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SR 144528-d<sub>3</sub>

" in MedChemExpress (MCE) Product Catalog:

3489

Inhibitors & Agonists

1

Fluorescent Dye

11

Biochemical Assay Reagents

8

Peptides

3

Inhibitory Antibodies

11

Natural
Products

35

Recombinant Proteins

3248

Isotope-Labeled Compounds

11

Antibodies

17

Click Chemistry

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0209S
    Metolazone-d7

    SR-720-22-d<sub>7sub>

    		 Thrombin Cardiovascular Disease
    Metolazone-d7 is deuterium labeled Metolazone. Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.
    Metolazone-d7
  • HY-169898S
    SR 144528-d3

    		Isotope-Labeled Compounds Others
    SR 144528-d3 is deuterium labeled SR 144528 .
    SR 144528-d3
  • HY-106716
    SR 41378

    		Others Neurological Disease
    SR 41378 is an orally active aminopyrazine derivative. SR 41378 has anticonvulsant, antianxiety and hypnotic activities .
    SR 41378
  • HY-RS13999
    SUB1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SUB1 Human Pre-designed siRNA Set A
    SUB1 Human Pre-designed siRNA Set A
  • HY-146227
    DNA topoisomerase II inhibitor 1

    		Topoisomerase Apoptosis Cancer
    DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .
    DNA topoisomerase II inhibitor 1
  • HY-14136S
    Rimonabant-d10

    SR141716-d<sub>10sub>

    		 Isotope-Labeled Compounds Cannabinoid Receptor Bacterial Infection Metabolic Disease Cancer
    Rimonabant-d10 is deuterium labeled Rimonabant. Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).
    Rimonabant-d10
  • HY-B0202S3
    Irbesartan-d7

    SR-47436-d<sub>7sub>; BMS-186295-d<sub>7sub>

    		 Apoptosis Angiotensin Receptor Isotope-Labeled Compounds Cardiovascular Disease Endocrinology
    Irbesartan-d7 is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .
    Irbesartan-d7
  • HY-B0202AS
    Irbesartan-d7 hydrochloride

    SR-47436-d<sub>7sub> hydrochloride; BMS-186295-d<sub>7sub> hydrochloride

    		 Apoptosis Angiotensin Receptor Isotope-Labeled Compounds Neurological Disease Metabolic Disease
    Irbesartan-d7 hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .
    Irbesartan-d7 hydrochloride
  • HY-10844S1
    Pretomanid-d5

    PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>

    		 Antibiotic Bacterial Isotope-Labeled Compounds Infection Cancer
    Pretomanid-d5 is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.
    Pretomanid-d5
  • HY-P10215
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2

    		Parasite Infection
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2
  • HY-B0202S4
    Irbesartan-13C,d4

    SR-47436-13C,d<sub>4sub>; BMS-186295-13C,d<sub>4sub>

    		 Angiotensin Receptor Apoptosis Isotope-Labeled Compounds Cardiovascular Disease
    Irbesartan- 13C,d4 (SR-47436- 13C,d4; BMS-186295- 13C,d4) is 13C-labeled Irbesartan (HY-B0202) .
    Irbesartan-13C,d4
  • HY-12753AS
    Debutyldronedarone-d7 hydrochloride

    SR35021-d<sub>7sub> hydrochloride

    		 Thyroid Hormone Receptor Isotope-Labeled Compounds Cardiovascular Disease
    Debutyldronedarone-d7 hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic .
    Debutyldronedarone-d7 hydrochloride
  • HY-18345
    SR 49059
    1 Publications Verification

    		 Vasopressin Receptor Cardiovascular Disease Endocrinology
    SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a Ki vaule of 1.4 nM .
    SR 49059
  • HY-105259
    SR 43845

    		Renin Cardiovascular Disease
    SR 43845 is a renin inhibitor. SR 43845 decreases blood pressure and inhibits plasma renin activity. SR 43845 can be used for hypertension research .
    SR 43845
  • HY-13751
    SR-31747

    		Sigma Receptor Inflammation/Immunology
    SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase .
    SR-31747
  • HY-145409
    SR-0813

    		Epigenetic Reader Domain Cancer
    SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 and EC50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC50 and EC50 values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity (Kd=3.5 μM) than ENL YEATS (Kd=30 nM). SR-0813 can be used for the research of acute leukemia .
    SR-0813
  • HY-149292
    SR-4133

    		Casein Kinase Cancer
    SR-4133 is a potent and highly CK1ε selective inhibitor with an IC50 of 58 nM. SR-4133 binds to the ATP-binding site of CK1ε. SR-4133 displays nanomolar growth inhibition of bladder cancer cells, and inhibits the phosphorylation of 4E-BP1 .
    SR-4133
  • HY-120853
    SR-4326

    		Others Others
    SR-4326 is an active compound.
    SR-4326
  • HY-120144
    SR-8993

    		Opioid Receptor Neurological Disease
    SR-8993 is a highly selective nociceptin receptor agonist that can penetrate the blood-brain barrier and has the activity of reducing alcohol intake and relieving withdrawal anxiety. SR-8993 has shown mild anxiolytic effects in animal models and can effectively reverse anxiety caused by acute alcohol withdrawal. SR-8993 further reduces restricted drinking, operant responses for alcohol, and increased drinking induced by long-term intermittent exposure to alcohol. SR-8993 also reduces stress- and cue-related alcohol-seeking relapse .
    SR-8993
  • HY-P2130
    SR 42128

    		Renin Cardiovascular Disease
    SR 42128 is a potent renin inhibitor. SR 42128 potently inhibits primate renins whereas other animal renins are much less inhibited .
    SR 42128
  • HY-100277
    Mifobate
    1 Publications Verification

    SR-202

    		 PPAR Metabolic Disease
    Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects .
    Mifobate
  • HY-135674
    SR-318

    		p38 MAPK TNF Receptor Inflammation/Immunology Cancer
    SR-318 is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity .
    SR-318
  • HY-120542
    SR 1824

    		PPAR Metabolic Disease
    SR 1824 is a non-agonist PPARγ ligand that blocks Cdk5-mediated phosphorylation. SR 1824 has anti-diabetic effects .
    SR 1824
  • HY-13300
    SR-3677
    1 Publications Verification

    		 ROCK Autophagy Cancer
    SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM.
    SR-3677
  • HY-12829
    SR-3306

    		JNK Neurological Disease
    SR-3306 is a selective, potent, highly brain penetrant JNK inhibitor.
    SR-3306
  • HY-101454
    SR0987
    2 Publications Verification

    		 ROR Inflammation/Immunology Cancer
    SR0987, a SR1078 analog, is a RORγt agonist, with an EC50 of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1 .
    SR0987
  • HY-108907
    SR-1277

    		Casein Kinase Cancer
    SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer .
    SR-1277
  • HY-122681
    SR-16435

    		Opioid Receptor Neurological Disease
    SR-16435 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor Ki=7.49; μ-Opioid receptor Ki=2.70). SR-16435 can relieve pain .
    SR-16435
  • HY-B1689AS
    Methantheline-d3 bromide

    MTB 51-d<sub>3sub>; Mantheline-d<sub>3sub>; Metantyl-d<sub>3sub>; Metanyl-d<sub>3sub>; Metaxan-d<sub>3sub>; Methanide-d<sub>3sub>

    		 Isotope-Labeled Compounds Others
    Methantheline-d3 (bromide) is the deuterium labeled Methantheline bromide[1].
    Methantheline-d3 bromide
  • HY-138007
    SR-1903

    		ROR PPAR LXR Metabolic Disease Inflammation/Immunology
    SR-1903 is an inverse agonist of RORγ and PPARγ (IC50 of ∼100 nM and 209 nM for RORγ and PPARγ, respectively) and a LXR agonist. SR-1903 exhibits anti-inflammatory and anti-diabetic efficacy in collagen-induced arthritis and diet-induced obesity mouse models .
    SR-1903
  • HY-120785A
    SR1555 hydrochloride

    		ROR Inflammation/Immunology
    SR1555 hydrochloride is the hydrochloride salt form of SR1555 (HY-120785). SR1555 hydrochloride is an inverse agonist for retinoic acid receptor-related orphan nuclear receptor γ (RORγ) with an IC50 of 1 μM. SR1555 hydrochloride inhibits the development and function of pro-inflammatory TH17 cell, increases the frequency of anti-inflammatory T regulatory (Treg) cells. SR1555 hydrochloride can be used for research about autoimmune diseases .
    SR1555 hydrochloride
  • HY-107596
    SR-3576

    		JNK Others
    SR-3576 is a highly potent and selective JNK3 inhibitor with an IC50 of 7 nM .
    SR-3576
  • HY-117248
    SR-3737

    		JNK p38 MAPK Neurological Disease
    SR-3737 is a JNK3 and p38 inhibitor (IC50: 12 and 3 nM) .
    SR-3737
  • HY-115881
    SR-1114

    		PROTACs Cancer
    SR-1114 is a first-in-class PROTAC ENL degrader. SR-1114 elicits rapid, CRBN-dependent degradation of ENL with DC50s of 150 nM, 311 nM, and 1.65 μM in MV4;11 , MOLM-13, and OCI/AML-2 cells, respectively .
    SR-1114
  • HY-13751A
    SR-31747 free base

    		Sigma Receptor Inflammation/Immunology
    SR-31747 free base is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase .
    SR-31747 free base
  • HY-156458
    SR-29065

    		REV-ERB Inflammation/Immunology
    SR-29065 is a selective REV-ERBα agonist, can be used for autoimmune disorders research .
    SR-29065
  • HY-W841840
    SR94

    		Sirtuin Neurological Disease Cancer
    SR94, a SR17 derivative, is a SIRT2 inhibitor that contains an arbitrary 6-member ring and different R2 groups. SR94 is promising for research of cancer, ischemia-reperfusion and neurodegenerative diseases .
    SR94
  • HY-15870
    SR 11302
    5+ Cited Publications

    		 AP-1 Inflammation/Immunology Cancer
    SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE) .
    SR 11302
  • HY-107664
    SR 142948

    		Neurotensin Receptor Neurological Disease
    SR 142948 is an orally active and selective non-peptide neurotensin receptor (NT) antagonist with IC50s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC50 of 3.9 nM. SR 142948 blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 shows blood-brain permeability and can be used in study of psychiatric disorders .
    SR 142948
  • HY-107664A
    SR 142948 dihydrochloride

    		Neurotensin Receptor Neurological Disease
    SR 142948 dihydrochloride is an orally active and selective non-peptide neurotensin receptor (NT) antagonist with IC50s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 dihydrochloride antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC50 of 3.9 nM. SR 142948 dihydrochloride blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 dihydrochloride shows blood-brain permeability and can be used in study of psychiatric disorders .
    SR 142948 dihydrochloride
  • HY-131454
    SR-717
    10+ Cited Publications

    		 STING Inflammation/Immunology Cancer
    SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .
    SR-717
  • HY-13300A
    SR-3677 dihydrochloride

    		ROCK Autophagy Cancer
    SR-3677 dihydrochloride (compound 5) is a potent and selective ROCK-I and ROCK-II inhibitor with an IC50 values of 56 nM and 3 nM .
    SR-3677 dihydrochloride
  • HY-113323S
    3-Methoxy-4-hydroxyphenylglycol-d3

    HMPG-d<sub>3sub>; MHPG-d<sub>3sub>; MOPEG-d<sub>3sub>

    		 Endogenous Metabolite Others
    3-Methoxy-4-hydroxyphenylglycol-d3 is the deuterium labeled 3-Methoxy-4-hydroxyphenylglycol.
    3-Methoxy-4-hydroxyphenylglycol-d3
  • HY-117413
    SR-17398

    		ULK Cancer
    SR-17398 is an inhibitor for Unc-51-Like Kinase 1 (ULK1) with an IC50 of 22.4 μM .
    SR-17398
  • HY-130250
    SR-4835
    10+ Cited Publications

    		 CDK Apoptosis Cancer
    SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death .
    SR-4835
  • HY-161362
    SR-3-65

    		PI3K Cancer
    SR-3-65 (compound 6) is a Indisulam (HY-13650) derivative,and inhibits the migration of gastric cancer cells. SR-3-65 attenuates PI3K/AKT/GSK-3β/β-catenin signaling pathway .
    SR-3-65
  • HY-125833
    Alpha-Naphthoflavone
    5+ Cited Publications

    		 Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis Cancer
    Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis [3] .
    Alpha-Naphthoflavone
  • HY-17413S
    Zidovudine-d3

    Azidothymidine-d<sub>3sub>; AZT-d<sub>3sub>; ZDV-d<sub>3sub>

    		 Isotope-Labeled Compounds HIV CRISPR/Cas9 Infection
    Zidovudine-d3 is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Zidovudine-d3
  • HY-B1773AS5
    Sodium Propionate-d3

    Mycoban-d<sub>3sub>; Napropion-d<sub>3sub>; Ocuseptine-d<sub>3sub>

    		 Isotope-Labeled Compounds Others
    Sodium Propionate-d3 is the deuterium labeled Sodium Propionate[1].
    Sodium Propionate-d3
  • HY-118961
    SR31527 chloride

    		Kinesin Cancer
    SR31527 chloride is a potent KIFC1 inhibitor with an IC50 value of 6.6 µM. SR31527 chloride decreases cell viability and colony formation .
    SR31527 chloride

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