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Pathways Recommended:	PROTAC

Results for "

PROTACs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ligands for Target Protein for PROTAC (141) PROTAC Linkers (2876) PROTAC-Linker Conjugates for PAC (8) PROTACs (623) 17β-HSD (1) AAK1 (1) Acetyl-CoA Carboxylase (2) ADC Cytotoxin (1) ADC Linker (209) Adrenergic Receptor (2) Akt (8) Aldose Reductase (1) Anaplastic lymphoma kinase (ALK) (10) Androgen Receptor (22) AP-1 (1) APC (3) Apoptosis (220) ATM/ATR (3) Aurora Kinase (4) AUTACs (1) Autophagy (202) Bacterial (2) Bcl-2 Family (17) BCL6 (3) Bcr-Abl (7) Biochemical Assay Reagents (1) Btk (16) c-Fms (1) c-Kit (1) c-Met/HGFR (3) c-Myc (2) CaMK (2) Casein Kinase (1) Caspase (3) CDK (49) Checkpoint Kinase (Chk) (1) Cytochrome P450 (6) Dengue virus (4) Deubiquitinase (2) Dipeptidyl Peptidase (1) DNA Methyltransferase (1) DNA/RNA Synthesis (3) DYRK (1) E1/E2/E3 Enzyme (8) E3 Ligase Ligand-Linker Conjugates (514) EGFR (24) Endogenous Metabolite (2) Ephrin Receptor (2) Epigenetic Reader Domain (142) Epoxide Hydrolase (1) ERK (3) Estrogen Receptor/ERR (25) FAK (9) Ferroptosis (8) FGFR (4) FKBP (12) Flavivirus (1) FLT3 (12) Fluorescent Dye (2) GLP Receptor (1) Glutaminase (2) Glutathione Peroxidase (5) GSK-3 (1) HBV (1) HDAC (18) Hedgehog (1) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (3) Histone Acetyltransferase (7) Histone Demethylase (3) Histone Methyltransferase (23) HIV (2) HSP (3) IAP (2) IKK (1) IKZF Family (1) Indoleamine 2,3-Dioxygenase (IDO) (3) Influenza Virus (1) IRAK (13) Isotope-Labeled Compounds (2) JAK (9) Keap1-Nrf2 (1) Leukotriene Receptor (2) Ligands for E3 Ligase (185) LIM Kinase (LIMK) (1) Liposome (8) LRRK2 (2) LYTACs (1) Macrophage migration inhibitory factor (MIF) (1) MAP4K (6) MDM-2/p53 (11) MEK (2) METTL3 (1) Microtubule/Tubulin (1) Mixed Lineage Kinase (3) Molecular Glues (6) Mps1 (3) NAMPT (4) NF-κB (1) Nuclear Factor of activated T Cells (NFAT) (1) Nuclear Hormone Receptor 4A/NR4A (1) p38 MAPK (2) PARP (13) PD-1/PD-L1 (5) PDGFR (2) PDK-1 (1) PERK (1) PGE synthase (1) Phosphatase (5) PI3K (1) PIKfyve (1) PIN1 (2) Polo-like Kinase (PLK) (1) Progesterone Receptor (1) Prostaglandin Receptor (2) Proteasome (1) Raf (4) RANKL/RANK (1) RAR/RXR (1) Ras (26) Reactive Oxygen Species (1) RIP kinase (4) ROS Kinase (1) Salt-inducible Kinase (SIK) (1) SARS-CoV (6) SF3B1 (1) SGK (1) SHP2 (1) Sirtuin (2) SNIPERs (7) Src (2) STAT (10) STING (5) TAM Receptor (2) Target Protein Ligand-Linker Conjugates (17) Tau Protein (2) TGF-beta/Smad (1) Trk Receptor (1) ULK (1) VEGFR (6) Virus Protease (3) Wee1 (1) Wnt (1) YAP (3) α-synuclein (3) β-catenin (3)
By Research Areas:	Cancer (4313) Cardiovascular Disease (4) Endocrinology (1) Infection (32) Inflammation/Immunology (52) Metabolic Disease (12) Neurological Disease (14)
Click Chemistry:	ADC Synthesis (57) TCO (57) DBCO (102) PROTAC Synthesis (782) Azide (480) BCN (34) Tetrazine (45) Alkynes (248)
Oligonucleotides:	Cosolvents (1) Pegylated Lipids (7) Emulsifiers (1) Bases (1)

4461

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

948

Click Chemistry

Oligonucleotides

Targets Recommended: PROTACs PROTAC Linkers Ligands for Target Protein for PROTAC PROTAC-Linker Conjugates for PAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-168257

PROTAC SMARCA2 degrader-30	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-30 (example 85) is a PROTAC SMARCA2 degrader with a DC₅₀ less than 100 nM in H1299 cells .

HY-163582

PROTAC SOS1 degrader-7	PROTACs Ras	Cancer
PROTAC SOS1 degrader-7 (Example 15) is a SOS1 PROTAC degrader. PROTAC SOS1 degrader-7 has anti-tumor activity . (Pink: SOS1 ligand (HY-163583); Black: linker (HY-163584); Blue: E3 ligase ligand (HY-W454906)) .

HY-162835

PROTAC SMARCA2/4-degrader-28	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-28 (PROTAC 1) is a *PROTAC*-based partial degrader of SMARCA2 and SMARCA4(Bliue: CRL2 ^VHL ligand (S,R,S)-AHPC (HY-125845); Black: linker (HY-159680); Pink: a SMARCA-BD ligand (+)-JQ-1 (HY-13030)) .

HY-153023

PROTAC STAT3 degrader-2	PROTACs STAT	Cancer
PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC₅₀ of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research . PROTAC STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-161173

PROTAC SOS1 degrader-5	PROTACs Ras	Cancer
PROTAC SOS1 degrader-5 (compound 4) is a potent PROTAC SOS1 degrader, with the DC₅₀ of 13 nM. PROTAC SOS1 degrader-5 strongly inhibits NCI-H358 cells proliferation with an IC₅₀ of 5 nM .

HY-152145

PROTAC SOS1 degrader-3	PROTACs Ras	Cancer
PROTAC SOS1 degrader-3 is a potent PROTAC SOS1 degrader. PROTAC SOS1 degrader-3 effectively targeted SOS1 for degradation through the ubiquitin-proteasome system .

HY-161882

PROTAC SMARCA2 degrader-8	PROTACs	Cancer
PROTAC SMARCA2 degrader-8 (compound 1) is a potent SMARCA2 degrader with a DC₅₀ of 28nM in A375 cells .

HY-163864

PROTAC SMARCA2/4-degrader-11	PROTACs	Cancer
SMARCA2 degrader-1 (compound I-321) is a PROTAC degrader of SMARCA with DC₅₀＜100nM (red: SMARCA inhibitor, black: linker (HY-Y1215), blue: E3 ligase ligand (HY-163927) ) .

HY-168225

PROTAC SMARCA2/4-degrader-35	PROTACs	Others
PROTAC SMARCA2/4-degrader-35 (Ex.42) is a SMARCA2/4 degrader with a DC₅₀ <2.5 nM. (Target ligand: HY-W874018; E3 ligand: HY-168226; linker: HY-168227; E3 ligand+linker: HY-168228)

HY-168638

PROTAC SOS1 ligand 1	Ligands for Target Protein for PROTAC	Cancer
PROTAC SOS1 ligand 1, a BI-3406 (HY-125817) analog, is a ligand for target SOS1 protein for PROTACT SIAIS562055 (HY-168637) .

HY-159454

PROTAC SMARCA2/4-degrader-3	PROTACs	Cancer
SMARCA2/4-degrader-3 (compound I-433) is a PROTAC SMARCA2/4-degrader based on VH032-NH2, with a degradation potency (DC₅₀) <100 nM in MV4-11 cells .

HY-169271

PROTAC SMARCA2 degrader-20	PROTACs	Cancer
PROTAC SMARCA2 degrader-20 (Compound I-40) is a PROTAC SMARCA2 degrader. PROTAC SMARCA2 degrader-20 has the potential for the research of cancer .

HY-150608

PROTAC STING Degrader-1	STING PROTACs	Inflammation/Immunology
PROTAC STING Degrader-1 (Compound SP23) is a STING PROTAC degrader with a DC₅₀ of 3.2 μM. PROTAC STING Degrader-1 shwos anti-inflammatory activity .

HY-145737

PROTAC SOS1 degrader-1	PROTACs Ras	Cancer
PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader with an DC₅₀ of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity .

HY-169269

PROTAC SMARCA2 degrader-18	PROTACs	Cancer
PROTAC SMARCA2 degrader-18 (Example144) is a PROTAC SMARCA2 degrader. PROTAC SMARCA2 degrader-18 has the potential for the research of non-small cell lung cancer (NSCLC) .

HY-169274

PROTAC SMARCA2 degrader-23	PROTACs	Cancer
PROTAC SMARCA2 degrader-23 (Example 1) is a potent and selective PROTAC SMARCA2 degrader, with a DC₅₀ of <100 nM. PROTAC SMARCA2 degrader-23 has the potential for the research of cancer .

HY-145737A

PROTAC SOS1 degrader-1 TFA	PROTACs Ras	Cancer
PROTAC SOS1 degrader-1 (TFA) is a potent PROTAC SOS1 degrader with an DC₅₀ of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity .

HY-162245

PROTAC SMARCA2 degrader-3	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-3 is a *PROTAC* degrader of the SWI/SNF ATPase subunits, SMARCA2. PROTAC SMARCA2 degrader-3 has anticancer effects (WO2023244764A1; Compound 153) .

HY-169273

PROTAC SMARCA2 degrader-22	PROTACs	Cancer
PROTAC SMARCA2 degrader-22 (Compound 5) is a PROTAC degrader for SMARCA2 with a degradation efficacy of 94% at 100 nM. PROTAC SMARCA2 degrader-22 inhibits the proliferation of cell A549 with an EC₅₀ < 250 nM .

HY-169278

PROTAC SMARCA2 degrader-26	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-26 (compound 45) is a potent SMARCA2 PROTAC degrader. PROTAC SMARCA2 degrader-26 induces SMARCA2 and SMARCA4 degradation in VCaP cells with the percent degradation of 94% and 57% for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2 degrader-26 shows antiproliferative activity .

HY-162834

PROTAC SMARCA2/4-degrader-27	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-27 (PROTAC 2) is a *PROTAC*-based degrader of SMARCA2 and SMARCA4. (Blue: CRL2 ^VHL ligand VH032-cyclopropane-F (HY-125905); Black: linker (HY-159678);Pink: a SMARCA-BD ligand 1 for PROTAC (HY-44012)) .

HY-169275

PROTAC SMARCA2 degrader-24	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-24 (Compound 34) is a PROTAC degrader for SMARCA2 with a DC₅₀ < 0.1 µM in HeLa. PROTAC SMARCA2 degrader-24 degrades SMARCA4 with a DC₅₀ > 10 μM in HeLa .

HY-169276

PROTAC SMARCA2 degrader-25	PROTACs	Cancer
PROTAC SMARCA2 degrader-25 (example 86) is a potent PROTAC SMARCA2 degrader with the DC₅₀ of ＜0.01 μM .

HY-159494

PROTAC sEH-degrader-1	PROTACs Epoxide Hydrolase	Metabolic Disease
sEH-degrader-1 (Compound 8) serves as an inhibitor for sEH, with IC₅₀ values of 3.8 nM and 210 nM against hsEH and msEH respectively. sEH-degrader-1 can effectively degrade sEH in mouse liver and brown adipose tissue (Red: UC-1728 (HY-114266), black: linker (HY-W248248), Blue: Thalidomide-5-piperazine (HY-W834174)) .

HY-162281

PROTAC SOS1 degrader-6	Others	Cancer
PROTAC SOS1 degrader-6 (compound 23) is a potent SOS1 PROTACs degrader with synergistic efficacy with KRAS ^G12C inhibitors .

HY-169270

PROTAC SMARCA2 degrader-19	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-19 (Compound 46) is a PROTAC degrader for SMARCA2, that degrades SMARCA2 in cell A549 and MV411 with a DC₅₀ < 100 nM. PROTAC SMARCA2 degrader-19 degrades SMARCA4 in cell MV411 with a DC₅₀ > 1000 nM .

HY-153674

PROTAC SOS1 degrader-4	PROTACs Ras	Cancer
PROTAC SOS1 degrader-4 (compound 10) is a potent SOS1 degrader. PROTAC SOS1 degrader-4 shows antiproliferative activity .

HY-168229

PROTAC SMARCA2 degrader-27	PROTACs	Cancer
PROTAC SMARCA2 degrader-27 (compound 4) is a PROTAC SMARCA2 degrader. PROTAC SMARCA2 degrader-27 has the potential to be used in cancer research (blue: SMARCA2 ligand, (HY-168232); black: linker, (HY-168231); pink: VHL ligand, (HY-168230)) .

HY-125878

PROTAC SGK3 degrader-1 3 Publications Verification SGK3-PROTAC1	PROTACs SGK	Cancer
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a von Hippel-Lindau ligand-based SKG3 PROTAC composed of a PEG3-C4-OBn (HY-130620) alkyl linker, an SGK3 degrader (red structure), and a VHL ligand (HY-150803, blue structure). PROTAC SGK3 degrader-1 (0.3 μM) induced 50% endogenous SGK3 degradation within 2 hours, and 80% SGK3 degradation was observed at 8 hours, accompanied by loss of phosphorylation of NDRG1 (SGK3 substrate) .

HY-153425

PROTAC SMARCA2 degrader-2	PROTACs	Cancer
PROTAC SMARCA2 degrader-2 is a potent and selective SMARCA2/4 PROTAC degrader with an IC₅₀ of <0.1 μΜ in HeLa HiBiT assay. PROTAC SMARCA2 degrader-2 is extracted from patent WO2023287787A1 and has the potential for SMARCA4-related or deficient cancer research .

HY-157804

PROTAC SARS-CoV-2 Mpro degrader-1	PROTACs SARS-CoV	Infection
PROTAC SARS-CoV-2 Mpro degrader-1 (compound 5) is a PROTAC degrader targeting the major SARS-CoV-2 protease with broad-spectrum antiviral activity .

HY-153424

PROTAC SMARCA2 degrader-1	Target Protein Ligand-Linker Conjugates	Cancer
PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC₅₀<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a target protein ligand-linker conjugate .

HY-169279

PROTAC SMARCA2/4-degrader-34	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2/4-degrader-34 (compound 38) is a potent is a potent SMARCA2 and SMARCA4 PROTAC degrader. PROTAC SMARCA2/4-degrader-34 shows PXR binding affinity with DC₅₀ value of 85.1 nM. PROTAC SMARCA2/4-degrader-34 decreases the protein expression of 3xFLAG-PXR. (Pink: Ligand for target protein (HY-169280); Black: Linker (HY-43048); Blue: Ligand for E3 ligase (HY-125845) .

HY-161634

PROTAC SOS1 degrader-8	PROTACs Ras	Cancer
PROTAC SOS1 degrader-8 (Compd 1) is a *PROTAC*-based SOS1 degrader (Red: SOS1 Ligand (HY-161635), Black: linker (HY-W056267), Blue: E3 ligase ligand (HY-161637)) .

HY-161636

PROTAC SOS1 degrader-9	PROTACs Ras	Cancer
PROTAC SOS1 degrader-9 (Compd 10) is a *PROTAC*-based SOS1 degrader (Red: SOS1 Ligand (HY-161635), Black: linker (HY-W056267), Blue: E3 ligase ligand (HY-161639)) .

HY-159450

PROTAC SMARCA2 degrader-6	PROTACs	Cancer
PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159462

PROTAC SMARCA2 degrader-10	PROTACs	Cancer
PROTAC SMARCA2 degrader-10 (compound I-507) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162746

PROTAC SMARCA2 degrader-9	PROTACs	Cancer
PROTAC SMARCA2 degrader-9 (compound I-285) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162747

PROTAC SMARCA2 degrader-17	PROTACs	Cancer
PROTAC SMARCA2 degrader-17 (compound I-290) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162742

PROTAC SMARCA2 degrader-16	PROTACs	Cancer
PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-103636

PROTAC Sirt2 Degrader-1	Sirtuin PROTACs	Cancer
PROTAC Sirt2 Degrader-1 is a SirReal-based *PROTAC, acts as a Sirt2* degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC₅₀ of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC₅₀s>100 μM) .

HY-169272

PROTAC SMARCA2 degrader-21	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for SMARCA, that degrades SMARCA2 with a DC₅₀ of 10-50 nM in A549 cell, and degrades SMARCA2 and SMARCA4 in MV411 with DC₅₀ of <1 nM and >100 nM, respectively .

HY-157805

PROTAC SARS-CoV-2 Mpro degrader-2	PROTACs SARS-CoV	Infection
PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent *PROTAC* degrader of SARS-CoV-2 M ^pro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC₅₀ = 10.8 μM), HCoV-OC43 (EC₅₀ = 1.6 μM) and HCoV-229E (EC₅₀ = 6.5 μM). PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an EC₅₀ of 0.89 μM .

HY-158036

PROTAC STING Degrader-2	PROTACs STING	Others Inflammation/Immunology
PROTAC STING degrader-2 is a protein Degrader that targets Stimulator of interferon genes (STING) (DC₅₀=0.53 μM). PROTAC STING Degrader-2 is combined with STING protein and E3 ubiquitin ligase in a covalent manner to induce the degradation of STING protein. PROTAC STING Degrader-2 can be used to investigate the role of STING in autoinflammation and autoimmune diseases (PINK: STING binder (HY-145009); Blue: VHL ligand (HY-164043); Black: linker) .

HY-159449

PROTAC SMARCA2 degrader-5	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-163502

PROTAC STAT3 degrader-3	PROTACs STAT	Cancer
PROTAC STAT3 degrader-3 (S3D1) is a STAT3 PROTAC degrader with anticancer activity (Structural notes: (Blue: Cereblon ligand (HY-10984), Black: linker; Pink: Pentafluorobenzenesulfonamide(Me)-CH2-CONH-benzamide (HY-163526)) .

HY-159451

PROTAC SMARCA2 degrader-7	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2 and SMARCA4 in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-163871

PROTAC SMARCA2/4-degrader-18	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-18 (Compound I-348) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-18 degrades SMARCA2 in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159531); Black: Linker (HY-76547); Blue: Ligand for E3 Ligase (HY-125845))

HY-163868

PROTAC SMARCA2/4-degrader-15	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-15 degrades SMARCA2 in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-N3024); Blue: Ligand for E3 Ligase (HY-125845))

HY-163870

PROTAC SMARCA2/4-degrader-17	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-17 degrades SMARCA2 in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W053507); Blue: Ligand for E3 Ligase (HY-125845))

Cat. No.	Product Name

HY-L129

Target Protein Ligand Library

43 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 43 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

HY-L128

E3 Ligase Ligand Library

55 compounds

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 55 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

HY-L151

PROTAC Library

272 compounds

PROTACs (Proteolysis-targeting chimeras) is a class of molecules that utilize ubiquitin-proteasome system (UPS) to ubiquitinate and degrade target proteins. The PROTACs molecule consists of two ligands joined by a linker. The one-to-one interaction between PROTACs and target proteins determines the high efficiency of PROTACs, making it a potential molecule for targeted protein degradation (TPD) therapy.

MCE supplies a unique collection of 272 PROTACs that effectively degrade target proteins with more powerful screening capability. MCE PROTAC Library is a useful tool for signal pathway research, protein degradation therapy research, drug discovery and drug repurposing, etc.

HY-L137

Molecular Glue Compound Library

41 compounds

Targeted protein degradation(TPD) is a novel and promising approach to new drug discovery and development. It shows great potential for treating diseases with “undruggable” pathogenic protein targets and for overcoming drug resistance. Molecular glues and PROTACs are both targeted protein degraders that have attracted the most attention.

Molecular glues are small molecular degraders that mainly induce novel interaction between an E3 ligase and a target protein to form a ternary complex, leading to protein ubiquitination and subsequent proteasome degradation. Compared with PROTACs, molecular glues generally possess more favorable drug-like properties, such as lower MW, higher cell permeability, and better oral absorption. Molecular glues are emerging as a promising new therapeutic strategy.

MCE supplies a unique collection of 41 molecular glues which target various proteins. MCE Molecular Glue Compound Library is a useful tool to conduct scientific research and disease mechanism study.

Cat. No.	Product Name	Type

HY-141085

Carboxyfluorescein-PEG12-NHS	Fluorescent Dyes/Probes
Carboxyfluorescein-PEG12-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-141057

Bis-(N,N’-amine-PEG3)-Cy5	Fluorescent Dyes/Probes
Bis-(N,N’-amine-PEG3)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-D2336

PROTAC Aster-A degrader-1	Fluorescent Dyes/Probes
PROTAC Aster-A degrader-1 (compound NGF3) is a degrader of the sterol transport protein Aster-A. PROTAC Aster-A degrader-1 can be used as a fluorescence probe. (Red: Aster-A inhibitor, black: linker, Blue: E3 ligase ligand) .

HY-133376

DBCO-NHCO-PEG12-biotin	Dyes
DBCO-NHCO-PEG12-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DBCO-NHCO-PEG12-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-141060

N,N'-bis-(azide-PEG3)-Cy5

Fluorescent Dyes/Probes

NN'-bis-(azide-PEG3)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N,N'-bis-(azide-PEG3)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-141066

N-(azide-PEG3)-N'-(Mal-PEG4)-Cy5

Fluorescent Dyes/Probes

N-(azide-PEG3)-N'-(Mal-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-(azide-PEG3)-N'-(Mal-PEG4)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130768

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid

Fluorescent Dyes/Probes

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker which contains azide, fluorescein and carboxylic acid moieties. N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Target	Research Area

HY-P5819A

xStAx-VHLL TFA	PROTACs β-catenin	Cancer
xStAx-VHLL TFA, a *PROTAC, sustains β-catenin* degradation and manifested strong inhibition of Wnt signaling. xStAx-VHLL TFA promotes β-catenin ubiquitination .

HY-P5819

xStAx-VHLL	Wnt APC PROTACs β-catenin	Cancer
xStAx-VHLL is a PROTAC β-catenin degrader that manifests strong inhibition of Wnt signaling and sustains degradation of β-catenin in cancer cells and the intestinal organoids derived from wild-type and APC ^–/– mice. xStAx-VHLL can be used as a promising anticancer agent .

HY-P10446

TAT-PiET-PROTAC	Epigenetic Reader Domain	Cancer
TAT-PiET-PROTAC is a proteolysis-targeting chimera (PROTAC)-modified TAT-PiET (HY-P10445). TAT-PiET is a cell-penetrating peptide targeting the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC can disrupt the interaction between the breast cancer oncogene BRD4/JMJD6 and inhibit the growth of breast cancer cells. TAT-PiET-PROTAC also resists the endocrine resistance of ERα-positive breast cancer cells and is a potential inhibitor of breast cancer .

HY-169235

DHHC3 degrader 1	Ligands for Target Protein for PROTAC	Cancer
DHHC3 degrader 1 is a PROTAC target protein ligand that is used to synthesize PCC16 chloride (HY-169232) .

HY-P5559

ND1-YL2	PROTACs	Cancer
ND1-YL2 is a *PROTAC* that selectively degrades SRC-1 via the N-degron pathway. ND1-YL2 significantly inhibits cancer invasion and migration in vitro and in vivo. ND1-YL2 can be used in cancer research .

HY-162946

Alkyne-P60	Ligands for Target Protein for PROTAC	Cancer
Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a ligand for target protein for PROTAC (HY-162943).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-156568B

SMD-3040 formate	Classification of Application Fields Disease Research Fields Cancer	PROTACs Epigenetic Reader Domain
SMD-3040 formate is a potent and selective smarca2 protac degrader with strong in vivo antitumor activity .

HY-W034918

Docosanedioic acid	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	ADC Linker PROTAC Linkers
Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-107608

Leukotriene B4 1 Publications Verification LTB4; 5(S),12(R)-DiHETE	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite PROTAC Linkers Leukotriene Receptor
Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-W034595

Eicosanedioic acid	Microorganisms Source classification	ADC Linker PROTAC Linkers
Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

HY-156698

HJM-561	Classification of Application Fields Disease Research Fields Cancer	PROTACs
HJM-561 is a potent, selective, orally bioavailable EGFR PROTAC. HJM-561 overcomes osimertinib (HY-15772)-resistant EGFR triple mutations and has anti-tumor activity .

HY-W024365

3-tert-Butyl-4-methoxyphenol	Structural Classification Monophenols Source classification Jatropha curcas Linn. Phenols Euphorbiaceae Plants	PROTAC Linkers
3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system .

Cat. No.	Product Name	Chemical Structure

HY-A0023AS2

Alogliptin-13C,d3 benzoate
Sulfo DBCO-PEG4-Maleimide TEA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-126534S

Abemaciclib metabolite M18-d8
Abemaciclib metabolite M18-d₈ is the deuterium labeled Abemaciclib metabolite M18. Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1][2].

HY-40171S

NH2-C2-NH-Boc-d4
NH2-C2-NH-Boc-d₄ is the deuterium labeled NH2-C2-NH-Boc[1]. NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[2].

HY-107608S

Leukotriene B4-d4
Leukotriene B4-d₄ is the deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2][3].

HY-140346AS

L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride

L-Azidohomoalanine-1,2,3,4- ¹³C₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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