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N-Methyl pyrrole-d<sub>4</sub>

" in MedChemExpress (MCE) Product Catalog:

By Targets:	P-glycoprotein (11) 11β-HSD (3) 17β-HSD (1) 5 alpha Reductase (4) 5-HT Receptor (66) Acetolactate Synthase (ALS) (1) ADC Cytotoxin (11) ADC Linker (3) Adenosine Receptor (8) Adrenergic Receptor (78) AIM2 (1) Akt (4) Aldehyde Dehydrogenase (ALDH) (1) Amino Acid Derivatives (26) Aminopeptidase (1) AMPK (7) Amyloid-β (6) Anaplastic lymphoma kinase (ALK) (8) Androgen Receptor (17) Angiotensin Receptor (22) Angiotensin-converting Enzyme (ACE) (14) Antibiotic (158) Antifolate (5) Apical Sodium-Dependent Bile Acid Transporter (2) Apoptosis (232) Aryl Hydrocarbon Receptor (5) ATM/ATR (1) ATP Citrate Lyase (2) Aurora Kinase (1) Autophagy (263) Bacterial (237) Bcl-2 Family (4) Bcr-Abl (10) BCRP (2) Beta-lactamase (1) Beta-secretase (1) Biochemical Assay Reagents (14) Btk (4) c-Fms (2) c-Kit (15) c-Met/HGFR (5) Calcineurin (2) Calcium Channel (63) Cannabinoid Receptor (10) Carbonic Anhydrase (7) Casein Kinase (1) Caspase (4) CaSR (2) Cathepsin (1) CCR (1) CD38 (1) CD73 (1) CDK (11) CFTR (7) Checkpoint Kinase (Chk) (1) Chloride Channel (2) Cholinesterase (ChE) (20) CMV (1) Complement System (6) COMT (5) COX (64) CRISPR/Cas9 (3) Cuproptosis (1) CXCR (1) Cyclophilin (2) Cytochrome P450 (30) Deubiquitinase (1) Dihydroorotate Dehydrogenase (4) Dipeptidyl Peptidase (14) DNA Alkylator/Crosslinker (10) DNA Methyltransferase (2) DNA/RNA Synthesis (72) Dopamine Receptor (43) Drug Metabolite (61) Drug-Linker Conjugates for ADC (6) DYRK (2) E1/E2/E3 Enzyme (2) EBI2/GPR183 (1) EGFR (20) Elastase (1) Endogenous Metabolite (799) Endothelin Receptor (3) Enterovirus (5) Epigenetic Reader Domain (2) ERK (8) Estrogen Receptor/ERR (39) Factor Xa (4) FAK (1) Fatty Acid Synthase (FASN) (3) Ferroportin (1) Ferroptosis (42) FGFR (11) FKBP (4) Flavivirus (2) FLT3 (7) Fluorescent Dye (3) Fungal (58) FXR (4) G protein-coupled Bile Acid Receptor 1 (2) GABA Receptor (26) Gap Junction Protein (2) Glucocorticoid Receptor (25) Glucosidase (2) Glucosylceramide Synthase (GCS) (2) Glutathione Reductase (1) Glutathione S-transferase (1) GlyT (6) GnRH Receptor (3) GPR35 (1) GPR55 (2) GSK-3 (3) HBV (8) HCV (17) HCV Protease (3) HDAC (17) Hedgehog (3) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (2) Histamine Receptor (34) Histone Acetyltransferase (6) Histone Demethylase (4) Histone Methyltransferase (3) HIV (54) HIV Integrase (11) HIV Protease (8) HMG-CoA Reductase (HMGCR) (15) HSP (4) HSV (13) IGF-1R (3) iGluR (114) IKK (2) Imidazoline Receptor (3) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (29) Insulin Receptor (1) Integrin (1) Interleukin Related (5) IRE1 (1) Isotope-Labeled Compounds (2036) JAK (7) JNK (1) Keap1-Nrf2 (10) Ketohexokinase (2) Kinesin (1) Leukotriene Receptor (9) Ligands for E3 Ligase (6) Ligands for Target Protein for PROTAC (1) Liposome (1) Lipoxygenase (3) LPL Receptor (6) LXR (1) mAChR (39) Macrophage migration inhibitory factor (MIF) (1) MDM-2/p53 (3) MEK (4) Melanocortin Receptor (1) Melatonin Receptor (9) mGluR (8) MicroRNA (1) Microtubule/Tubulin (18) Mineralocorticoid Receptor (10) Mitochondrial Metabolism (6) Mitophagy (39) MMP (7) Molecular Glues (9) Monoamine Oxidase (8) Monoamine Transporter (1) mTOR (2) Myosin (4) Na+/K+ ATPase (5) nAChR (12) NADPH Oxidase (1) Neprilysin (7) Neurokinin Receptor (3) Neuropeptide Y Receptor (1) NF-κB (31) NO Synthase (19) NOD-like Receptor (NLR) (3) Notch (7) Nuclear Hormone Receptor 4A/NR4A (2) Nucleoside Antimetabolite/Analog (57) Opioid Receptor (4) Orexin Receptor (OX Receptor) (1) Orthopoxvirus (12) Oxidative Phosphorylation (3) P2X Receptor (1) P2Y Receptor (7) p38 MAPK (4) PACAP Receptor (2) PAK (7) Parasite (70) PARP (5) PDGFR (20) PGC-1α (1) PGE synthase (1) Phosphatase (8) Phosphodiesterase (PDE) (21) Phospholipase (6) PI3K (3) PKA (2) PKC (7) Potassium Channel (28) PPAR (22) Progesterone Receptor (25) Prostaglandin Receptor (22) PROTAC Linkers (13) Protease Activated Receptor (PAR) (1) Proteasome (1) Proton Pump (22) Raf (8) RAR/RXR (5) Ras (2) Reactive Oxygen Species (38) Renin (2) RET (6) Reverse Transcriptase (8) ROS Kinase (5) RSV (7) SARS-CoV (39) Ser/Thr Protease (3) Serotonin Transporter (25) SGLT (6) Sigma Receptor (1) Sirtuin (6) Small Interfering RNA (siRNA) (1) Sodium Channel (28) Src (6) STAT (5) Syk (1) TAM Receptor (3) Tau Protein (1) TGF-beta/Smad (5) Thrombin (8) Thrombopoietin Receptor (3) Thymidylate Synthase (5) Thyroid Hormone Receptor (6) TNF Receptor (5) Toll-like Receptor (TLR) (4) TOPK (1) Topoisomerase (22) Trk Receptor (3) TRP Channel (14) Tyrosinase (6) Vasopressin Receptor (2) VD/VDR (14) VEGFR (29) Virus Protease (16) Wee1 (1) Xanthine Oxidase (3) β-catenin (4) γ-secretase (1)
By Research Areas:	Cancer (765) Cardiovascular Disease (214) Endocrinology (189) Infection (396) Inflammation/Immunology (334) Metabolic Disease (372) Neurological Disease (482)
Click Chemistry:	PROTAC Synthesis (7) Azide (6) Alkynes (17)
Oligonucleotides:	Fillers (1) Pre-designed siRNA Sets (1) siRNAs (1)

3217

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Inhibitory Antibodies

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Isotope-Labeled Compounds

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Targets Recommended: P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W054223

N-Methyl lactam	Others	Others
N-Methyl lactam (Compound 3b), a peramiue analogue, has feeding-deterrent activity against adult weevils .

HY-131466

N-Methyl Palbociclib	Drug Metabolite	Others
N-Methyl Palbociclib is an impurity of Palbociclib (HY-50767). Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor.

HY-W001239S

N-Methyl pyrrole-d3	Isotope-Labeled Compounds	Others
N-Methyl pyrrole-d₃ is the deuterium labeled N-Methyl pyrrole[1].

HY-W001239S1

N-Methyl pyrrole-d4	Isotope-Labeled Compounds	Others
N-Methyl pyrrole-d₄ is the deuterium labeled N-Methyl pyrrole[1].

HY-135412

N-Methyl Duloxetine hydrochloride	Sodium Channel	Neurological Disease
N-Methyl Duloxetine hydrochloride is an analgesic. N-Methyl Duloxetine (hydrochloride) elicits both tonic and use-dependent block of neuronal Na ⁺ channels .

HY-131459S

N-Methyl Metribuzin-d3	Isotope-Labeled Compounds	Others
N-Methyl Metribuzin-d₃ is the deuterium labeled N-Methyl Metribuzin[1].

HY-132476S

N-Methyl Gatifloxacin-d3	Isotope-Labeled Compounds	Others
N-Methyl Gatifloxacin-d₃ is the deuterium labeled N-Methyl Gatifloxacin[1].

HY-137773

N-Methyl pemetrexed	Drug Metabolite	Cancer
N-Methyl pemetrexed is an impurity of Pemetrexed. Pemetrexed is an antifolate cytotoxic agent that can be used for the research of cancer .

HY-144147S

N-Methyl Quinidine-d3 iodide	Isotope-Labeled Compounds	Others
N-Methyl Quinidine-d₃ (iodide) is the deuterium labeled N-Methyl Quinidine iodide[1].

HY-134092

N-Methyl Leukotriene C4 N-Methyl-LTC4	Others	Inflammation/Immunology
N-Methyl Leukotriene C4 stimulates contraction of airway smooth muscle in animals, with efficacy varying by tissue and species. For example, it can stimulate the lungs of bullfrogs to contract .

HY-E70339

*Phenylethanolamine N-methyl* transferase, bovine**	Endogenous Metabolite	Others
Phenylethanolamine N-methyl transferase, bovine is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

HY-E70341

*Histamine N-methyl* transferase, rat**	Endogenous Metabolite	Others
Histamine N-methyl transferase, rat is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

HY-W131494S

*(N)-Methyl* omeprazole-d3**	Isotope-Labeled Compounds	Others
(N)-Methyl omeprazole-d₃ is the deuterium labeled (N)-Methyl omeprazole[1].

HY-113472S

N-Methyl-4-pyridone-3-carboxamide-d3	Isotope-Labeled Compounds	Others
N-Methyl-4-pyridone-3-carboxamide-d₃ is deuterium labeled N-Methyl-4-pyridone-3-carboxamide.

HY-B1213AS

*Trimipramine-d3 (N-methyl-d3) (maleate)*	Bacterial 5-HT Receptor Isotope-Labeled Compounds	Others
Trimipramine-d₃ (N-methyl-d₃) (maleate) is the deuterium labeled Trimipramine (N-methyl) maleate[1].

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-113472

N-Methyl-4-pyridone-3-carboxamide	Drug Metabolite	Others
N-Methyl-4-pyridone-3-carboxamide is a metabolite of coffee pyridines .

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-17387S1

(-)-Huperzine A-d4 hydrochloride Huperzine A-d<sub>4sub>	iGluR Cholinesterase (ChE) Apoptosis Isotope-Labeled Compounds	Neurological Disease
(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease ^[4] .

HY-41680S

4-Aminobenzonitrile-d4 4-Aminobenzonitrile-d<sub>4sub>; 4-Cyanoaniline-d<sub>4sub>; 4-Cyanobenzenamine-d<sub>4sub>	Isotope-Labeled Compounds	Others
4-Aminobenzonitrile-d₄ is the deuterium labeled 4-Aminobenzonitrile[1].

HY-66005S

Acetaminophen-d4 Paracetamol-d<sub>4sub>; 4-Acetamidophenol-d<sub>4sub>; 4'-Hydroxyacetanilide-d<sub>4sub>	COX Histone Acetyltransferase Endogenous Metabolite	Inflammation/Immunology
Acetaminophen-d₄ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

HY-Y1042S

4-Cyanophenol-d4 4-Hydroxybenzonitrile-d<sub>4sub>; 4-Hydroxycyanobenzene-d<sub>4sub>; NSC 400524-d<sub>4sub>	Isotope-Labeled Compounds	Others
4-Cyanophenol-d₄ is the deuterium labeled 4-Cyanophenol[1].

HY-W089645

*2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide* N-Methyl-n-triMethylsilyltrifluoroacetamide	Others	Metabolic Disease
2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide (N-Methyl-n-trimethylsilyltrifluoroacetamide) is an ester product.

HY-151869S

*Benzenemethanamine,N-(methyl-d3)-,hydrochloride*	Isotope-Labeled Compounds	Others
Benzenemethanamine,N-(methyl-d₃)-,hydrochloride is the deuterium labeled Benzenemethanamine,N-(methyl)-,hydrochloride[1].

HY-17413S2

Zidovudine-d4 Azidothymidine-d<sub>4sub>; AZT-d<sub>4sub>; ZDV-d<sub>4sub>	CRISPR/Cas9 HIV Isotope-Labeled Compounds	Infection Cancer
Zidovudine-d₄ is deuterated labeled Zidovudine (HY-17413). Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.

HY-B1008S

4-Aminobenzoic acid-d4 PABA-d<sub>4sub>; Vitamin Bx-d<sub>4sub>; Vitamin H1-d<sub>4sub>; p-Aminobenzoic acid-d<sub>4sub>	Isotope-Labeled Compounds Endogenous Metabolite	Others
4-Aminobenzoic acid-d₄ is the deuterium labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.

HY-N0006S1

Demethoxycurcumin-d4 Curcumin II-d<sub>4sub>; Desmethoxycurcumin-d<sub>4sub>; Monodemethoxycurcumin-d<sub>4sub>	Apoptosis Autophagy Bacterial	Cancer
Demethoxycurcumin-d₄ is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin (Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties[1].

HY-19391

UK-240455	iGluR	Neurological Disease
UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist.

HY-143822S

N-Methyl-N’-nitrosopiperazine-d4	Isotope-Labeled Compounds	Others
N-Methyl-N’-nitrosopiperazine-d₄ is the deuterium labeled N-Methyl-N’-nitrosopiperazine[1].

HY-W010366

N-Methyl-L-threonine	Amino Acid Derivatives	Others
N-Methyl-L-threonine is a threonine derivative .

HY-20561

N-Methyl-L-valine	Amino Acid Derivatives	Others
N-Methyl-L-valine is a valine derivative .

HY-B0329S

Isoniazid-d4 INH-d<sub>4sub>; Isonicotinic acid hydrazide-d<sub>4sub>; Isonicotinic hydrazide-d<sub>4sub>	Bacterial Autophagy Mitophagy Antibiotic	Infection
Isoniazid-d₄ is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].

HY-100048S

Acetylisoniazid-d4 Acetylisoniazide-d<sub>4sub>; N-Monoacetylisoniazid-d<sub>4sub>; NSC 36084-d<sub>4sub>	Isotope-Labeled Compounds	Others
Acetylisoniazid-d₄ is the deuterium labeled Acetylisoniazid[1].

HY-118861S

Enclomiphene-d4 hydrochloride (E)-Clomiphene-d<sub>4sub> hydrochloride; trans-Clomiphene-d<sub>4sub> hydrochloride; Enclomifene-d<sub>4sub> hydrochloride	Isotope-Labeled Compounds Estrogen Receptor/ERR	Inflammation/Immunology
Enclomiphene-d₄ (hydrochloride) is a deuterium labeled Enclomiphene. Enclomiphene-d₄ (hydrochloride) is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property[1].

HY-109015S

Tucidinostat-d4 Chidamide-d<sub>4sub>; HBI-8000-d<sub>4sub>; CS 055-d<sub>4sub>	Isotope-Labeled Compounds HDAC	Cancer
Tucidinostat-d₄ is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively[1].

HY-19696AS

Tauroursodeoxycholate-d4 sodium Tauroursodeoxycholic acid-d<sub>4sub> sodium; TUDCA-d<sub>4sub> sodium; UR 906-d<sub>4sub> sodium	Isotope-Labeled Compounds ERK Caspase Apoptosis Endogenous Metabolite	Cancer
Tauroursodeoxycholate-d₄ (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S1

Tauroursodeoxycholate-d4 Tauroursodeoxycholic acid-d<sub>4sub>; TUDCA-d<sub>4sub>; UR 906-d<sub>4sub>	Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-B0389S24

D-Glucose-d4 Glucose-d<sub>4sub>; D-(+)-Glucose-d<sub>4sub>; Dextrose-d<sub>4sub>	Endogenous Metabolite	Metabolic Disease Cancer
D-Glucose-d₄ is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec

HY-B0696AS

Tiagabine-d4 hydrochloride NO050328-dd<sub>4sub> hydrochloride; NO328-d<sub>4sub> hydrochloride; TGB-d<sub>4sub> hydrochloride	GABA Receptor Isotope-Labeled Compounds	Neurological Disease
Tiagabine-d₄ hydrochloride is deuterated labeled Tiagabine hydrochloride (HY-B0696A). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC₅₀s of 67, 446 and 182 nM for [ ³H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .

HY-13273S

Ostarine-d4 MK-2866-d<sub>4sub>; GTX-024-d<sub>4sub>; Enobosarm-d<sub>4sub>	Isotope-Labeled Compounds Androgen Receptor	Cancer
Ostarine-d4 is a deuterated labeled Ostarine .

HY-20561A

N-Methyl-D-valine	Amino Acid Derivatives	Others
N-Methyl-D-valine is a valine derivative .

HY-111054

N-methyl-N-dithiocarboxyglucamine MDCG	Endogenous Metabolite	Inflammation/Immunology
N-methyl-N-dithiocarboxyglucamine (MDCG) mobilizes and promotes excretion of metallothione-bound ¹⁰⁹Cd. N-methyl-N-dithiocarboxyglucamine shows effects on acute and chronic Cd intoxication .

HY-B0184S1

Felbamate-d5 Felbamyl-d<sub>5sub>; Felbatol-d<sub>5sub>; Taloxa-d<sub>5sub>	iGluR	Neurological Disease
Felbamate-d₅ is the deuterium labeled Felbamate[1]. Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA)[2][3].

HY-34498S

4-Chloro-2-methylphenol-d4 4-Chloro-o-cresol-d<sub>4sub>; 4-Chlorocresol-d<sub>4sub>; 5-Chloro-2-hydroxytoluene-d<sub>4sub>	Isotope-Labeled Compounds	Others
4-Chloro-2-methylphenol-d₄ is the deuterium labeled 4-Chloro-2-methylphenol[1].

HY-10581AS1

Gatifloxacin-d4 hydrochloride AM-1155-d<sub>4sub> hydrochloride; BMS-206584-d<sub>4sub> hydrochloride; PD135432-d<sub>4sub> hydrochloride	Antibiotic Bacterial Topoisomerase Isotope-Labeled Compounds	Infection
Gatifloxacin-d₄ (AM-1155-d₄; BMS-206584-d₄; PD135432-d₄) hydrochloride is deuterium-labeled Gatifloxacin (hydrochloride) (HY-10581A) .

HY-107542S

Oleoylethanolamide-d4 N-Oleoylethanolamide-d<sub>4sub>; Oleamide MEA-d<sub>4sub>; Oleic acid monoethanolamide-d<sub>4sub>	Isotope-Labeled Compounds Endogenous Metabolite PPAR	Cardiovascular Disease Metabolic Disease
Oleoylethanolamide-d₄ is the deuterium labeled Oleoylethanolamide. Oleoylethanolamide is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis.

HY-B0017S

Telbivudine-d4 Epavudine-d<sub>4sub>; L-Thymidine-d<sub>4sub>; NV 02B-d<sub>4sub>	Isotope-Labeled Compounds HBV	Infection
Telbivudine-d₄ is deuterium labeled Telbivudine. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication[1].

HY-B0579S

Cyclosporin A-d4 Cyclosporine A-d<sub>4sub>; Ciclosporin A-d<sub>4sub>; CsA-d<sub>4sub>	Antibiotic Complement System Phosphatase	Inflammation/Immunology Cancer
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-N5034S

Phosphorylethanolamine-d4 Monoaminoethyl phosphate-d<sub>4sub>; NSC 254167-d<sub>4sub>; O-Phosphoethanolamine-d<sub>4sub>	Isotope-Labeled Compounds	Metabolic Disease
Phosphorylethanolamine-d₄ (Monoaminoethyl phosphate-d₄; NSC 254167-d₄) is a deuterium labeled Phosphorylethanolamine (HY-N5034). Phosphorylethanolamine is an endogenous metabolite.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[4].

HY-111054A

N-methyl-N-dithiocarboxyglucamine sodium MDCG sodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound ¹⁰⁹Cd in mouse model. N-methyl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity .

HY-W751835

Baloxavir-d4 Maximum Cited Publications 30 Publications Verification Baloxavir acid-d<sub>4sub>; S-033447-d<sub>4sub>	Classification of Application Fields Disease Research Fields Cancer	Isotope-Labeled Compounds
Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-W015424

N-Methyl-DL-glutamic acid	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-Methyl-DL-glutamic acid is a L-Glutamic acid (HY-14608) analog with cytotoxic effects .

HY-21754

Hygric acid N-Methyl-L-proline	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Rutaceae Plants Disease Research Fields Citrus reticulata Blanco	Others
Hygric acid (N-Methyl-L-proline) is a proline analogue found in the citrus juices and the juice of bergamot .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[4].

HY-111054

N-methyl-N-dithiocarboxyglucamine MDCG	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
N-methyl-N-dithiocarboxyglucamine (MDCG) mobilizes and promotes excretion of metallothione-bound ¹⁰⁹Cd. N-methyl-N-dithiocarboxyglucamine shows effects on acute and chronic Cd intoxication .

HY-107277

Hapepunine	Structural Classification Alkaloids Liliaceae Other Alkaloids Source classification Fritillaria camschatcensis (L.) Ker Gawl. Plants	Others
Hapepunine is a N-methyl-22,26-epiminochole stene, that can be isaolated from the aerial parts of Fritillaria camtschatcensis .

HY-W065053

*trans-N-Methyl-4-methoxyproline*	Natural Products Source classification Allium sativum L. Plants Amaryllidaceae	Amino Acid Derivatives
trans-N-Methyl-4-methoxyproline is a natural product that can be isolated from the stems of Petiveria alliacea and is also a Proline derivative .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[3][4].

HY-N0662

Amentoflavone 5+ Cited Publications DideMethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[4].

HY-P99294

Ganitumab AMG 479; Human Anti-IGF1R Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	IGF-1R
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (K_D=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .

HY-N0662R

Amentoflavone (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[4].

HY-W001963

Pyrrole-2-carboxylic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Marine natural products Source classification Other Diseases Endogenous metabolite Marine microorganism Disease Research Fields	Endogenous Metabolite
Pyrrole-2-carboxylic acid is a natural alkaloid from the marine bacterium Pelomonas puraquae sp. Nov.

HY-77817

Pyrrole-2-carboxaldehyde 2-Formylpyrrole	Alkaloids Structural Classification other families Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Others
Pyrrole-2-carboxaldehyde has vibrational and electronic characteristics used to establish the existence of dimeric form in solid phase and monomeric form in solution phase .

HY-126788

Antibiotic DC 102 DC 102	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic
Antibiotic DC 102 is a new glycosidic pyrrole(1,4)benzodiazepine antibiotic with a MIC value of 42 μg/mL target Bacillus subtilis No. 10707. Antibiotic DC 102 has an LD₅₀ value of 1.5mg/mL(i.p) in mouse .

HY-B0504S

Creatinine-d3 3 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-100807

Quinolinic acid 3 Publications Verification	Alkaloids Structural Classification Microorganisms Disease markers Pyridine Alkaloids Nervous System Disorder Endogenous metabolite	Endogenous Metabolite iGluR
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction .

HY-N0973

1-(4-Methoxycinnamoyl)pyrrole	Structural Classification Alkaloids Source classification Piperaceae Plants Piper nigrum Linn.	Others
1-(4-Methoxycinnamoyl)pyrrole is a Alkaloids product that can be isolated from the herbs of Piper nigrum L. .

HY-123706

Salinosporamide C	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite
Salinosporamide C (compound 4) is a decarboxylated pyrrole analog. Salinosporamide C is the secondary metabolite of the obligate marine actinomycete Salinispora tropical .

HY-N1866

N-(3-Phenylpropanoyl)pyrrole	Structural Classification Alkaloids Pyrrole Alkaloids Piper sarmentosum Roxb. Source classification Piperaceae Plants	Others
N-(3-Phenylpropanoyl)pyrrole is a natural product, that can be isolated from the fresh roots, fruits and leaves of Piper sarmentosum .

HY-100807R

Quinolinic acid (Standard) 3 Publications Verification	Structural Classification Alkaloids Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Pyridine Alkaloids Nervous System Disorder Endogenous metabolite	Endogenous Metabolite iGluR
Quinolinic acid (Standard) is the analytical standard of Quinolinic acid. This product is intended for research and analytical applications. Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction .

HY-17551

NMDA 15+ Cited Publications N-Methyl-D-aspartic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	iGluR Endogenous Metabolite
NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.

HY-N6794

10Z-Hymenialdisine (Z)-Hymenialdisine; Hymenialdisine	Alkaloids Structural Classification Pyrrole Alkaloids Animals Classification of Application Fields Marine natural products Source classification Sponge Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	AMPK VEGFR PDGFR
10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities .

HY-N2311

Ibotenic acid 5+ Cited Publications (RS)-Ibotenic acid; DL-Ibotenic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	iGluR
Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Q_m) receptor sites.

HY-N2370

24-Hydroxycholesterol 1 Publications Verification	Structural Classification Animals Source classification Steroids	iGluR LXR
24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.

HY-113632

Debromohymenialdisine 10Z-Debromohymenialdisine	Structural Classification Natural Products Classification of Application Fields Marine natural products Sponge Disease Research Fields Cancer	Raf MEK
Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC₅₀ value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation .

HY-W065835

2-Bromoaldisine	Structural Classification Alkaloids Pyrrole Alkaloids Marine natural products Source classification	HIV
2-Bromoaldisine is a pyrrole alkaloid that can be isolated from the Red Sea: marine sponge Stylissa carter. 2-Bromoaldisine inhibits HIV-1 vector infection. 2-Bromoaldisine inhibits Raf/MEK/MAPK pathway .

HY-45609

L-Cysteine S-sulfate sodium hydrate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	iGluR Endogenous Metabolite
L-Cysteine S-sulfate sodium hydrate is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate sodium hydrate is the substrate for cystine lyase, it can be used in mass spectrometry operations .

HY-113084

L-Cysteine S-sulfate	Structural Classification Natural Products Immune System Disorder Neurological Disease Classification of Application Fields Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	iGluR Endogenous Metabolite
L-Cysteine S-sulfate is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptor agonist. L-Cysteine S-sulfate is the substrate for cystine lyase, and can be used in mass spectrometry operations .

HY-100787

L-Cysteine S-sulfate sodium	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	iGluR Endogenous Metabolite
L-Cysteine S-sulfate sodium is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate sodium hydrate is the substrate for cystine lyase, it can be used in mass spectrometry operations .

HY-129692

Withanone 1 Publications Verification	Structural Classification Source classification Withania somnifera Plants Solanaceae Steroids	iGluR
Withanone is an active constituent from Withania somnifera roots with multifunctional neuroprotective effect in alleviating cognitive dysfunction. Withanone affords protection against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in Neuron-like cells .

HY-N0368R

Linalool (Standard)	Cardiovascular Disease Structural Classification Classification of Application Fields Terpenoids Source classification Amberboa moschata (L.) DC. Plants Umbelliferae Endogenous metabolite Disease Research Fields	iGluR Apoptosis Endogenous Metabolite
Linalool (Standard) is the analytical standard of Linalool. This product is intended for research and analytical applications. Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity .Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome .

HY-N11061

Withaphysalin D	Structural Classification Physalis minima Linn. Source classification Plants Solanaceae Steroids	iGluR
Withaphysalin D is a selective antagonist against the N-methyl-D-aspartate receptor (NMDAR) containing GluN2B. Withaphysalin D can be isolated from water lilies and has neuroprotective properties. Withaphysalin D is able to cross the blood-brain barrier .

HY-P1293

Conantokin G	Structural Classification Natural Products Animals Source classification	iGluR
Conantokin G, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G inhibits NMDA-evoked currents in murine cortical neurons with an IC₅₀ of 480 nM. Conantokin G has neuroprotective properties .

HY-101037

Sarcosine 1 Publications Verification N-Methylglycine; Sarcosin	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Classification of Application Fields Source classification Disease markers Endocrine diseases Amino acids Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite GlyT
Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-P1293A

Conantokin G TFA	Natural Products Animals Source classification	iGluR
Conantokin G TFA, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G TFA inhibits NMDA-evoked currents in murine cortical neurons with an IC₅₀ of 480 nM. Conantokin G TFA has neuroprotective properties .

HY-Y0966

Glycine 5+ Cited Publications	Structural Classification Neurological Disease Classification of Application Fields Source classification Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite iGluR VEGFR
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis ^[4] .

HY-129692R

Withanone (Standard)	Structural Classification Source classification Withania somnifera Solanaceae Plants Steroids	iGluR
Withanone (Standard) is the analytical standard of Withanone. This product is intended for research and analytical applications. Withanone is an active constituent from Withania somnifera roots with multifunctional neuroprotective effect in alleviating cognitive dysfunction. Withanone affords protection against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in Neuron-like cells .

HY-N6704

Enniatin A1	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields Cancer	ERK Apoptosis
Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC₅₀ of 49 μM in rat liver microsomes .

HY-101037R

Sarcosine (Standard)	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Source classification Disease markers Endocrine diseases Amino acids Endogenous metabolite	Endogenous Metabolite GlyT
Sarcosine (Standard) is the analytical standard of Sarcosine. This product is intended for research and analytical applications. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-17387

(-)-Huperzine A 4 Publications Verification Huperzine A	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Anti-aging Terpenoids Huperziaceae Sesquiterpenes Pyridine Alkaloids Huperzia serrata Plants Disease Research Fields	Cholinesterase (ChE) Apoptosis iGluR
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease ^[4] .

HY-Y0966R

Glycine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite Cancer	Endogenous Metabolite iGluR VEGFR
Glycine (Standard) is the analytical standard of Glycine. This product is intended for research and analytical applications. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis ^[4] .

HY-N0215

L-Phenylalanine 2 Publications Verification Phenylalanine	Structural Classification Microorganisms Animals Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Calcium Channel iGluR Endogenous Metabolite
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca ⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (K_B of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals ^[4].

HY-126637

Marasmic acid	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial Fungal
Marasmic acid is a sesquiterpenoid with unsaturated dialdehyde functionality, first isolated from the Basidiomycete Marasmus conigenus. Marasmic acid has antibacterial, antifungal, cytotoxic and mutagenic activities, and its broad-spectrum activity is related to the α,β-unsaturated aldehyde group. However, its detailed biological mechanism of action has not been clarified. Previous studies have suggested that marasmic acid may exert its effects by reacting with endogenous nucleophiles or forming pyrrole derivatives. This study found that marasmic acid interferes with the membrane sensor histidine kinase MoSln1p of M. oryzae, superactivates the HOG pathway and causes cell death, indicating that its mechanism of action is different from other unsaturated dialdehyde sesquiterpenoids.

HY-N0215R

L-Phenylalanine (Standard)	Structural Classification Microorganisms Animals Source classification Amino acids Endogenous metabolite	Calcium Channel iGluR Endogenous Metabolite
L-Phenylalanine (Standard) is the analytical standard of L-Phenylalanine. This product is intended for research and analytical applications. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals ^[4].

Cat. No.	Product Name	Chemical Structure

HY-113472S

N-Methyl-4-pyridone-3-carboxamide-d3
N-Methyl-4-pyridone-3-carboxamide-d₃ is deuterium labeled N-Methyl-4-pyridone-3-carboxamide.

HY-W001239S

N-Methyl pyrrole-d3
N-Methyl pyrrole-d₃ is the deuterium labeled N-Methyl pyrrole[1].

HY-W001239S1

N-Methyl pyrrole-d4
N-Methyl pyrrole-d₄ is the deuterium labeled N-Methyl pyrrole[1].

HY-131459S

N-Methyl Metribuzin-d3
N-Methyl Metribuzin-d₃ is the deuterium labeled N-Methyl Metribuzin[1].

HY-132476S

N-Methyl Gatifloxacin-d3
N-Methyl Gatifloxacin-d₃ is the deuterium labeled N-Methyl Gatifloxacin[1].

HY-144147S

N-Methyl Quinidine-d3 iodide
N-Methyl Quinidine-d₃ (iodide) is the deuterium labeled N-Methyl Quinidine iodide[1].

HY-W131494S

*(N)-Methyl* omeprazole-d3**
(N)-Methyl omeprazole-d₃ is the deuterium labeled (N)-Methyl omeprazole[1].

HY-132485S

N-Methyl Pantoprazole-d3 (Mixture of 1 and 3 isomers)
N-Methyl Pantoprazole-d3 (Mixture of 1 and 3 isomers) is the deuterium labeled N-Methyl Pantoprazole (Mixture of 1 and 3 isomers) .

HY-B1213AS

*Trimipramine-d3 (N-methyl-d3) (maleate)*
Trimipramine-d₃ (N-methyl-d₃) (maleate) is the deuterium labeled Trimipramine (N-methyl) maleate[1].

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-17387S1

(-)-Huperzine A-d4 hydrochloride

(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease ^[4] .

HY-41680S

4-Aminobenzonitrile-d4
4-Aminobenzonitrile-d₄ is the deuterium labeled 4-Aminobenzonitrile[1].

HY-66005S

Acetaminophen-d4
Acetaminophen-d₄ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

HY-Y1042S

4-Cyanophenol-d4
4-Cyanophenol-d₄ is the deuterium labeled 4-Cyanophenol[1].

HY-151869S

*Benzenemethanamine,N-(methyl-d3)-,hydrochloride*
Benzenemethanamine,N-(methyl-d₃)-,hydrochloride is the deuterium labeled Benzenemethanamine,N-(methyl)-,hydrochloride[1].

HY-17413S2

Zidovudine-d4
Zidovudine-d₄ is deuterated labeled Zidovudine (HY-17413). Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.

HY-B1008S

4-Aminobenzoic acid-d4
4-Aminobenzoic acid-d₄ is the deuterium labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.

HY-N0006S1

Demethoxycurcumin-d4
Demethoxycurcumin-d₄ is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin (Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties[1].

HY-143822S

N-Methyl-N’-nitrosopiperazine-d4
N-Methyl-N’-nitrosopiperazine-d₄ is the deuterium labeled N-Methyl-N’-nitrosopiperazine[1].

HY-B0329S

Isoniazid-d4
Isoniazid-d₄ is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].

HY-100048S

Acetylisoniazid-d4
Acetylisoniazid-d₄ is the deuterium labeled Acetylisoniazid[1].

HY-118861S

Enclomiphene-d4 hydrochloride
Enclomiphene-d₄ (hydrochloride) is a deuterium labeled Enclomiphene. Enclomiphene-d₄ (hydrochloride) is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property[1].

HY-109015S

Tucidinostat-d4
Tucidinostat-d₄ is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively[1].

HY-19696AS

Tauroursodeoxycholate-d4 sodium
Tauroursodeoxycholate-d₄ (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S1

Tauroursodeoxycholate-d4
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-B0389S24

D-Glucose-d4
D-Glucose-d₄ is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec

HY-B0696AS

Tiagabine-d4 hydrochloride
Tiagabine-d₄ hydrochloride is deuterated labeled Tiagabine hydrochloride (HY-B0696A). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC₅₀s of 67, 446 and 182 nM for [ ³H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .

HY-13273S

Ostarine-d4
Ostarine-d4 is a deuterated labeled Ostarine .

HY-B0184S1

Felbamate-d5
Felbamate-d₅ is the deuterium labeled Felbamate[1]. Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA)[2][3].

HY-34498S

4-Chloro-2-methylphenol-d4
4-Chloro-2-methylphenol-d₄ is the deuterium labeled 4-Chloro-2-methylphenol[1].

HY-10581AS1

Gatifloxacin-d4 hydrochloride
Gatifloxacin-d₄ (AM-1155-d₄; BMS-206584-d₄; PD135432-d₄) hydrochloride is deuterium-labeled Gatifloxacin (hydrochloride) (HY-10581A) .

HY-107542S

Oleoylethanolamide-d4
Oleoylethanolamide-d₄ is the deuterium labeled Oleoylethanolamide. Oleoylethanolamide is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis.

HY-B0017S

Telbivudine-d4
Telbivudine-d₄ is deuterium labeled Telbivudine. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication[1].

HY-B0579S

Cyclosporin A-d4
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-N5034S

Phosphorylethanolamine-d4
Phosphorylethanolamine-d₄ (Monoaminoethyl phosphate-d₄; NSC 254167-d₄) is a deuterium labeled Phosphorylethanolamine (HY-N5034). Phosphorylethanolamine is an endogenous metabolite.

HY-16582AS

Sonidegib-d4
Sonidegib-d4 is a isotope of Sonidegib. Sonidegib is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively .

HY-W700069

Gatifloxacin-d4
Gatifloxacin-d4 is the deuterium labeled Gatifloxacin .

HY-78004S1

1,2-Diphenylethane-d4
1,2-Diphenylethane-d4 (Dibenzil-d4; s-Diphenylethane-d4; Bibenzyl-d4) is the deuterium labeled Bibenzyl (HY-78004) .

HY-17422S1

Acyclovir-d4

Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1][2][3]. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[4].

HY-B0548AS1

Hydroxyzine-d4' dihydrochloride
Hydroxyzine-d₄ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2].

HY-B0035S

Sulfamethazine-d4
Sulfamethazine-d₄ is a deuterium labeled Sulfamethazine (Sulfadimidine). Sulfamethazine is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections)[1][2].

HY-B1217S

Bronopol-d4
Bronopol-d₄ is deuterium labeled Bronopol.

HY-W089645S

N-Methyl-N-(trimethylsilyl)trifluoroacetamide-d9
N-Methyl-N-(trimethylsilyl)trifluoroacetamide-d₉ is the deuterium labeled N-Methyl-N-(trimethylsilyl)trifluoroacetamide[1].

HY-W014839S1

Cyclamic acid-d4 sodium
Cyclamic acid-d4 (sodium) is the deuterium labeled Cyclamic acid (sodium) .

HY-157075S

(Z)-Rilpivirine-d4
(Z)-Rilpivirine-d₄ (R278474-d₄; TMC278-d₄; DB08864-d₄) is deuterium-labeled (Z)-Rilpivirine .

HY-15455S

Roflumilast-d4
Roflumilast-d₄ is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells[1][2].

HY-B1431S

Butylparaben-d4
Butylparaben-d₄ is the deuterium labeled Butylparaben. Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.

HY-N0570S

Hydroxytyrosol-d4
Hydroxytyrosol-d₄ is the deuterium labeled Hydroxytyrosol. Hydroxytyrosol (DOPET) is a phenolic compound drawn from the olive tree and its leaves with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].

HY-B1290S

2-Phenylethanol-d4

2-Phenylethanol-d₄ is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.

HY-Y1630S

NSC 10281-d4
NSC 10281-d₄ is the deuterium labeled NSC 10281[1].

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