium* (Standard)**	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Formic acid (ammonium) (Standard) is the analytical standard of Formic acid (ammonium). This product is intended for research and analytical applications. Formic acid ammonium salt is an endogenous metabolite.

HY-119695AR

*Simvastatin acid ammonium* (Standard)**	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species
Simvastatin acid (ammonium) (Standard) is the analytical standard of Simvastatin acid (ammonium). This product is intended for research and analytical applications. Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-76225

Ammonium glycyrrhizinate 20+ Cited Publications MonoAmmonium glycyrrhizinate; Glycyrrhizic acid Ammonium salt; Ammonium glycyrrhizate	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Source classification Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields	Others
Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.

HY-P0018B

Pepstatin Ammonium Maximum Cited Publications 32 Publications Verification Pepstatin A Ammonium	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	HIV Protease Autophagy
Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease .

HY-125954A

Uridine diphosphate glucuronic acid ammonium UDP-α-D-glucuronic acid Ammonium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid (ammonium) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid (ammonium), as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-N8277

Kdo2-Lipid A ammonium 2 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Toll-like Receptor (TLR) TNF Receptor
Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for *TLR4. Kdo2-Lipid A ammonium* stimulates the release of both TNF and PGE2 .

HY-N6911B

Licorice-saponin H2 ammonium (18β,20α)-Glycyrrhizic acid Ammonium	Triterpenes Structural Classification Leguminosae Terpenoids Source classification Plants Glycyrrhiza uralensis Fisch.	Others
Licorice-saponin H2 ammonium (compound 7) is a type of oleanolic acid triterpene glycoside that can be isolated from the roots of licorice .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[4].

HY-Y0261A

Ammonium sulphate,≥99.0%,AR	Classification of Application Fields Disease Research Fields Cancer	Others
Ammonium sulphate,≥99.0%,AR is an inorganic sulfate salt used for molecular biology .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[3][4].

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[4].

HY-N12231

Carbazomycin B	Structural Classification Monophenols Microorganisms Source classification Phenols	Antibiotic Bacterial Lipoxygenase
Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC₅₀ Of 1.5 µM ^[1]sup>[2]sup>[3]sup>[4].

HY-P99294

Ganitumab AMG 479; Human Anti-IGF1R Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	IGF-1R
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (K_D=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .

HY-N0662R

Amentoflavone (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[4].

HY-N11122

7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol	Structural Classification Natural Products Rhodiola rosea Linn. Source classification Crassulaceae Plants	Others
7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol is a cuminol glycoside. 7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol can be isolated from Rhodiola rosea sup>[1].

HY-B0504S

Creatinine-d3 3 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-N8824

Maackiaflavanone	Structural Classification Flavonoids Leguminosae Flavonones Source classification Maackia amurensis Rupr. et Maxim. Plants	Others
Maackiaflavanone (compound 4) is a kind of prenylated flavanone. Maackia can be isolated from M. amurensi.

HY-N3872

Ethyl β-D-glucopyranoside	Scabiosa stellata L. Structural Classification Natural Products Caprifoliaceae Source classification Plants	Others
Ethyl β-D-glucopyranoside (compound 10) is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellata LS.

HY-N8859

Isoiridogermanal 16-Hydroxyiridal	Structural Classification Natural Products Source classification Lridaceae Plants	Others
Isoiridogermanal can be isolated from the extract of rhizomes of Iris tectorum Maxim. Isoiridogermanal is cytotoxic with IC50 values of 11 μM and 23 μM against MCF-7 and C32 cell lines.

HY-N6790

Nonactin Ammonium ionophore I	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields	Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic HSP
Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including *K ⁺, and NH₄* ⁺ . Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin . Nonactin inhibits the surface expression of endogenous HSP60** .

HY-N3980

Guaiol Champacol; Guaiac alcohol	Infection Structural Classification Natural Products Classification of Application Fields Source classification Distemonanthus benthamianus Baill. Plants Compositae Disease Research Fields	Autophagy RAD51
Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC₅₀ of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions ^{[4]sup .}

HY-N8930

Eupatorin-5-methyl ether	Structural Classification Galinsoga parviflora Cav. Flavonoids Flavones Labiatae Source classification Plants	Others
Eupatorin-5-methyl ether (TMF) can be isolated from Orthosiphon stamineus. Eupatorin-5-methyl ether is a kind of flavonoid compound. Eupatorin-5-methyl ether inhibits NO production (IC50 5.5 μM).

HY-N3980R

Guaiol (Standard)	Structural Classification Natural Products Source classification Distemonanthus benthamianus Baill. Plants Compositae	Autophagy RAD51
Guaiol (Standard) is the analytical standard of Guaiol. This product is intended for research and analytical applications. Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions ^[3][4] .

Cat. No.	Product Name	Chemical Structure

HY-W727879

Upadacitinib-15N,d2

Upadacitinib- ¹⁵N,d₂ (ABT-494- ¹⁵N,d₂) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib- ¹⁵N,d₂ (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC₅₀=43 nM). Upadacitinib- ¹⁵N,d₂ (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib- ¹⁵N,d₂ (ABT-494) can be used for several autoimmune disorders research .

HY-129242S

Tempone-15N,d16
Tempone- ¹⁵N,d₁₆ is the deuterium and ¹⁵N labeled Tempone[1].

HY-16973S

Fluralaner-13C2,15N,d3
Fluralaner- ¹³C₂, ¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.

HY-A0042S2

Rufinamide-15N,d2-1
Rufinamide- ¹⁵N,d₂-1 (CGP 33101- ¹⁵N,d₂-1; E 2080- ¹⁵N,d₂-1; RUF 331- ¹⁵N,d₂-1) is ¹⁵N- and deuterium-labeled Rufinamide (HY-A0042) .

HY-10981S2

Lenvatinib-15N,d4
Lenvatinib- ¹⁵N,d₄ is ¹⁵N and deuterated labeled Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, *FGFR1-4, PDGFR, KIT, and RET*, shows potent antitumor activities .

HY-A0042S1

Rufinamide-15N,d2
Rufinamide- ¹⁵N,d₂ is the deuterium and ¹⁵N labeled Rufinamide[1]. Rufinamide is a new antiepileptic agent that differs structurally from other antiepileptic agents and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS)[2][3].

HY-N0650S9

L-Serine-15N,d3
L-Serine- ¹⁵N,d₃ is the deuterium and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0229S14

L-Alanine-15N,d4
L-Alanine- ¹⁵N,d₄ is the deuterium and ¹⁵N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

HY-B0084S4

Dienogest-13C,15N,d4

Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-N0229S5

L-Alanine-13C3,15N,d4
L-Alanine- ¹³C₃, ¹⁵N,d₄ is the deuterium, ¹³C-, and 15-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

HY-17427S

Emtricitabine-15N,d2
Emtricitabine- ¹⁵N,d₂ is a ¹⁵N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-N0650S3

L-Serine-13C3,15N,d3
L-Serine- ¹³C₃, ¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-A0166S

Cilastatin-15N,d3
Cilastatin- ¹⁵N,d₃ is a ¹⁵N-labeled and deuterium labeled Cilastatin. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin is an antibacterial adjunct[1][2][3].

HY-N0717S2

L-Valine-13C5,15N,d8
L-Valine- ¹³C₅, ¹⁵N,d₈ is the deuterium, ¹³C-, and 15-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].

HY-N0717S3

L-Valine-13C5,15N,d2
L-Valine- ¹³C₅, ¹⁵N,d₂ is the deuterium, ¹³C-, and 15-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].

HY-B0250S

Lamivudine-15N,d2
Lamivudine- ¹⁵N,d₂ is ¹⁵N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-147737S

Ammonium-15N,d4 chloride
Ammonium- ¹⁵N,d₄ (chloride) is the deuterium and ¹⁵N labeled Ammonium chloride[1].

HY-N0215S14

L-Phenylalanine-15N,d8

L-Phenylalanine- ¹⁵N,d₈ is the deuterium and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-13613S2

Dutasteride-13C,15N,d
Dutasteride- ¹³C, ¹⁵N,d is ¹⁵N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .

HY-N0215S9

L-Phenylalanine-13C9,15N,d8

L-Phenylalanine- ¹³C₉, ¹⁵N,d₈ is the deuterium, ¹³C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-W653882

Carbamazepine-d2,15N
Carbamazepine-d2,15N is a deuterated labeled Carbamazepine-d2,15N .

HY-N0091S7

Hypoxanthine-15N4 1 Publications Verification
Hypoxanthine- ¹⁵N₄ is the ¹⁵N labeled Hypoxanthine[1]. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia[2].

HY-108213S1

Inosinic acid-15N4 dilithium
Inosinic acid- ¹⁵N₄ dilithium (5'-IMP-15N4 (dilithium); IMP-15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-15N4 (dilithium)) is ¹⁵N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .

HY-B0445S

NAD+-13C5 ammonium
NAD+-13C5 (ammonium) is the ¹³C labled NAD+ (HY-B0445), with an ammonium .

HY-108213S

Inosinic acid-13C10,15N4 dilithium
Inosinic acid- ¹³C₁₀, ¹⁵N₄ dilithium (5'-IMP-13C10,15N4 (dilithium); IMP-13C10,15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-13C10,15N4 (dilithium)) is ¹³C- and ¹⁵N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .

HY-N0091S

Hypoxanthine-13C5,15N4
Hypoxanthine- ¹³C₅, ¹⁵N₄ is a ¹⁵N-labeled and ¹³C-labled Dansyl chloride.

HY-B0456S

Riboflavin-13C4,15N2
Riboflavin- ¹³C₄, ¹⁵N₂is the ¹³C-labeled and ¹⁵N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.

HY-B0456S1

Riboflavin-5-Phosphate-13C4,15N2-1
Riboflavin-5-Phosphate- ¹³C₄, ¹⁵N₂-1 is the ¹³C-labeled and ¹⁵N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.

HY-N0455AS1

L-Arginine-15N4 hydrochloride
L-Arginine- ¹⁵N₄ (hydrochloride) is the ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis[1].

HY-N0667S2

L-Asparagine-15N2 monohydrate
L-Asparagine- ¹⁵N₂ (monohydrate) is the ¹⁵N-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-D0184S2

2'-Deoxycytidine-15N3
2'-Deoxycytidine- ¹⁵N₃ is the ¹⁵N labeled 2'-Deoxycytidine[1]. 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu)[2].

HY-Y0271S

Urea-15N2
Urea- ¹⁵N₂ is the ¹⁵N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

HY-N1150S9

Thymidine-15N2
Thymidine- ¹⁵N₂ is the ¹⁵N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].

HY-B0139AS

Flucytosine-15N3 hydrochloride
Flucytosine- ¹⁵N₃ hydrochloride is ¹⁵N labeled Flucytosine.

HY-15306S

Eltrombopag-13C4

1 Publications Verification

Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells ^[4] .}

HY-B1654S

Flavin adenine dinucleotide-13C5 ammonium
Flavin adenine dinucleotide- ¹³C5 (FAD- ¹³C5) ammonium is ¹³C labeled Flavin adenine dinucleotide (HY-B1654). Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

HY-119695AS1

Simvastatin acid-d9 ammonium

Simvastatin acid-d₉ ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-N0543S

Allantoin-13C2,15N4
Allantoin- ¹³C₂, ¹⁵N₄ is the ¹³C and ¹⁵N labeled Allantoin[1]. Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth[2].

HY-N0623S8

L-Tryptophan-15N2
L-Tryptophan- ¹⁵N₂ is the ¹⁵N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0097S3

Guanosine-15N5
Guanosine- ¹⁵N₅ is the ¹⁵N labeled Guanosine[1]. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity[2].

HY-N0455AS9

L-Arginine-15N4,d7 hydrochloride
L-Arginine- ¹⁵N₄,d₇ (hydrochloride) is the deuterium and ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-119695AS2

Simvastatin acid-d3 ammonium
Simvastatin acid-d₃ (Tenivastatin-d₃) ammonium is deuterium-labeled Simvastatin acid (ammonium) (HY-119695A) .

HY-N0455AS8

L-Arginine-13C6,15N4 hydrochloride
L-Arginine- ¹³C₆, ¹⁵N₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-90006S3

5-Fluorouracil-13C4,15N2

5-Fluorouracil- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].

HY-W012926S

Dihydrouracil-13C4,15N2
Dihydrouracil- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Dihydrouracil[1]. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].

HY-B0228S11

Adenosine-15N5

Adenosine- ¹⁵N₅ (Adenine riboside- ¹⁵N₅; D-Adenosine- ¹⁵N₅) is the ¹⁵N labled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-17563S4

2'-Deoxyguanosine-15N5
2'-Deoxyguanosine- ¹⁵N₅ (Deoxyguanosine- ¹⁵N₅; Guanine deoxyriboside- ¹⁵N₅) is ¹⁵N labeled 2'-Deoxyguanosine (HY-17563). 2'-Deoxyguanosine (Deoxyguanosine) is deoxyguanosine.

HY-B1028S

Pantethine-15N2

Pantethine- ¹⁵N₂ is the ¹⁵N₂ labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration ^[4] .

HY-119695AS

Simvastatin acid-d6 ammonium

Simvastatin acid-d₆ (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].

HY-D0184S3

2'-Deoxycytidine-13C9,15N3
2'-Deoxycytidine- ¹³C₉, ¹⁵N₃ (Deoxycytidine- ¹³C₉, ¹⁵N₃; Cytosine deoxyriboside- ¹³C₉, ¹⁵N₃; Deoxyribose cytidine- ¹³C₉, ¹⁵N₃) is ¹³C and ¹⁵N-labeled 2'-Deoxycytidine (HY-D0184). 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).

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Species:	Human (16)
Tag:	GFP (3) His (13) Strep (5) Tag Free (1) GST (1) Trx (1) Flag (7)
Source:	HEK293 (10) Sf9 insect cells (1) E. coli (5)


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Ammonium-<sup>15</sup>N,d<sub>4</sub>

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