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MDV3100 carboxylic acid-d<sub>6</sub>

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3583

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3183

Isotope-Labeled Compounds

Antibodies

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Targets Recommended: Amino Acid Derivatives Hydroxycarboxylic Acid Receptor (HCAR) Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter P-glycoprotein G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-70002BS

*Enzalutamide carboxylic* acid-d6** MDV3100 carboxylic acid-d<sub>6sub>	Autophagy Androgen Receptor Isotope-Labeled Compounds	Cancer
Enzalutamide carboxylic acid-d₆ is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid). Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide[1].

HY-70002B

*Enzalutamide carboxylic* acid** 1 Publications Verification MDV3100 carboxylic acid	Drug Metabolite	Cancer
Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist .

HY-70002

Enzalutamide Maximum Cited Publications 154 Publications Verification MDV3100	Androgen Receptor Autophagy	Cancer
Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC₅₀ of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator .

HY-70002S1

Enzalutamide-d6 MDV3100-d<sub>6sub>	Androgen Receptor	Cancer
Enzalutamide-d₆ is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells[1].

HY-70002S

Deutenzalutamide Enzalutamide-d<sub>3sub>; MDV3100-d<sub>3sub>	Androgen Receptor Autophagy	Cancer
Deutenzalutamide (Enzalutamide-d₃) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells .

HY-70002A

N-desmethyl Enzalutamide N-desmethyl MDV 3100	Androgen Receptor	Cancer
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .

HY-70002AS

N-desmethyl Enzalutamide-d6 N-desmethyl MDV 3100-d<sub>6sub>	Androgen Receptor	Cancer
N-desmethyl Enzalutamide-d₆ is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].

HY-70002R

Enzalutamide (Standard)	Androgen Receptor Autophagy	Cancer
Enzalutamide (Standard) is the analytical standard of Enzalutamide. This product is intended for research and analytical applications. Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC₅₀ of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator .

HY-141749AS

*Clopidogrel carboxylic* acid-d4** CLPM-d<sub>4sub>; SR 26334-d<sub>4sub>	Isotope-Labeled Compounds	Cardiovascular Disease
Clopidogrel carboxylic acid-d₄ is a deuterated derivative of Clopidogrel carboxylic acid, which is an inactive metabolite of the antiplatelet agent Clopidogrel (HY-15283) in plasma. Clopidogrel carboxylic acid-d₄ can be used to further explore the metabolic characteristics of Clopidogrel .

HY-141749S

*(Rac)-Clopidogrel carboxylic* acid-d4** (Rac)-CLPM-d<sub>4sub>; (Rac)-SR 26334-d<sub>4sub>	Isotope-Labeled Compounds	Others
(Rac)-Clopidogrel carboxylic acid-d₄ is the deuterium labeled (Rac)-Clopidogrel carboxylic acid[1].

HY-75087S

*(R)-Pyrrolidine-2-carboxylic* acid-d3** (+)-(R)-Proline-d<sub>3sub>; (R)-(+)-Proline-d<sub>3sub>; (R)-2-Carboxypyrrolidine-d<sub>3sub>; (R)-Proline-d<sub>3sub>	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
(R)-Pyrrolidine-2-carboxylic acid-d₃ is the deuterium labeled (R)-pyrrolidine-2-carboxylic acid. (R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-B0236S

6-Aminocaproic acid-d6 EACA-d<sub>6sub>; Epsilon-Amino-n-caproic acid-d<sub>6sub>; 6-Aminohexanoic acid-d<sub>6sub>	Isotope-Labeled Compounds	Metabolic Disease
6-Aminocaproic acid-d₆ is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-101329S

*Anthracene-9-carboxylic* acid-d9** 9-Anthracenecarboxylic acid-d<sub>9sub>	Chloride Channel	Others
Anthracene-9-carboxylic acid-d₉ is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-B0236S1

6-Aminocaproic acid-d10 EACA-d<sub>10sub>; Epsilon-Amino-n-caproic acid-d<sub>10sub>; 6-Aminohexanoic acid-d<sub>10sub>	Isotope-Labeled Compounds	Metabolic Disease
6-Aminocaproic acid-d₁₀ is the deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

HY-100560S

Abscisic acid-d6 (S)-(+)-Abscisic acid-d<sub>6sub>; ABA-d<sub>6sub>	Proton Pump	Metabolic Disease
Abscisic acid-d₆ is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H+-ATPase)[1].

HY-N0593S2

Deoxycholic acid-d6 Cholanoic acid-d<sub>6sub>; Desoxycholic acid-d<sub>6sub>	Isotope-Labeled Compounds G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite	Metabolic Disease
Deoxycholic acid-d₆ is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

HY-D1823

*Vari Fluor 647A Carboxylic* acid（free acid）** VF 647A carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 647A Carboxylic acid (VF 647A Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-B1350S

Fusidic acid-d6 Fusidate-d<sub>6sub>; SQ-16603-d<sub>6sub>	Bacterial Antibiotic	Infection
Fusidic acid-d₆ is the deuterium labeled Fusidic acid. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome[1][2].

HY-D1821

*Vari Fluor 750 Carboxylic* acid（free acid）** VF 750 carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 750 Carboxylic acid (VF 750 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1822

*Vari Fluor 555 Carboxylic* acid（free acid）** VF 555 carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 555 Carboxylic acid (VF 555 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1828

*Vari Fluor 640 Carboxylic* acid（free acid）** VF 640 carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 640 Carboxylic acid (VF 640 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1824

*Vari Fluor 488 Carboxylic* acid（free acid）** VF 488 carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 488 Carboxylic acid (VF 488 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1825

*Vari Fluor 532 Carboxylic* acid（free acid）** VF 532 carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 532 Carboxylic acid (VF 532 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1826

*Vari Fluor 594 Carboxylic* acid（free acid）** VF 594 carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 594 Carboxylic acid (VF 594 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1827

*Vari Fluor 660 Carboxylic* acid（free acid）** VF 660 carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 660 Carboxylic acid (VF 660 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1829

*Vari Fluor 568 Carboxylic* acid（free acid）** VF 568 carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 568 Carboxylic acid (VF 568 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-D1830

*Vari Fluor 680 Carboxylic* acid（free acid）** VF 680 carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 680 Carboxylic acid (VF 680 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .

HY-157071S

*Seliciclib Carboxylic* Acid-d7**	Isotope-Labeled Compounds	Others
Seliciclib Carboxylic Acid-d₇ is deuterium-labeled Seliciclib Carboxylic Acid .

HY-W016473S

*Adamantane-carboxylic* Acid-d15**	Isotope-Labeled Compounds	Others
Adamantane-carboxylic Acid-d₁₅ is the deuterium labeled Adamantane-1-carboxylic acid[1].

HY-N0610AS

Cinnamic acid-d6 3-Phenylacrylic acid-d<sub>6sub>; β-Phenylacrylic acid-d<sub>6sub>	Endogenous Metabolite	Cancer
Cinnamic acid-d₆ is the deuterium labeled Cinnamic acid. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.

HY-W017763S

*Tetrahydrofuran-2-carboxylic* acid-d7**	Isotope-Labeled Compounds	Others
Tetrahydrofuran-2-carboxylic acid-d₇ is the deuterium labeled Tetrahydrofuran-2-carboxylic acid[1].

HY-Y0001S1

*Cyclopropane-1-carboxylic* Acid-d1**	Isotope-Labeled Compounds	Others
Cyclopropane-1-carboxylic Acid-d₁ is the deuterium labeled Cyclopropane-1-carboxylic Acid[1].

HY-131314S

*Ibuprofen carboxylic* acid-d3**	Isotope-Labeled Compounds	Others
Ibuprofen carboxylic acid-d₃ is the deuterium labeled Ibuprofen carboxylic acid[1].

HY-12222S

Obeticholic acid-d5 INT-747-d<sub>5sub>; 6-ECDCA-d<sub>5sub>; 6-Ethylchenodeoxycholic acid-d<sub>5sub>	FXR Autophagy	Others
Obeticholic acid-d₅ is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].

HY-W002011S

*Quinoline-2-carboxylic* acid-d6**	Endogenous Metabolite	Metabolic Disease
Quinoline-2-carboxylic acid-d₆ is the deuterium labeled Quinoline-2-carboxylic acid[1]. Quinoline-2-carboxylic acid is an endogenous metabolite.

HY-W285163S

*1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic* acid-d8** Formyl Ciprofloxacin-d<sub>8sub>	Isotope-Labeled Compounds	Others
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d₈ is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.

HY-D1319

*Cyanine5 carboxylic* acid chloride** Cy5 acid chloride	Fluorescent Dye	Others
Cyanine5 carboxylic acid chloride (Cy5 acid chloride) is a fluorescent dye containing a non-activated carboxylic acid (Ex=646 nm, Em=662 nm). Cyanine5 carboxylic acid chloride is an non-reactive dye that can be used in control samples .

HY-131503S

13-Methyltetradecanoic acid-d6 13-MTD-d<sub>6sub>; 13-Methylmyristic acid-d<sub>6sub>	Isotope-Labeled Compounds Apoptosis	Cancer
13-Methyltetradecanoic acid-d6 is a deuterated labeled 13-Methyltetradecanoic acid . 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-14649S3

Retinoic acid-d6 Vitamin A acid-d<sub>6sub>; all-trans-Retinoic acid-d<sub>6sub>; ATRA-d<sub>6sub>	Isotope-Labeled Compounds RAR/RXR PPAR Autophagy Endogenous Metabolite	Cancer
Retinoic acid-d₆ is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].

HY-12765S

*Losartan-d4 (carboxylic* acid)** E-3174 d<sub>4sub>; EXP-3174 d<sub>4sub>	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan-d₄ (carboxylic acid) is the deuterium labeled Losartan (EXP-3174), which is an angiotensin II receptor antagonist.

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-30004S

*1-Aminocyclopropane-1-carboxylic* acid-d4**	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
1-Aminocyclopropane-1-carboxylic acid-d₄ is the deuterium labeled 1-Aminocyclopropane-1-carboxylic acid. Aminocyclopropane-1-carboxylic acid is an endogenous metabolite[1].

HY-101108S

Tazarotenic acid-d6 AGN 190299-d<sub>6sub>	Isotope-Labeled Compounds Drug Metabolite	Others
Tazarotenic acid-d₆ is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-W246043

*3-Pyridine-2,4,5,6-d4-carboxylic* acid, ethyl ester** Ethyl Nicotinate-d<sub>4sub>	Isotope-Labeled Compounds	Others
3-Pyridine-2,4,5,6-d₄ -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-d4-carboxylic acid, ethyl ester[1].

HY-B0167S

Salicylic acid-d6 2-Hydroxybenzoic acid-d<sub>6sub>	COX Autophagy Mitophagy Apoptosis	Inflammation/Immunology Cancer
Salicylic acid-d₆ is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].

HY-D2176

*AF 555 carboxylic* acid**	Fluorescent Dye	Others
AF 555 carboxylic acid is a derivative of the orange fluorescent dye AF 555. AF 555 carboxylic acid is widely used in cell dyes, biological dyes, biomolecules and particle fluorescent labeling. AF 555 exhibits average excitation wavelengths under green laser and red laser of 510 nm and 610 nm, respectively .

HY-D1650

*BDP 630/650 carboxylic* acid**	Fluorescent Dye	Others
BDP 630/650 carboxylic acid is a bright far-red fluorophore based on a borondipyrromethene scaffold. BDP 630/650 carboxylic acid is a BDP linker containing carboxylic acid. BDP 630/650 carboxylic acid can react with primary amine groups to form a stable amide bond. (λ_ex=630 nm, λ_em=650 nm) .

HY-W018790S

4-Dimethylamino benzoic acid-d6 4-dimethylamino benzoic acid-d<sub>6sub>	Isotope-Labeled Compounds	Others
4-Dimethylamino benzoic acid-d₆ is deuterium labeled 4-Dimethylaminobenzoic acid.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-I0096

*Indole-2-carboxylic* acid**	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite iGluR
Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid (I2CA) specifically and competitively inhibits the potentiation by glycine of NMDA-gated current .

HY-33037

*Phenazine-1-carboxylic* acid**	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Alkaloids Marine natural products Source classification Disease Research Fields	Fungal
Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation .

HY-W002011

*Quinoline-2-carboxylic* acid**	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Quinoline-2-carboxylic acid is an endogenous metabolite.

HY-75308

*Azetidine-2-carboxylic* acid** 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Amino acids Beta vulgaris Linn. Plants Disease Research Fields Cancer Chenopodiaceae	Others
Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent .

HY-30004

*1-Aminocyclopropane-1-carboxylic* acid**	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity. .

HY-N2321

*Salsolinol-1-carboxylic* acid** 1 Publications Verification	Structural Classification Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Endogenous metabolite	Others
Salsolinol-1-carboxylic acid is an endogenous alkaloid in the central nervous system (CNS) .

HY-W050044

*L-Azetidine-2-carboxylic* acid**	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Azetidine-2-carboxylic acid is an endogenous metabolite.

HY-W001963

*Pyrrole-2-carboxylic* acid**	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Marine natural products Source classification Other Diseases Endogenous metabolite Marine microorganism Disease Research Fields	Endogenous Metabolite
Pyrrole-2-carboxylic acid is a natural alkaloid from the marine bacterium Pelomonas puraquae sp. Nov.

HY-40161R

*Indole-3-carboxylic* acid (Standard)**	Alkaloids Structural Classification Human Gut Microbiota Metabolites Source classification Endogenous metabolite Indole Alkaloids	Endogenous Metabolite
Indole-3-carboxylic acid (Standard) is the analytical standard of Indole-3-carboxylic acid. This product is intended for research and analytical applications. Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .

HY-N6877

*Purpurogallin carboxylic* acid**	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae Cancer	Others
Purpurogallin carboxylic acid, isolated from Macleaya microcarpa (Maxim.) Fedde, is an oxidation product of gallic acid in fermented tea. Purpurogallin carboxylic acid has anti-cancer activity .

HY-W031757

*Anthraquinone-2-carboxylic* acid**	Quinones Structural Classification other families Classification of Application Fields Anthraquinones Brazilian taheebo Plants Inflammation/Immunology Disease Research Fields	Others
Anthraquinone-2-carboxylic acid is a major anthraquinone isolated from Brazilian taheebo, with anti-inflammatory activity and antinociceptive .

HY-40161

*Indole-3-carboxylic* acid**	Alkaloids Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite
Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .

HY-66047

*2,4-Dihydroxypyrimidine-5-carboxylic* Acid**	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2,4-Dihydroxypyrimidine-5-carboxylic Acid is an endogenous metabolite.

HY-W002304

*(R)-5-Oxopyrrolidine-2-carboxylic* acid**	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(R)-5-Oxopyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-N1635

*1-Methoxyindole-3-carboxylic* acid**	Structural Classification Alkaloids Source classification Plants Brassicaceae Isatis indigotica Fortune Indole Alkaloids	Others
1-Methoxyindole-3-carboxylic acid (compound 5) is synthetic from a phytoalexin nucleophilic substitution reaction selectively at the 2-position .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-N9192

*2,2-Dimethyl-8-prenylchromene 6-carboxylic* acid**	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Piperaceae Plants Piper aduncum Disease Research Fields	Others
2,2-Dimethyl-8-prenylchromene 6-carboxylic acid (compound 2) is a natural product that can be found in Piper aduncum .

HY-N1905

*4-Methoxy-β-carboline-1-carboxylic* acid methylester**	Alkaloids Structural Classification Simaroubaceae Ailanthus altissima (Mill.) Swingle Source classification Plants Indole Alkaloids	Others
4-Methoxy-β-carboline-1-carboxylic acid methylester is an alkaloid with the structure of canthin-6-one and β-carboline .

HY-75087

*(R)-pyrrolidine-2-carboxylic* acid** (+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(R)-pyrrolidine-2-carboxylic acid ((+)-(R)-Proline) is a proline isomer that exhibits high renal and hepatotoxicity in rats. (R)-pyrrolidine-2-carboxylic acid can be used to study amino acid metabolism and toxicity mechanisms .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-N4226

*1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic* acid**	Structural Classification Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	AP-1
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-N7692

Polyporusterone A	Classification of Application Fields Source classification Polyporaceae Other Diseases Poria cocos Plants Disease Research Fields Steroids	Others
Polyporusterone A is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone A has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis) .

HY-N7693

Polyporusterone B	Classification of Application Fields Source classification Polyporaceae Other Diseases Poria cocos Plants Disease Research Fields Steroids	Others
Polyporusterone B is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone B has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis) .

HY-N0662R

Amentoflavone (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-B0504S

Creatinine-d3 3 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-Y0569

D-Gluconic acid (solution)	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Fungal
D-Gluconic acid is the carboxylic acid by the oxidation with antiseptic and chelating properties.

HY-79494

Glyoxalic acid 1 Publications Verification NSC 27785; Formylformic acid; Oxalaldehydic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endocrine diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glyoxalic acid (NSC 27785) is an organic compound that is both an aldehyde and a carboxylic acid.

HY-Y0569B

D-Gluconic acid calcium hydrate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Fungal Endogenous Metabolite
D-Gluconic acid calcium hydrate is the carboxylic acid by the oxidation with antiseptic and chelating properties.

HY-W012946

2-Furoic acid Pyromucic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	ATP Citrate Lyase Acyltransferase Endogenous Metabolite
2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation . 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats .

HY-N12911

Tanzawaic acid E	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Others
Tanzawaic acid E is a carboxylic acid and can be isolated from Penicillium steckii .

HY-Y0569C

D-Gluconic acid potassium	Infection Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Endogenous Metabolite Fungal
D-Gluconic acid potassium is an orally active carboxylic acid by the oxidation with antiseptic and chelating properties .

HY-129503

2-Heptyl-4-quinolone	Structural Classification Alkaloids Microorganisms Source classification Quinoline Alkaloids	Others
2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .

HY-Y0030

3-Hydroxypicolinic acid 3-hydroxypyridine-2-carboxylic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Hydroxypicolinic acid is a picolinic acid derivative, and belongs to the pyridine family.

HY-N0140

Ursolic acid Maximum Cited Publications 11 Publications Verification Prunol; Urson; Malol	Triterpenes Structural Classification Ziziphus jujuba Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Rhamnaceae Disease Research Fields Cancer	Autophagy Endogenous Metabolite
Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

HY-W012946R

2-Furoic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	ATP Citrate Lyase Acyltransferase Endogenous Metabolite
2-Furoic acid (Standard) is the analytical standard of 2-Furoic acid. This product is intended for research and analytical applications. 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation . 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats .

HY-79494R

Glyoxalic acid (Standard) NSC 27785 (Standard); Formylformic acid (Standard); Oxalaldehydic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite	Endogenous Metabolite
Glyoxalic acid (Standard) is the analytical standard of Glyoxalic acid. This product is intended for research and analytical applications. Glyoxalic acid (NSC 27785) is an organic compound that is both an aldehyde and a carboxylic acid.

HY-41404

Piperonylic acid 2H-1,3-benzodioxole-5-carboxylic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Piperaceae Plants Disease Research Fields Piper nigrum Linn.	Cytochrome P450 Interleukin Related EGFR IGF-1R
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .

HY-Y0569CR

D-Gluconic acid potassium (Standard)	Structural Classification Source classification Endogenous metabolite Saccharides Monosaccharides	Endogenous Metabolite Fungal
D-Gluconic acid (potassium) (Standard) is the analytical standard of D-Gluconic acid (potassium). This product is intended for research and analytical applications. D-Gluconic acid potassium is an orally active carboxylic acid by the oxidation with antiseptic and chelating properties .

HY-Y0569BR

D-Gluconic acid calcium hydrate (Standard)	Structural Classification Source classification Endogenous metabolite Saccharides Monosaccharides	Fungal Endogenous Metabolite
D-Gluconic acid (calcium hydrate) (Standard) is the analytical standard of D-Gluconic acid (calcium hydrate). This product is intended for research and analytical applications. D-Gluconic acid calcium hydrate is the carboxylic acid by the oxidation with antiseptic and chelating properties.

HY-N0216BS

Benzoic-3,5 Acid-d2	Classification of Application Fields	Isotope-Labeled Compounds
Benzoic-3,5 Acid-d₂ is the deuterium labeled Benzoic-3,5 Acid[1].

HY-N0140R

Ursolic acid (Standard)	Triterpenes Structural Classification Ziziphus jujuba Terpenoids Source classification Plants Endogenous metabolite Rhamnaceae	Autophagy Endogenous Metabolite
Ursolic acid (Standard) is the analytical standard of Ursolic acid. This product is intended for research and analytical applications. Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

HY-N1272

Secaubryenol	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Other Diseases Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Secaubryenol is a class of 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla. Secaubryenol does not display any cytotoxic effect at a dose of 10 μg/mL .

HY-40135

L-Hydroxyproline (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid	Alkaloids Structural Classification Immune System Disorder Pyrrole Alkaloids Classification of Application Fields Source classification Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.

HY-115773

NMTCA NMTPRO; N-Nitroso-2-methylthiazolidine 4-carboxylic acid; N-nitrosomethylthioproline	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NMTCA (NMTPRO) is a sulfur-containing N-nitrosamino acid. NMTCA can be used as an indicator of endogenous nitrosation by gas chromatography-thermalenergyanalysis .

HY-N0823

Lithospermic acid (+)-Lithospermic acid	Structural Classification Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Source classification Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Others
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in vitro and in vivo .

Cat. No.	Product Name	Chemical Structure

HY-70002BS

*Enzalutamide carboxylic* acid-d6**
Enzalutamide carboxylic acid-d₆ is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid). Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide[1].

HY-70002S1

Enzalutamide-d6
Enzalutamide-d₆ is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells[1].

HY-70002S

Deutenzalutamide
Deutenzalutamide (Enzalutamide-d₃) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells .

HY-70002AS

N-desmethyl Enzalutamide-d6

N-desmethyl Enzalutamide-d₆ is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].

HY-B0236S

6-Aminocaproic acid-d6

6-Aminocaproic acid-d₆ is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

HY-101329S

*Anthracene-9-carboxylic* acid-d9**
Anthracene-9-carboxylic acid-d₉ is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].

HY-141749AS

*Clopidogrel carboxylic* acid-d4**
Clopidogrel carboxylic acid-d₄ is a deuterated derivative of Clopidogrel carboxylic acid, which is an inactive metabolite of the antiplatelet agent Clopidogrel (HY-15283) in plasma. Clopidogrel carboxylic acid-d₄ can be used to further explore the metabolic characteristics of Clopidogrel .

HY-141749S

*(Rac)-Clopidogrel carboxylic* acid-d4**
(Rac)-Clopidogrel carboxylic acid-d₄ is the deuterium labeled (Rac)-Clopidogrel carboxylic acid[1].

HY-75087S

*(R)-Pyrrolidine-2-carboxylic* acid-d3**
(R)-Pyrrolidine-2-carboxylic acid-d₃ is the deuterium labeled (R)-pyrrolidine-2-carboxylic acid. (R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-B0236S1

6-Aminocaproic acid-d10

6-Aminocaproic acid-d₁₀ is the deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

HY-100560S

Abscisic acid-d6
Abscisic acid-d₆ is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H+-ATPase)[1].

HY-N0593S2

Deoxycholic acid-d6
Deoxycholic acid-d₆ is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

HY-B1350S

Fusidic acid-d6
Fusidic acid-d₆ is the deuterium labeled Fusidic acid. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome[1][2].

HY-157071S

*Seliciclib Carboxylic* Acid-d7**
Seliciclib Carboxylic Acid-d₇ is deuterium-labeled Seliciclib Carboxylic Acid .

HY-W016473S

*Adamantane-carboxylic* Acid-d15**
Adamantane-carboxylic Acid-d₁₅ is the deuterium labeled Adamantane-1-carboxylic acid[1].

HY-N0610AS

Cinnamic acid-d6
Cinnamic acid-d₆ is the deuterium labeled Cinnamic acid. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.

HY-W017763S

*Tetrahydrofuran-2-carboxylic* acid-d7**
Tetrahydrofuran-2-carboxylic acid-d₇ is the deuterium labeled Tetrahydrofuran-2-carboxylic acid[1].

HY-Y0001S1

*Cyclopropane-1-carboxylic* Acid-d1**
Cyclopropane-1-carboxylic Acid-d₁ is the deuterium labeled Cyclopropane-1-carboxylic Acid[1].

HY-131314S

*Ibuprofen carboxylic* acid-d3**
Ibuprofen carboxylic acid-d₃ is the deuterium labeled Ibuprofen carboxylic acid[1].

HY-12222S

Obeticholic acid-d5
Obeticholic acid-d₅ is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].

HY-W002011S

*Quinoline-2-carboxylic* acid-d6**
Quinoline-2-carboxylic acid-d₆ is the deuterium labeled Quinoline-2-carboxylic acid[1]. Quinoline-2-carboxylic acid is an endogenous metabolite.

HY-W285163S

*1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic* acid-d8**
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d₈ is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.

HY-131503S

13-Methyltetradecanoic acid-d6
13-Methyltetradecanoic acid-d6 is a deuterated labeled 13-Methyltetradecanoic acid . 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-14649S3

Retinoic acid-d6

Retinoic acid-d₆ is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].

HY-12765S

*Losartan-d4 (carboxylic* acid)**
Losartan-d₄ (carboxylic acid) is the deuterium labeled Losartan (EXP-3174), which is an angiotensin II receptor antagonist.

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-30004S

*1-Aminocyclopropane-1-carboxylic* acid-d4**
1-Aminocyclopropane-1-carboxylic acid-d₄ is the deuterium labeled 1-Aminocyclopropane-1-carboxylic acid. Aminocyclopropane-1-carboxylic acid is an endogenous metabolite[1].

HY-101108S

Tazarotenic acid-d6
Tazarotenic acid-d₆ is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-W246043

*3-Pyridine-2,4,5,6-d4-carboxylic* acid, ethyl ester**
3-Pyridine-2,4,5,6-d₄ -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-d4-carboxylic acid, ethyl ester[1].

HY-B0167S

Salicylic acid-d6
Salicylic acid-d₆ is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].

HY-W018790S

4-Dimethylamino benzoic acid-d6
4-Dimethylamino benzoic acid-d₆ is deuterium labeled 4-Dimethylaminobenzoic acid.

HY-W011560S

*3-Methylflavone-8-carboxylic* acid-d5**
3-Methylflavone-8-carboxylic acid-d₅ is the deuterium labeled 3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid[1].

HY-A0143S

Dihomo-γ-linolenic acid-d6
Dihomo-γ-linolenic acid-d₆ (DGLA-d₆) is the deuterium labeled Dihomo-γ-linolenic acid. Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].

HY-12771S2

O-Desmethyl Mebeverine acid-d6
O-Desmethyl Mebeverine acid-d₆ is deuterium labeled O-desmethyl Mebeverine acid.

HY-108398AS

Mead acid-d6
Mead acid-d₆ is the deuterium labeled Mead acid. Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency[1].

HY-W000793S

*5-Methoxy-1H-indole-3-carboxylic* acid-d3**
5-Methoxy-1H-indole-3-carboxylic acid-d₃ is the deuterium labeled 5-methoxy-1H-indole-3-carboxylic acid[1].

HY-N0351S1

p-Coumaric acid-d6
p-Coumaric acid-d₆ is the deuterium labeled p-Coumaric acid (HY-N0351). p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities[1][2].

HY-B0715S

Pentoxifylline-d6

Pentoxifylline-d₆ is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].

HY-15494S1

Picropodophyllin-d6
Picropodophyllin-d₆ (AXL1717-d₆) is deuterium labeled Picropodophyllin. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

HY-B1873S

Methoxychlor-d6
Methoxychlor-d₆ is the deuterium labeled Methoxychlor[1].

HY-W056964S

Naphthalene-2,6-dicarboxylic acid-d6
Naphthalene-2,6-dicarboxylic acid-d₆ is the deuterium labeled Naphthalene-2,6-dicarboxylic acid[1].

HY-W018728S

3,5-Dimethylbenzoic acid-d9
3,5-Dimethylbenzoic acid-d₉ is the deuterium labeled 3,5-Dimethylbenzoic acid[1].

HY-119695AS

Simvastatin acid-d6 ammonium

Simvastatin acid-d₆ (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].

HY-12765S1

Losartan carboxylic acid-d4 hydrochloride

Losartan carboxylic acid-d₄ (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].

HY-76542S

Vitamin D2-d6
Vitamin D2-d₆ is the deuterium labeled Vitamin D2. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D[1][2].

HY-N0537S9

Xylose-d6
Xylose-d₆ is the deuterium labeled Xylose.

HY-N1214S

Squalene-d6
Squalene-d6 is a deuterium labeled Squalene. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-N0067S

γ-Aminobutyric acid-d6
γ-Aminobutyric acid-d₆ is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].

HY-41681S

6-Chloro-1-hexanol-d6
6-Chloro-1-hexanol-d₆ is the deuterium labeled 6-Chloro-1-hexanol[1].

HY-19655S

Cethromycin-d6
Cethromycin-d₆ (ABT-773-d₆; Abbott-195773-d₆; A-195773-d₆) is deuterium-labeled Cethromycin (HY-19655) .

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