Search Result

Results for "

Givinostat impurity 1-d<sub>10</sub>

" in MedChemExpress (MCE) Product Catalog:

By Targets:	P-glycoprotein (12) 11β-HSD (3) 5 alpha Reductase (4) 5-HT Receptor (145) Acetolactate Synthase (ALS) (1) ADC Cytotoxin (13) Adenosine Receptor (11) Adenylate Cyclase (3) Adrenergic Receptor (106) AIM2 (1) Akt (5) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (1) Amino Acid Derivatives (2) Aminopeptidase (1) AMPK (7) Amyloid-β (7) Anaplastic lymphoma kinase (ALK) (8) Androgen Receptor (17) Angiotensin Receptor (27) Angiotensin-converting Enzyme (ACE) (14) Antibiotic (162) Antifolate (6) Apical Sodium-Dependent Bile Acid Transporter (2) Apoptosis (235) Aryl Hydrocarbon Receptor (5) ATM/ATR (1) ATP Citrate Lyase (2) ATP Synthase (1) Aurora Kinase (1) Autophagy (264) Bacterial (245) Bcl-2 Family (3) Bcr-Abl (10) BCRP (2) Beta-lactamase (2) Beta-secretase (1) Biochemical Assay Reagents (19) Bombesin Receptor (1) Btk (10) c-Fms (2) c-Kit (15) c-Met/HGFR (6) Calcineurin (2) Calcium Channel (59) CaMK (2) Cannabinoid Receptor (10) Carbonic Anhydrase (8) Casein Kinase (6) Caspase (4) CaSR (2) Cathepsin (1) CD19 (1) CD73 (1) CDK (13) CFTR (5) CGRP Receptor (1) Checkpoint Kinase (Chk) (1) Chloride Channel (2) Cholinesterase (ChE) (17) Complement System (5) COMT (5) COX (68) CRISPR/Cas9 (3) Cuproptosis (1) CXCR (1) Cyclophilin (2) Cytochrome P450 (28) Deubiquitinase (1) Dihydroorotate Dehydrogenase (1) Dipeptidyl Peptidase (14) Disulfidptosis (4) DNA Alkylator/Crosslinker (8) DNA Methyltransferase (3) DNA/RNA Synthesis (73) Dopamine Receptor (88) Drug Metabolite (200) Drug-Linker Conjugates for ADC (6) DYRK (2) E1/E2/E3 Enzyme (2) EBI2/GPR183 (1) EGFR (21) Elastase (1) Endogenous Metabolite (781) Endothelin Receptor (3) Enterovirus (5) Epigenetic Reader Domain (2) ERK (9) Estrogen Receptor/ERR (41) Factor Xa (6) FAK (1) Farnesyl Transferase (1) Fatty Acid Synthase (FASN) (3) Ferroptosis (43) FGFR (11) FKBP (3) Flavivirus (2) FLT3 (7) Fluorescent Dye (1) Fungal (60) FXR (5) G protein-coupled Bile Acid Receptor 1 (2) GABA Receptor (26) Gap Junction Protein (2) GCGR (2) Glucocorticoid Receptor (26) Glucosidase (1) Glucosylceramide Synthase (GCS) (2) Glutaminase (1) Glutathione Peroxidase (1) Glutathione Reductase (1) Glutathione S-transferase (1) GlyT (2) GnRH Receptor (5) GPR35 (1) GPR55 (2) GSK-3 (3) HBV (8) HCV (29) HCV Protease (3) HDAC (20) Hedgehog (3) Hexokinase (2) HIF/HIF Prolyl-Hydroxylase (3) Hippo (MST) (1) Histamine Receptor (39) Histone Acetyltransferase (5) Histone Demethylase (4) Histone Methyltransferase (3) HIV (56) HIV Integrase (11) HIV Protease (8) HMG-CoA Reductase (HMGCR) (18) HSP (4) HSV (12) IGF-1R (3) iGluR (21) IKK (2) Imidazoline Receptor (3) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (28) Insulin Receptor (1) Integrin (1) Interleukin Related (6) IRE1 (1) Isotope-Labeled Compounds (2131) JAK (8) JNK (3) Keap1-Nrf2 (11) Ketohexokinase (2) Kinesin (1) Leukotriene Receptor (9) Ligands for E3 Ligase (6) Ligands for Target Protein for PROTAC (1) Liposome (1) Lipoxygenase (4) LPL Receptor (6) mAChR (39) Macrophage migration inhibitory factor (MIF) (1) MDM-2/p53 (4) MEK (4) Melanocortin Receptor (1) Melatonin Receptor (9) mGluR (8) MicroRNA (1) Microtubule/Tubulin (21) Mineralocorticoid Receptor (10) Mitochondrial Metabolism (6) Mitophagy (35) Mixed Lineage Kinase (1) MMP (4) Molecular Glues (9) Monoamine Oxidase (8) Monoamine Transporter (1) mTOR (1) Myosin (4) Na+/K+ ATPase (5) nAChR (11) NADPH Oxidase (1) Neprilysin (7) Neurokinin Receptor (5) NF-κB (32) NO Synthase (19) NOD-like Receptor (NLR) (3) Notch (6) Nuclear Hormone Receptor 4A/NR4A (2) Nucleoside Antimetabolite/Analog (56) Opioid Receptor (5) Orexin Receptor (OX Receptor) (1) Organoid (1) Orthopoxvirus (10) Oxidative Phosphorylation (1) P2X Receptor (2) P2Y Receptor (7) p38 MAPK (4) PAK (8) Parasite (66) PARP (4) PD-1/PD-L1 (1) PDGFR (19) PGC-1α (1) PGE synthase (2) Phosphatase (11) Phosphodiesterase (PDE) (25) Phospholipase (5) PI3K (6) Piezo Channel (1) PKA (2) PKC (7) Potassium Channel (26) PPAR (24) Progesterone Receptor (25) Prostaglandin Receptor (25) PROTAC Linkers (2) Protease Activated Receptor (PAR) (1) Proteasome (1) Proton Pump (23) Raf (7) RAR/RXR (5) Ras (4) Reactive Oxygen Species (41) Renin (2) RET (6) Reverse Transcriptase (9) ROCK (1) ROS Kinase (5) RSV (7) SARS-CoV (40) Ser/Thr Protease (1) Serotonin Transporter (24) SGLT (7) Sigma Receptor (4) Sirtuin (6) Small Interfering RNA (siRNA) (46) Sodium Channel (25) Src (5) STAT (5) STING (1) Syk (1) TAM Receptor (3) Tau Protein (1) TGF-beta/Smad (4) TGF-β Receptor (1) Thrombin (10) Thrombopoietin Receptor (3) Thymidylate Synthase (5) Thyroid Hormone Receptor (7) TNF Receptor (6) Toll-like Receptor (TLR) (5) TOPK (1) Topoisomerase (24) Transthyretin (TTR) (1) Trk Receptor (4) TRP Channel (15) TrxR (1) Tyrosinase (6) Vasopressin Receptor (3) VD/VDR (24) VEGFR (27) Virus Protease (16) Wee1 (1) Xanthine Oxidase (4) β-catenin (4) γ-secretase (1)
By Research Areas:	Cancer (817) Cardiovascular Disease (261) Endocrinology (216) Infection (423) Inflammation/Immunology (385) Metabolic Disease (395) Neurological Disease (506)
Click Chemistry:	Azide (5) Alkynes (15)
Oligonucleotides:	Pre-designed siRNA Sets (46) siRNAs (46)

3550

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

3006

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14842

*Givinostat* 5+ Cited Publications ITF-2357	HDAC	Inflammation/Immunology Cancer
Givinostat (ITF-2357) is a HDAC inhibitor with an IC₅₀ of 198 and 157 nM for *HDAC1* and HDAC3, respectively. Givinostat can be used for Duchenne muscular dystrophy (DMD) research ^[1].

HY-131269

*Febuxostat impurity* 7**	Drug Metabolite	Others
Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1].

HY-143960S

Givinostat impurity 1-d10 hydrochloride	Drug Metabolite Isotope-Labeled Compounds	Others
Givinostat impurity 1-d₁₀ (hydrochloride) is the deuterium labeled Givinostat impurity 1 hydrochloride[1].

HY-143961S

Givinostat impurity 5-d4	Drug Metabolite Isotope-Labeled Compounds	Others
Givinostat impurity 5-d₄ is the deuterium labeled Givinostat impurity 5[1].

HY-131270R

*Febuxostat impurity* 8 (Standard)**	Drug Metabolite	Others
Febuxostat impurity 8 (Standard) is the analytical standard of Febuxostat impurity 8. This product is intended for research and analytical applications. Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM ^[1].

HY-131251

Cetirizine 3-chloro impurity	Drug Metabolite	Others
Cetirizine 3-chloro impurity is an impurity of Cetirizine 3-chloro ^[1].

HY-131270

*Febuxostat impurity* 8**	Drug Metabolite	Others
Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1].

HY-131271

*Febuxostat impurity* 6**	Drug Metabolite	Others
Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1].

HY-143951S

*Disulfiram impurity* 1-d10**	Drug Metabolite Isotope-Labeled Compounds	Others
Disulfiram impurity 1-d₁₀ is the deuterium labeled Disulfiram impurity 1[1].

HY-143956S

*Fluorofenidone impurity* 1-d3**	Drug Metabolite Isotope-Labeled Compounds	Others
Fluorofenidone impurity 1-d₃ is the deuterium labeled Fluorofenidone impurity 1[1].

HY-143974S

*Imiquimod impurity* 1-d6**	Drug Metabolite Isotope-Labeled Compounds	Others
Imiquimod impurity 1-d₆ is the deuterium labeled Imiquimod impurity 1[1].

HY-144913S

*Bempedoic acid impurity* 1-d4**	Isotope-Labeled Compounds	Others
Bempedoic acid impurity 1-d₄ is the deuterium labeled Bempedoic acid impurity 1[1].

HY-164226

*Rosuvastatin impurity-1*	Others	Others
Rosuvastatin impurity-1 is a reference substance of rosuvastatin impurities.

HY-164229

*Mianserin impurity-1*	Others	Others
Rosuvastatin impurity-1 is a reference substance of rosuvastatin impurities.

HY-164228

*Vericiguat impurity-3*	Others	Others
Vericiguat impurity-3 is an impurity of Vericiguat (HY-16774). Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator ^[1].

HY-143986S

*DM50 impurity* 1-d9**	Drug Metabolite Isotope-Labeled Compounds	Others
DM50 impurity 1-d₉ is the deuterium labeled DM50 impurity 1[1].

HY-143987S

*DM51 impurity* 1-d9**	Drug Metabolite Isotope-Labeled Compounds	Others
DM51 impurity 1-d₉ is the deuterium labeled DM51 impurity 1[1].

HY-14842B

Givinostat hydrochloride monohydrate 5+ Cited Publications ITF-2357 hydrochloride monohydrate	HDAC	Cancer
Givinostat hydrochloride monohydrate (ITF-2357 hydrochloride monohydrate) is a HDAC inhibitor with an IC₅₀ of 198 and 157 nM for *HDAC1* and HDAC3, respectively.

HY-131272R

*Febuxostat dicarboxylic acid impurity* (Standard)**	Drug Metabolite	Others
Febuxostat dicarboxylic acid impurity (Standard) is the analytical standard of Febuxostat dicarboxylic acid impurity. This product is intended for research and analytical applications. Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM ^[1].

HY-131273R

*Febuxostat amide impurity* (Standard)**	Drug Metabolite	Others
Febuxostat amide impurity (Standard) is the analytical standard of Febuxostat amide impurity. This product is intended for research and analytical applications. Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM ^[1]

HY-131272

Febuxostat dicarboxylic acid impurity	Drug Metabolite	Others
Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1].

HY-131273

Febuxostat amide impurity	Drug Metabolite	Others
Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1]

HY-133777

*Ciprofibrate impurity* A**	PPAR	Cancer
Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate (Win35833) is a potent peroxisome proliferator, increases the phosphorylation level of the PPARalpha ^[1].

HY-100663

*Gefitinib impurity* 2**	EGFR	Others Cancer
Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity ^[1] .

HY-134686

*Edoxaban impurity* 4**	Factor Xa Thrombin	Cardiovascular Disease
Edoxaban impurity 4 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K_is of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention ^[1] .

HY-134685

*Edoxaban impurity* 6**	Factor Xa Thrombin	Cardiovascular Disease
Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K_is of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention ^[1] .

HY-143986S1

*DM50 impurity* 1-d9-1**	Drug Metabolite Isotope-Labeled Compounds	Others
DM50 impurity 1-d₉-1 is the deuterium labeled DM50 impurity 1[1].

HY-14842A

Givinostat hydrochloride 5+ Cited Publications ITF-2357 hydrochloride	HDAC	Cancer
Givinostat (ITF-2357) hydrochloride is a HDAC inhibitor with an IC₅₀ of 198 and 157 nM for *HDAC1* and HDAC3, respectively ^[1] .

HY-133774

*Trityl olmesartan medoxomil impurity* III**	Drug Metabolite	Others
Trityl olmesartan medoxomil impurity III is an impurity of Trityl olmesartan medoxomil. Trityl olmesartan medoxomil is an intermediate of Olmesartan medoxomil ^[1].

HY-141410

Fluticasone dimer impurity	Drug Metabolite	Others
Fluticasone dimer impurity is a dimeric impurity of Fluticasone Propionate ^[1]. Fluticasone propionate is a corticosteroid with comparatively high receptor affinity and topical activity .

HY-131255

Ziprasidone amino acid Ziprasidone impurity C; Ziprasidone open ring impurity	5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone amino acid (Ziprasidone Impurity C) is an impurity of Ziprasidone. Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist. Ziprasidone exhibits potent effects of antipsychotic activity ^[1].

HY-131265

*Mesalamine impurity* P**	PPAR PAK NF-κB	Inflammation/Immunology Cancer
Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB ^[1].

HY-W178868S

*Lodoxamide impurity* 1-d5**	Drug Metabolite Isotope-Labeled Compounds	Others
Lodoxamide impurity 1-d₅ is deuterium labeled n-Ethyl-2-hydroxyacetamide.

HY-131276R

*Olmesartan lactone impurity* (Standard)**	Angiotensin Receptor	Cardiovascular Disease
Olmesartan lactone impurity (Standard) is the analytical standard of Olmesartan lactone impurity. This product is intended for research and analytical applications. Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study ^[1] .

HY-131276

Olmesartan lactone impurity	Angiotensin Receptor	Cardiovascular Disease
Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study ^[1] .

HY-400785

*Dapagliflozin impurity* A**	Others	Cancer
Dapagliflozin impurity A (Compound A) is a dapagliflozin peroxide, a genotoxic impurity, can cause damage to human genetic material at very low concentrations, leading to genetic mutations and possibly tumorigenesis ^[1].

HY-131256

*Cetirizine Impurity* C**	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine Impurity C is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist ^{[1] ^{^{[2] ^.}}}

HY-131256A

*Cetirizine Impurity* C dihydrochloride**	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine Impurity C dihydrochloride is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist ^{[1] ^{^{[2] ^.}}}

HY-133780

*Afatinib impurity* 11**	EGFR Autophagy	Cancer
Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC₅₀s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR ^wt, EGFR ^L858R, EGFR ^L858R/T790M and HER2, respectively ^[1].

HY-121899

1-Oxo Ibuprofen Ibuprofen EP impurity J	Drug Metabolite	Others
1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively ^[1] .

HY-107495

*Betahistine EP Impurity* C** NSC19005	Histamine Receptor	Inflammation/Immunology
Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine ^[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA) .

HY-100069

*Fluazinam impurity* 1**	Fungal	Infection
Fluazinam impurity 1 is an impurity of Fluazinam with antifungal activity. Fluazinam impurity 1 is active against *Sphaerotheca fuliginea, Pyricularia oryzae* and *Rhizoctonia solani* ^[1].

HY-100069R

*Fluazinam impurity* 1 (Standard)**	Fungal	Infection
Fluazinam impurity 1 (Standard) is the analytical standard of Fluazinam impurity 1. This product is intended for research and analytical applications. Fluazinam impurity 1 is an impurity of Fluazinam with antifungal activity. Fluazinam impurity 1 is active against Sphaerotheca fuliginea, Pyricularia oryzae and Rhizoctonia solani ^[1].

HY-W568314

*Vericiguat impurity-1*	Others	Others
Vericiguat impurity-1 is the impurity of Vericiguat (HY-16774). Vericiguat impurity-1 can be used as impurity standards in impurity analysis, to develop selective and quantitative methods to determine impurities ^[1].

HY-164227

*Vericiguat impurity-2*	Biochemical Assay Reagents	Others
Vericiguat impurity-2 is the impurity of Vericiguat (HY-16774). Vericiguat impurity-2 can be used as impurity standards in impurity analysis, in order to develop selective and quantitative methods to determine impurities ^[1].

HY-W103960

*Mirabegron impurity-1*	Others	Metabolic Disease
Mirabegron impurity-1 is a potent and selective β₃- adrenergic receptor agonist. Mirabegron impurity-1 has the activity of inhibiting metabolism. Mirabegron impurity-1 can be used in the study of the treatment of bladder impurity ^[1].

HY-131965

*Imidacloprid impurity* 1**	Others	Others
Imidacloprid impurity 1 (IMP-2) is the impurity found during the synthesis of Ivermectin (HY-15310) ^[1].

HY-W103960R

*Mirabegron impurity-1 (Standard)*	Others	Metabolic Disease
Mirabegron impurity-1 (Standard) is the analytical standard of Mirabegron impurity-1. This product is intended for research and analytical applications. Mirabegron impurity-1 is a potent and selective β3- adrenergic receptor agonist. Mirabegron impurity-1 has the activity of inhibiting metabolism. Mirabegron impurity-1 can be used in the study of the treatment of bladder impurity ^[1].

HY-131281

*Ivabradine impurity* 1**	Drug Metabolite	Others
Ivabradine impurity 1 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker ^[1].

HY-131282

*Ivabradine impurity* 2**	Drug Metabolite	Others
Ivabradine impurity 2 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0229

Zolmitriptan BW-311C90; 311C90	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Indole Alkaloids	5-HT Receptor Endogenous Metabolite
Zolmitriptan (BW-311C90; 311C90) is a 5-HT1B/1D receptor partial agonist with K_is of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, 5-HT1F receptor, respectively. Zolmitriptan can be used for the research of migraine ^[1] .

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[1] .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[1] .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively ^[1].

HY-W778546

7-epi-10-Deacetyl baccatin III	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus baccata L.	Others
7-epi-10-Deacetyl baccatin III can be isolated from the degradation impurities in Docetaxel (HY-B0011) ^[1].

HY-W778547

7-epi-10-Oxo-10-deacetyl baccatin III 10-Dehydrobaccatin V	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus baccata L.	Others
7-epi-10-Oxo-10-deacetyl baccatin III (10-Dehydrobaccatin V) can be isolated from the degradation impurities in Docetaxel (HY-B0011) ^[1].

HY-119387

Chevalone B	Other Terpenoids Structural Classification Microorganisms Terpenoids Source classification	Bacterial
Chevalone B was isolated from the ethyl acetate extract of the marine sponge-associated fungus Aspergillus similanensis. The structure of Chevalone B was confirmed by 1D and 2D NMR spectroscopy. Chevalone B showed antimicrobial activity against Gram-positive and Gram-negative bacteria, Candida albicans, and multidrug-resistant strains from the environment. Studies on Chevalone B have shown its potential value in antimicrobial applications.

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). ^[1].

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations ^[1].

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[1] [4].

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[1] .

HY-N0662R

Amentoflavone (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[1] .

HY-B0504S

Creatinine-d3 3 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-112023

Lumisterol 3 (>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP impurity C	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D ^[1].

HY-N10530

Lactodifucotetraose Difucosyllactose ; 2′,3-Difucosyllactose	Natural Products Polysaccharides Classification of Application Fields Animals Other Diseases Disease Research Fields Saccharides	Others
Lactodifucotetraose (Difucosyllactose) is a tetrasaccharide isolated from human milk. Lactodifucotetraose constitutes of D-glucose, 1 D-galactose, and L-fucose ^[1].

HY-126848

Diclofenac acyl glucuronide D-1-O-G	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Drug Metabolite Endogenous Metabolite
Diclofenac acyl glucuronide (D-1-O-G) is a major bile metabolite directly involved in small intestinal ulceration in rats ^[1].

HY-134529

D-Ribofuranose1-dihydrogenphosphate Ribose 1-phosphate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Ribofuranose1-dihydrogenphosphate, also known as ribose 1-phosphate, is the material for the synthesis of 5-fluorouracil (FUra) by uridine phosphorylase ^[1].

HY-134529A

D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine Ribose 1-phosphate dicyclohexanamine	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine, also known as ribose 1-phosphate, is the material for the synthesis of 5-fluorouracil (FUra) by uridine phosphorylase ^[1].

HY-N8549A

5-Dihydrocortisone	Structural Classification Classification of Application Fields Cardiacglycosides Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
5-Dihydrocortisone is a 5-Dihydrocortisone with mixture of isomers. 5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver ^[1]

HY-B0471

Phenylephrine hydrochloride Maximum Cited Publications 15 Publications Verification (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Cardiovascular Disease Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
(R)-(-)-Phenylephrine hydrochloride is a selective *α₁-adrenoceptor* agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-N0096

Rotundine (-)-Tetrahydropalmatine; L-Tetrahydropalmatine	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	5-HT Receptor Dopamine Receptor
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of *5-HT_1A* with an IC₅₀ of 370 nM.

HY-N2003

D-Tetrahydropalmatine	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Classification of Application Fields Source classification Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Dopamine Receptor
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis ^[1]. D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor .

HY-N5102

D-(+)-Fucose	Ipomoea muricata Source classification Other Diseases Plants Convolvulaceae Disease Research Fields Saccharides	Others
D-(+)-Fucose is a nonmetabolizable analogue of l-arabinose. D-(+)-Fucose prevents growth of Escherichia coli B/r on a mineral salts medium plus l-arabinose by inhibiting induction of the l-arabinose operon ^[1]. D-fucose is a potent inducer of beta-methylgalactoside permease (MGP) .

HY-B0471R

Phenylephrine hydrochloride (Standard)	Structural Classification Alkaloids Monophenols Other Alkaloids Source classification Phenols Endogenous metabolite	Adrenergic Receptor Endogenous Metabolite
Phenylephrine (hydrochloride) (Standard) is the analytical standard of Phenylephrine (hydrochloride). This product is intended for research and analytical applications. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-N5102R

D-(+)-Fucose (Standard)	Ipomoea muricata Source classification Plants Convolvulaceae Saccharides	Others
D-(+)-Fucose (Standard) is the analytical standard of D-(+)-Fucose. This product is intended for research and analytical applications. D-(+)-Fucose is a nonmetabolizable analogue of l-arabinose. D-(+)-Fucose prevents growth of Escherichia coli B/r on a mineral salts medium plus l-arabinose by inhibiting induction of the l-arabinose operon ^[1]. D-fucose is a potent inducer of beta-methylgalactoside permease (MGP) .

Cat. No.	Product Name	Chemical Structure

HY-143960S

Givinostat impurity 1-d10 hydrochloride
Givinostat impurity 1-d₁₀ (hydrochloride) is the deuterium labeled Givinostat impurity 1 hydrochloride[1].

HY-143961S

Givinostat impurity 5-d4
Givinostat impurity 5-d₄ is the deuterium labeled Givinostat impurity 5[1].

HY-143951S

*Disulfiram impurity* 1-d10**
Disulfiram impurity 1-d₁₀ is the deuterium labeled Disulfiram impurity 1[1].

HY-143956S

*Fluorofenidone impurity* 1-d3**
Fluorofenidone impurity 1-d₃ is the deuterium labeled Fluorofenidone impurity 1[1].

HY-143974S

*Imiquimod impurity* 1-d6**
Imiquimod impurity 1-d₆ is the deuterium labeled Imiquimod impurity 1[1].

HY-144913S

*Bempedoic acid impurity* 1-d4**
Bempedoic acid impurity 1-d₄ is the deuterium labeled Bempedoic acid impurity 1[1].

HY-143986S

*DM50 impurity* 1-d9**
DM50 impurity 1-d₉ is the deuterium labeled DM50 impurity 1[1].

HY-143987S

*DM51 impurity* 1-d9**
DM51 impurity 1-d₉ is the deuterium labeled DM51 impurity 1[1].

HY-143986S1

*DM50 impurity* 1-d9-1**
DM50 impurity 1-d₉-1 is the deuterium labeled DM50 impurity 1[1].

HY-W178868S

*Lodoxamide impurity* 1-d5**
Lodoxamide impurity 1-d₅ is deuterium labeled n-Ethyl-2-hydroxyacetamide.

HY-142217S

*Quetiapine dimer impurity-d8*
Quetiapine dimer impurity-d₈ is the deuterium labeled Quetiapine dimer impurity[1].

HY-W021399S

*Lidocaine impurity* 5-d6**
Lidocaine impurity 5-d₆ is deuterium labeled Lidocaine impurity 5.

HY-143954S

*Epinephrine impurity* 19-d3 hydrochloride**
Epinephrine impurity 19-d₃ (hydrochloride) is the deuterium labeled Epinephrine impurity 19[1].

HY-143968S

*Ketotifen impurity* 3-d4**
Ketotifen impurity 3-d₄ is the deuterium labeled Ketotifen impurity 3[1].

HY-143970S

*Ivabradine impurity* 7-d6**
Ivabradine impurity 7-d₆ is the deuterium labeled Ivabradine impurity 7[1].

HY-143975S

*Loxapine impurity* 2-d8**
Loxapine impurity 2-d₈ is the deuterium labeled Loxapine impurity 2[1].

HY-143984S

*Minodronic acid impurity* 2-d4**
Minodronic acid impurity 2-d₄ is the deuterium labeled Minodronic acid impurity 2[1].

HY-143988S

*Nefazodone impurity* 3-d6**
Nefazodone impurity 3-d₆ is the deuterium labeled Nefazodone impurity 3[1].

HY-144146S

*Pramipexole impurity* 7-d10**
Pramipexole impurity 7-d₁₀ is the deuterium labeled Pramipexole impurity 7[1].

HY-143938S

*Cyclobenzaprine impurity* 2-d3 hydrochloride**
Cyclobenzaprine impurity 2-d₃ (hydrochloride) is the deuterium labeled Cyclobenzaprine impurity 2 hydrochloride[1].

HY-144141S

*Nortriptyline impurity* 3-d3 hydrochloride**
Nortriptyline impurity 3-d₃ (hydrochloride) is the deuterium labeled Nortriptyline impurity 3 hydrochloride[1].

HY-144142S

*Orphenadrine impurity* 6-d3 hydrochloride**
Orphenadrine impurity 6-d₃ (hydrochloride) is the deuterium labeled Orphenadrine impurity 6 hydrochloride[1].

HY-143965S

*Imidacloprid impurity* 2-d4 hydrochloride**
Imidacloprid impurity 2-d₄ (hydrochloride) is the deuterium labeled Imidacloprid impurity 2-d₄ (hydrochloride)[1].

HY-142592S

*Clozapine EP impurity* D-d8**
Clozapine EP impurity D-d₈ is the deuterium labeled Clozapine EP impurity D[1].

HY-143907S

*Atorvastatin EP impurity* H-d5**
Atorvastatin EP impurity H-d₅ is the deuterium labeled Atorvastatin EP impurity H[1].

HY-143990S

*Modafinil EP impurity* B-d5**
Modafinil EP impurity B-d₅ is the deuterium labeled Modafinil EP impurity B[1].

HY-144242S

*Voriconazole EP impurity* D-d3**
Voriconazole EP impurity D-d₃ is the deuterium labeled Voriconazole EP impurity D[1].

HY-143941S

*Hydroxychloroquine EP impurity* D-d5 dihydrochloride**
Hydroxychloroquine EP impurity D-d₅ (dihydrochloride) is the deuterium labeled Hydroxychloroquine EP impurity D dihydrochloride[1].

HY-143977S

*Loxapine impurity* 3-d8 iodide**
Loxapine impurity 3-d₈ (iodide) is the deuterium labeled Loxapine impurity 3 iodide[1].

HY-143982S

*Mianserin EP impurity* E-d4 hydrochloride**
Mianserin EP impurity E-d₄ (hydrochloride) is the deuterium labeled Mianserin EP impurity E hydrochloride[1].

HY-144203S

*Trospium EP impurity* C-d8 chloride**
Trospium EP impurity C-d₈ (chloride) is the deuterium labeled Trospium EP impurity C chloride[1].

HY-143925S

*Betahistine impurity* 5-13C,d3**
Betahistine impurity 5- ¹³C,d₃ is the ¹³C- and deuterium labeled Betahistine impurity 5[1].

HY-143985S

*Maytansinoid DM4 impurity* 5-d6**
Maytansinoid DM4 impurity 5-d₆ is the deuterium labeled Maytansinoid DM4 impurity 5[1].

HY-143992S

*Maytansinoid DM4 impurity* 2-d6**
Maytansinoid DM4 impurity 2-d₆ is the deuterium labeled Maytansinoid DM4 impurity 2[1].

HY-143993S

*Maytansinoid DM4 impurity* 3-d6**
Maytansinoid DM4 impurity 3-d₆ is the deuterium labeled Maytansinoid DM4 impurity 3[1].

HY-143997S

*(Rac)-Nicotine EP impurity* A-d4 hydrochloride**
(Rac)-Nicotine EP impurity A-d₄ (hydrochloride) is the deuterium labeled (Rac)-Nicotine EP impurity A hydrochloride[1].

HY-144221S

*Tiotropium bromide EP impurity* A-d6**
Tiotropium bromide EP impurity A-d₆ is the deuterium labeled Tiotropium bromide EP impurity A[1].

HY-16562S

Irinotecan-d10
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1].

HY-143963S

Irbesartan impurity 20-d4

Irbesartan impurity 20-d₄ is the deuterium labeled Irbesartan impurity 20[1]. Irbesartan impurity 20-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-143964S

Irbesartan impurity 14-d4

Irbesartan impurity 14-d₄ is the deuterium labeled Irbesartan impurity 14[1]. Irbesartan impurity 14-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-143980S

Losartan impurity 21-d4

Losartan impurity 21-d₄ is the deuterium labeled Losartan impurity 21[1]. Losartan impurity 21-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-144150S

*Pelubiprofen impurity* 2-13C2,d6**
Pelubiprofen impurity 2- ¹³C₂,d₆ is the ¹³C- and deuterium labeled Pelubiprofen impurity 2[1].

HY-Y0504S1

Trimethylammonium chloride-d10
Trimethylammonium chloride-d₁₀ is the deuterium labeled Trimethylammonium chloride[1]. Trimethylammonium chloride is an endogenous metabolite.

HY-W654320

Piperin-d10
Piperin-d₁₀ is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL ^[1] .

HY-13738S4

Raloxifene-d10-1
Raloxifene-d₁₀-1 is the deuterium labeled Raloxifene[1]. Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[2].

HY-W270557S

*Lodoxamide impurity* 2-d10**
Lodoxamide impurity 2-d₁₀ is deuterium labeled 2-(Diethylamino)-2-oxoacetic acid.

HY-B1674S

(±)-Leucine-d10
(±)-Leucine-d₁₀ is the deuterium labeled (±)-Leucine. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08%[1].

HY-13272S2

Dacomitinib-d10 dihydrochloride
Dacomitinib-d₁₀ (dihydrochloride) is the deuterium labeled Dacomitinib dihydrochloride. Dacomitinib (PF-00299804) dihydrochloride is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively[1].

HY-13272S3

Dacomitinib-d10
Dacomitinib-d₁₀ is deuterium labeled Dacomitinib. Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively[1].

HY-B0801AS

Fexofenadine-d10 hydrochloride
Fexofenadine-d₁₀ (hydrochloride) is deuterium labeled Fexofenadine (hydrochloride). Fexofenadine hydrochloride (MDL-16455 hydrochloride), a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial (person aged ≥16 years)[1].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks