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Antitumor Activity

" in MedChemExpress (MCE) Product Catalog:

3105

Inhibitors & Agonists

3

Screening Libraries

7

Fluorescent Dye

6

Biochemical Assay Reagents

56

Peptides

63

Inhibitory Antibodies

536

Natural
Products

49

Isotope-Labeled Compounds

87

Click Chemistry

873

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156568B
    SMD-3040 formate

    		PROTACs Epigenetic Reader Domain Inflammation/Immunology Cancer
    SMD-3040 formate is a potent and selective smarca2 protac degrader with strong in vivo antitumor activity .
    SMD-3040 formate
  • HY-146970
    Lankacyclinone C

    		Antibiotic Cancer
    Lankacyclinone C is a lankacidin C congener lacking the δ-lactone moiety, with antitumor activity .
    Lankacyclinone C
  • HY-121350
    Merodantoin

    		Others Cancer
    Merodantoin has significant antitumor activity in vitro and in vivo, and has less toxicity to normal cells and tissues .
    Merodantoin
  • HY-115949
    Antitumor agent-47

    		Others Cancer
    Antitumor agent-47 (Compound 3e) is a silibinin derivative with an antitumor activity. Antitumor agent-47 shows cytotoxic activity against NCI-H1299 and HT29 cells with IC50 values of 8.07 µM and 6.27 µM, respectively .
    Antitumor agent-47
  • HY-115950
    Antitumor agent-48

    		Others Cancer
    Antitumor agent-48 (Compound 4a) is a 2,3-dehydrosilybin derivative with an antitumor activity. Antitumor agent-48 shows cytotoxic activity against MCF-7, NCI-H1299, HepG2 and HT29 cells with IC50 values of 8.06 µM, 13.1 µM, 16.51 µM and 12.44 µM, respectively .
    Antitumor agent-48
  • HY-126878
    11-Oxahomoaminopterin

    		Antifolate Infection Cancer
    11-Oxahomoaminopterin shows antifolate activity and inhibits Lactobacillus casei DHFFZ with antimicrobial and antitumor activities .
    11-Oxahomoaminopterin
  • HY-122474
    Acetylaranotin

    		Others Cancer
    Acetylaranotin is a metabolite produced by the fungus Arachniotus aureus, exhibiting antitumor activity. Acetylaranotin is utilized in research within the field of oncology for its potential in anti-cancer applications .
    Acetylaranotin
  • HY-162163
    TLR7 agonist 19

    		Toll-like Receptor (TLR) Cancer
    TLR7 agonist 19 (Compound 14) is a Toll-like receptor 7 (TLR7) agonist with excellent pharmacokinetic properties and synergistic antitumor activity.
    TLR7 agonist 19
  • HY-P99539
    Ubamatamab

    REGN4018

    		 CD3 Cancer
    Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity .
    Ubamatamab
  • HY-115937
    c-Met-IN-9

    		c-Met/HGFR Apoptosis Cancer
    c-Met-IN-9, a 4-phenoxypyridine derivative, is a c-Met kinas inhibitor with an IC50 of 12 nM. c-Met-IN-9 induces cells apoptosis, and has antitumor activities .
    c-Met-IN-9
  • HY-105463
    Saptomycin D

    		Antibiotic Bacterial Infection Cancer
    Saptomycin D is an antibiotic with antitumor activity isolated from the Streptomyces sp. HP530 strain. Saptomycin D exhibits potent inhibitory effects against Gram-positive bacteria, while demonstrating weaker inhibitory activities against certain Gram-negative bacteria and yeasts. Saptomycin D also displays remarkable antitumor properties. Saptomycin D is applicable in research within the field of oncology .
    Saptomycin D
  • HY-N10174
    Tomaymycin

    		Antibiotic Infection
    Tomaymycin is an antitumor antibiotic. Tomaymycin has antimicrobial activity against Grampositive bacteria .
    Tomaymycin
  • HY-137193
    5,6-Dihydroabiraterone

    		Drug Metabolite Cancer
    5,6-Dihydroabiraterone is the metabolism of Abiraterone (HY-70013). Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, and shows antitumor activity in CRPC (castration-resistant prostate cancer) .
    5,6-Dihydroabiraterone
  • HY-122356
    Ambazone monohydrate

    		Bacterial Cancer
    Ambazone monohydrate is an orally active membrane active antitumor agent. Ambazone monohydrate also shows antibacterial and weak antiviral activities .
    Ambazone monohydrate
  • HY-122356A
    Ambazone

    		Bacterial Cancer
    Ambazone is an orally active membrane active antitumor agent. Ambazone also shows antibacterial and weak antiviral activities .
    Ambazone
  • HY-W592871
    10-Hydroxy-2-decenoic acid

    10-HDA

    		 mTOR Cardiovascular Disease Inflammation/Immunology Cancer
    10-Hydroxy-2-decenoic acid (10-HDA) is the major lipid component of royal jelly produced by honeybees. 10-Hydroxy-2-decenoic acid has several health-beneficial effects in mammals, such as antitumor activity, anti-inflammatory activity, and antiangiogenic activity. 10-Hydroxy-2-decenoic acid also extends the lifespan of C. elegans .
    10-Hydroxy-2-decenoic acid
  • HY-161840
    Antitumor agent-176

    		FGFR Cancer
    Antitumor agent-176 (Compound 22), an antitumor agent, can effectively bind to FGF2 and inhibit the activation of fibroblast growth factor receptor (FGFR) in multiple myeloma (MM) cells, exhibiting significant antitumor activity both in vivo and in vitro against MM .
    Antitumor agent-176
  • HY-N9488
    Girinimbine

    Girinimbin

    		 Apoptosis Bacterial Parasite Infection Inflammation/Immunology Cancer
    Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities .
    Girinimbine
  • HY-W011102
    S-Trityl-L-cysteine

    NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine

    		 Kinesin Apoptosis Cancer
    S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities .
    S-Trityl-L-cysteine
  • HY-N9292
    Friedelin-3,4-lactone

    		Others Cancer
    Friedelin-3,4-lactone (Compound 4) is a triterpene can be isolated from the leaves of Garcia parViflora with weak antitumor activity .
    Friedelin-3,4-lactone
  • HY-162249
    ASP6918

    		Ras Cancer
    ASP6918 is a potent and orally active KRAS G12C inhibitor with an IC50 value of 0.028 µM. ASP6918 inhibits cell growth. ASP6918 shows antitumor activity .
    ASP6918
  • HY-147426
    Zifcasiran

    ADS-007; ARO HIF2

    		 HIF/HIF Prolyl-Hydroxylase Cancer
    Zifcasiran is a hypoxia-inducible factor (HIF) synthesis reducer. Zifcasiran shows antitumor activities and can be used in advanced renal cell carcinoma research .
    Zifcasiran
  • HY-147426A
    Zifcasiran sodium

    ADS-007 sodium; ARO HIF2 sodium

    		 HIF/HIF Prolyl-Hydroxylase Cancer
    Zifcasiran sodium is a hypoxia-inducible factor (HIF) synthesis reducer. Zifcasiran sodium shows antitumor activities and can be used in advanced renal cell carcinoma research .
    Zifcasiran sodium
  • HY-146046
    Antitumor agent-56

    		Apoptosis Inflammation/Immunology Cancer
    Antitumor agent-56 (Compound 33) is a triptolide derivative with antitumor, anti-inflammatory and NO release activities. Antitumor agent-56 significantly inhibits the growth of melanoma. Antitumor agent-56 is orally active .
    Antitumor agent-56
  • HY-117481
    NSC-639829

    		Others Cancer
    NSC-639829 is a Benzoylphenylurea (BPU) analogue which has antitumor activity. NSC-639829 is promising for research of refractory metastatic cancer .
    NSC-639829
  • HY-156244
    PROTAC GDI2 Degrader-1

    		PROTACs Cancer
    PROTAC GDI2 Degrader-1 (compound 21) is a potent PROTAC GDI2 degrader. PROTAC GDI2 Degrader-1 exhibits excellent in vivo antitumor activity in the GDI2-overexpressing pancreatic xenograft models .
    PROTAC GDI2 Degrader-1
  • HY-105416
    Calphostin C

    UCN-1028C

    		 Antibiotic PKC Apoptosis Infection Cancer
    Calphostin C is a potent and specific inhibitor of protein kinase C. Calphostin C is an antitumor antibiotic. Calphostin C has 1000 times more inhibitory to protein kinase C with an IC50 of 0.05 μM than other protein kinases. Calphostin C induces apoptosis in some tumor cell lines. Calphostin C has potent cytotoxic activity and antitumor activity .
    Calphostin C
  • HY-129252
    Prothracarcin

    		Antibiotic Bacterial Infection Cancer
    Prothracarcin is an antibiotic with antitumor activity that exerts its tumor cell toxicity by covalently binding to the C-2 amino group of guanine residues in the minor groove of DNA. Prothracarcin also shows antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria such as Escherichia coli .
    Prothracarcin
  • HY-106052
    Bofumustine

    ICIG 1105; NSC 279194; RFCNU

    		 DNA/RNA Synthesis Cancer
    Bofumustine (ICIG 1105) is a nitrosourea compound with antitumor activity. Bofumustine can interfere with the replication and division of tumor cell DNA through alkylation, leading to the death of tumor cells. Bofumustine can be used in the field of cancer research .
    Bofumustine
  • HY-106689
    Dihydro-5-azacytidine

    DHAC; NSC 264880

    		 Nucleoside Antimetabolite/Analog DNA Methyltransferase Cancer
    Dihydro-5-azacytidine (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine has an antitumor activity .
    Dihydro-5-azacytidine
  • HY-153543
    TLR7/8 agonist 8

    		Toll-like Receptor (TLR) Cancer
    TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade .
    TLR7/8 agonist 8
  • HY-12941
    AM-7209

    		MDM-2/p53 Cancer
    AM-7209 is a potent and selective MDM2-p53 interaction inhibitor with a Kd of 38 pM. AM-7209 inhibits the MDM2 amplified SJSA-1 osteosarcoma cell line with an IC50 of 1.6 nM. AM-7209 shows antitumor activities .
    AM-7209
  • HY-P10511
    Pantinin-3

    		Apoptosis Infection Cancer
    Pantinin-3 is an antimicrobial peptide with antitumor activity found in the venom of the emperor scorpion (Pandinus imperator). Pantinin-3 shows selective toxicity against breast cancer cells (MDA-MB-231) and prostate cancer cells (DU-145). Pantinin-3 can induce apoptosis in tumor cells. Pantinin-3 can be used in cancer research .
    Pantinin-3
  • HY-P10550
    VGB4

    		VEGFR Cancer
    VGB4 is a VEGF-A and VEGF-B antagonist peptide that duplicates two binding domains of VEGF-B (loop 1 and loop3) and are linked together by the receptor-binding domain of VEGF-A (loop3). VGB4 has significant anti-angiogenic and anti-tumor activities and can regulate tumor growth and metastasis through multiple mechanisms. VGB4 could be used in anti-tumor research .
    VGB4
  • HY-114233
    MC-GGFG-Exatecan
    2 Publications Verification

    MC-GGFG-DX8951

    		 Drug-Linker Conjugates for ADC Topoisomerase Cancer
    MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC) .
    MC-GGFG-Exatecan
  • HY-126534A
    Abemaciclib metabolite M18 hydrochloride
    1 Publications Verification

    LSN3106729 hydrochloride

    		 Ligands for Target Protein for PROTAC CDK Cancer
    Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader .
    Abemaciclib metabolite M18 hydrochloride
  • HY-125117
    Simocyclinone D8

    		DNA/RNA Synthesis Bacterial Infection Cancer
    Simocyclinone D8 is an anthracycline antibiotic with antibacterial and antitumor activity against Gram-positive bacteria. Simocyclinone D8 inhibits DNA gyrase and thus has an inhibitory effect on a variety of tumor cell lines .
    Simocyclinone D8
  • HY-147812
    POLA1 inhibitor 1
    1 Publications Verification

    		 Others Cancer
    POLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line .
    POLA1 inhibitor 1
  • HY-P9956
    Siltuximab

    CNTO-328

    		 Interleukin Related Cancer
    Siltuximab is an anti-IL-6 (interleukin-6) monoclonal antibody, and shows antitumor activity. Siltuximab can be used in Multicentric Castleman's Disease (MCD) and COVID-19 research .
    Siltuximab
  • HY-144121
    Ph-Ph+

    		Bacterial Fungal Apoptosis Infection Cancer
    Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities .
    Ph-Ph+
  • HY-126643
    Wedeloside

    		Others Others Cancer
    Wedeloside is a diterpenoid amino glycoside isolated from the plant Wedelia asperrima. Wedeloside is capable of inhibiting ADP-stimulated respiration in mitochondria and possesses potential anti-tumor activity. Wedeloside is applicable in drug development and toxicological research .
    Wedeloside
  • HY-158230
    SN-398

    		Topoisomerase Cancer
    SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC50=1.562 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells .
    SN-398
  • HY-148128
    TAM470

    		Microtubule/Tubulin ADC Cytotoxin Cancer
    TAM470 is a novel cytolysin, inhibiting tubulin polymerization and microtubule depolymerization. TAM470 can be used in the synthesis of OMTX705 as payload molecule, OMTX705 is a novel FAP-targeting antibody-drug conjugates (ADCs) with antitumor activity .
    TAM470
  • HY-N2682
    (7R,8S)-Dehydrodiconiferyl alcohol

    		Others Cancer
    (7R,8S)-Dehydrodiconiferyl alcohol is a natural product that can be isolated from the thorns of Gleditsia sinensis. (7R,8S)-Dehydrodiconiferyl alcohol shows antitumor activity .
    (7R,8S)-Dehydrodiconiferyl alcohol
  • HY-158109
    M3554

    		Others Cancer
    M3554 is a novel anti-GD2 ADC designed based on humanized ch14.18 anti-GD2 antibody and has anti-tumor activity. The cytotoxicity of M3554 against the GD2-positive neuroblastoma cell line CHP134 was in the subnanomolar IC50 range.
    M3554
  • HY-145768
    PD-1/PD-L1-IN-18

    		PD-1/PD-L1 Cancer
    PD-1/PD-L1-IN-18 (Compound L31) is a small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction. PD-1/PD-L1-IN-18 blocks PD-1/PD-L1 with the IC50 of 1.054 μM. Antitumor Activity .
    PD-1/PD-L1-IN-18
  • HY-168043
    STAT3-IN-35

    		STAT Cancer
    STAT3-IN-35 is a STAT3 inhibitor that binds to SH2 domain. STAT3-IN-35 inhibits the phosphorylation of STAT3 and possesses antiproliferative activities against triple-negative breast cancer (TNBC) cell lines. STAT3-IN-35 also has a toxicity and potent antitumor activity in a TNBC xenograft model .
    STAT3-IN-35
  • HY-P99633
    Garivulimab

    BGB-A333

    		 PD-1/PD-L1 Apoptosis Cancer
    Garivulimab (BGB-A333) is a humanized IgG1-variant monoclonal antibody that specifically targets and binds to PD-L1. Garivulimab selectively blocks the interaction of PD-L1 and PD-1. Garivulimab has antitumor activity .
    Garivulimab
  • HY-P99422
    Adebrelimab

    SHR-1316

    		 PD-1/PD-L1 Apoptosis Cancer
    Adebrelimab (SHR-1316) is a humanized IgG4 monoclonal PD-L1 (PD-1/PD-L1) antibody. Adebrelimab has promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC) .
    Adebrelimab
  • HY-160096
    M3541

    		ATM/ATR Cancer
    M3541 is a potent, ATP-competitive and selective ATM inhibitor with an IC50 of 0.25 nM. M3541 shows remarkable selectivity against other protein kinases. M3541 suppresses double-strand breaks (DSB) repair and has antitumor activities .
    M3541

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