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Results for "

M

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (1212) Cardiovascular Disease (68) Endocrinology (26) Infection (345) Inflammation/Immunology (198) Metabolic Disease (79) Neurological Disease (351)
Click Chemistry:	ADC Synthesis (1) DBCO (4) PROTAC Synthesis (41) Azide (32) Alkynes (27)
Oligonucleotides:	miRNA mimics (4) Nucleosides and their Analogs (10) miRNA antagomirs (4) Nucleoside Phosphoramidites (1) Fillers (2) Flavoring Agents (1) miRNA inhibitors (4) Phospholipids (1) Cap Analogs (30) Antisense Oligonucleotides (1) siRNAs (19) pH Modifiers (1) miRNA agomirs (4) Pegylated Lipids (3) MicroRNAs (16) Aptamers (4) Pre-designed siRNA Sets (19) CpG ODNs (4) Adjuvant (7) Cationic Lipids (3) Polymers (11) Cap 1 (11) Cap 0 (8) Sweetening Agents (3)

2289

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

101

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

254

Natural
Products

296

Recombinant Proteins

108

Isotope-Labeled Compounds

Antibodies

Click Chemistry

117

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19619

m-3M3FBS 5 Publications Verification	Phospholipase Apoptosis	Cancer
m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis .

HY-W855075A

Methyl coenzyme M ammonium	Others	Others
Methyl-coenzyme M can reversibly synthesize methane in methanogenic, ANME-1 and ANME-2 archaea under the catalysis of methyl-coenzyme M Reductase .

HY-149704

M1/M2/M4 muscarinic agonist 1	mAChR	Neurological Disease
M1/M2/M4 muscarinic agonist 1 (Compound 42) is a muscarinic M4/M1/M2 agonist with EC₅₀ values of 6.5, 26 and 210 nM for M4/M1/M2, respectively. M1/M2/M4 muscarinic agonist 1 can be used for research on mental diseases, such as schizophrenia, delusion, etc .

HY-149731

M1/M2/M4 muscarinic agonist 2	mAChR	Neurological Disease
M1/M2/M4 muscarinic agonist 2 (compound 43) is a muscarinic mAChR M1/M2/M4 agonist with EC₅₀s of 30 nM, 200 nM and 6.2 nM, respectively .

HY-149733

M1/M2/M4 muscarinic agonist 3	mAChR	Neurological Disease
M1/M2/M4 muscarinic agonist 3 (compound 45) is a muscarinic mAChR M1/M2/M4 agonist with EC₅₀s of 3.2 nM, 32 nM and 1.7 nM, respectively .

HY-149702

M1/M4 muscarinic agonist 1	mAChR	Neurological Disease
M1/M4 muscarinic agonist 1 (compound 41) is a selective muscarinic M4/M1 agonist with EC₅₀ values of 14 and 55 nM for M4 and M1, respectively. M1/M4 muscarinic agonist 1 can be used for research on mental diseases, such as schizophrenia, delusional disorder, etc .

HY-149732

M1/M4 muscarinic agonist 3	mAChR	Neurological Disease
M1/M4 muscarinic agonist 3 (compound 44) is a muscarinic mAChR M1/M4 agonist with EC₅₀s of 31 nM and 9.3 nM, respectively .

HY-149703

M1/M4 muscarinic agonist 2	Others	Neurological Disease
M1/M4 muscarinic antagonist 2 (compound 40) is a selective M1 and M4 agonist with IC₅₀19 nM and 42 nM, respectively .

HY-105142

M-5011	Others	Inflammation/Immunology
M-5011 is a potent and orally active anti-inflammatory agent. M-5011 shows potent antinociceptive effects and inhibits kaolin (HY-W115786)-induced writhing. M-5011 decreases peritoneal 6-keto-PGF1 alpha levels with low ulcerogenic activities. M-5011 shows anti-inflammatory and anti-pyretic effects and analgesic effect .

HY-Y1313

3-Nitrobenzoic acid m-Carboxynitrobenzene; m-Nitrobenzenecarboxylic acid; m-Nitrobenzoic acid	Bacterial	Infection
3-Nitrobenzoic acid (m-Carboxynitrobenzene; m-Nitrobenzenecarboxylic acid; m-Nitrobenzoic acid) is a strong antioxidant and antimicrobial agent that can inhibit the generation of free radicals and kill bacteria and fungi. 3-Nitrobenzoic acid is a kind of biological materials or organic compounds that are widely used in life science research .

HY-136434

m-Chloramphenicol m-threo-Chloramphenicol	Antibiotic	Others
m-Chloramphenicol (m-threo-Chloramphenicol) is an impurity of Chloramphenicol. Chloramphenicol, a broad-spectrum antibiotic, acts as a potent inhibitor of bacterial protein biosynthesis .

HY-12830

M-110	Pim	Cancer
M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC₅₀=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC₅₀s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC₅₀s of 0.6 to 0.9 μM .

HY-128347

M‑89	Epigenetic Reader Domain	Inflammation/Immunology Cancer
M-89 is a highly potent and specific menin inhibitor, with a K_d of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia .

HY-110181

M8-B	TRP Channel	Metabolic Disease
M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb) .

HY-103639A

M62812	Toll-like Receptor (TLR)	Infection
M62812 is a toll-like receptor 4 (TLR4) signaling inhibitor. M62812 inhibits endothelial and leukocyte activation and prevents lethal septic shock in mice. M62812 can reduces LPS-induced coagulation and inflammatory responses. M62812 can be used for the research of sepsis .

HY-164186

M9-5 sodium	Cyclophilin	Others
M9-5 sodium is an aptamer targeting cyclophilin B. M9-5 binds to the MiaPaCa-2 secretory protein with high affinity and can be used as a blood biomarker for the detection of pancreatic cancer.

HY-136997

M-5MPEP	Others	Others
M-5MPEP is an active compound.

HY-153359

M3913	Others	Cancer
M3913 is an antitumor compound. M3913 has antiproliferation activity against cancer cells .

HY-124069

M-525	Epigenetic Reader Domain	Cancer
M-525 is a first-in-class, highly potent, irreversible and covalent menin-MLL protein-protein interaction inhibitor. M-525 binds to menin with an IC₅₀ of 3 nM and achieves low nanomolar potencies in cell growth inhibition and in suppression of MLL regulated gene expression in MLL leukemia cells. Anti-leukemia activity .

HY-131161

M-MLV Reverse transcriptase M-MLV RT	Reverse Transcriptase	Infection
M-MLV Reverse transcriptase (M-MLV RT) is a kind of Reverse transcriptase, from the moroni mouse leukemia virus (MoMLV) .

HY-141891

M435-1279	E1/E2/E3 Enzyme	Cancer
M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1 .

HY-113356

m-Tyramine	Endogenous Metabolite	Neurological Disease
m-Tyramine is an endogenous trace amine neuromodulator. m-Tyramine has effects on the adrenergic and dopaminergic receptor ^{[1, 2]}.

HY-104050

M-31850 1 Publications Verification	Others	Metabolic Disease
M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor with IC₅₀s of 6.0 µM and 3.1 µM for human HexA and human HexB, respectively. M-31850 also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a K_i of 2.5 μM .

HY-103347

M50054	Apoptosis	Inflammation/Immunology
M50054 is a potent inhibitor of apoptosis. M50054 inhibits Etoposide-induced caspase-3 activation of U937 cells with an IC₅₀ of 79 μg/mL. M50054 does not directly inhibit the enzymatic activity of caspase-3. M50054 can be used for the research anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia .

HY-160096

M3541	ATM/ATR	Cancer
M3541 is a potent, ATP-competitive and selective ATM inhibitor with an IC₅₀ of 0.25 nM. M3541 shows remarkable selectivity against other protein kinases. M3541 suppresses double-strand breaks (DSB) repair and has antitumor activities .

HY-133738

M-808	Epigenetic Reader Domain	Cancer
M-808 is a highly potent and efficacious covalent Menin-MLL interaction inhibitor, with a binding IC₅₀ value of 2.6 nM .

HY-P1729

M-2420	Fluorescent Dye	Neurological Disease
M-2420 is a fluorogenic substrate containing β-secretase site of the Swedish mutation of amyloid precursor protein (APP) .

HY-132234

M-1211	Epigenetic Reader Domain	Cancer
M‑1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression .

HY-W007346S

m-Anisaldehyde-d3	Endogenous Metabolite	Metabolic Disease
m-Anisaldehyde-d₃ is the deuterium labeled m-Anisaldehyde[1]. m-Anisaldehyde is an endogenous metabolite.

HY-78086R

m-Tolualdehyde (Standard)	Endogenous Metabolite Bacterial	Infection
m-Tolualdehyde (Standard) is the analytical standard of m-Tolualdehyde. This product is intended for research and analytical applications. m-Tolualdehyde (3-Methylbenzaldehyde) is a compound that can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a LD50 of 1.97 μg/cm3 .

HY-115928

M24	Bcl-2 Family	Cancer
M24 is a Mcl-1 selective inhibitor. M24 exhibits good binding affinity against Mcl-1 with K_i value of 0.33 μM. M24 exhibits good anti-proliferative activity and induce apoptosis in HepG2 cells .

HY-114592

M199	Toll-like Receptor (TLR) Interleukin Related TNF Receptor	Inflammation/Immunology
M199 is a potent TLR3/TLR9 signaling inhibitor. M199 induces secretion of IL-6, IL-8 and TNFα in human PBMCs. M199 is used as a selective inducer of the immune response .

HY-P5900

m3-Huwentoxin IV m3-HwTx-IV	Sodium Channel	Neurological Disease
m3-Huwentoxin IV (m3-HwTx-IV) is a potent Na_V inhibitor with IC₅₀s of 3.3, 6.8, 7.2, 8.4, 11.9 and 369 nM against hNa_V1.7, hNa_V1.6, hNa_V1.3, hNa_V1.1, hNa_V1.2 and hNa_V1.4, respectively in QPatch assay. m3-Huwentoxin IV dose-dependently suppresses spontaneous pain induced by the Na_V1.7 activator OD1 in a rodent pain model .

HY-P1399

Pep2m, myristoylated Myr-Pep2m	PKC	Neurological Disease
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC) .

HY-113357R

m-Coumaric acid (Standard)	Endogenous Metabolite	Inflammation/Immunology
m-Coumaric acid (Standard) is the analytical standard of m-Coumaric acid. This product is intended for research and analytical applications. m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant.

HY-B0843AR

Metalaxyl-M (Standard)	Fungal	Infection
Metalaxyl-M (Standard) is the analytical standard of Metalaxyl-M. This product is intended for research and analytical applications. Metalaxyl-M ((R)-Metalaxyl) is the active (R)-enantiomer of Metalaxyl. Metalaxyl-M is a broad-spectrum fungicide that inhibits protein and ribosomal RNA synthesis in fungi. Metalaxyl is used for research of plant diseases caused by pathogens of the Oomycota division .

HY-155613

M867	Caspase	Cancer
M867 is a selective and reversible inhibitor of caspase-3 with an IC₅₀ of 1.4 nM and K_i of 0.7 nM. M867 has anti apoptotic activity .

HY-111547

M1001	HIF/HIF Prolyl-Hydroxylase	Cancer
M1001 is a weak hypoxia-inducible factor-2α (HIF-2α) agonist. M1001 can bind to the HIF-2α PAS-B domain, with a K_d of 667 nM. M1001 can be used in chronic kidney disease research .

HY-145982

m7GpppCmpG	Nucleoside Antimetabolite/Analog	Others
m7GpppCmpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppCmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures .

HY-145981

m7GpppCpG	Nucleoside Antimetabolite/Analog	Others
m7GpppCpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppCpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures .

HY-145979

m7GpppUmpG	Nucleoside Antimetabolite/Analog	Others
m7GpppUmpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppUmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures .

HY-145980

m7GpppUpG	Nucleoside Antimetabolite/Analog	Others
m7GpppUpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppUpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures .

HY-P1025A

M40 TFA	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas .

HY-135356R

m-Nifedipine (Standard)	Drug Metabolite	Cardiovascular Disease
m-Nifedipine (Standard) is the analytical standard of m-Nifedipine. This product is intended for research and analytical applications. m-Nifedipine is an impurity of Nifedipine (BAY-a-1040). Nifedipine is a potent calcium channel blocker and agent of choice for cardiac insufficiencies .

HY-122097

M7594_0037	Others	Cancer
M7594_0037 is a potent inhibitor of human peptide deformylase (HsPDF) that has anti-tumor activity .

HY-124718

p32 Inhibitor M36 M36	PKC	Cancer
p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1 .

HY-158819

m7(3'OMeG)(5')ppp(5')m6(2'OMeA)pG trisodium	DNA/RNA Synthesis	Others
m7(3'OMeG)(5')ppp(5')m6(2'OMeA)pG trisodium is a cap analog that can be used for in vitro transcription of mRNA.

HY-120285

M-0002 hydrochloride RWJ-351647 hydrochloride; SPD-556 hydrochloride	Others	Endocrinology
M-0002 hydrochloride (RWJ-351647 hydrochloride) is a biologically active compound that acts as an antagonist of the vasopressin V2 receptor. M-0002 hydrochloride is potentially useful for inhibiting ascites. M-0002 hydrochloride shows excellent properties that are favorable for clinical development .

HY-153888

M351-110	Others	Others
M351-110 is a T-cell activating V-domain immunoglobulin inhibitory factor agonist for cancer research .

HY-114702

M77976 1 Publications Verification	PDHK	Metabolic Disease
M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC₅₀ of 648 μM. M77976 is potential for the research of obesity and diabetes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-128975

m-Tyramine hydrobromide	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
m-Tyramine hydrobromide is an endogenous trace amine neuromodulator. m-Tyramine hydrobromide has effects on the adrenergic and dopaminergic receptor ^{[1, 2]}.

HY-W015343

3-Methoxyphenylacetic acid m-Methoxyphenylacetic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Endogenous Metabolite
3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot .

HY-78086

m-Tolualdehyde 3-Methylbenzaldehyde	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Source classification Other Diseases Plants Disease Research Fields Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Endogenous Metabolite Bacterial
m-Tolualdehyde (3-Methylbenzaldehyde) is a compound that can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a LD₅₀ of 1.97 μg/cm ³ .

HY-W007346

m-Anisaldehyde 3-Methoxybenzaldehyde	Structural Classification Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
m-Anisaldehyde is an endogenous metabolite.

HY-113357

m-Coumaric acid	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant.

HY-122942

Moracin M	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Endogenous metabolite Inflammation/Immunology Disease Research Fields Morus alba Linn.	Phosphodiesterase (PDE) Endogenous Metabolite NF-κB Autophagy
Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC₅₀ values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity .

HY-113356

m-Tyramine	Monophenols Source classification Disease markers Phenols Endogenous metabolite Cardiovascular System Disorder	Endogenous Metabolite
m-Tyramine is an endogenous trace amine neuromodulator. m-Tyramine has effects on the adrenergic and dopaminergic receptor ^{[1, 2]}.

HY-78086R

m-Tolualdehyde (Standard)	Structural Classification Ketones, Aldehydes, Acids Labiatae Source classification Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Endogenous Metabolite Bacterial
m-Tolualdehyde (Standard) is the analytical standard of m-Tolualdehyde. This product is intended for research and analytical applications. m-Tolualdehyde (3-Methylbenzaldehyde) is a compound that can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a LD50 of 1.97 μg/cm3 .

HY-113357R

m-Coumaric acid (Standard)	Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Endogenous Metabolite
m-Coumaric acid (Standard) is the analytical standard of m-Coumaric acid. This product is intended for research and analytical applications. m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant.

HY-N12544

Magnoloside M	Structural Classification Magnolia utilis (Dandy) V.S.Kumar Source classification Magnoliaceae Phenols Polyphenols Plants	Others
Magnoloside M is a magnoside isolated from magnolia .

HY-W053507

m-Tolylacetic acid 3-Methylbenzeneacetic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Drug Metabolite
m-Tolylacetic acid (3-Methylbenzeneacetic acid) is a hydroaromatic dicarboxylic acids excreted in the urine as metabolite of tolueneacetic acid .

HY-W018759

3-Ethylphenol m-Hydroxyethylbenzene	Structural Classification Monophenols Microorganisms Bog bilberry Vaccinium uliginosum L. Source classification Rosaceae Phenols Plants	Others
3-Ethylphenol (m-Hydroxyethylbenzene) is a Phenylpropanoids product that can be isolated from the fruits of Syringa vulgaris .

HY-Y0603

3-Hydroxyacetophenone m-Hydroxyacetophenone	Structural Classification Monophenols other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Plants Disease Research Fields	Others
3-Hydroxyacetophenone (m-Hydroxyacetophenone) is the hydroxy-substituted alkyl phenyl ketone that can be used in synthesis of enantiopure (-)-rivastigmine .

HY-32144

1-(3-Nitrophenyl)ethanone m-Nitroacetophenone	Structural Classification Natural Products Source classification Styracaceae Plants Styrax tonkinensis (Pierre) Craib ex Hartwich	Others
1-(3-Nitrophenyl)ethanone (m-Nitroacetophenone) is a Diterpenoids product that can be isolated from the leaves of Suregada glomerulata(Bl.) Baill. .

HY-N6669

Methyl 3-O-methylgallate 1 Publications Verification M3OMG	Sanguisorba officinalis Linn. Source classification Rosaceae Phenols Polyphenols Plants	Others
Methyl 3-O-methylgallate (M3OMG) possesses antioxidant effect and can protect neuronal cells from oxidative damage .

HY-P99225

Mirvetuximab M9346A	Classification of Application Fields Disease Research Fields Cancer	Antifolate
Mirvetuximab (M9346A) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of novel folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research .

HY-N13018

M145724 (3Z,6E)-1-N-Methylalbonoursin	Structural Classification Natural Products Microorganisms Source classification	Endogenous Metabolite
M145724 ((3Z,6E)-1-N-Methylalbonoursin) is a metabolite, which can be isolated from Streptomyces albus .

HY-P99480

Bintrafusp alfa M7824; MSB0011359C	Classification of Application Fields Disease Research Fields Cancer	TGF-β Receptor
Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer .

HY-P99333

Volociximab M200; Eos 200-4	Classification of Application Fields Disease Research Fields Cancer	Integrin
Volociximab (M200) is a chimeric human/murine IgG4 antibody IIA1 targeting integrin α5β1 (EC₅₀=0.2 nM). Integrin α5β1 is a major fibronectin receptor involved in angiogenesis. Volociximab has antiangiogenic and antitumor activities and inhibits the proliferation of human umbilical vein vascular endothelial cells (HUVECs) .

HY-N3248

Momordicoside G Momordicacoside G	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Momordica charantia Linn.	Endogenous Metabolite Reactive Oxygen Species Apoptosis
Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury .

HY-N0098

Vanillin 3 Publications Verification p-Vanillin; m-Methoxy-p-hydroxybenzaldehyde; p-Hydroxy-m-methoxybenzaldehyde	Structural Classification Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine.

HY-76006

3-Hydroxybenzaldehyde M-Hydroxybenzaldehyde	Cardiovascular Disease Structural Classification Monophenols Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Plants Disease Research Fields	Aldehyde Dehydrogenase (ALDH) NF-κB p38 MAPK
3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis .

HY-N10394

Metachromins X	Quinones Structural Classification Classification of Application Fields Animals Terpenoids Sesquiterpenes Marine natural products Benzene Quinones Sponge Disease Research Fields Cancer	Others
Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

HY-N10670

Bursehernin Methylpluviatolide	Structural Classification Hernandia sonora Linn. other families Source classification Lignans Phenylpropanoids Plants	Apoptosis
Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity .

HY-N1039A

Manool	Natural Products Classification of Application Fields Labiatae Source classification Plants Pteris semipinnata L. Sp. Disease Research Fields Cancer Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Others
Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle .

HY-122496

Malvidin chloride Syringidin	Structural Classification Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Anthocyans Flavonoids Microorganisms other families Phenols Polyphenols Disease Research Fields Cancer	Apoptosis
Malvidin (chloride) is a bioactive compound isolated from grape. Malvidin shows cytotoxicity through the arrest of the G₂/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer .

HY-N0098R

Vanillin (Standard) 3 Publications Verification p-Vanillin (Standard); m-Methoxy-p-hydroxybenzaldehyde (Standard); p-Hydroxy-m-methoxybenzaldehyde (Standard)	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Vanillin (Standard) is the analytical standard of Vanillin. This product is intended for research and analytical applications. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine.

HY-P99672

Istiratumab MM 141; MM-005	Classification of Application Fields Disease Research Fields Cancer	IGF-1R EGFR
Istiratumab (M-6495) is bispecific monoclonal antibody targeting IGF-1R and ErbB3. Istiratumab induces IGF-1R and ErbB3 receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers .

HY-N3294

Mesuol	Structural Classification Natural Products Mesua ferrea L. Source classification Plants Calophyllaceae	Reactive Oxygen Species
Mesuol, a natural product isolated from M. ferrea L. seed oil, has antioxidant and immunomodulatory effects .

HY-N8824

Maackiaflavanone	Structural Classification Flavonoids Leguminosae Flavonones Source classification Maackia amurensis Rupr. et Maxim. Plants	Others
Maackiaflavanone (compound 4) is a kind of prenylated flavanone. Maackia can be isolated from M. amurensi.

HY-117275

Meclofenamic acid 4 Publications Verification Meclofenamate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite
Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-117275A

Meclofenamic acid sodium hydrate Meclofenamate sodium hydrate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite
Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-N12124

Monascuspiloin Monascinol	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Akt mTOR AMPK Androgen Receptor Apoptosis Autophagy
Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC₅₀ of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC₅₀ of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation AMPK signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice .

HY-141472

7-Methylguanosine 5'-diphosphate sodium 7-Methyl-GDP sodium; m7GDP sodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues .

HY-N2558

Murrayone	Classification of Application Fields Source classification Murraya paniculata (L.) Jack. Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields Cancer	Others
Murrayone, a coumarin-containing compound extracted from M. paniculata, is the most bioactive substance in this species and is a cancer metastasis chemopreventive agent based on its unique pharmacological properties .

HY-N3257

Millewanin G	Structural Classification Flavonoids Leguminosae Millettia pachycarpa Benth. Source classification Plants Isoflavones	Estrogen Receptor/ERR
Millewanin G is a prenylated isoflavonoid with antiestrogenic activity (IC₅₀=29 μM). Millewanin G can be isolated from the leaves of M. pachycarpa cultivated in Japan .

HY-N10293

Monaschromone	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields	Fungal Endogenous Metabolite
Monaschromone, a polyketide metabolite, significantly inhibits the growth of B. cinerea, A. solani, M. oryzae, and G. saubinettii, with the MIC values ranging from 6.25 to 12.5 μM .

HY-135252

N-Desbutyroyl acebutolol Deacyl acebutolol; M and B 17127	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-Desbutyroyl Acebutolol (compound Ⅲ) is a metabolite of Acebutolol (HY-17497) .

HY-N7423

Methyl isoferulate Isoferulic acid methyl ester	Structural Classification Monophenols Microorganisms Source classification Phenols	Influenza Virus
Methyl isoferulate (Isoferulic acid methyl ester) is an anti-H1N1 swine flu compound. Methyl isoferulate exerts its anti-swine flu activity by blocking the influenza M2 proton channel .

HY-126416

Methyl tanshinonate	Structural Classification Natural Products Labiatae Source classification Samanea saman (Jacq.) Merr. Plants	SARS-CoV
Methyl tanshinonate is a tanshinone, that can be isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae). Methyl tanshinonate is a potent inhibitor of M ^pro enzyme in SARS-CoV (IC₅₀ = 21.1 µM). Methyl tanshinonate can be used for diabetes and SARS-CoV research .

HY-Y0760

3-Methoxybenzoic acid 3-Anisic acid; 3-Methoxybenzoic acid; NSC 27014; NSC 9264; m-Methoxybenzoic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Methoxybenzoic acid can be used in the synthesis of 3-methoxybenzoates of europium (III) and gadolinium (III).

HY-126637

Marasmic acid	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial Fungal
Marasmic acid is a sesquiterpenoid with unsaturated dialdehyde functionality, first isolated from the Basidiomycete Marasmus conigenus. Marasmic acid has antibacterial, antifungal, cytotoxic and mutagenic activities, and its broad-spectrum activity is related to the α,β-unsaturated aldehyde group. However, its detailed biological mechanism of action has not been clarified. Previous studies have suggested that marasmic acid may exert its effects by reacting with endogenous nucleophiles or forming pyrrole derivatives. This study found that marasmic acid interferes with the membrane sensor histidine kinase MoSln1p of M. oryzae, superactivates the HOG pathway and causes cell death, indicating that its mechanism of action is different from other unsaturated dialdehyde sesquiterpenoids.

HY-N1529

Gomisin M1 (±)-Gomisin M1	Structural Classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	HIV
Gomisin M1 ((±)-Gomisin M1) is a potent anti-HIV agent with an EC₅₀ of <0.65 μM .

HY-122493

Illudin M	Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields Cancer	DNA Alkylator/Crosslinker Apoptosis
Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities .

HY-117220

Aspochalasin M	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Others
Aspochalasin M is a colorless solid. Aspochalasin M shows modest activity against HL-60 cells with an IC₅₀ of 20.0 μM. Aspochalasin M has the potential for the research of leukemic disease .

HY-N3963

Gomisin M2 (+)-Gomisin M2	Classification of Application Fields Neurological Disease Source classification Lignans Plants Infection Monophenols Phenols Phenylpropanoids Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.	HIV
Gomisin M2 ((+)-Gomisin M2) is a lignan isolated from the fruits of Schisandra rubriflora with anti-HIV activity (EC₅₀ of 2.4 μM). Gomisin M2 exhibits anti-cancer and anti-allergic activities and has the potential for Alzheimer’s disease research .

HY-130596

DC-86-M	Structural Classification Microorganisms Antibiotics Source classification Disease Research Anticancer	Antibiotic Bacterial
DC-86-M is an antibiotic, which can be isolated from Streptomyces luteogriseus. DC-86-M exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Vibrio anguillarum, and Proteus vulgaris, with MIC <1 μg/mL. DC-86-M exhibits antitumor activity against mouse sarcoma 180 with LD₅₀ of 25 mg/kg .

HY-N8956

Pachysamine M	Structural Classification Alkaloids Buxaceae Other Alkaloids Source classification Pachysandra terminalis Siebold & Zucc. Plants	Others
Pachysamine M (Compound 5) is a pregnane alkaloid. Pachysamine M is isolated from naturalPachysandra terminalisSieb. et Zucc .

HY-N2244

Hosenkoside M (+)-Hosenkoside M	Triterpenes Structural Classification Classification of Application Fields Terpenoids Impatiens balsamina Linn. Source classification Balsaminaceae Plants Inflammation/Immunology Disease Research Fields	Others
Hosenkoside M is a baccharane glycoside isolated from the seeds of impatiens balsamina.

HY-N6833

Rebaudioside M	Structural Classification Classification of Application Fields Source classification Plants Compositae Sweeteners Food Research Trifolium hybridum L. other families Terpenoids Other Diseases Diterpenoids Disease Research Fields	Others
Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M has antidiabetics, antihypertension, anti-inflammatory, antioxidant, anticaries and anticancer benefits. Rebaudioside M is more than 350 times sweeter than sucrose. Rebaudioside M can be used in food and beverage .

Cat. No.	Product Name	Chemical Structure

HY-19939S

VX-984 4 Publications Verification
VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium .

HY-15772S

Osimertinib-d6
Osimertinib-d₆ is a deuterium labeled osimertinib. Osimertinib is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer[1].

HY-W007346S

m-Anisaldehyde-d3
m-Anisaldehyde-d₃ is the deuterium labeled m-Anisaldehyde[1]. m-Anisaldehyde is an endogenous metabolite.

HY-B0843AS

Metalaxyl-M-d6
Metalaxyl-M-d6 is the deuterium labeled Metalaxyl-M[1]. Metalaxyl-M ((R)-Metalaxyl) is the active (R)-enantiomer of Metalaxyl. Metalaxyl-M is a broad-spectrum fungicide that inhibits protein and ribosomal RNA synthesis in fungi. Metalaxyl is used for research of plant diseases caused by pathogens of the Oomycota division[2].

HY-113357S

m-Coumaric acid-13C3
m-Coumaric acid- ¹³C₃ is the ¹³C-labeled m-Coumaric acid. m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant.

HY-151002S

M8 metabolite of Carvedilol-d5
M8 metabolite of Carvedilol-d₅ is the deuterium labeled M8 metabolite of Carvedilol[1].

HY-Y0589S

m-Cyanobenzoic acid-13C6
m-Cyanobenzoic acid- ¹³C₆ is the ¹³C labeled m-Cyanobenzoic acid[1].

HY-Y1313S

3-Nitrobenzoic acid-d4
3-Nitrobenzoic acid-d₄ is the deuterium labeled 3-Nitrobenzoic acid[1].

HY-115127S

3-Methylanisole-d3
3-Methylanisole-d₃ is the deuterium labeled 3-Methylanisole[1].

HY-Y1675S

NSC 65593-d4
NSC 65593-d₄ is the deuterium labeled NSC 65593[1].

HY-117275S1

Meclofenamic acid-13C6
Meclofenamic acid- ¹³C₆ is the ¹³C₆ labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.

HY-15772S1

Osimertinib-13C,d3
Osimertinib- ¹³C,d₃ is the deuterium and ¹³C labeled Osimertinib. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively.

HY-117275S

Meclofenamic acid-d4
Meclofenamic acid-d₄ is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker[1][2][3].

HY-Y0721S

3-Bromofluorobenzene-13C6
3-Bromofluorobenzene- ¹³C₆ is the ¹³C labeled 3-Bromofluorobenzene[1].

HY-W101642S

1,3-Diisopropylbenzene-d18
1,3-Diisopropylbenzene-d₁₈ is the deuterium labeled 1,3-Diisopropylbenzene[1].

HY-W016152S

1-Bromo-3-methoxybenzene-d3
1-Bromo-3-methoxybenzene-d₃ is the deuterium labeled 1-Bromo-3-methoxybenzene. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-107434S

Molindone-d8
Molindone-d₈ is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses[1][2].

HY-14940S

Volinanserin-d4 hydrochloride
Volinanserin-d₄ (hydrochloride) is the deuterium labeled Volinanserin hydrochlorid. Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity[1][2].

HY-W018728S

3,5-Dimethylbenzoic acid-d9
3,5-Dimethylbenzoic acid-d₉ is the deuterium labeled 3,5-Dimethylbenzoic acid[1].

HY-116429S

Maresin 1-d5
Maresin 1-d₅ is the deuterium labeled Maresin 1. Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].

HY-N0098S2

Vanillin-13C6
Vanillin- ¹³C₆ is the ¹³C labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].

HY-B0481S1

Miglitol-d4
Miglitol-d₄ is deuterium labeled Miglitol.

HY-N0098S

Vanillin-13C,d3
Vanillin- ¹³C,d₃ is the ¹³C and deuterium labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].

HY-I0746S

3-Aminobenzoic acid-d4
3-Aminobenzoic acid-d₄ is the deuterium labeled 3-Aminobenzoic acid[1].

HY-Y0251S

3-Nitrophthalic acid-d3
NSC 3120-d₃ is the deuterium labeled NSC 3120[1].

HY-10564S

Sarpogrelate-d3 hydrochloride

Sarpogrelate-d₃ (hydrochloride) is the deuterium labeled Sarpogrelate hydrochloride. Sarpogrelate hydrochloride (MCI-9042) is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis[1][2][3].

HY-143809S

Repaglinide M1-d5
Repaglinide M1-d₅ is the deuterium labeled Repaglinide M1[1].

HY-154749S

Repaglinide M2-d5
Repaglinide M2-d₅ is deuterated labeled Repaglinide M2.

HY-W001940S

DL-m-Tyrosine-d3
DL-m-Tyrosine-d₃ is the deuterium labeled DL-m-Tyrosine. DL-m-Tyrosine shows effects on Arabidopsis root growth. Carbidopa combination with DL-m-tyrosine shows a potent hypotensive effect[1][2].

HY-144145S

Hydroxy Pioglitazone (M-II)-d4
Hydroxy Pioglitazone (M-II)-d₄ is the deuterium labeled Hydroxy Pioglitazone (M-II)[1].

HY-I0678S

Regorafénib N-oxyde-d3 (M2)
Regorafénib N-oxyde-d₃(M2) is the deuterium labeled Regorafénib N-oxyde M2[1]. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively[2].

HY-103005S

Ramelteon metabolite M-II-d3
Ramelteon metabolite M-II-d₃ is the deuterium labeled Ramelteon metabolite M-II. Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist[1][2].

HY-132468S

Keto Pioglitazone-d4 (M-III-d4)
Keto Pioglitazone-d4 (M-III-d4) is the deuterium labeled Keto Pioglitazone (M-III) .

HY-108226S1

Regorafenib N-oxide and N-desmethyl (M5)-13C6
Regorafenib N-oxide and N-desmethyl (M5)- ¹³C₆ is the ¹³C-labeled Regorafenib N-oxide and N-desmethyl (M5)[1].

HY-129336S

Abemaciclib metabolite M20-d8
Abemaciclib metabolite M20-d₈ is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor[1].

HY-126534S

Abemaciclib metabolite M18-d8
Abemaciclib metabolite M18-d₈ is the deuterium labeled Abemaciclib metabolite M18. Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1][2].

HY-132379S

Hydroxy Pioglitazone-d5 (M-IV) (Mixture of-diastereomers)
Hydroxy Pioglitazone-d₅ (M-IV) (Mixture of-diastereomers) is the deuterium labeled Hydroxy Pioglitazone (M-IV) (Mixture of-diastereomers)[1].

HY-128669S

Abemaciclib metabolite M2-d6
Abemaciclib metabolite M2-d₆ is the deuterium labeled Abemaciclib metabolite M2. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1][2].

HY-I0678S1

Regorafénib N-oxyde (M2)-13C,d3
Regorafénib N-oxyde (M2)- ¹³C,d₃ is the ¹³C- and deuterium labeled Regorafénib N-oxyde (M2). Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

HY-108226S

Regorafenib N-oxide and N-desmethyl (M5)-d3
Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-16637S1

Folic acid-d4
Folic acid-d₄ is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-16637S

Folic acid-d2
Folic acid-d₂ (Vitamin B9-d₂) is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-16637S3

Folic acid-13C5
Folic acid- ¹³C₅ is the ¹³C-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-B0406AS

Bethanechol-d6 chloride
Bethanechol-d₆ (chloride) is the deuterium labeled Bethanechol chloride. Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system[1].

HY-12100S

Umeclidinium-d5 bromide
Umeclidinium-d₅ (bromide) is the deuterium labeled Umeclidinium bromide. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-12100S1

Umeclidinium-d10 bromide
Umeclidinium-d₁₀ (bromide) is the deuterium labeled Umeclidinium bromide. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-B0726S

Pilocarpine-d3 hydrochloride
Pilocarpine-d₃ (hydrochloride) is deuterium labeled Pilocarpine (Hydrochloride). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-A0030S

Fesoterodine-d7 fumarate
Fesoterodine-d₇ (fumarate) is the deuterium labeled Fesoterodine fumarate[1]. Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine Fumarate is used for the overactive bladder (OAB)[2][3].

HY-159578S

VU6036864
VU6036864 (compound 45) is an orally active, selective mAChR M5 antagonist with IC₅₀=20 nM for human M5. VU6036864 is >500-fold selective for human M1-4, with BBB characteristic and high oral bioavailability (%F>100%) .

HY-B0726S1

Pilocarpine-d5 hydrochloride
Pilocarpine-d₅ hydrochloride is deuterated labeled Pilocarpine hydrochloride (HY-B0726). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

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