Search Result

Results for "

NOD/SCID female mice

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NOD-like Receptor (NLR) (41) 11β-HSD (4) 5 alpha Reductase (1) 5-HT Receptor (24) Acyltransferase (1) ADC Cytotoxin (1) Adenosine Deaminase (1) Adenosine Receptor (10) Adenylate Cyclase (1) Adiponectin Receptor (1) Adrenergic Receptor (10) AIM2 (1) Akt (19) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (2) Amino Acid Derivatives (1) Aminoacyl-tRNA Synthetase (1) Aminopeptidase (4) AMPK (17) Amylases (3) Amylin Receptor (1) Amyloid-β (24) Anaplastic lymphoma kinase (ALK) (10) Androgen Receptor (15) Angiotensin-converting Enzyme (ACE) (2) ANGPTL (1) Annexin A (1) Antibiotic (69) Antifolate (3) AP-1 (2) Apical Sodium-Dependent Bile Acid Transporter (3) Apolipoprotein (1) Apoptosis (227) Arrestin (2) Aryl Hydrocarbon Receptor (6) ASCT (3) Atg8/LC3 (2) ATM/ATR (1) ATP Synthase (2) Autophagy (49) Bacterial (132) Bcl-2 Family (15) Bcr-Abl (1) BCRP (3) Beclin1 (2) Beta-lactamase (6) Beta-secretase (5) Biochemical Assay Reagents (22) Bombesin Receptor (3) Bradykinin Receptor (4) Btk (3) c-Fms (3) c-Met/HGFR (12) c-Myc (2) Calcium Channel (27) CaMK (1) Cannabinoid Receptor (9) Carbonic Anhydrase (2) Casein Kinase (5) Caspase (20) CaSR (3) Cathepsin (3) CCR (1) CD20 (1) CD3 (3) CD38 (2) CD6 (1) CDK (17) Ceramidase (1) CFTR (1) Chemerin Receptor (1) Chloride Channel (1) Cholecystokinin Receptor (3) Cholinesterase (ChE) (23) ClpP (2) CMV (4) Complement System (3) COMT (1) COX (16) CRISPR/Cas9 (1) Cuproptosis (3) CXCR (5) Cytochrome P450 (22) DAGL (1) DAPK (1) Dengue virus (2) Deubiquitinase (4) DGK (1) Dihydroorotate Dehydrogenase (4) Dipeptidyl Peptidase (3) Discoidin Domain Receptor (2) DNA Methyltransferase (2) DNA-PK (1) DNA/RNA Synthesis (32) Dopamine Receptor (18) Dopamine Transporter (5) Dopamine β-hydroxylase (1) Drug Metabolite (8) Drug-Linker Conjugates for ADC (4) Dynamin (1) DYRK (3) E1/E2/E3 Enzyme (6) E3 Ligase Ligand-Linker Conjugates (2) EAAT (1) EBI2/GPR183 (2) EBV (4) EGFR (15) Elastase (1) Endogenous Metabolite (112) Enterovirus (3) Ephrin Receptor (1) Epigenetic Reader Domain (16) Epoxide Hydrolase (3) ERK (15) Estrogen Receptor/ERR (22) Eukaryotic Initiation Factor (eIF) (2) FAAH (1) FABP (2) Factor Xa (2) FAK (4) FAP (1) Farnesyl Transferase (1) FATP (1) Fatty Acid Synthase (FASN) (4) FBPase (1) Ferroptosis (16) FGFR (5) Filovirus (1) FLAP (2) Flavivirus (6) FLT3 (7) Fluorescent Dye (14) FOXO (1) Free Fatty Acid Receptor (2) Fungal (30) FXR (8) G protein-coupled Bile Acid Receptor 1 (1) G Protein-coupled Receptor Kinase (GRK) (1) G-quadruplex (3) GABA Receptor (12) Galectin (1) Gap Junction Protein (2) GCGR (7) GHSR (1) GLP Receptor (11) Glucocorticoid Receptor (6) Glucokinase (5) Glucosidase (9) Glucosylceramide Synthase (GCS) (1) GLUT (3) Glutaminase (2) Glutathione Peroxidase (4) Glutathione S-transferase (5) GlyT (1) GnRH Receptor (6) GPR109A (1) GPR119 (4) GPR52 (1) GPR68 (2) GPR88 (1) GSK-3 (6) Guanylate Cyclase (1) Haspin Kinase (2) HBV (13) HCN Channel (1) HCV (2) HDAC (23) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (5) Histamine Receptor (20) Histone Acetyltransferase (9) Histone Demethylase (6) Histone Methyltransferase (9) HIV (17) HIV Integrase (1) HMG-CoA Reductase (HMGCR) (1) HSP (11) HSV (9) Huntingtin (3) ICMT (1) IFNAR (5) IGF-1R (1) iGluR (19) IKK (12) Imidazoline Receptor (1) Indoleamine 2,3-Dioxygenase (IDO) (7) Influenza Virus (18) Insulin Receptor (3) Integrin (5) Interleukin Related (46) IRAK (5) IRE1 (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (32) Itk (3) JAK (10) JNK (10) Keap1-Nrf2 (20) Lactate Dehydrogenase (3) LAG-3 (3) Legumain (1) Leukotriene Receptor (1) Ligands for Target Protein for PROTAC (1) LIM Kinase (LIMK) (1) Lipase (2) Lipocalin Family (1) Liposome (9) Lipoxygenase (2) LPL Receptor (3) LRRK2 (4) LXR (1) mAChR (5) MAGL (4) MAP3K (2) MAP4K (2) MARCKS (2) Mas-related G-protein-coupled Receptor (MRGPR) (4) MCHR1 (GPR24) (2) MDM-2/p53 (15) MEK (5) Melanocortin Receptor (3) Melatonin Receptor (2) MetAP (1) mGluR (16) MicroRNA (1) Microtubule/Tubulin (22) Mineralocorticoid Receptor (1) Mitochondrial Metabolism (10) Mitophagy (5) MMP (19) Molecular Glues (1) Monoamine Oxidase (23) Mps1 (1) mTOR (10) MyD88 (1) Na+/Ca2+ Exchanger (3) Na+/H+ Exchanger (NHE) (2) Na+/K+ ATPase (6) nAChR (14) NADPH Oxidase (2) NAMPT (4) Necroptosis (1) NEKs (5) Neprilysin (3) Neurokinin Receptor (1) Neuropeptide Y Receptor (5) NF-κB (50) NO Synthase (16) Notch (5) NTPDase (1) Nuclear Hormone Receptor 4A/NR4A (3) OGA (1) Opioid Receptor (12) Orexin Receptor (OX Receptor) (4) Orphan Receptor (1) Orthopoxvirus (6) Oxidative Phosphorylation (4) P-glycoprotein (6) P-selectin (2) P2X Receptor (3) P2Y Receptor (3) p38 MAPK (18) p62 (3) PACAP Receptor (1) PAK (1) Parasite (49) PARP (11) PCSK9 (2) PD-1/PD-L1 (7) PDGFR (1) PDHK (2) PDI (3) Penicillin-binding protein (PBP) (4) PERK (3) PGE synthase (5) Phosphatase (7) Phosphodiesterase (PDE) (11) Phospholipase (2) Photosystem II (2) PI3K (16) Pim (7) PKA (9) PKC (12) PKD (4) Platelet-activating Factor Receptor (PAFR) (1) Polo-like Kinase (PLK) (1) Porcupine (1) Potassium Channel (8) PPAR (24) Progesterone Receptor (10) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (8) PROTAC Linkers (4) PROTACs (20) Protease Activated Receptor (PAR) (4) Proteasome (7) Protein Arginine Deiminase (2) Proton Pump (2) PSMA (3) PTEN (2) PTHR (4) Pyroptosis (5) Pyruvate Kinase (1) Radionuclide-Drug Conjugates (RDCs) (6) Raf (2) RANKL/RANK (2) RAR/RXR (8) Ras (14) Reactive Oxygen Species (28) Renin (1) RET (4) REV-ERB (1) Reverse Transcriptase (2) Ribosomal S6 Kinase (RSK) (3) RIP kinase (11) ROCK (5) ROR (7) ROS Kinase (9) RSV (2) RXFP Receptor (1) Salt-inducible Kinase (SIK) (3) SARS-CoV (28) Ser/Thr Protease (11) Serotonin Transporter (4) SGK (2) SGLT (4) SHP2 (2) Sigma Receptor (8) Sirtuin (12) Small Interfering RNA (siRNA) (9) Smo (1) SOD (3) Sodium Channel (19) Somatostatin Receptor (3) Src (4) SRPK (1) STAT (17) Stearoyl-CoA Desaturase (SCD) (5) STING (2) STK33 (1) Survivin (1) Syk (2) TAM Receptor (3) Tau Protein (5) Telomerase (2) TET Protein (1) TGF-beta/Smad (9) TGF-β Receptor (9) Thrombin (2) Thymidylate Synthase (1) Thyroid Hormone Receptor (2) Tie (2) TMV (1) TNF Receptor (24) Toll-like Receptor (TLR) (29) Topoisomerase (12) Transferrin Receptor (1) Transmembrane Glycoprotein (1) Trk Receptor (6) TRP Channel (15) Tryptophan Hydroxylase (1) TSH Receptor (2) Tyrosinase (1) URAT1 (2) Urea Transporter (1) VEGFR (5) Virus Protease (10) Wee1 (1) Wnt (8) Xanthine Oxidase (5) YAP (3) YB-1 (1) α-synuclein (4) β-catenin (2) β-glucuronidase (1) γ-secretase (7)
By Research Areas:	Cancer (740) Cardiovascular Disease (136) Endocrinology (94) Infection (299) Inflammation/Immunology (524) Metabolic Disease (299) Neurological Disease (435)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (2) Alkynes (13)
Oligonucleotides:	Solvents (2) Preservatives (1) Nucleosides and their Analogs (1) Fillers (1) Phospholipids (1) Antisense Oligonucleotides (6) siRNAs (9) pH Modifiers (1) Aptamers (3) Pre-designed siRNA Sets (9) CpG ODNs (2) Cationic Lipids (5) Adjuvant (1)

2042

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

169

Peptides

MCE Kits

Inhibitory Antibodies

347

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: NOD-like Receptor (NLR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W018723

4-Aminobenzamidine dihydrochloride 1 Publications Verification p-Aminobenzamidine dihydrochloride	Ser/Thr Protease	Cancer
4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor, also acting as a relatively weak urokinase type plasminogen activator (uPA) inhibitor (K_i=82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice .

HY-100691

NOD-IN-1 5+ Cited Publications	NOD-like Receptor (NLR)	Inflammation/Immunology
NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, *NOD1* and *NOD2, with IC₅₀* of 5.74 μM and 6.45 μM, respectively.

HY-147506

NOD2 antagonist 1	NOD-like Receptor (NLR)	Inflammation/Immunology
NOD2 antagonist 1 (compound 32) is a potent and selective *NOD2* antagonist with an IC₅₀ of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs .

HY-163274

NOD1 antagonist-1	NOD-like Receptor (NLR)	Inflammation/Immunology
NOD1 antagonist-1 (compound 37) exhibits an antagonistic activity towards *NOD1* and a weak NOD1/NOD2 selectivity, with IC₅₀s of 9.18 μM and 20.8 μM, respectively .

HY-168023

NOD1-IN-1	NOD-like Receptor (NLR)	Inflammation/Immunology
NOD1/-IN-1 (Compound 2) is a potent RIPK2 inhibitor with an IC₅₀ value of 0.65 nM determined by ADP-Glo assays. NOD1/-IN-1 selectively inhibits the *NOD1* pathway (with an IC₅₀ of 33 nM for NOD1), blocking the production of pro-inflammatory cytokines and thereby reducing inflammation. NOD1/-IN-1 is applicable for research in the field of colitis .

HY-168024

NOD1/2-IN-1	RIP kinase NOD-like Receptor (NLR)	Inflammation/Immunology
NOD1/2-IN-1 (Compound 18) is a potent RIPK2 inhibitor with an IC₅₀ value of 1.4 nM, as determined by the ADP-Glo assay. NOD1/2-IN-1 blocks the production of pro-inflammatory cytokines by inhibiting the *NOD1/NOD2* pathways, with IC₅₀ values of 18 nM and 170 nM for NOD1 and NOD2, respectively, thereby reducing inflammatory responses. NOD1/2-IN-1 can be used in studies related to colitis .

HY-146034

NOD1/2 antagonist-1	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
NOD1/2 antagonist-1 (compound 36b) is a potent *NOD1/2* (nucleotide-binding oligomerization domain-like receptor 1/2) dual antagonist, with IC₅₀ values of 1.13 (NOD1) and 0.77 μM (NOD2), respectively. NOD1/2 antagonist-1 has a acceptable T_1/2 (67.6 min). NOD1/2 antagonist-1 (compound 36b) can improve the antitumor efficacy of Paclitaxel (PTX) .

HY-159965

NOD1-RIPK2-IN-1	NOD-like Receptor (NLR) RIP kinase Interleukin Related	Inflammation/Immunology
NOD1-RIPK2-IN-1 (Compound 37) is a *NOD1-RIPK2* signaling pathway inhibitor with IC₅₀ values of 42 nM and 1.52 nM for *NOD1* and RIPK2, respectively. NOD1-RIPK2-IN-1 reduces the secretion of the pro-inflammatory cytokine IL-8 and can be used in the research of inflammation and immune-related diseases .

HY-168158

NOD2 agonist 3	NOD-like Receptor (NLR)	Inflammation/Immunology
NOD2 agonist 3 (Compound 5) is a potent *NOD2* agonist, with an EC₅₀ of 111.45 nM. NOD2 agonist 3 shows immunopotentiating effects .

HY-168136

NOD2 agonist 1	NOD-like Receptor (NLR)	Cancer
NOD2 agonist 1 (compund 3) is a potent *NOD2* agonist (EC50=4.6 nM) .

HY-RS09403

NOD1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NOD1 Human Pre-designed siRNA Set A contains three designed siRNAs for NOD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NOD1 Human Pre-designed siRNA Set A NOD1 Human Pre-designed siRNA Set A

HY-RS09404

Nod1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nod1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nod1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nod1 Mouse Pre-designed siRNA Set A Nod1 Mouse Pre-designed siRNA Set A

HY-RS09405

Nod1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nod1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nod1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nod1 Rat Pre-designed siRNA Set A Nod1 Rat Pre-designed siRNA Set A

HY-RS09406

NOD2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NOD2 Human Pre-designed siRNA Set A contains three designed siRNAs for NOD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NOD2 Human Pre-designed siRNA Set A NOD2 Human Pre-designed siRNA Set A

HY-RS09407

Nod2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nod2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nod2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nod2 Mouse Pre-designed siRNA Set A Nod2 Mouse Pre-designed siRNA Set A

HY-RS09408

Nod2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nod2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nod2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nod2 Rat Pre-designed siRNA Set A Nod2 Rat Pre-designed siRNA Set A

HY-168137

NOD2 agonist 2	Others	Inflammation/Immunology
NOD2 agonist 2 (compund 23) enhances antigen presentation by mouse bone marrow-derived dendritic cells (BMDCs), highlighting its potential as a vaccine adjuvant .

HY-149428

AD4 1 Publications Verification	PROTACs	Cancer
AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC₅₀: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy .

HY-158776

SLU-10482	Parasite	Infection
SLU-10482 is an orally active anti-parasitic agent, that inhibits Cryptosporidium parvum with an IC₅₀ of 0.0687 μM. SLU-10482 exhibits anti-infective efficacy in C. parvum infected mice with an AC₅₀ of 0.0686 μM .

HY-150186

RXFP2 agonist 2	RXFP Receptor	Metabolic Disease
RXFP2 agonist 2 is a selective，orally active and allosteric RXFP2 agonist with an EC₅₀ value of 0.38 µM. RXFP2 agonist 2 induces osteoblast mineralization. RXFP2 agonist 2 increases bone formation in female mice. RXFP2 agonist 2 has the potential for the research of osteoporosis .

HY-164039

Talorasib	Others	Cancer
Talorasib (compound 1-2) has antitumor activity .

HY-123782

(Rac)-UK-414495	Neprilysin	Metabolic Disease
(Rac)-UK-414495 (example 7) is a potent neutral endopeptidase (NEP) inhibitor. (Rac)-UK-414495 causes potentiation of cAMP in the sexual genitalia of the female .

HY-N12874

(E,E,Z)-10,12,14-Hexadecatrienal	Others	Others
(E,E,Z)-10,12,14-Hexadecatrienal is a pheromone that can be produced by female Manduca sexta .

HY-N12873

(E,E,E,)-10,12,14-Hexadecatrienal	Others	Others
(E,E,E,)-10,12,14-Hexadecatrienal is a pheromone that can be produced by female Manduca sexta .

HY-B1711

Norfenefrine	Adrenergic Receptor	Endocrinology
Norfenefrine is an orally active, endogenously found α-adrenergic agonist and can be used for the research of female stress incontinence .

HY-155864

AJ2-30	Others	Inflammation/Immunology
AJ2-30 is a SLCl5A4 inhibitor. AJ2-30 inhibits TLR9-mediated B cell activation. AJ2-30 block endogenous NOD signaling in human and mouse macrophages. AJ2-30 can be used for research of inflammation .

HY-W040047

Pregnanediol 3-glucuronide	Endogenous Metabolite	Endocrinology
Pregnanediol 3-glucuronide is the major terminal metabolite of progesterone, playing an important role in physiological processes, such as the female menstrual cycle, pregnancy (supports gestation), embryogenesis and maternal immune response of humans and other species .

HY-100426A

Osemozotan hydrochloride MKC242	5-HT Receptor	Neurological Disease
Osemozotan hydrochloride (MKC242) is a selective 5-HT_1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder .

HY-118912

BMH-9	Orphan Receptor Others	Inflammation/Immunology Cancer
BMH-9 (Compound Z54) is a modulator for nuclear receptor subfamily 2, group F, member 6 (NR2F6) (also known as nuclear orphan receptor Ear2) . BMH-9 is an activator for p53 signaling pathway through interaction with DNA. BMH-9 inhibits proliferation of human cancer cells, exhibits antitumor efficacy in NOD-SCID mouse models .

HY-B1192

Estradiol benzoate 10+ Cited Publications β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Estrogen Receptor/ERR HBV Bcl-2 Family	Neurological Disease
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

HY-W099584

Butyl tetradecanoate Myristic SCID butyl ester	Biochemical Assay Reagents	Others
Butyl tetradecanoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-125858

MI-1061 1 Publications Verification	MDM-2/p53 E1/E2/E3 Enzyme Apoptosis	Cancer
MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC₅₀=4.4 nM; K_i=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity .

HY-125858A

MI-1061 TFA 1 Publications Verification	MDM-2/p53 E1/E2/E3 Enzyme Apoptosis	Cancer
MI-1061 TFA is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC₅₀=4.4 nM; K_i=0.16 nM). MI-1061 TFA potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity .

HY-24238

DLCI-1	Others	Others
DLCI-1 is a potent and selective oral inhibitor of cytochrome P450 2A6 (CYP2A6) that markedly reduces nicotine self-administration in both male and female mice.

HY-B1192R

Estradiol benzoate (Standard)	Estrogen Receptor/ERR HBV Bcl-2 Family	Neurological Disease
Estradiol benzoate (Standard) is the analytical standard of Estradiol benzoate. This product is intended for research and analytical applications. Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

HY-B0860

Diuron	ATP Synthase Others	Cancer
Diuron is a phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (2,500 ppm, dietary) increases the incidence of urinary bladder urothelial carcinomas in male and female mice by 73 and 27%, respectively.

HY-169240

MX69-102	MDM-2/p53	Cancer
MX69-102 (compound MX69-102) is an MDM-2/p53 inhibitor, inducing MDM2 degradation, resulting in p53 activation and cancer cell apoptosis. MX69-102 shows effective inhibition on xenografted human MDM2-overexpressing ALL in SCID mice. .

HY-133800

Volvaltrate B	Biochemical Assay Reagents	Cancer
Volvaltrate B is an anticancer agent, iridoid, can be obtained from the root of valerian (Valeriana officinalis). Volvaltrate B is effective against ovarian tumors in female mice. Volvaltrate B has the potential to study cancer .

HY-P99588

Stamulumab MYO-029	TGF-β Receptor	Metabolic Disease
Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research .

HY-P2300

Cyclo(Arg-Gly-Asp-D-Phe-Cys) Cyclo(RGDfC)	Integrin	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .

HY-P5544

M-TriDAP N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid	NOD-like Receptor (NLR)	Others
M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a *NOD1/2* agoist and biological active peptide .

HY-P5544A

M-TriDAP TFA N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid TFA	NOD-like Receptor (NLR)	Others
M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) TFA is a *NOD1/2* agoist and biological active peptide .

HY-136555

GSK717 5+ Cited Publications	NOD-like Receptor (NLR)	Inflammation/Immunology
GSK717 is a potent, selective *NOD2* (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC₅₀ of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells .

HY-B0860R

Diuron (Standard)	Others	Cancer
Diuron (Standard) is the analytical standard of Diuron. This product is intended for research and analytical applications. Diuron is a phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (2,500 ppm, dietary) increases the incidence of urinary bladder urothelial carcinomas in male and female mice by 73 and 27%, respectively.

HY-P1726A

MSG606 TFA	Melanocortin Receptor	Cancer
MSG606 TFA is a potent human MC1 receptor antagonist (IC₅₀=17 nM). MSG606 TFA also partial agonist at human MC3 and MC5 receptors (EC₅₀ values are 59 and 1300 nM, respectively). MSG606 TFA exhibits binding affinity for A375 melanoma cells in vitro. MSG606 TFA reverses the induced hyperalgesia in female mice, with no effect in male mice.

HY-158421

MS-L6	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
MS-L6 is a potent inhibitor of oxidative phosphorylation (OXPHOS) that can acts as electron transport chain complexes I (ETC-I) combining inhibition of NADH oxidation and uncoupling effect .

HY-168270

PROTAC ER Degrader-11	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ER Degrader-11 (Example 26-1) is a potent PROTAC ER degrader, with the IC₅₀ of 0.66 nM. PROTAC ER Degrader-11 plays an important role in cancer research(Sturcture Note:(Blue: Cereblon ligand (HY-W797329), Black: linker (HY-W262798)；Pink: ER ligand (HY-168271)) .

HY-W777963

(2E)-Octadecenal	Others	Endocrinology
(2E)-Octadecenal is a female pheromone targeting Lepidoptera insects, isolated from female Tineola bisselliella .

HY-W701835

(E,E)-10,12-Hexadecadienal	Others	Endocrinology
(E,E)-10,12-Hexadecadienal is a female pheromone isolated from female Earias insulana .

HY-W749641

(7Z,9E)-Dodecadienyl acetate	Others	Endocrinology
(7Z,9E)-Dodecadienyl acetate is a female pheromone isolated from female grapevine moths .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W040047

Pregnanediol 3-glucuronide	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
Pregnanediol 3-glucuronide is the major terminal metabolite of progesterone, playing an important role in physiological processes, such as the female menstrual cycle, pregnancy (supports gestation), embryogenesis and maternal immune response of humans and other species .

HY-B1192

Estradiol benzoate 10+ Cited Publications β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Classification of Application Fields Disease Research Fields Cancer	Estrogen Receptor/ERR HBV Bcl-2 Family
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

HY-W742821

(Z)-11-Octadecenal	Structural Classification Natural Products Animals Source classification	Others
(Z)-11-Octadecenal is a female pheromone with diurnal stability, isolated from the pheromone glands of female rice leaffolder moths .

HY-N12874

(E,E,Z)-10,12,14-Hexadecatrienal	Structural Classification Natural Products Animals Source classification	Others
(E,E,Z)-10,12,14-Hexadecatrienal is a pheromone that can be produced by female Manduca sexta .

HY-N12873

(E,E,E,)-10,12,14-Hexadecatrienal	Structural Classification Natural Products Animals Source classification	Others
(E,E,E,)-10,12,14-Hexadecatrienal is a pheromone that can be produced by female Manduca sexta .

HY-133800

Volvaltrate B	Structural Classification Iridoids Terpenoids Source classification Valeriana officinalis Linn. Plants Valerianaceae	Biochemical Assay Reagents
Volvaltrate B is an anticancer agent, iridoid, can be obtained from the root of valerian (Valeriana officinalis). Volvaltrate B is effective against ovarian tumors in female mice. Volvaltrate B has the potential to study cancer .

HY-W777963

(2E)-Octadecenal	Structural Classification Natural Products Animals Source classification	Others
(2E)-Octadecenal is a female pheromone targeting Lepidoptera insects, isolated from female Tineola bisselliella .

HY-W701835

(E,E)-10,12-Hexadecadienal	Structural Classification Natural Products Animals Source classification	Others
(E,E)-10,12-Hexadecadienal is a female pheromone isolated from female Earias insulana .

HY-W749641

(7Z,9E)-Dodecadienyl acetate	Structural Classification Natural Products Animals Source classification	Others
(7Z,9E)-Dodecadienyl acetate is a female pheromone isolated from female grapevine moths .

HY-W747112

(Z)-10-Hexadecenal	Structural Classification Natural Products Animals Source classification	Others
(Z)-10-Hexadecenal is a fruit-type female pheromone isolated from the abdominal tip extracts of female Dichocrocis punctiferalis .

HY-N12935

(Z)-13-Hexadecen-11-ynyl acetate	Structural Classification Natural Products Animals Source classification	Others
(Z)-13-Hexadecen-11-ynyl acetate is a female message isolated from the female glands of the oak moth (Thaumetopoea processionea) .

HY-W753500

(E,E)-9,11-Tetradecadienyl acetate	Structural Classification Natural Products Animals Source classification	Others
(E,E)-9,11-Tetradecadienyl acetate is a female sex pheromone isolated from light-induced isomerization products in female coastal noctuid moths .

HY-N12891

(5E,7Z)-5,7-Dodecadienal	Structural Classification Natural Products Animals Source classification	Others
(5E,7Z)-5,7-Dodecadienal is a female sex pheromone isolated from female western tent caterpillars (M. californicum (Packard)) .

HY-134108

(3E,13Z)-Octadecadien-1-ol	Structural Classification Natural Products Animals Source classification	Others
(3E,13Z)-Octadecadien-1-ol is a female sex pheromone attracting males, isolated from female Sequoia resin moths (Synanthedon sequoiae) .

HY-N12883

(E,E)-11,13-Hexadecadien-1-ol	Structural Classification Natural Products Animals Source classification	Others
(E,E)-11,13-Hexadecadien-1-ol is a synthetic isomer of the hexane extract of the unmated female or female pheromone glands that can attract male Amyelois transitella (Walker) (Lepidoptera: Pyralidae) .

HY-128900

11-cis-Vaccenyl acetate	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
11-cis-Vaccenyl acetate is male-specific lipid that mediates aggregation behavior in both male and female flies, which activates a few dozen olfactory neurons located in T1 sensilla on the antenna of both male and female flies .

HY-W289164

Nonyl acetate	Structural Classification Natural Products Animals Source classification	Others
Nonyl acetate is a female pheromone isolated from pea moths (C. nigricana) .

HY-W749143

Bombykal	Structural Classification Natural Products Animals Source classification	Others
Bombykal is a female pheromone isolated from the abdominal components of Bombys mori L .

HY-N12910

(Z)-9-Hexadecenyl acetate	Structural Classification Natural Products Animals Source classification	Others
(Z)-9-Hexadecenyl acetate is a female sex pheromone isolated from 3-day-old female Mamestra configurata. (Z)-9-Hexadecenyl acetate can induce an electroantennographic response and attract 2-day-old male moths .

HY-P1751

Ceratotoxin B	Infection Natural Products Classification of Application Fields Animals Source classification Disease Research Fields	Bacterial
Ceratotoxins B is antibacterial peptide produced by the sexually mature females of Ceratitis capitata. Lytic and antibacterial activity .

HY-W150928

Tridecyl acetate	Structural Classification Natural Products Animals Source classification	Others
Tridecyl acetate is a species-specific female sex pheromone isolated from Adoxophyes sp. (smaller tea tortrix, STT) .

HY-W742595

(E,E)-10,12-Hexadecadienol	Structural Classification Natural Products Animals Source classification	Others
(E,E)-10,12-Hexadecadienol is a female pheromone isolated from legume pod borer .

HY-W042284

Tetradecyl acetate	Natural Products Microorganisms Classification of Application Fields Animals Source classification Metabolic Disease Disease Research Fields	Others
Tetradecyl acetate is a sex pheromone produced by Ctenopseustis obliquana females. Tetradecyl acetate can be used to disrupt the mating of pest species .

HY-W745644

(Z)-7-Hexadecenal	Structural Classification Natural Products Animals Source classification	Others
(Z)-7-Hexadecenal is a sex pheromone that attracts male insects, isolated from female Heliothis virescens moths .

HY-N7145

Bombykol Isobombycol	Natural Products Classification of Application Fields Animals Source classification Disease Research Fields Endocrinology	Others
Bombykol, the first insect sex pheromone, is identified as the female-produced sex attractant of the silkworm moth Bombyx mori .

HY-N0139

Troxerutin 1 Publications Verification Trihydroxyethylrutin	Flavonols Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Plants Monophenols Flavonoids other families Phenols Inflammation/Immunology Disease Research Fields	NOD-like Receptor (NLR)
Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated *NOD* activation.

HY-N10171

GB-2a	Structural Classification Flavonoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis Other Flavonoids	Others
GB-2a is a bioflavonoids that can be isolated from Rheedia gardneriana. GB-2a has significant analgesic activity in mice with 58.9% inhibition .

HY-N12895

(Z,Z)-7,11-Hexadecadienyl acetate (Z,Z)-Gossyplure	Structural Classification Natural Products Animals Source classification	Others
(Z)-7,11-Hexadecadienyl acetate is a female sex pheromone used to attract male insects, isolated from Plutella xylostella .

HY-W747086

(Z)-5-Dodecen-1-ol	Structural Classification Natural Products Animals Source classification	Others
(Z)-5-Dodecen-1-ol is a female pheromone isolated from the pheromone glands of rice leaf folders (Plusia festucae) .

HY-W087952

(R)-(-)-2-Butanol	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Others
(R)-(-)-2-Butanol is released by the females of the white grub beetle, Dasylepida ishigakiensis, to attract males. (R)-(-)-2-Butanol is an intermediate of pharmaceutical synthesis by coupling .

HY-N12882

(Z)-10-Hexadecen-1-ol	Structural Classification Natural Products Animals Source classification	Others
(Z)-10-Hexadecen-1-ol is a insect sex pheromones, which can be secreted by some female nocturnal moths, or by the heads of male bumblebees (Bombus spp.) .

HY-N2953

Borapetoside E	Structural Classification Natural Products Source classification Plants Menispermaceae Tinospora crispa (L.) Hook. f. et Thoms	Fatty Acid Synthase (FASN)
Borapetoside E can be isolated from T. crispa. Borapetoside E improves hyperglycemia, insulin resistance, hepatic steatosis, hyperlipidemia, and oxygen consumption in obese mice. Borapetoside E also inhibits SREBPs expression in the liver and adipose tissue .

HY-N12896

(7Z)-7-Hexadecen-1-ol ENT-35163	Structural Classification Natural Products Animals Source classification	Others
(7Z)-7-Hexadecen-1-ol (ENT-35163) is a sex pheromone that inhibits male attraction, isolated from female Euxoa tessellata (Harris) .

HY-W717924

(Z)-14-Methyl-8-hexadecenal	Structural Classification Natural Products Rhizophora apiculata Blume Source classification Rhizophoraceae Plants	Others
(Z)-14-Methyl-8-hexadecenal is a sex pheromone that can induce mating responses in male Trogoderma beetles, isolated from the spiracular exhalation distillates of female beetles .

HY-W654264

2-Methylbutyrylcarnitine chloride	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite Integrin
2-Methylbutyrylcarnitine (chloride) is a gut microbial metabolite which binds to integrin α2β1 in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. 2-Methylbutyrylcarnitine (chloride) enhances platelet hyperreactivity and thrombus formation in mice. 2-Methylbutyrylcarnitine (chloride) is a branched-chain acylcarnitine .

HY-N0139R

Troxerutin (Standard) Trihydroxyethylrutin (Standard)	Structural Classification Flavonoids other families Neurological Disease Classification of Application Fields Source classification Phenols Metabolic Disease Plants Inflammation/Immunology Disease Research Fields	NOD-like Receptor (NLR)
Troxerutin (Standard) is the analytical standard of Troxerutin. This product is intended for research and analytical applications. Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated *NOD* activation.

HY-N12920

(Z)-3-Dodecenyl acetate Z3-12:Ac	Structural Classification Natural Products Animals Source classification	Others
(Z)-3-Dodecenyl acetate (Z3-12:Ac) is a specific sex pheromone attracting females, isolated from pentane extracts of mature unmated male yellow mealworm beetles .

HY-W747088

(2Z,13Z)-Octadecadienyl acetate	Structural Classification Natural Products Animals Source classification	Others
(2Z,13Z)-Octadecadienyl acetate is a female pheromone that attracts male clearwing moths and disrupts mating, isolated from Japanese persimmon clearwing moths (Synanthedon tenuis (Lepidoptera: Sesiidae)) .

HY-113365

Cholestenone 4-Cholesten-3-one	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent that is metabolized primarily in the liver as an intermediate oxidation product of cholesterol. Cholestenone inhibits human dermal fibroblast migration and fights Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also alleviates metabolic disorders caused by obesity in db/db mice .

HY-W750129

(3E,8Z)-3,8-Tetradecadienyl acetate	Structural Classification Natural Products Animals Source classification	Others
(3E,8Z)-3,8-Tetradecadienyl acetate is an insect sex pheromone that can be isolated from unmated female South American potato tuber moths (Scrobipalpula absoluta) .

HY-101735

(9Z,11E)-Prodlure (9Z,11E)-Tetradecadien-1-yl acetate; Ferodin SL; Litlure A	Structural Classification Natural Products Microorganisms Classification of Application Fields Animals Source classification Disease Research Fields Endocrinology	Others
(9Z,11E)-Prodlure ((9Z,11E)-Tetradecadien-1-yl acetate) is the main component of the sex pheromone of female Spodoptera littoralis .

HY-133984

(7Z)-7-Tricosene	Structural Classification Natural Products Animals Source classification	Others
(7Z)-7-Tricosene is a pheromone and can be produced by Aleochar curtula .

HY-N12921

(E)-8-Dodecenol	Structural Classification Natural Products Animals Source classification	Others
(E)-8-Dodecenol is a pheromone that increases the frequency of electro-pulse spikes in mid-receptor neurons of codling moth (Cydia pomonella L.). (E)-8-Dodecenol is isolated from female codling moths .

HY-N12885

(11Z,13E)-Hexadecadienal	Structural Classification Natural Products Animals Source classification	Others
(11Z,13E)-Hexadecadienal is a synthetic isomer of the hexane extract of the unmated female or female pheromone glands that can attract male Amyelois transitella (Walker) (Lepidoptera: Pyralidae) when mixed with (11Z,13Z)-hexadecadien-1-ol, (11Z,13E)-hexadecadien-1-ol, (3Z,6Z,9Z,12Z,15Z)-tricosapentaene (C23 pentaene) .

HY-109517

Calf thymus DNA 1 Publications Verification DNA from calf thymus, Thymonucleic acid	Natural Products Animals Source classification Inflammation/Immunology Disease Research Fields Cancer	DNA/RNA Synthesis
Calf thymus DNA (DNA from calf thymus) is high quality double-stranded template DNA isolated from the thymus of male and female calves. Calf thymus DNA can be used for the research of the interaction between DNA and agents .

HY-N12879

(R)-10,14-Dimethylpentadecyl isobutyrate (R)-10Me 14Me-15:iBu	Structural Classification Natural Products Animals Source classification	Others
(R)-10,14-Dimethylpentadecyl isobutyrate ((R)-10Me 14Me-15:iBu) is a female sex pheromone with insect electroantennographic (EGA) activity, isolated from tea tussock moth .

HY-N1503

Methyl deacetylasperulosidate 6α-Hydroxygeniposide; Deacetylasperulosidic acid methyl ester	Structural Classification Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Metabolic Disease Plants Disease Research Fields Hedyotis diffusa Willd.	Others
Methyl deacetylasperulosidate is an iridoid and shows purgative effects in mice and lowers the blood glucose level in normal mice .

HY-N12880

(10E,12Z)-10,12-Hexadecadien-1-ol Z10,E12-16:OH	Structural Classification Natural Products Animals Source classification	Others
(10E,12Z)-10,12-Hexadecadien-1-ol (Z10,E12-16:OH) is a microlepidopteran attractant isolated from female scent glands .

HY-N1389

Carmine Carmine red	Structural Classification Natural Products Animals Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Fluorescent Dye
Carmine (Carmine red), a natural red dye extracted from the dried females of the insect Dactylopius coccus var. Costa (cochineal). Carmine is a widely used food additive. Carmine provokes both an immediate hypersensitivity and a delayed systemic response with cutaneous expression .

HY-112234

L-Sepiapterin Sepiapterin	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70 ^S6K-dependent VEGFR-2 expression .

Cat. No.	Product Name	Chemical Structure

HY-B0141S

Estradiol-d3
Estradiol-d₃ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-B0141S1

Estradiol-d4 1 Publications Verification
Estradiol-d₄ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S3

Estradiol-d2
Estradiol-d₂ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S2

Estradiol-d5
Estradiol-d₅ is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S6

Estradiol-d2-1
Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3][4].

HY-B0554S

Norethindrone-d6

Norethindrone-d₆ is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Norethindrone-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-109506S1

DPPC-d9
DPPC-d₉ is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].

HY-B0141S4

Estradiol-13C6
Estradiol- ¹³C₆ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S5

Estradiol-13C2
Estradiol- ¹³C₂ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B1710S

Norethindrone acetate-d8
Norethindrone acetate-d₈ is the deuterium labeled Norethindrone acetate. Norethindrone acetate is a female hormone used for the research of endometriosis[1]. Norethindrone acetate-d8 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-109506S

DPPC-d62
DPPC-d₆₂ is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].

HY-109506S3

DPPC-d9-1
DPPC-d₉-1 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].

HY-B0448S1

Phenytoin-15n2,13c
Phenytoin- ¹⁵N₂, ¹³C is the ¹³C and ¹⁵N labeled Phenytoin[1]. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[2][3].

HY-B1002S

Oxolinic acid-d5
Oxolinic acid-d₅ is the deuterium labeled Oxolinic acid. Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].

HY-113354S

Anserine-d4

Anserine-d₄ is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].

HY-B1198S

Piperonyl butoxide-d9
Piperonyl butoxide-d₉ is the deuterium labeled Piperonyl butoxide.Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice .

HY-N1428S3

Citric acid-13C3
Citric acid- ¹³C₃ is the ¹³C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4].

HY-124412S

Paynantheine-d3
Paynantheine-d₃ is a deuterium labeled Paynantheine. Paynantheine is an alkaloid that can be isolated from Mitragyna speciosa. Paynantheine can decrease alcohol intake in mice .

HY-D0195S

Acesulfame-d4 potassium
Acesulfame-d₄ potassiumis the deuterium labeledAcesulfame (potassium)(HY-D0195) . Acesulfame potassium is an artificial sweetener. Acesulfame potassium (long-term) affects cognitive functions, potentially via altering neuro-metabolic functions in mice .

HY-169222S

RORγ/DHODH-IN-2
RORγ/DHODH-IN-2 (Compound 1311) is an orally active dual inhibitor of RORγ/DHODH with IC₅₀ values of 11.9 nM and 90 nM, respectively. RORγ/DHODH-IN-2 exhibits antiviral activity by inhibiting the activity of SARS-CoV-2, HCMV, HAdV5, and MPXV, with IC₅₀ values of 27 nM, 20 nM, 9.1 nM, and 1.8 nM, respectively .

HY-14393S

Emodin-d4

Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

HY-B0534S1

Moclobemide-d4
Moclobemide-d₄ is deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HY-B0149S3

Tranexamic acid-13C2,15N
Tranexamic acid- ¹³C₂, ¹⁵N (Cyclocapron- ¹³C₂, ¹⁵N) is the ¹³C₂ and ¹⁵N labeled Tranexamic acid. Tranexamic acid is an antifibrinolytic agent that alleviates liver damage and fibrosis in mouse models of chronic bile duct injury .

HY-145119S

Mindeudesivir
GS-621763-d₁ is the deuterium labeled GS-621763 (HY-145119) . GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .

HY-109120S

Odevixibat-d5
Odevixibat-d₅ is deuterated labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-B0534S

Moclobemide-d8
Moclobemide-d₈ (Ro111163-d₈) is the deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC₅₀ of 6.061 μM for hMAO-A .Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HY-N6608S

Physostigmine-d3

Physostigmine-d₃ is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].

HY-109120S1

Odevixibat-13C6
Odevixibat- ¹³C₆ is ¹³C labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-100442S

Paquinimod-d5
Paquinimod-d5 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

HY-100442S1

Paquinimod-d5-1
Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

HY-109506S2

(Rac)-DPPC-d6
(Rac)-DPPC-d6 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .

HY-101064S2

Fmoc-leucine-d3
Fmoc-leucine-d₃ is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].

HY-101064S3

Fmoc-leucine-d10
Fmoc-leucine-d₁₀ is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].

HY-113354S1

Anserine-d4 hydrochloride

Anserine-d₄ hydrochloride is the deuterium labeled Anserine (HY-113354). Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .

HY-109506S9

DPPC-13C2
DPPC-13C2 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .

HY-145119AS

Mindeudesivir hydrobromide
Mindeudesivir (JT001; VV116; GS-621763-d₁) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 .

HY-N1428S6

Citric acid-d4-1
Citric acid-d₄-1 is deuterated labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.

HY-N9484S

Menthofuran-13C2

Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

HY-113161S

L-Octanoylcarnitine-d3
L-Octanoylcarnitine-d₃ is the deuterium-labeled L-Octanoylcarnitine (HY-113161). L-Octanoylcarnitine-d₃ is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine-d₃ can be used for the research of breast cancer .

HY-17623S

Tegoprazan-d6

Tegoprazan (CJ-12420; RQ-00000004), a potassium-competitive acid blocker, is a reversible, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC₅₀ values ranging from 0.29-0.52 μM for porcine, canine, and human H ⁺/K ⁺-ATPases in vitro. Tegoprazan significantly improves colitis in mice and enhances the intestinal epithelial barrier function. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases .

HY-12678S

Entrectinib-d4

Entrectinib-d4 (NMS-E628-d4; RXDX-101-d4) is the deuterium labeled Entrectinib (HY-12678). Entrectinib is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC₅₀ values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice .

HY-119980S

Fluphenazine-d8

Fluphenazine-d₈ is the deuterium labeled Fluphenazine. Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .

HY-113421S

Linoleoyl ethanolamide-d4

Linoleoyl ethanolamide-d4 is a deuterated labeled Linoleoyl ethanolamide . Linoleoyl ethanolamide (Linoleic acid monoethanolamide) is classified as a fatty acid ethanolamide. Linoleoyl ethanolamide only weakly binds G-protein-coupled cannabinoid receptors of type-1（CB1）and CB2 receptors, and inhibits the binding of ^[3H]CP-55,940 with K_is of 10 and 25 μM, respectively. Linoleoyl ethanolamide is 4-fold less potent than anandamide at causing catalepsy in mice and it does not prolong sleep time .

HY-W782079

Geraniol-d6 (Major)
Geraniol-d6 (Major) is the deuterated labeled Geraniol (Major). Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes .

HY-12678S1

Entrectinib-d8

Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC₅₀ values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-163816

Antiproliferative agent-53-d3

Antiproliferative agent-53-d3 (Compound C1) is an inhibitor for theta-mediated end joining (TMEJ) in HEK293 cell with an IC₅₀ of 0.14 µM. Antiproliferative agent-53-d3 is the inhibitor for CYP2C19 and CYP2C9 with IC₅₀ of 0.77 and 3.1 µM. Antiproliferative agent-53-d3 inhibits the proliferation of DNA repair-compromised cells, with IC₅₀ of 8.1 µM for BRCA2 ^-/- DLD-1. Antiproliferative agent-53-d3 exhibits good pharmacokinetic characteristics in CD-1 mice .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks