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Ganglioside GD3-d<sub>3</sub>

" in MedChemExpress (MCE) Product Catalog:

2984

Inhibitors & Agonists

14

Biochemical Assay Reagents

5

Peptides

5

Inhibitory Antibodies

18

Natural
Products

16

Recombinant Proteins

2900

Isotope-Labeled Compounds

3

Antibodies

16

Click Chemistry

1

Oligonucleotides

Cat. No. Product Name Chemical Structure
  • HY-113323S
    3-Methoxy-4-hydroxyphenylglycol-d3 is the deuterium labeled 3-Methoxy-4-hydroxyphenylglycol.
    3-Methoxy-4-hydroxyphenylglycol-d3
  • HY-B1773AS5
    Sodium Propionate-d3 is the deuterium labeled Sodium Propionate[1].
    Sodium Propionate-d3
  • HY-B0113S
    Omeprazole-d3 is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].
    Omeprazole-d<sub>3</sub>
  • HY-166325A
    Ganglioside GD3-d3 (ammonium) is an ester product.
    Ganglioside GD3-d3 ammonium
  • HY-10844S1
    Pretomanid-d5 is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.
    Pretomanid-d5
  • HY-152002S
    Ganglioside GM3-d3 ammonium is a deuterated labeled Ganglioside GM3 ammonium .
    Ganglioside GM3-d3 ammonium
  • HY-146876S
    C18:0 GM1 Ganglioside-d5 (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).
    C18:0 GM1 Ganglioside-d5 ammonium
  • HY-114456AS
    Ganglioside GM3-d5 (Bovine Milk ammonium salt) is deuterium labeled Ganglioside GM3 (Bovine Milk ammonium salt).
    Ganglioside GM3-d5 Bovine Milk ammonium salt
  • HY-B1689AS
    Methantheline-d3 (bromide) is the deuterium labeled Methantheline bromide[1].
    Methantheline-d3 bromide
  • HY-17413S
    Zidovudine-d3 is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Zidovudine-d3
  • HY-70002S
    Deutenzalutamide (Enzalutamide-d3) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells .
    Deutenzalutamide
  • HY-B0457AS
    Clomipramine-d3 is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively[1][2].
    Clomipramine-d3
  • HY-66005S1
    Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].
    Acetaminophen-d3
  • HY-B0141AS
    Alpha-Estradiol-d3 is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
    Alpha-Estradiol-d3
  • HY-N0176S
    Dihydroartemisinin-d3 is the deuterium labeled Dihydroartemisinin. Dihydroartemisinin is a potent anti-malaria agent.
    Dihydroartemisinin-d3
  • HY-W008794S
    Normetanephrine-d3 (hydrochloride) is the deuterium labeled Normetanephrine hydrochloride. Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE)[1].
    Normetanephrine-d3 hydrochloride
  • HY-30151S
    Methoxsalen-d3 is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].
    Methoxsalen-d3
  • HY-13777S1
    Zoledronic acid-d3 is the deuterium labeled Zoledronic acid .
    Zoledronic acid-d3
  • HY-A0070AS3
    Liothyronine-d3 is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively [3].
    Liothyronine-d3
  • HY-B0647S1
    Butylphthalide-d3 is the deuterium labeled Butylphthalide. Butylphthalide(3-n-Butylphthalide), an anti-cerebral-ischemia agent, is first isolated from the seeds of celery and showes efficacy in animal models of stroke.
    Butylphthalide-d3
  • HY-115127S
    3-Methylanisole-d3 is the deuterium labeled 3-Methylanisole[1].
    3-Methylanisole-d3
  • HY-15330
    Vitamin D2-d3 (Ergocalciferol-d3) is the deuterium labeled vitamin D2.
    Vitamin D2-d3
  • HY-B0264S
    Guaifenesin-d3 is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough[1][2].
    Guaifenesin-d3
  • HY-15027S
    5-Aminosalicylic Acid-d3 (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
    5-Aminosalicylic Acid-d3 hydrochloride
  • HY-13636S
    Fulvestrant-d3 is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].
    Fulvestrant-d3
  • HY-10581AS
    Gatifloxacin-d3 (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
    Gatifloxacin-d3 hydrochloride
  • HY-17509S
    Deracoxib-d3 is the deuterium labeled Deracoxib. Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).
    Deracoxib-d3
  • HY-15027S1
    5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].
    5-Aminosalicylic acid-d3
  • HY-B0579S1
    Cyclosporin A-d3 is the d3-labeled Cyclosporin A (HY-B0579)[1].
    Cyclosporin A-d3
  • HY-13757AS1
    Tamoxifen-d3 is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].
    Tamoxifen-d3
  • HY-B1260S2
    Cetrimonium-d3 (bromide) is the deuterium labeled Cetrimonium bromide[1].
    Cetrimonium-d3 bromide
  • HY-B1658S
    Frovatriptan-d3 (hydrochloride) is the deuterium labeled Frovatriptan[1]. Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura[2].
    Frovatriptan-d3 hydrochloride
  • HY-13757S
    Tamoxifen-d3 hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells [3].Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .
    Tamoxifen-d3 hydrochloride
  • HY-B0171S
    Antipyrine-d3 is the deuterium labeled Antipyrine. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity[1][2].
    Antipyrine-d3
  • HY-B0479S
    Thiamphenicol-d3 is a deuterium labeled Thiamphenicol. Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2].
    Thiamphenicol-d3
  • HY-N0136S
    Taxifolin-d3 is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
    Taxifolin-d3
  • HY-N0108S
    Physcion-d3 (Parietin-d3) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects [3].
    Physcion-d3
  • HY-15772S3
    Asandeutertinib (Osimertinib-d3; AZD-9291-d3) is a epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, with antineoplastic effect .
    Asandeutertinib
  • HY-B0215S
    Acetylcysteine-d3 is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].
    Acetylcysteine-d3
  • HY-15455S2
    Roflumilast-d3 is deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.
    Roflumilast-d3
  • HY-14654S
    Aspirin-d3 is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.
    Aspirin-d3
  • HY-B1037S
    Salbutamol-d3 is the deuterium labeled Salbutamol. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).
    Salbutamol-d3
  • HY-B0272S
    Rifampicin-d3 is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities[1][2].
    Rifampicin-d3
  • HY-N1150S
    Thymidine-d3 is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3].
    Thymidine-d3
  • HY-Y0842S1
    Formamide-d3 is the deuterium labeled Formamide. Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.
    Formamide-d3
  • HY-127165S1
    Velnacrine-d3 (maleate) is the deuterium labeled Velnacrine maleate[1].
    Velnacrine-d3 maleate
  • HY-B0094S
    Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].
    Artemisinin-d3
  • HY-10219S
    Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
    Rapamycin-d3
  • HY-121309S
    Doxorubicinone-d3 is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
    Doxorubicinone-d3
  • HY-A0088S
    Cefotaxime-d3 (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4][5].
    Cefotaxime-d3 sodium

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