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Pathways Recommended: GPCR/G Protein
Results for "

Gαq/o-protein

" in MedChemExpress (MCE) Product Catalog:

3187

Inhibitors & Agonists

16

Screening Libraries

51

Fluorescent Dye

136

Biochemical Assay Reagents

480

Peptides

8

MCE Kits

121

Inhibitory Antibodies

361

Natural
Products

409

Recombinant Proteins

111

Isotope-Labeled Compounds

92

Antibodies

58

Click Chemistry

252

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P3910
    [Val4] Angiotensin III

    		Angiotensin Receptor Cardiovascular Disease
    [Val4] Angiotensin III is an angiotension III peptide. [Val4] Angiotensin III is a potent full agonist of Gαq and βarr2 response, with pEC50 values of 8.31 and 8.44, respectively .
    [Val4] Angiotensin III
  • HY-N7120
    Penicillin G procaine hydrate

    PGP hydrate

    		 Bacterial Antibiotic Infection
    Penicillin G Procaine hydrate (PGP hydrate), a β-lactam antibiotic, is a crystalline complex produced by chemically combining penicillin G with procaine .
    Penicillin G procaine hydrate
  • HY-110173
    TC-G 1005

    		G protein-coupled Bile Acid Receptor 1 Metabolic Disease
    TC-G 1005 is a potent, selective and orally active agonist of the BA receptor Takeda G protein-coupled receptor 5 (TGR5), with EC50s of 0.72 and 6.2 nM for hTGR5 and mTGR5, respectively. TC-G 1005 can reduce glucose levels in vivo .
    TC-G 1005
  • HY-161317
    Gαq/11 protein-IN-1

    		Trace Amine-associated Receptor (TAAR) Cancer
    Gαq/11 protein-IN-1 (compound F33) is an inhibitor of Gαq/11 protein with an IC50 value of 9.4 μM. Gαq/11 protein-IN-1 has antitumor activity .
    Gαq/11 protein-IN-1
  • HY-P5617
    Cathepsin G(1-5)

    		Bacterial Others
    Cathepsin G(1-5) is an antimicrobial peptide that can be found in the clostripain-digested cathepsin G mixture .
    Cathepsin G(1-5)
  • HY-N7120R
    Penicillin G procaine (hydrate) (Standard)

    		Bacterial Antibiotic Infection
    Penicillin G procaine (hydrate) (Standard) is the analytical standard of Penicillin G procaine (hydrate). This product is intended for research and analytical applications. Penicillin G Procaine hydrate (PGP hydrate), a β-lactam antibiotic, is a crystalline complex produced by chemically combining penicillin G with procaine .
    Penicillin G procaine (hydrate) (Standard)
  • HY-N10071
    Poricoic acid G

    		Others Cancer
    Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans .
    Poricoic acid G
  • HY-D0303AR
    Chrysoidine G (Standard)

    		Fluorescent Dye Others
    Chrysoidine G (Standard) is the analytical standard of Chrysoidine G. This product is intended for research and analytical applications. Chrysoidine G (Solvent Orange 3 hydrochloride) is an industrial azoic dye (cationic dye). Chrysoidine G (Solvent Orange 3 hydrochloride) is used for the construction of most textile dyestuffs and also in synthetic industrial compounds. Chrysoidine G (Solvent Orange 3 hydrochloride) concentration can be determined by UV-Vis spectroscopy .
    Chrysoidine G (Standard)
  • HY-120816
    WU-07047

    		Calcium Channel Cardiovascular Disease
    WU-07047, a simplified analog of YM-254890 (HY-111557), is a selective Gαq/11 inhibitor. WU-07047 can inhibit nucleotide exchange .
    WU-07047
  • HY-P1376
    G-Protein antagonist peptide

    		mAChR Adrenergic Receptor Endocrinology
    G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.
    G-Protein antagonist peptide
  • HY-D0303A
    Chrysoidine G

    Solvent Orange 3 hydrochloride

    		 Fluorescent Dye Others
    Chrysoidine G (Solvent Orange 3 hydrochloride) is an industrial azoic dye (cationic dye). Chrysoidine G (Solvent Orange 3 hydrochloride) is used for the construction of most textile dyestuffs and also in synthetic industrial compounds. Chrysoidine G (Solvent Orange 3 hydrochloride) concentration can be determined by UV-Vis spectroscopy .
    Chrysoidine G
  • HY-P1376A
    G-Protein antagonist peptide TFA

    		mAChR Adrenergic Receptor Endocrinology
    G-Protein antagonist peptide TFA is a truncated substance P-related peptide, competes with receptor for G protein binding. G-Protein antagonist peptide TFA inhibits the activation of Gi or Go by M2 muscarinic cholinergic receptor (M2 mAChR) or of Gs by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis .
    G-Protein antagonist peptide TFA
  • HY-111557
    YM-254890
    5+ Cited Publications

    		 P2Y Receptor Cardiovascular Disease
    YM-254890 is a selective Gαq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway, with an IC50 value below 0.6 μM .
    YM-254890
  • HY-150751
    ODN TTAGGG

    ODN A151

    		 Toll-like Receptor (TLR) AIM2 Inflammation/Immunology
    ODN TTAGGG (A151), inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. ODN TTAGGG is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .
    ODN TTAGGG
  • HY-150747
    ODN 6016

    		IFNAR Inflammation/Immunology
    ODN 6016 is a CpG-A oligonucleotides. ODN 6016 can induce IFN-α production, can be used for researching immune disorders including immunodeficiency caused by HIV-1. ODN 6016 sequence: T-sp-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G .
    ODN 6016
  • HY-150748
    ODN D-SL01

    		Toll-like Receptor (TLR) Inflammation/Immunology Cancer
    ODN D-SL01, a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN D-SL01 has strong immunostimulatory activity in a variety of vertebrate species and has anticancer activity. ODN D-SL01 sequence: 5'- T-C-G-C-G-A-C-G-T-T-C-G-C-C-C-G-A-C-G-T-T-C-G-G-T-A-3' .
    ODN D-SL01
  • HY-160485
    G-4'G-7S

    		Fluorescent Dye Endocrinology
    G-4'G-7S is a endogenous metabolite of genistein (HY-14596). G-4'G-7S can be used for the research of estrogenic activity .
    G-4'G-7S
  • HY-150745
    ODN 24987

    		Toll-like Receptor (TLR) Inflammation/Immunology
    ODN 24987 is a Guanine-modified inhibitory oligonucleotides (ODN), targeting TLR9. ODN 24987 can inhibit IL-6 and IFN-α release. ODN 24987 can be used for research immune disorders. ODN 24987 sequence: 5’-C-C-T-G-G-C-c7G-G-G-G-3’ .
    ODN 24987
  • HY-117037
    FR900359

    		Apoptosis ERK Cardiovascular Disease Cancer
    FR900359 is a depsipeptide selective inhibitor of Gαq/11/14 in mammalia, can inhibits ERK pathway. FR900359 suppresses the proliferation of melanoma cells and decreases of blood pressure. FR900359 also protected against airway hyperreactivity in murine models of allergen sensitization in Ovalbumins(HY-W250978)–induced sensitization model of asthma. FR900359 can be used for cancer and cardiovascular disease research .
    FR900359
  • HY-114994
    MS437

    		TSH Receptor Endocrinology
    MS437 is a potent TSH receptor (TSHR) stimulator with an EC50 value of 13x10 -8 M. MS437 shows potent activation of Gsα, Gαq and Gα12 and up-regulation of thyroglobulin (Tg), sodium iodine symporter (NIS) and TSHR gene expressions .
    MS437
  • HY-150746
    ODN 24991

    		Toll-like Receptor (TLR) Inflammation/Immunology
    ODN 24991, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a TLR3, TLR7 and TLR9 (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 24991 disrupts TLR3-, TLR7- and TLR9-mediated immune cell immune responses. ODN 24991 sequence: 5'-C-C-T-G-G-C-c7rGm-G-G-G-3' .
    ODN 24991
  • HY-117082
    UTL-5g

    GBL-5g

    		 TNF Receptor Inflammation/Immunology
    UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by Cisplatin through TNF-α inhibition among other factors .
    UTL-5g
  • HY-N3248
    Momordicoside G

    Momordicacoside G

    		 Endogenous Metabolite Reactive Oxygen Species Apoptosis Inflammation/Immunology Cancer
    Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury .
    Momordicoside G
  • HY-106592A
    U-74389G

    PNU74389G (meleate)

    		 Reactive Oxygen Species Cardiovascular Disease Others
    U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity .
    U-74389G
  • HY-164478
    G-631

    		PARP Cancer
    G-631 is a selective inhibitor for tankyrase. G-631 inhibits tankyrase auto-PARsylation (poly ADP ribosylation) with an IC50 of 7 nM, and inhibits Wnt signaling pathway. G-631 exhibits good pharmacokinetic characteristics in mice .
    G-631
  • HY-148016
    I-287

    		Protease Activated Receptor (PAR) ERK Inflammation/Immunology
    I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. I-287 reduces Complete Freund's adjuvant (HY-153808)-induced inflammation in mice and can be used for inflammation/immunology research .
    I-287
  • HY-W247098
    Dihydrorhodamine 6G

    DHR 6G

    		 Reactive Oxygen Species Cancer
    Dihydrorhodamine 6G (DHR 6G) is the reduced form of Rhodamine 6G, which is used as fluorescent mitochondrial dye. It is nonfluorescent, but it readily enters most of the cells and is oxidized by oxidative species or by cellular redox systems to the fluorescent rhodamine 6G that accumulates in mitochondrial membranes. Dihydrorhodamine 6G is useful for detecting reactive oxygen species (ROS) including superoxide .
    Dihydrorhodamine 6G
  • HY-102036
    G-744

    		Btk Inflammation/Immunology
    G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis .
    G-744
  • HY-161672
    G-5758

    		Liposome IRE1 Cancer
    G-5758 is an orally available IRE1α inhibitor with an IC50 of 38 nM for XBP1s. G-5758 is well tolerated in multiple myeloma models (KMS-11) at oral doses up to 500 mg/kg in rats. G-5758 exhibits pharmacodynamics comparable to that of induced IRE1 knockdown .
    G-5758
  • HY-120454
    G-479

    		MEK Potassium Channel Cancer
    G-479 is the inhibitor for MEK and hERG channel (IC50=14 μM). G-479 inhibits the proliferation of HCT-116 and A375 with IC50 of 0.049 μM and 0.004 μM. G-479 exhibits good metabolic stability in liver microsomes and good pharmacokinetic characteristics in rats .
    G-479
  • HY-158523
    A2[3]G1 & A2[6]G1 glycan (G1)

    A2[3]G1 & A2[6]G1 N-linked oligosaccharide

    		 Biochemical Assay Reagents Others
    A2[3]G1 & A2[6]G1 glycan (G1) (A2[3]G1 & A2[6]G1 N-linked oligosaccharide) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
    A2[3]G1 & A2[6]G1 glycan (G1)
  • HY-103450
    G36

    		Estrogen Receptor/ERR Endocrinology Cancer
    G-36 is a cell-permeable nonsteroidal antagonist of the G protein-coupled estrogen receptor (GPER/GPR30), which selectively inhibits estrogen-mediated PI3K activation through GPER, rather than Erα. G-36 also inhibits estrogen-mediated calcium mobilization (IC50=112 nM). G-36 is promising for research in the field of cancer .
    G36
  • HY-158473
    FA2[3]G1 & FA2[6]G1 glycan (G1F)

    FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide

    		 Biochemical Assay Reagents Others
    FA2[3]G1 & FA2[6]G1 glycan (G1F) (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
    FA2[3]G1 & FA2[6]G1 glycan (G1F)
  • HY-P6294
    Pseudostellarin G

    		Tyrosinase Others
    Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin .
    Pseudostellarin G
  • HY-P0066
    Contulakin G

    		Neurotensin Receptor Neurological Disease
    Contulakin G is an O-glycosylated invertebrate neurotensin. Contulakin-G is a weaker agonist for the neurotensin receptor. Contulakin G is also a potent antinociceptive agent .
    Contulakin G
  • HY-17561
    G-418 disulfate
    35+ Cited Publications

    Geneticin sulfate; Antibiotic G-418 sulfate

    		 Bacterial Antibiotic Infection
    G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells .
    G-418 disulfate
  • HY-158442
    A2G2 glycan (G2)

    A2G2 N-linked oligosaccharide; A2G(4)2 glycan

    		 Biochemical Assay Reagents Others
    A2G2 glycan (G2) (A2G2 N-linked oligosaccharide; A2G(4)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
    A2G2 glycan (G2)
  • HY-158452
    A3G3 glycan (G3)

    A3G3 N-linked oligosaccharide; A3G(4)3 glycan

    		 Biochemical Assay Reagents Others
    A3G3 glycan (G3) (A3G3 N-linked oligosaccharide; A3G(4)3 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
    A3G3 glycan (G3)
  • HY-107216
    G-1
    25+ Cited Publications

    		 Estrogen Receptor/ERR Cancer
    G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM.
    G-1
  • HY-P1185
    Antagonist G

    		Vasopressin Receptor Apoptosis Cardiovascular Disease Cancer
    Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy .
    Antagonist G
  • HY-P2794
    G0775

    		Bacterial Infection Neurological Disease Inflammation/Immunology
    G0775 is a molecule with potent, broad-spectrum activity against Gram-negative bacteria. G0775 is active against MDR bacteria. G0775 binds the LepB protease domain .
    G0775
  • HY-158448
    FA2G2 glycan (G2F)

    FA2G2 N-linked oligosaccharide; F(6)A2G2

    		 Biochemical Assay Reagents Others
    FA2G2 glycan (G2F) (FA2G2 N-linked oligosaccharide; F(6)A2G2) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
    FA2G2 glycan (G2F)
  • HY-N9240
    Acerogenin G

    		Others Others
    Acerogenin G is a synthetic diarylheptane. Acerogenin G is first isolated from Acer nikoense .
    Acerogenin G
  • HY-108718
    G-418

    Geneticin; Antibiotic G-418

    		 Bacterial Parasite Antibiotic Infection
    G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis .
    G-418
  • HY-116897
    G202-0362

    		Drug Derivative Others
    G202-0362 is an active compound.
    G202-0362
  • HY-150927
    G12Si-2

    		Ras Cancer
    G12Si-2, an analog of G12Si-1 (HY-150926), is a negative control tool. G12Si-2 is not a covalent inhibitor of the G12S mutant of K-Ras .
    G12Si-2
  • HY-158480
    FA2[3]G1 & FA2[6]G1 glycan (G1F), procainamide labelled

    FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, procainamide labelled

    		 Biochemical Assay Reagents Others
    FA2[3]G1 & FA2[6]G1 glycan (G1F), procainamide labelled (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
    FA2[3]G1 & FA2[6]G1 glycan (G1F), procainamide labelled
  • HY-158479
    FA2[3]G1 & FA2[6]G1 glycan (G1F), APTS labelled

    FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, APTS labelled

    		 Biochemical Assay Reagents Others
    FA2[3]G1 & FA2[6]G1 glycan (G1F), APTS labelled (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
    FA2[3]G1 & FA2[6]G1 glycan (G1F), APTS labelled
  • HY-P10036
    G-Subtide

    		PKG Others
    G-Subtide is a G-substrate peptide localized in Purkinje cells of the cerebellum. G-Subtide has little activity distinct from background and is a preferentially phosphorylated peptide substrate of recombinant PfPKG2 protein .
    G-Subtide
  • HY-115452
    G5-7

    		JAK Apoptosis Cancer
    G5-7, an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr 1068) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. G5-7 has the potential for glioma study .
    G5-7

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