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(Rac)-Juvenile Hormone III-d<sub>3</sub>

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (903) Cardiovascular Disease (266) Endocrinology (515) Infection (391) Inflammation/Immunology (390) Metabolic Disease (559) Neurological Disease (489)
Click Chemistry:	Azide (2) Alkynes (24)
Oligonucleotides:	Liposomal Film-forming Agents (1) Pre-designed siRNA Sets (1) Emulsifiers (1) Antisense Oligonucleotides (4) siRNAs (1)

3634

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

366

Peptides

Inhibitory Antibodies

130

Natural
Products

Recombinant Proteins

2877

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Thyroid Hormone Receptor Nuclear Hormone Receptor 4A/NR4A PTHR GHR GHSR TSH Receptor GnRH Receptor MCHR1 (GPR24) P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7240

(Rac)-Juvenile hormone III	Others	Endocrinology
(Rac)-Juvenile hormone III, a natural compound that can be isolated from farnesoic acid ,is the most widely distributed Juvenile hormone homologue .

HY-N7240S

*(Rac)-Juvenile* Hormone III-d3**	Isotope-Labeled Compounds	Others
Juvenile Hormone III-d₃ is the deuterium labeled Juvenile Hormone III[1].

HY-106373A

*Adrenocorticotropic hormone* TFA** ACTH TFA; Adrenocorticotrophic Hormone TFA	Androgen Receptor	Metabolic Disease
Adrenocorticotropic hormone (ACTH) TFA is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone regulates cortisol and androgen production .

HY-B0141S

Estradiol-d3 β-Estradiol-d<sub>3sub>; 17β-Estradiol-d<sub>3sub>; 17β-Oestradiol-d<sub>3sub>	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d₃ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-D0931S

*Sudan III-d6* Sudan Red III-d<sub>6sub>; Tetrazobenzene-β-naphthol-d<sub>6sub>; 111440 Red-d<sub>6sub>	Isotope-Labeled Compounds	Others
Sudan III-d₆ (Sudan Red III-d₆; Tetrazobenzene-β-naphthol-d₆) is a deuterium labeled Sudan III (HY-D0931). Sudan III is a hydrophobic bisazo dye .

HY-A0070AS3

Liothyronine-d3 Triiodothyronine-d<sub>3sub>; 3,3',5-Triiodo-L-thyronine-d<sub>3sub>; T3-d<sub>3sub>	Endogenous Metabolite Thyroid Hormone Receptor Isotope-Labeled Compounds	Endocrinology Cancer
Liothyronine-d₃ is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively ^[3].

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-106373

Adrenocorticotropic hormone ACTH; Adrenocorticotrophic Hormone	Androgen Receptor	Endocrinology
Adrenocorticotropic hormone (ACTH) is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone regulates cortisol and androgen production .

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-13632S2

Exemestane-d3 FCE 24304-d<sub>3sub>; EXE-d<sub>3sub>	Isotope-Labeled Compounds Cytochrome P450	Endocrinology Cancer
Exemestane-d₃ is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].

HY-B0648S

Medroxyprogesterone-d3 17α-Hydroxy-6α-methylprogesterone-d<sub>3sub>; U8840-d<sub>3sub>	Progesterone Receptor	Endocrinology
Medroxyprogesterone-d₃ is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

HY-N0583S3

Hydrocortisone-d3 Cortisol-d<sub>3sub>	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Hydrocortisone-d₃ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

HY-18569S3

3-Indoleacetic acid-d7 Indole-3-acetic acid-d<sub>7sub>; 3-IAA-d<sub>7sub>	Endogenous Metabolite Molecular Glues	Others
3-Indoleacetic acid-d₇ is the deuterium labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-N0384S

Homovanillic acid-d3 Vanilacetic acid-d<sub>3sub>	Endogenous Metabolite	Metabolic Disease
Homovanillic acid-d₃ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-B0234S

Estrone-13C3 E1-¹³C<sub>3sub>; Oestrone-¹³C<sub>3sub>	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estrone- ¹³C₃ is the ¹³C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

HY-P2279

*Parathyroid hormone* (1-34) (rat)** 1 Publications Verification	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
Parathyroid hormone (1-34) (rat) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis .

HY-P2279A

*Parathyroid hormone* (1-34) (rat) acetate** 1 Publications Verification	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
Parathyroid hormone (1-34) (rat) (acetate) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis .

HY-B1192S

Estradiol benzoate-d3 β-Estradiol 3-benzoate-d<sub>3sub>; 17β-Estradiol 3-benzoate-d<sub>3sub>	Estrogen Receptor/ERR	Neurological Disease
Estradiol benzoate-d₃ is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability[1][2][3][4].

HY-18569S1

3-Indoleacetic acid-d4 Indole-3-acetic acid-d<sub>4sub>; 3-IAA-d<sub>4sub>	Isotope-Labeled Compounds	Others
3-Indoleacetic acid-d₄ (Indole-3-acetic acid-d₄; 3-IAA-d₄)is the deuterium labeled3-Indoleacetic acid(HY-18569) . 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .

HY-P0089

*Human growth hormone-releasing factor* Growth Hormone Releasing Factor human; Somatorelin (1-44) amide (human)	GHSR	Endocrinology
Human growth hormone-releasing factor (Growth Hormone Releasing Factor human) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary .

HY-B0891S1

17α-Hydroxyprogesterone-13C3 17-Hydroxyprogesterone-¹³C<sub>3sub>; 17-OHP-¹³C<sub>3sub>	Progesterone Receptor Endogenous Metabolite	Others
17α-Hydroxyprogesterone- ¹³C₃ is the ¹³C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

HY-B1689AS

Methantheline-d3 bromide MTB 51-d<sub>3sub>; Mantheline-d<sub>3sub>; Metantyl-d<sub>3sub>; Metanyl-d<sub>3sub>; Metaxan-d<sub>3sub>; Methanide-d<sub>3sub>	Isotope-Labeled Compounds	Others
Methantheline-d₃ (bromide) is the deuterium labeled Methantheline bromide[1].

HY-153477

*Thyroid hormone* receptor beta agonist-1**	Thyroid Hormone Receptor	Cancer
Thyroid hormone receptor beta agonist-1 (compound 3) is a thyroid beta-agonist .

HY-P0089A

*Human growth hormone-releasing factor TFA* Growth Hormone Releasing Factor human TFA; Somatorelin (1-44) amide (human) (TFA)	GHSR	Endocrinology
Human growth hormone-releasing factor TFA (Growth Hormone Releasing Factor human TFA) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary .

HY-18569S2

3-Indoleacetic acid-2,2-d2 Indole-3-acetic acid-2,2-d<sub>2sub>; 3-IAA-2,2-d<sub>2sub>	Endogenous Metabolite	Others
3-Indoleacetic acid-2,2-d₂ is the deuterium labeled 3-Indoleacetic acid. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-18569S4

3-Indoleacetic acid-13C6 Indole-3-acetic acid-¹³C<sub>6sub>; 3-IAA-¹³C<sub>6sub>	Endogenous Metabolite Molecular Glues	Others
3-Indoleacetic acid- ¹³C₆ is the ¹³C labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-113323S

3-Methoxy-4-hydroxyphenylglycol-d3 HMPG-d<sub>3sub>; MHPG-d<sub>3sub>; MOPEG-d<sub>3sub>	Endogenous Metabolite	Others
3-Methoxy-4-hydroxyphenylglycol-d₃ is the deuterium labeled 3-Methoxy-4-hydroxyphenylglycol.

HY-N0384S4

Homovanillic acid-d3-1 Vanilacetic acid-d<sub>3sub>-1	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency .

HY-17413S

Zidovudine-d3 Azidothymidine-d<sub>3sub>; AZT-d<sub>3sub>; ZDV-d<sub>3sub>	Isotope-Labeled Compounds HIV CRISPR/Cas9	Infection
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-B1773AS5

Sodium Propionate-d3 Mycoban-d<sub>3sub>; Napropion-d<sub>3sub>; Ocuseptine-d<sub>3sub>	Isotope-Labeled Compounds	Others
Sodium Propionate-d₃ is the deuterium labeled Sodium Propionate[1].

HY-P0059

Teriparatide 5 Publications Verification Human parathyroid Hormone-(1-34); hPTH (1-34)	PTHR Thyroid Hormone Receptor	Others Cancer
Teriparatide (Human parathyroid hormone-(1-34)) is a PTH1 receptor agonist. Teriparatide (Human parathyroid hormone-(1-34)) can be used for osteoporosis research .

HY-P0059A

Teriparatide acetate hydrate Human parathyroid Hormone-(1-34) acetate hydrate; hPTH (1-34) acetate hydrate	PTHR Thyroid Hormone Receptor	Others Cancer
Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) is a PTH1 receptor agonist. Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) can be used for osteoporosis research .

HY-B0113S

*Omeprazole-d<sub>3sub>* 1 Publications Verification H 16868-d<sub>3sub>	Proton Pump Bacterial Autophagy	Infection Metabolic Disease Cancer
Omeprazole-d₃ is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].

HY-70002S

Deutenzalutamide Enzalutamide-d<sub>3sub>; MDV3100-d<sub>3sub>	Androgen Receptor Autophagy	Cancer
Deutenzalutamide (Enzalutamide-d₃) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells .

HY-B0457AS

Clomipramine-d3 Chlorimipramine-d<sub>3sub>; G-34586-d<sub>3sub>; NSC-169865-d<sub>3sub>	Serotonin Transporter Dopamine Receptor	Neurological Disease
Clomipramine-d₃ is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively[1][2].

HY-B0141AS

Alpha-Estradiol-d3 Alfatradiol-d<sub>3sub>; Epiestradiol-d<sub>3sub>; Epiestrol-d<sub>3sub>	5 alpha Reductase Endogenous Metabolite	Inflammation/Immunology
Alpha-Estradiol-d₃ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-N0176S

Dihydroartemisinin-d3 Dihydroqinghaosu-d<sub>3sub>; β-Dihydroartemisinin-d<sub>3sub>; Artenimol-d<sub>3sub>	Parasite NF-κB Autophagy Apoptosis	Infection Cancer
Dihydroartemisinin-d₃ is the deuterium labeled Dihydroartemisinin. Dihydroartemisinin is a potent anti-malaria agent.

HY-30151S

Methoxsalen-d3 8-Methoxypsoralen-d<sub>3sub>; Xanthotoxin-d<sub>3sub>; 8-MOP-d<sub>3sub>	Cytochrome P450	Inflammation/Immunology
Methoxsalen-d₃ is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

HY-13777S1

Zoledronic acid-d3 Zoledronate-d<sub>3sub>; CGP 42446-d<sub>3sub>; CGP42446A-d<sub>3sub>; ZOL 446-d<sub>3sub>	Isotope-Labeled Compounds	Others
Zoledronic acid-d3 is the deuterium labeled Zoledronic acid .

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis	Cancer
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[3] .

HY-B0647S1

Butylphthalide-d3 3-n-Butylphthalide-d<sub>3sub>; 3-Butylphthalide-d<sub>3sub>	Isotope-Labeled Compounds	Neurological Disease
Butylphthalide-d₃ is the deuterium labeled Butylphthalide. Butylphthalide(3-n-Butylphthalide), an anti-cerebral-ischemia agent, is first isolated from the seeds of celery and showes efficacy in animal models of stroke.

HY-115127S

3-Methylanisole-d3 m-Methoxytoluene-d<sub>3sub>; m-Methylanisole-d<sub>3sub>	Isotope-Labeled Compounds	Others
3-Methylanisole-d₃ is the deuterium labeled 3-Methylanisole[1].

HY-15330

Vitamin D2-d3 Ergocalciferol-d<sub>3sub>; Calciferol-d<sub>3sub>; VD2-d<sub>3sub>	Isotope-Labeled Compounds VD/VDR Endogenous Metabolite	Metabolic Disease
Vitamin D2-d₃ (Ergocalciferol-d₃) is the deuterium labeled vitamin D2.

HY-B0264S

Guaifenesin-d3 Guaiacol glyceryl ether-d<sub>3sub>; Guaiphenesin-d<sub>3sub>; Glycerol guaiacolate-d<sub>3sub>	Isotope-Labeled Compounds	Neurological Disease Inflammation/Immunology
Guaifenesin-d₃ is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough[1][2].

HY-15027S

5-Aminosalicylic Acid-d3 hydrochloride Mesalamine-d<sub>3sub> hydrochloride; 5-ASA-d<sub>3sub> hydrochloride; Mesalazine-d<sub>3sub> hydrochloride	Isotope-Labeled Compounds PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic Acid-d₃ (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-13636S

Fulvestrant-d3 ICI 182780-d<sub>3sub>; ZD 9238-d<sub>3sub>; ZM 182780-d<sub>3sub>	Isotope-Labeled Compounds Estrogen Receptor/ERR Autophagy Apoptosis	Cancer
Fulvestrant-d₃ is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].

HY-10581AS

Gatifloxacin-d3 hydrochloride AM-1155-d<sub>3sub> hydrochloride; BMS-206584-d<sub>3sub> hydrochloride; PD135432-d<sub>3sub> hydrochloride	Isotope-Labeled Compounds Bacterial Topoisomerase Antibiotic	Infection
Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

HY-17509S

Deracoxib-d3 SC 046-d<sub>3sub>; SC 46-d<sub>3sub>; SC 59046-d<sub>3sub>	Isotope-Labeled Compounds COX Apoptosis	Inflammation/Immunology
Deracoxib-d₃ is the deuterium labeled Deracoxib. Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).

HY-15027S1

5-Aminosalicylic acid-d3 Mesalamine-d<sub>3sub>; 5-ASA-d<sub>3sub>; Mesalazine-d<sub>3sub>	Isotope-Labeled Compounds Endogenous Metabolite NF-κB PAK PPAR	Inflammation/Immunology Cancer
5-Aminosalicylic acid-d₃ is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7240

(Rac)-Juvenile hormone III	Structural Classification Natural Products Animals Source classification	Others
(Rac)-Juvenile hormone III, a natural compound that can be isolated from farnesoic acid ,is the most widely distributed Juvenile hormone homologue .

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[3] .

HY-B0504S

Creatinine-d3 3 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-P0002

Protirelin 3 Publications Verification Thyrotropin-releasing-Hormone; TRH	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Thyroid Hormone Receptor Endogenous Metabolite
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[3] .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[3] .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[3][4].

HY-17571

Oxytocin 10+ Cited Publications α-Hypophamine; Oxytocic Hormone	Structural Classification Natural Products Monophenols Animals Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Oxytocin Receptor Endogenous Metabolite
Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

HY-A0070

Liothyronine sodium 15+ Cited Publications Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology Cancer	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively ^[3].

HY-A0070C

Liothyronine hydrochloride Triiodothyronine hydrochloride; 3,3',5-Triiodo-L-thyronine hydrochloride; T3 hydrochloride	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology Cancer	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively ^[3].

HY-A0070B

Liothyronine sodium hydrate 15+ Cited Publications Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology Cancer	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively ^[3].

HY-N0662R

Amentoflavone (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[3] .

HY-N2798

Lariciresinol-4,4'-dimethyl ether-9-acetate	Structural Classification Araucaria angustifolia (Bertol.) O. Kuntze Source classification Lignans Araucariaceae Phenylpropanoids Plants	Others
Lariciresinol-4,4'-dimethyl ether-9-acetate (compound IIId) is a derivative of larch resin alcohol .

HY-125572

Gibberellin A7 GA7	Human Gut Microbiota Metabolites Classification of Application Fields Gibberellins Source classification Other Diseases Plants Phytohormone Endogenous metabolite Disease Research Fields Agricultural Research	Others
Gibberellin A7 (GA7) is a plant hormone. Gibberellin A7 is the metabolite of Gibberella fujikuroi. Gibberellin A7 promotes the plant growth and elongation of cells .

HY-A0070A

Liothyronine 15+ Cited Publications Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with K_is of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR ^[3].

HY-A0070R

Liothyronine sodium (Standard)	Structural Classification Monophenols Source classification Phenols Endogenous metabolite	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine (sodium) (Standard) is the analytical standard of Liothyronine (sodium). This product is intended for research and analytical applications. Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively ^[3].

HY-A0070AR

Liothyronine (Standard) Triiodothyronine (Standard); 3,3',5-Triiodo-L-thyronine (Standard); T3 (Standard)	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine (Standard) is the analytical standard of Liothyronine. This product is intended for research and analytical applications. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively ^[3].

HY-113415A

Testosterone sulfate (pyridinium) 1 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Drug Metabolite
Testosterone sulfate pyridinium is a Testosterone sulfate with a pyridinium. Testosterone sulfate is the metabolite of Testosterone. Testosterone is the main male sex hormone which determination is useful for assessment of androgen status .

HY-N9441

Ascr#7	Structural Classification Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Others
Ascr#7, an ascaroside, is a hormone of nematodes. Ascr#7 is expressed during nematode development. Ascarosides can induce formation of long-lived and highly stress resistant dauer larvae .

HY-137178

20α,22R-Dihydroxycholesterol	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
20α,22R-Dihydroxycholesterol is an endogenous metabolic intermediate. 20α,22R-Dihydroxycholesterol involved in the biosynthesis of cholesterol to steroid hormones .

HY-129974

3,3'-Diiodo-L-thyronine 3,3'-T2	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite COX
3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity .

HY-125572R

Gibberellin A7 (Standard)	Human Gut Microbiota Metabolites Source classification Plants Endogenous metabolite	Others
Gibberellin A7 (Standard) is the analytical standard of Gibberellin A7. This product is intended for research and analytical applications. Gibberellin A7 (GA7) is a plant hormone. Gibberellin A7 is the metabolite of Gibberella fujikuroi. Gibberellin A7 promotes the plant growth and elongation of cells .

HY-B0234

Estrone 5 Publications Verification E1; Oestrone	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Steroids Cancer	Estrogen Receptor/ERR Endogenous Metabolite
Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells .

HY-128030

Makisterone A	Classification of Application Fields Source classification Chenopodium quinoa Willd. Plants Disease Research Fields Endocrinology Steroids Chenopodiaceae	Others
Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera .

HY-N12638

Endolide F	Structural Classification Microorganisms Cyclopeptides Source classification	Vasopressin Receptor
Endolide F (Compound 2) is a proline-containing lactone. Endolide F is a moderate antagonist of the arginine antidiuretic hormone V1A receptor .

HY-N13014

Indole-3-acetyl β-D-glucopyranose	Structural Classification Source classification Solanum lycopersicum L. Solanaceae Plants Saccharides Monosaccharides	Others
Indole-3-acetyl β-D-glucopyranose is a glucose esterified derivative of the plant hormone indole-3-acetic acid (IAA). Indole-3-acetyl β-D-glucopyranose is involved in regulating plant growth and can be used to study the metabolism and regulatory mechanisms of plant hormones .

HY-122530

Juvocimene I	Structural Classification Natural Products Ocimum basilicum L. Labiatae Source classification Plants	Others
Juvocimene I is a potent juvenile hormone mimic. Juvocimene I can be isolated from the essential oil of sweet basil,Ocimum basilicum L .

HY-W008452

H-Tyr(3-I)-OH	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-N7443

Gibberellin A1	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Other Diseases Plants Phaseolus vulgaris Linn. Endogenous metabolite Disease Research Fields	Others
Gibberellin A1 is a kind of plant hormones. Gibberellin A1 is a growth-promoting acids isolated from immature seed of Phaseolus multiflorus .

HY-B0141

Estradiol 70+ Cited Publications β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol	Structural Classification Classification of Application Fields Source classification Endocrine diseases Endogenous metabolite Monophenols Sunscreen Disease markers Phenols Cosmetic Research Disease Research Fields Steroids Cancer	Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-N8393

Ascr#18	Infection Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Disease Research Fields	Bacterial Fungal
Ascr#18, an ascaroside, is a hormone of nematodes. Ascr#18 is expressed during nematode development. Ascr#18 increases resistance in Arabidopsis, tomato, potato and barley to viral, bacterial, oomycete, fungal and nematode infections .

HY-12956

Dinoprost 2 Publications Verification Prostaglandin F2α; PGF2α	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis
Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .

HY-113313

Aldosterone 5+ Cited Publications	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level .

HY-N0160

Kinetin 5 Publications Verification 6-Furfuryladenine; N6-Furfuryladenine	Structural Classification Natural Products other families Neurological Disease Classification of Application Fields Source classification Plants Phytohormone Disease Research Fields Cytokinin Agricultural Research	SOD
Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects .

HY-12956A

Dinoprost tromethamine salt 2 Publications Verification Prostaglandin F2α tromethamine salt; PGF2α THAM; Prostaglandin F2α THAM	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis
Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour .

HY-101402

Cyclo(his-pro) Cyclo(histidyl-proline); Histidylproline diketopiperazine	Structural Classification Natural Products Source classification Endogenous metabolite	NF-κB Endogenous Metabolite
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

HY-12956R

Dinoprost (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis
Dinoprost (Standard) is the analytical standard of Dinoprost. This product is intended for research and analytical applications. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .

HY-101402A

Cyclo(his-pro) TFA Cyclo(histidyl-proline) TFA; Histidylproline diketopiperazine TFA	Structural Classification Natural Products Source classification Endogenous metabolite	NF-κB Endogenous Metabolite
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

HY-N0160R

Kinetin (Standard)	Structural Classification Natural Products other families Source classification Plants	SOD
Kinetin (Standard) is the analytical standard of Kinetin. This product is intended for research and analytical applications. Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects .

HY-N6979

Crustecdysone 4 Publications Verification 20-Hydroxyecdysone	Cardiovascular Disease Structural Classification other families Animals Classification of Application Fields Source classification Plants Compositae Endogenous metabolite Canavalia gladiata (Jacq.) DC. Disease Research Fields Steroids	Caspase Autophagy Endogenous Metabolite
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) ^[3].

HY-17462

Adrenosterone (+)-Adrenosterone	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Androgen Receptor Endogenous Metabolite
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells ^[3].

HY-12956AR

Dinoprost tromethamine salt (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis
Dinoprost (tromethamine salt) (Standard) is the analytical standard of Dinoprost (tromethamine salt). This product is intended for research and analytical applications. Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour .

HY-N6979R

Crustecdysone (Standard)	Structural Classification other families Animals Source classification Plants Compositae Endogenous metabolite Canavalia gladiata (Jacq.) DC. Steroids	Caspase Autophagy Endogenous Metabolite
Crustecdysone (Standard) is the analytical standard of Crustecdysone. This product is intended for research and analytical applications. Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) ^[3].

HY-17571A

Oxytocin acetate 10+ Cited Publications α-Hypophamine acetate; Oxytocic Hormone acetate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Cancer	Oxytocin Receptor Endogenous Metabolite
Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

HY-107953

Chorionic gonadotrophin 2 Publications Verification hCG; Chorionic gonadotropic Hormone	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite
Chorionic gonadotrophin (hCG) is a gonadotropin that can be isolated from the anterior pituitary gland. Chorionic gonadotrophin has potential applications in ovarian and follicular development .

HY-P3960

(Glu2)-TRH	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Thyroid Hormone Receptor Endogenous Metabolite
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS .

HY-121973

Juvocimene II	Structural Classification Natural Products Ocimum basilicum L. Labiatae Source classification Plants	Others
Juvocimene II is a compound with extremely high juvenile hormone (JH) activity, exhibiting potent insect hormone mimetic capabilities .

Cat. No.	Product Name	Chemical Structure

HY-N7240S

*(Rac)-Juvenile* Hormone III-d3**
Juvenile Hormone III-d₃ is the deuterium labeled Juvenile Hormone III[1].

HY-B0141S

Estradiol-d3
Estradiol-d₃ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-N0583S3

Hydrocortisone-d3
Hydrocortisone-d₃ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

HY-18569S3

3-Indoleacetic acid-d7
3-Indoleacetic acid-d₇ is the deuterium labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-D0931S

*Sudan III-d6*
Sudan III-d₆ (Sudan Red III-d₆; Tetrazobenzene-β-naphthol-d₆) is a deuterium labeled Sudan III (HY-D0931). Sudan III is a hydrophobic bisazo dye .

HY-A0070AS3

Liothyronine-d3
Liothyronine-d₃ is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively ^[3].

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-13632S2

Exemestane-d3
Exemestane-d₃ is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].

HY-B0648S

Medroxyprogesterone-d3
Medroxyprogesterone-d₃ is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

HY-N0384S

Homovanillic acid-d3
Homovanillic acid-d₃ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-B0234S

Estrone-13C3
Estrone- ¹³C₃ is the ¹³C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

HY-B1192S

Estradiol benzoate-d3
Estradiol benzoate-d₃ is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability[1][2][3][4].

HY-18569S1

3-Indoleacetic acid-d4
3-Indoleacetic acid-d₄ (Indole-3-acetic acid-d₄; 3-IAA-d₄)is the deuterium labeled3-Indoleacetic acid(HY-18569) . 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .

HY-B0891S1

17α-Hydroxyprogesterone-13C3
17α-Hydroxyprogesterone- ¹³C₃ is the ¹³C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

HY-B1689AS

Methantheline-d3 bromide
Methantheline-d₃ (bromide) is the deuterium labeled Methantheline bromide[1].

HY-18569S2

3-Indoleacetic acid-2,2-d2
3-Indoleacetic acid-2,2-d₂ is the deuterium labeled 3-Indoleacetic acid. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-18569S4

3-Indoleacetic acid-13C6
3-Indoleacetic acid- ¹³C₆ is the ¹³C labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-113323S

3-Methoxy-4-hydroxyphenylglycol-d3
3-Methoxy-4-hydroxyphenylglycol-d₃ is the deuterium labeled 3-Methoxy-4-hydroxyphenylglycol.

HY-N0384S4

Homovanillic acid-d3-1
Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency .

HY-17413S

Zidovudine-d3

Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-B1773AS5

Sodium Propionate-d3
Sodium Propionate-d₃ is the deuterium labeled Sodium Propionate[1].

HY-B0113S

*Omeprazole-d<sub>3sub>* 1 Publications Verification
Omeprazole-d₃ is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].

HY-70002S

Deutenzalutamide
Deutenzalutamide (Enzalutamide-d₃) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells .

HY-B0457AS

Clomipramine-d3
Clomipramine-d₃ is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively[1][2].

HY-B0141AS

Alpha-Estradiol-d3
Alpha-Estradiol-d₃ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-N0176S

Dihydroartemisinin-d3
Dihydroartemisinin-d₃ is the deuterium labeled Dihydroartemisinin. Dihydroartemisinin is a potent anti-malaria agent.

HY-30151S

Methoxsalen-d3
Methoxsalen-d₃ is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

HY-13777S1

Zoledronic acid-d3
Zoledronic acid-d3 is the deuterium labeled Zoledronic acid .

HY-B0647S1

Butylphthalide-d3
Butylphthalide-d₃ is the deuterium labeled Butylphthalide. Butylphthalide(3-n-Butylphthalide), an anti-cerebral-ischemia agent, is first isolated from the seeds of celery and showes efficacy in animal models of stroke.

HY-115127S

3-Methylanisole-d3
3-Methylanisole-d₃ is the deuterium labeled 3-Methylanisole[1].

HY-15330

Vitamin D2-d3
Vitamin D2-d₃ (Ergocalciferol-d₃) is the deuterium labeled vitamin D2.

HY-B0264S

Guaifenesin-d3
Guaifenesin-d₃ is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough[1][2].

HY-15027S

5-Aminosalicylic Acid-d3 hydrochloride
5-Aminosalicylic Acid-d₃ (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-13636S

Fulvestrant-d3
Fulvestrant-d₃ is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].

HY-10581AS

Gatifloxacin-d3 hydrochloride

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

HY-17509S

Deracoxib-d3
Deracoxib-d₃ is the deuterium labeled Deracoxib. Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).

HY-15027S1

5-Aminosalicylic acid-d3
5-Aminosalicylic acid-d₃ is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].

HY-B0579S1

Cyclosporin A-d3
Cyclosporin A-d₃ is the d3-labeled Cyclosporin A (HY-B0579)[1].

HY-13757AS1

Tamoxifen-d3

Tamoxifen-d₃ is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].

HY-B1260S2

Cetrimonium-d3 bromide
Cetrimonium-d₃ (bromide) is the deuterium labeled Cetrimonium bromide[1].

HY-B1658S

Frovatriptan-d3 hydrochloride
Frovatriptan-d₃ (hydrochloride) is the deuterium labeled Frovatriptan[1]. Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura[2].

HY-13757S

Tamoxifen-d3 hydrochloride

Tamoxifen-d₃ hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells ^[3].Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .

HY-N0007S

Bisdemethoxycurcumin-d8
Bisdemethoxycurcumin-d₈ is the deuterium labeled Bisdemethoxycurcumin. Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.

HY-B0075S1

Melatonin-d3

Melatonin-d₃ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].

HY-B0171S

Antipyrine-d3
Antipyrine-d₃ is the deuterium labeled Antipyrine. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity[1][2].

HY-B0479S

Thiamphenicol-d3
Thiamphenicol-d₃ is a deuterium labeled Thiamphenicol. Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2].

HY-N0136S

Taxifolin-d3
Taxifolin-d₃ is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].

HY-N0108S

Physcion-d3
Physcion-d₃ (Parietin-d₃) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC₅₀ and a K_d of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects ^[3].

HY-15772S3

Asandeutertinib
Asandeutertinib (Osimertinib-d3; AZD-9291-d3) is a epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, with antineoplastic effect .

HY-B0215S

Acetylcysteine-d3

Acetylcysteine-d₃ is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies ^[3] .

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