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Seliciclib Carboxylic Acid-d<sub>7</sub>

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (12) Apical Sodium-Dependent Bile Acid Transporter (2) Fatty Acid Synthase (FASN) (6) G protein-coupled Bile Acid Receptor 1 (5) P-glycoprotein (11) 11β-HSD (3) 5 alpha Reductase (4) 5-HT Receptor (65) Acetolactate Synthase (ALS) (1) Acyltransferase (3) ADC Cytotoxin (12) ADC Linker (11) Adenosine Receptor (8) Adrenergic Receptor (78) AIM2 (1) Akt (7) Aldehyde Dehydrogenase (ALDH) (2) Aminopeptidase (2) AMPK (9) Amyloid-β (8) Anaplastic lymphoma kinase (ALK) (8) Androgen Receptor (17) Angiotensin Receptor (27) Angiotensin-converting Enzyme (ACE) (14) Antibiotic (167) Antifolate (5) AP-1 (1) Apoptosis (237) Aryl Hydrocarbon Receptor (5) ATM/ATR (1) ATP Citrate Lyase (5) Aurora Kinase (1) Autophagy (266) Bacterial (254) Bcl-2 Family (4) Bcr-Abl (10) BCRP (2) Beta-lactamase (1) Beta-secretase (1) Biochemical Assay Reagents (65) Btk (4) c-Fms (2) c-Kit (15) c-Met/HGFR (5) Calcineurin (2) Calcium Channel (63) Cannabinoid Receptor (11) Carbonic Anhydrase (7) Casein Kinase (1) Caspase (4) CaSR (2) Cathepsin (1) CCR (1) CD38 (1) CD73 (1) CDK (15) CFTR (5) CGRP Receptor (2) Checkpoint Kinase (Chk) (1) Chloride Channel (5) Cholinesterase (ChE) (16) CMV (1) Complement System (5) COMT (5) COX (72) CRISPR/Cas9 (3) Cuproptosis (1) CXCR (1) Cyclophilin (2) Cytochrome P450 (31) Deubiquitinase (1) Dihydroorotate Dehydrogenase (1) Dipeptidyl Peptidase (14) Disulfidptosis (4) DNA Alkylator/Crosslinker (8) DNA Methyltransferase (2) DNA Stain (1) DNA/RNA Synthesis (72) Dopamine Receptor (43) Drug Metabolite (73) Drug-Linker Conjugates for ADC (8) DYRK (2) E1/E2/E3 Enzyme (3) E3 Ligase Ligand-Linker Conjugates (3) EBI2/GPR183 (1) EGFR (21) Elastase (1) Endogenous Metabolite (948) Endothelin Receptor (5) Enterovirus (5) Epigenetic Reader Domain (4) ERK (7) Estrogen Receptor/ERR (39) Factor Xa (5) FAK (1) Ferroportin (1) Ferroptosis (45) FGFR (11) FKBP (4) Flavivirus (2) FLT3 (7) Fluorescent Dye (58) Fungal (66) FXR (8) GABA Receptor (27) Gap Junction Protein (2) GCGR (6) GLP Receptor (6) Glucocorticoid Receptor (25) Glucokinase (1) Glucosidase (1) Glucosylceramide Synthase (GCS) (2) Glutathione Peroxidase (1) Glutathione Reductase (1) Glutathione S-transferase (1) GlyT (3) GnRH Receptor (3) GPR109A (2) GPR35 (1) GPR55 (2) GSK-3 (3) HBV (8) HCV (17) HCV Protease (3) HDAC (17) Hedgehog (3) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (2) Histamine Receptor (32) Histone Acetyltransferase (6) Histone Demethylase (4) Histone Methyltransferase (3) HIV (53) HIV Integrase (11) HIV Protease (8) HMG-CoA Reductase (HMGCR) (15) HSP (20) HSV (13) ICMT (1) IGF-1R (4) iGluR (28) IKK (2) Imidazoline Receptor (3) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (30) Insulin Receptor (1) Integrin (1) Interleukin Related (8) IRE1 (1) Isotope-Labeled Compounds (2229) JAK (7) JNK (1) Keap1-Nrf2 (12) Ketohexokinase (2) Kinesin (1) Leukotriene Receptor (9) Ligands for E3 Ligase (10) Ligands for Target Protein for PROTAC (2) Liposome (17) Lipoxygenase (3) LPL Receptor (6) mAChR (35) MARCKS (2) MDM-2/p53 (4) MEK (3) Melanocortin Receptor (1) Melatonin Receptor (9) mGluR (10) MicroRNA (1) Microtubule/Tubulin (18) Mineralocorticoid Receptor (10) Mitochondrial Metabolism (6) Mitophagy (39) MMP (6) Molecular Glues (9) Monoamine Oxidase (8) Monoamine Transporter (1) mTOR (3) Myosin (4) Na+/K+ ATPase (5) nAChR (11) NADPH Oxidase (1) Neprilysin (7) Neurokinin Receptor (3) NF-κB (31) NO Synthase (20) NOD-like Receptor (NLR) (5) Notch (7) Nuclear Hormone Receptor 4A/NR4A (2) Nucleoside Antimetabolite/Analog (57) Opioid Receptor (3) Orexin Receptor (OX Receptor) (1) Orthopoxvirus (12) Oxidative Phosphorylation (1) Oxytocin Receptor (1) P-selectin (1) P2X Receptor (1) P2Y Receptor (7) p38 MAPK (3) PAK (7) Parasite (64) PARP (4) PD-1/PD-L1 (3) PDGFR (19) PGC-1α (1) PGE synthase (1) Phosphatase (8) Phosphodiesterase (PDE) (21) Phospholipase (6) PI3K (6) PKA (2) PKC (9) Potassium Channel (26) PPAR (25) Progesterone Receptor (25) Prostaglandin Receptor (23) PROTAC Linkers (14) PROTACs (1) Protease Activated Receptor (PAR) (1) Proteasome (1) Proton Pump (22) Radionuclide-Drug Conjugates (RDCs) (1) Raf (7) RAR/RXR (7) Ras (2) Reactive Oxygen Species (39) Renin (2) RET (6) Reverse Transcriptase (8) ROS Kinase (5) RSV (7) RXFP Receptor (1) SARS-CoV (39) Ser/Thr Protease (1) Serotonin Transporter (24) SGLT (6) Sigma Receptor (1) Sirtuin (6) Small Interfering RNA (siRNA) (1) Sodium Channel (27) Src (5) STAT (5) Syk (1) TAM Receptor (3) Tau Protein (1) TGF-beta/Smad (5) Thrombin (8) Thrombopoietin Receptor (3) Thymidylate Synthase (5) Thyroid Hormone Receptor (6) TNF Receptor (6) Toll-like Receptor (TLR) (4) TOPK (1) Topoisomerase (23) Trk Receptor (3) TRP Channel (14) Tyrosinase (8) Vasopressin Receptor (4) VD/VDR (16) VEGFR (25) Virus Protease (15) Wee1 (1) Xanthine Oxidase (3) YAP (1) β-catenin (4) γ-secretase (1)
By Research Areas:	Cancer (846) Cardiovascular Disease (248) Endocrinology (192) Infection (419) Inflammation/Immunology (359) Metabolic Disease (484) Neurological Disease (438)
Click Chemistry:	ADC Synthesis (1) DBCO (4) PROTAC Synthesis (1) Azide (3) Tetrazine (1) Alkynes (15)
Oligonucleotides:	Nucleosides and their Analogs (1) Pegylated Lipids (3) Pre-designed siRNA Sets (1) Phospholipids (11) Cationic Lipids (2) siRNAs (1)

3655

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

3257

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Amino Acid Derivatives Hydroxycarboxylic Acid Receptor (HCAR) Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1 P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-70002BS

*Enzalutamide carboxylic* acid-d6** MDV3100 Carboxylic Acid-d<sub>6sub>	Autophagy Androgen Receptor Isotope-Labeled Compounds	Cancer
Enzalutamide carboxylic acid-d₆ is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid). Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide[1].

HY-101329S

*Anthracene-9-carboxylic* acid-d9** 9-AnthraceneCarboxylic Acid-d<sub>9sub>	Chloride Channel	Others
Anthracene-9-carboxylic acid-d₉ is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].

HY-157071S

Seliciclib Carboxylic Acid-d7	Isotope-Labeled Compounds	Others
Seliciclib Carboxylic Acid-d₇ is deuterium-labeled Seliciclib Carboxylic Acid .

HY-30237S

(R)-Roscovitine-d7 Seliciclib-d<sub>7sub>; CYC202-d<sub>7sub>	CDK Isotope-Labeled Compounds	Cancer
(R)-Roscovitine-d₇ (Seliciclib-d₇; CYC202-d₇) is deuterium-labeled (R)-Roscovitine (HY-30237) .

HY-141749AS

*Clopidogrel carboxylic* acid-d4** CLPM-d<sub>4sub>; SR 26334-d<sub>4sub>	Isotope-Labeled Compounds	Cardiovascular Disease
Clopidogrel carboxylic acid-d₄ is a deuterated derivative of Clopidogrel carboxylic acid, which is an inactive metabolite of the antiplatelet agent Clopidogrel (HY-15283) in plasma. Clopidogrel carboxylic acid-d₄ can be used to further explore the metabolic characteristics of Clopidogrel .

HY-141749S

*(Rac)-Clopidogrel carboxylic* acid-d4** (Rac)-CLPM-d<sub>4sub>; (Rac)-SR 26334-d<sub>4sub>	Isotope-Labeled Compounds	Others
(Rac)-Clopidogrel carboxylic acid-d₄ is the deuterium labeled (Rac)-Clopidogrel carboxylic acid[1].

HY-75087S

*(R)-Pyrrolidine-2-carboxylic* acid-d3** (+)-(R)-Proline-d<sub>3sub>; (R)-(+)-Proline-d<sub>3sub>; (R)-2-Carboxypyrrolidine-d<sub>3sub>; (R)-Proline-d<sub>3sub>	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
(R)-Pyrrolidine-2-carboxylic acid-d₃ is the deuterium labeled (R)-pyrrolidine-2-carboxylic acid. (R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-41463S

4-(Butylamino)benzoic acid-d7 4-(Butylamino)benzoic Acid-d<sub>7sub>; NSC 44300-d<sub>7sub>; p-Butylaminobenzoic Acid-d<sub>7sub>	Isotope-Labeled Compounds	Others
4-(Butylamino)benzoic acid-d₇ is the deuterium labeled 4-(Butylamino)benzoic acid[1].

HY-N2334AS

Glycochenodeoxycholic acid-d7 sodium Chenodeoxycholylglycine-d<sub>7sub> (sodium); Sodium glycochenodeoxycholate-d<sub>7sub>	Endogenous Metabolite Apoptosis	Cancer
Glycochenodeoxycholic acid-d₇ (sodium) is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].

HY-D1823

*Vari Fluor 647A Carboxylic* acid（free acid）** VF 647A Carboxylic Acid（free Acid）	Fluorescent Dye	Others
Vari Fluor 647A Carboxylic acid (VF 647A Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-W017387S3

α-Ketoisocaproic acid-d7 4-Methyl-2-oxopentanoate-d<sub>7sub>; 2-Ketoisocaproic Acid-d<sub>7sub>	Isotope-Labeled Compounds	Others
α-Ketoisocaproic acid-d₇ is the deuterium labeled α-Ketoisocaproic acid[1].

HY-D1821

*Vari Fluor 750 Carboxylic* acid（free acid）** VF 750 Carboxylic Acid（free Acid）	Fluorescent Dye	Others
Vari Fluor 750 Carboxylic acid (VF 750 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1822

*Vari Fluor 555 Carboxylic* acid（free acid）** VF 555 Carboxylic Acid（free Acid）	Fluorescent Dye	Others
Vari Fluor 555 Carboxylic acid (VF 555 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1828

*Vari Fluor 640 Carboxylic* acid（free acid）** VF 640 Carboxylic Acid（free Acid）	Fluorescent Dye	Others
Vari Fluor 640 Carboxylic acid (VF 640 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1824

*Vari Fluor 488 Carboxylic* acid（free acid）** VF 488 Carboxylic Acid（free Acid）	Fluorescent Dye	Others
Vari Fluor 488 Carboxylic acid (VF 488 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1825

*Vari Fluor 532 Carboxylic* acid（free acid）** VF 532 Carboxylic Acid（free Acid）	Fluorescent Dye	Others
Vari Fluor 532 Carboxylic acid (VF 532 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1826

*Vari Fluor 594 Carboxylic* acid（free acid）** VF 594 Carboxylic Acid（free Acid）	Fluorescent Dye	Others
Vari Fluor 594 Carboxylic acid (VF 594 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1827

*Vari Fluor 660 Carboxylic* acid（free acid）** VF 660 Carboxylic Acid（free Acid）	Fluorescent Dye	Others
Vari Fluor 660 Carboxylic acid (VF 660 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1829

*Vari Fluor 568 Carboxylic* acid（free acid）** VF 568 Carboxylic Acid（free Acid）	Fluorescent Dye	Others
Vari Fluor 568 Carboxylic acid (VF 568 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1830

*Vari Fluor 680 Carboxylic* acid（free acid）** VF 680 Carboxylic Acid（free Acid）	Fluorescent Dye	Others
Vari Fluor 680 Carboxylic acid (VF 680 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-W016473S

*Adamantane-carboxylic* Acid-d15**	Isotope-Labeled Compounds	Others
Adamantane-carboxylic Acid-d₁₅ is the deuterium labeled Adamantane-1-carboxylic acid[1].

HY-W017763S

*Tetrahydrofuran-2-carboxylic* acid-d7**	Isotope-Labeled Compounds	Others
Tetrahydrofuran-2-carboxylic acid-d₇ is the deuterium labeled Tetrahydrofuran-2-carboxylic acid[1].

HY-Y0001S1

*Cyclopropane-1-carboxylic* Acid-d1**	Isotope-Labeled Compounds	Others
Cyclopropane-1-carboxylic Acid-d₁ is the deuterium labeled Cyclopropane-1-carboxylic Acid[1].

HY-131314S

*Ibuprofen carboxylic* acid-d3**	Isotope-Labeled Compounds	Others
Ibuprofen carboxylic acid-d₃ is the deuterium labeled Ibuprofen carboxylic acid[1].

HY-D1319

*Cyanine5 carboxylic* acid chloride** Cy5 Acid chloride	Fluorescent Dye	Others
Cyanine5 carboxylic acid chloride (Cy5 acid chloride) is a fluorescent dye containing a non-activated carboxylic acid (Ex=646 nm, Em=662 nm). Cyanine5 carboxylic acid chloride is an non-reactive dye that can be used in control samples .

HY-W002011S

*Quinoline-2-carboxylic* acid-d6**	Endogenous Metabolite	Metabolic Disease
Quinoline-2-carboxylic acid-d₆ is the deuterium labeled Quinoline-2-carboxylic acid[1]. Quinoline-2-carboxylic acid is an endogenous metabolite.

HY-W285163S

*1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic* acid-d8** Formyl Ciprofloxacin-d<sub>8sub>	Isotope-Labeled Compounds	Others
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d₈ is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.

HY-18569S3

3-Indoleacetic acid-d7 Indole-3-acetic Acid-d<sub>7sub>; 3-IAA-d<sub>7sub>	Endogenous Metabolite Molecular Glues	Others
3-Indoleacetic acid-d₇ is the deuterium labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-12765S

*Losartan-d4 (carboxylic* acid)** E-3174 d<sub>4sub>; EXP-3174 d<sub>4sub>	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan-d₄ (carboxylic acid) is the deuterium labeled Losartan (EXP-3174), which is an angiotensin II receptor antagonist.

HY-30004S

*1-Aminocyclopropane-1-carboxylic* acid-d4**	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
1-Aminocyclopropane-1-carboxylic acid-d₄ is the deuterium labeled 1-Aminocyclopropane-1-carboxylic acid. Aminocyclopropane-1-carboxylic acid is an endogenous metabolite[1].

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-30237

(R)-Roscovitine 25+ Cited Publications Seliciclib; CYC202	CDK	Cancer
(R)-Roscovitine (Seliciclib) is an orally bioavailable and selective CDKs inhibitor with IC₅₀s of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively.

HY-W246043

*3-Pyridine-2,4,5,6-d4-carboxylic* acid, ethyl ester** Ethyl Nicotinate-d<sub>4sub>	Isotope-Labeled Compounds	Others
3-Pyridine-2,4,5,6-d₄ -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-d4-carboxylic acid, ethyl ester[1].

HY-D2176

*AF 555 carboxylic* acid**	Fluorescent Dye	Others
AF 555 carboxylic acid is a derivative of the orange fluorescent dye AF 555. AF 555 carboxylic acid is widely used in cell dyes, biological dyes, biomolecules and particle fluorescent labeling. AF 555 exhibits average excitation wavelengths under green laser and red laser of 510 nm and 610 nm, respectively .

HY-10585AS

Valproic acid-d7 sodium Sodium Valproate-d<sub>7sub>(sodium)	Isotope-Labeled Compounds HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite	Cancer
Valproic acid-d₇ (sodium) is the deuterium labeled Valproic acid (sodium salt). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].

HY-D1650

*BDP 630/650 carboxylic* acid**	Fluorescent Dye	Others
BDP 630/650 carboxylic acid is a bright far-red fluorophore based on a borondipyrromethene scaffold. BDP 630/650 carboxylic acid is a BDP linker containing carboxylic acid. BDP 630/650 carboxylic acid can react with primary amine groups to form a stable amide bond. (λ_ex=630 nm, λ_em=650 nm) .

HY-41494S

O-Toluic acid-d7 2-Methylbenzoic Acid-d<sub>7sub>	Endogenous Metabolite	Others
O-Toluic acid-d7 is the deuterium labeled o-Toluic acid[1]. o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.

HY-76547S1

p-Toluic acid-d7 4-Methylbenzoic Acid-d<sub>7sub>	Endogenous Metabolite	Others
p-Toluic acid-d7 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.

HY-W011560S

*3-Methylflavone-8-carboxylic* acid-d5**	Isotope-Labeled Compounds	Others
3-Methylflavone-8-carboxylic acid-d₅ is the deuterium labeled 3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid[1].

HY-112403

(S)-Roscovitine (S)-Seliciclib; (S)-CYC202	CDK	Neurological Disease
(S)-Roscovitine ((S)-Seliciclib; (S)-CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S)-Roscovitine shows neuroprotective efficacy. (S)-Roscovitine has the potential for the research of stroke .

HY-107327S

Carazolol-d7 (±)-Carazolol-d<sub>7sub>; DL-Carazolol-d<sub>7sub>; Suacron-d<sub>7sub>	Adrenergic Receptor	Others
Carazolol-d₇ is the deuterium labeled Carazolol[1].

HY-N0006S

Demethoxycurcumin-d7 Curcumin II-d<sub>7sub>; Desmethoxycurcumin-d<sub>7sub>; Monodemethoxycurcumin-d<sub>7sub>	Isotope-Labeled Compounds Apoptosis Autophagy Bacterial	Inflammation/Immunology Cancer
Demethoxycurcumin-d₇ is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin(Curcumin II), a major active curcuminoid, possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.

HY-W000793S

*5-Methoxy-1H-indole-3-carboxylic* acid-d3**	Isotope-Labeled Compounds	Others
5-Methoxy-1H-indole-3-carboxylic acid-d₃ is the deuterium labeled 5-methoxy-1H-indole-3-carboxylic acid[1].

HY-N0610S1

trans-Cinnamic acid-d7 trans-3-Phenylacrylic Acid-d<sub>7sub>	Bacterial Endogenous Metabolite	Infection
trans-Cinnamic acid-d₇ is the deuterium labeled trans-Cinnamic acid[1]. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1[2].

HY-66005S2

Acetaminophen-d7 Paracetamol-d<sub>7sub>; 4-Acetamidophenol-d<sub>7sub>; 4'-Hydroxyacetanilide-d<sub>7sub>	COX Endogenous Metabolite Histone Acetyltransferase	Inflammation/Immunology
Acetaminophen-d₇ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-B0389S6

D-Glucose-d7 Glucose-d<sub>7sub>; D-(+)-Glucose-d<sub>7sub>; Dextrose-d<sub>7sub>	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose-d₇7 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].

HY-107352S

Fosfenopril-d7 Fosinoprilat-d<sub>7sub>; Fosinoprilic Acid-d<sub>7sub>; SQ 27519-d<sub>7sub>	Angiotensin-converting Enzyme (ACE) Interleukin Related NF-κB TNF Receptor Toll-like Receptor (TLR) Isotope-Labeled Compounds	Others
Fosfenopril-d₇ is deuterium labeled Fosfenopril.

HY-D0711S2

Indocyanine green-d7 Foxgreen-d<sub>7sub>; IC Green-d<sub>7sub>; Cardiogreen-d<sub>7sub>	Isotope-Labeled Compounds Fluorescent Dye	Others
Indocyanine green-d7 (Foxgreen-d7) is the deuterium labeled Indocyanine green (HY-D0711). Indocyanine green is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-I0096

*Indole-2-carboxylic* acid**	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite iGluR
Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid (I2CA) specifically and competitively inhibits the potentiation by glycine of NMDA-gated current .

HY-W002011

*Quinoline-2-carboxylic* acid**	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Quinoline-2-carboxylic acid is an endogenous metabolite.

HY-33037

*Phenazine-1-carboxylic* acid**	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Alkaloids Marine natural products Source classification Disease Research Fields	Fungal
Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation .

HY-75308

*Azetidine-2-carboxylic* acid** 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Amino acids Beta vulgaris Linn. Plants Disease Research Fields Cancer Chenopodiaceae	Others
Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent .

HY-30004

*1-Aminocyclopropane-1-carboxylic* acid**	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity. .

HY-N2321

*Salsolinol-1-carboxylic* acid** 1 Publications Verification	Structural Classification Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Endogenous metabolite	Others
Salsolinol-1-carboxylic acid is an endogenous alkaloid in the central nervous system (CNS) .

HY-W050044

*L-Azetidine-2-carboxylic* acid**	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Azetidine-2-carboxylic acid is an endogenous metabolite.

HY-W001963

*Pyrrole-2-carboxylic* acid**	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Marine natural products Source classification Other Diseases Endogenous metabolite Marine microorganism Disease Research Fields	Endogenous Metabolite
Pyrrole-2-carboxylic acid is a natural alkaloid from the marine bacterium Pelomonas puraquae sp. Nov.

HY-40161R

*Indole-3-carboxylic* acid (Standard)**	Alkaloids Structural Classification Human Gut Microbiota Metabolites Source classification Endogenous metabolite Indole Alkaloids	Endogenous Metabolite
Indole-3-carboxylic acid (Standard) is the analytical standard of Indole-3-carboxylic acid. This product is intended for research and analytical applications. Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .

HY-N6877

*Purpurogallin carboxylic* acid**	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae Cancer	Others
Purpurogallin carboxylic acid, isolated from Macleaya microcarpa (Maxim.) Fedde, is an oxidation product of gallic acid in fermented tea. Purpurogallin carboxylic acid has anti-cancer activity .

HY-W031757

*Anthraquinone-2-carboxylic* acid**	Quinones Structural Classification other families Classification of Application Fields Anthraquinones Brazilian taheebo Plants Inflammation/Immunology Disease Research Fields	Others
Anthraquinone-2-carboxylic acid is a major anthraquinone isolated from Brazilian taheebo, with anti-inflammatory activity and antinociceptive .

HY-40161

*Indole-3-carboxylic* acid**	Alkaloids Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite
Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .

HY-66047

*2,4-Dihydroxypyrimidine-5-carboxylic* Acid**	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2,4-Dihydroxypyrimidine-5-carboxylic Acid is an endogenous metabolite.

HY-W002304

*(R)-5-Oxopyrrolidine-2-carboxylic* acid**	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(R)-5-Oxopyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-N1635

*1-Methoxyindole-3-carboxylic* acid**	Structural Classification Alkaloids Source classification Plants Brassicaceae Isatis indigotica Fortune Indole Alkaloids	Others
1-Methoxyindole-3-carboxylic acid (compound 5) is synthetic from a phytoalexin nucleophilic substitution reaction selectively at the 2-position .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-N9192

*2,2-Dimethyl-8-prenylchromene 6-carboxylic* acid**	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Piperaceae Plants Piper aduncum Disease Research Fields	Others
2,2-Dimethyl-8-prenylchromene 6-carboxylic acid (compound 2) is a natural product that can be found in Piper aduncum .

HY-N1905

*4-Methoxy-β-carboline-1-carboxylic* acid methylester**	Alkaloids Structural Classification Simaroubaceae Ailanthus altissima (Mill.) Swingle Source classification Plants Indole Alkaloids	Others
4-Methoxy-β-carboline-1-carboxylic acid methylester is an alkaloid with the structure of canthin-6-one and β-carboline .

HY-75087

*(R)-pyrrolidine-2-carboxylic* acid** (+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(R)-pyrrolidine-2-carboxylic acid ((+)-(R)-Proline) is a proline isomer that exhibits high renal and hepatotoxicity in rats. (R)-pyrrolidine-2-carboxylic acid can be used to study amino acid metabolism and toxicity mechanisms .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-W751835

Baloxavir-d4 Maximum Cited Publications 30 Publications Verification Baloxavir Acid-d<sub>4sub>; S-033447-d<sub>4sub>	Classification of Application Fields Disease Research Fields Cancer	Isotope-Labeled Compounds
Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-N4226

*1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic* acid**	Structural Classification Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	AP-1
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-131669

Dasatinib metabolite M6 Dasatinib Carboxylic Acid	Classification of Application Fields Disease Research Fields Cancer	Drug Metabolite
Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib (HY-10181). Dasatinib is a potent and orally active dual Bcr-Abl and Src family tyrosine kinase inhibitor .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-P2947

ALDH Aldehyde dehydrogenase (NAD(P))	Classification of Application Fields Disease Research Fields Cancer	Aldehyde Dehydrogenase (ALDH)
ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The ALDHs are one of many enzyme systems the body utilizes to alleviate aldehyde stress .

HY-P99294

Ganitumab AMG 479; Human Anti-IGF1R Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	IGF-1R
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (K_D=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .

HY-N7692

Polyporusterone A	Classification of Application Fields Source classification Polyporaceae Other Diseases Poria cocos Plants Disease Research Fields Steroids	Others
Polyporusterone A is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone A has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis) .

HY-N7693

Polyporusterone B	Classification of Application Fields Source classification Polyporaceae Other Diseases Poria cocos Plants Disease Research Fields Steroids	Others
Polyporusterone B is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone B has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis) .

HY-N0662R

Amentoflavone (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-B0504S

Creatinine-d3 3 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-Y0569

D-Gluconic acid (solution)	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Fungal
D-Gluconic acid is the carboxylic acid by the oxidation with antiseptic and chelating properties.

HY-79494

Glyoxalic acid 1 Publications Verification NSC 27785; Formylformic Acid; Oxalaldehydic Acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endocrine diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glyoxalic acid (NSC 27785) is an organic compound that is both an aldehyde and a carboxylic acid.

HY-Y0569B

D-Gluconic acid calcium hydrate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Fungal Endogenous Metabolite
D-Gluconic acid calcium hydrate is the carboxylic acid by the oxidation with antiseptic and chelating properties.

HY-W012946

2-Furoic acid Pyromucic Acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	ATP Citrate Lyase Acyltransferase Endogenous Metabolite
2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation . 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats .

HY-N12911

Tanzawaic acid E	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Others
Tanzawaic acid E is a carboxylic acid and can be isolated from Penicillium steckii .

HY-Y0569C

D-Gluconic acid potassium	Infection Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Endogenous Metabolite Fungal
D-Gluconic acid potassium is an orally active carboxylic acid by the oxidation with antiseptic and chelating properties .

HY-129503

2-Heptyl-4-quinolone	Structural Classification Alkaloids Microorganisms Source classification Quinoline Alkaloids	Others
2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .

HY-Y0030

3-Hydroxypicolinic acid 3-hydroxypyridine-2-Carboxylic Acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Hydroxypicolinic acid is a picolinic acid derivative, and belongs to the pyridine family.

HY-N0140

Ursolic acid 10+ Cited Publications Prunol; Urson; Malol	Triterpenes Structural Classification Ziziphus jujuba Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Rhamnaceae Disease Research Fields Cancer	Autophagy Endogenous Metabolite
Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

HY-W012946R

2-Furoic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	ATP Citrate Lyase Acyltransferase Endogenous Metabolite
2-Furoic acid (Standard) is the analytical standard of 2-Furoic acid. This product is intended for research and analytical applications. 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation . 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats .

HY-79494R

Glyoxalic acid (Standard) NSC 27785 (Standard); Formylformic Acid (Standard); Oxalaldehydic Acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite	Endogenous Metabolite
Glyoxalic acid (Standard) is the analytical standard of Glyoxalic acid. This product is intended for research and analytical applications. Glyoxalic acid (NSC 27785) is an organic compound that is both an aldehyde and a carboxylic acid.

HY-41404

Piperonylic acid 2H-1,3-benzodioxole-5-Carboxylic Acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Piperaceae Plants Disease Research Fields Piper nigrum Linn.	Cytochrome P450 Interleukin Related EGFR IGF-1R
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .

HY-Y0569CR

D-Gluconic acid potassium (Standard)	Structural Classification Source classification Endogenous metabolite Saccharides Monosaccharides	Endogenous Metabolite Fungal
D-Gluconic acid (potassium) (Standard) is the analytical standard of D-Gluconic acid (potassium). This product is intended for research and analytical applications. D-Gluconic acid potassium is an orally active carboxylic acid by the oxidation with antiseptic and chelating properties .

HY-Y0569BR

D-Gluconic acid calcium hydrate (Standard)	Structural Classification Source classification Endogenous metabolite Saccharides Monosaccharides	Fungal Endogenous Metabolite
D-Gluconic acid (calcium hydrate) (Standard) is the analytical standard of D-Gluconic acid (calcium hydrate). This product is intended for research and analytical applications. D-Gluconic acid calcium hydrate is the carboxylic acid by the oxidation with antiseptic and chelating properties.

HY-N0216BS

Benzoic-3,5 Acid-d2	Classification of Application Fields	Isotope-Labeled Compounds
Benzoic-3,5 Acid-d₂ is the deuterium labeled Benzoic-3,5 Acid[1].

HY-N0140R

Ursolic acid (Standard)	Triterpenes Structural Classification Ziziphus jujuba Terpenoids Source classification Plants Endogenous metabolite Rhamnaceae	Autophagy Endogenous Metabolite
Ursolic acid (Standard) is the analytical standard of Ursolic acid. This product is intended for research and analytical applications. Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

Cat. No.	Product Name	Chemical Structure

HY-70002BS

*Enzalutamide carboxylic* acid-d6**
Enzalutamide carboxylic acid-d₆ is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid). Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide[1].

HY-101329S

*Anthracene-9-carboxylic* acid-d9**
Anthracene-9-carboxylic acid-d₉ is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].

HY-157071S

Seliciclib Carboxylic Acid-d7
Seliciclib Carboxylic Acid-d₇ is deuterium-labeled Seliciclib Carboxylic Acid .

HY-30237S

(R)-Roscovitine-d7
(R)-Roscovitine-d₇ (Seliciclib-d₇; CYC202-d₇) is deuterium-labeled (R)-Roscovitine (HY-30237) .

HY-141749AS

*Clopidogrel carboxylic* acid-d4**
Clopidogrel carboxylic acid-d₄ is a deuterated derivative of Clopidogrel carboxylic acid, which is an inactive metabolite of the antiplatelet agent Clopidogrel (HY-15283) in plasma. Clopidogrel carboxylic acid-d₄ can be used to further explore the metabolic characteristics of Clopidogrel .

HY-141749S

*(Rac)-Clopidogrel carboxylic* acid-d4**
(Rac)-Clopidogrel carboxylic acid-d₄ is the deuterium labeled (Rac)-Clopidogrel carboxylic acid[1].

HY-75087S

*(R)-Pyrrolidine-2-carboxylic* acid-d3**
(R)-Pyrrolidine-2-carboxylic acid-d₃ is the deuterium labeled (R)-pyrrolidine-2-carboxylic acid. (R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-41463S

4-(Butylamino)benzoic acid-d7
4-(Butylamino)benzoic acid-d₇ is the deuterium labeled 4-(Butylamino)benzoic acid[1].

HY-N2334AS

Glycochenodeoxycholic acid-d7 sodium

Glycochenodeoxycholic acid-d₇ (sodium) is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].

HY-W017387S3

α-Ketoisocaproic acid-d7
α-Ketoisocaproic acid-d₇ is the deuterium labeled α-Ketoisocaproic acid[1].

HY-W016473S

*Adamantane-carboxylic* Acid-d15**
Adamantane-carboxylic Acid-d₁₅ is the deuterium labeled Adamantane-1-carboxylic acid[1].

HY-W017763S

*Tetrahydrofuran-2-carboxylic* acid-d7**
Tetrahydrofuran-2-carboxylic acid-d₇ is the deuterium labeled Tetrahydrofuran-2-carboxylic acid[1].

HY-Y0001S1

*Cyclopropane-1-carboxylic* Acid-d1**
Cyclopropane-1-carboxylic Acid-d₁ is the deuterium labeled Cyclopropane-1-carboxylic Acid[1].

HY-131314S

*Ibuprofen carboxylic* acid-d3**
Ibuprofen carboxylic acid-d₃ is the deuterium labeled Ibuprofen carboxylic acid[1].

HY-W002011S

*Quinoline-2-carboxylic* acid-d6**
Quinoline-2-carboxylic acid-d₆ is the deuterium labeled Quinoline-2-carboxylic acid[1]. Quinoline-2-carboxylic acid is an endogenous metabolite.

HY-W285163S

*1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic* acid-d8**
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d₈ is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.

HY-18569S3

3-Indoleacetic acid-d7
3-Indoleacetic acid-d₇ is the deuterium labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-12765S

*Losartan-d4 (carboxylic* acid)**
Losartan-d₄ (carboxylic acid) is the deuterium labeled Losartan (EXP-3174), which is an angiotensin II receptor antagonist.

HY-30004S

*1-Aminocyclopropane-1-carboxylic* acid-d4**
1-Aminocyclopropane-1-carboxylic acid-d₄ is the deuterium labeled 1-Aminocyclopropane-1-carboxylic acid. Aminocyclopropane-1-carboxylic acid is an endogenous metabolite[1].

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-W246043

*3-Pyridine-2,4,5,6-d4-carboxylic* acid, ethyl ester**
3-Pyridine-2,4,5,6-d₄ -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-d4-carboxylic acid, ethyl ester[1].

HY-10585AS

Valproic acid-d7 sodium

Valproic acid-d₇ (sodium) is the deuterium labeled Valproic acid (sodium salt). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].

HY-41494S

O-Toluic acid-d7
O-Toluic acid-d7 is the deuterium labeled o-Toluic acid[1]. o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.

HY-76547S1

p-Toluic acid-d7
p-Toluic acid-d7 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.

HY-W011560S

*3-Methylflavone-8-carboxylic* acid-d5**
3-Methylflavone-8-carboxylic acid-d₅ is the deuterium labeled 3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid[1].

HY-107327S

Carazolol-d7
Carazolol-d₇ is the deuterium labeled Carazolol[1].

HY-N0006S

Demethoxycurcumin-d7
Demethoxycurcumin-d₇ is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin(Curcumin II), a major active curcuminoid, possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.

HY-W000793S

*5-Methoxy-1H-indole-3-carboxylic* acid-d3**
5-Methoxy-1H-indole-3-carboxylic acid-d₃ is the deuterium labeled 5-methoxy-1H-indole-3-carboxylic acid[1].

HY-N0610S1

trans-Cinnamic acid-d7
trans-Cinnamic acid-d₇ is the deuterium labeled trans-Cinnamic acid[1]. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1[2].

HY-66005S2

Acetaminophen-d7
Acetaminophen-d₇ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-B0389S6

D-Glucose-d7
D-Glucose-d₇7 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].

HY-107352S

Fosfenopril-d7
Fosfenopril-d₇ is deuterium labeled Fosfenopril.

HY-D0711S2

Indocyanine green-d7
Indocyanine green-d7 (Foxgreen-d7) is the deuterium labeled Indocyanine green (HY-D0711). Indocyanine green is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography .

HY-W018728S

3,5-Dimethylbenzoic acid-d9
3,5-Dimethylbenzoic acid-d₉ is the deuterium labeled 3,5-Dimethylbenzoic acid[1].

HY-12057S1

Vemurafenib-d7
Vemurafenib-d₇ is deuterium labeled Vemurafenib. Vemurafenib (PLX4032) is a first-in-class, selective, potent inhibitor of B-RAF kinase, with IC50s of 31 and 48 nM for RAFV600E and c-RAF-1, respectively[1][4]. Vemurafenib induces cell autophagy[5].

HY-Y0376S

DMPA-d7
DMPA-d₇ is the deuterium labeled DMPA[1].

HY-12765S1

Losartan carboxylic acid-d4 hydrochloride

Losartan carboxylic acid-d₄ (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].

HY-Y1309S1

1-Naphthol-d7
1-Naphthol-d7 is the deuterium labeled Naphthol .

HY-135328S

Norverapamil-d7
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-17025S

Rifabutin-d7
Rifabutin-d₇ is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-107855S

DL-Mevalonolactone-d7
DL-Mevalonolactone-d₇ is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

HY-41700S3

D-Alanine-d7
D-Alanine-d₇ is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.

HY-B0236S1

6-Aminocaproic acid-d10

6-Aminocaproic acid-d₁₀ is the deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

HY-B0236S

6-Aminocaproic acid-d6

6-Aminocaproic acid-d₆ is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

HY-B0679S

Lubiprostone-d7
Lubiprostone-d₇ (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (RU0211) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation[1][2].

HY-50898S1

Lapatinib-d7 dihydrochloride
Lapatinib-d₇ (dihydrochloride) is the deuterium labeled Lapatinib dihydrochloride. Lapatinib (GW572016) dihydrochloride is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].

HY-12296S

Navtemadlin-d7
Navtemadlin-d₇ is the deuterium labeled Navtemadlin. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].

HY-13720AS

Pergolide-d7 mesylate
Pergolide-d₇ (mesylate) is the deuterium labeled Pergolide mesylate. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research[1][2].

HY-12785S1

Albendazole sulfoxide-d7
Albendazole sulfoxide-d₇ is the deuterium labeled Albendazole sulfoxide. Albendazole sulfoxide (Ricobendazole), the main active metabolite of Albendazole, exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1].

HY-14268S1

Febuxostat-d7
Febuxostat-d₇ is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a Ki of 0.6 nM[1].

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