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Pathways Recommended:	GPCR/G Protein

Results for "

G Protein-Coupled Receptor 88

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adhesion G Protein-coupled Receptors (AGPCRs) (2) G protein-coupled Bile Acid Receptor 1 (23) G Protein-coupled Receptor Kinase (GRK) (27) GPR119 (3) GPR139 (1) GPR171 (2) GPR35 (7) GPR55 (5) GPR6 (1) GPR68 (3) GPR84 (7) Mas-related G-protein-coupled Receptor (MRGPR) (15) 5 alpha Reductase (1) 5-HT Receptor (14) AAK1 (6) Acyltransferase (2) ADC Cytotoxin (11) ADC Linker (68) Adenosine Receptor (10) Adrenergic Receptor (3) AIM2 (2) Akt (39) Aldehyde Dehydrogenase (ALDH) (2) Amino Acid Derivatives (48) Aminopeptidase (4) AMPK (10) Amylases (3) Amyloid-β (10) Anaplastic lymphoma kinase (ALK) (19) Androgen Receptor (8) Angiotensin Receptor (17) Angiotensin-converting Enzyme (ACE) (5) Antibiotic (64) Antibody-Drug Conjugates (ADCs) (2) Antifolate (1) AP-1 (2) APC (1) Apelin Receptor (APJ) (19) Apolipoprotein (5) Apoptosis (649) Arenavirus (1) Arp2/3 Complex (5) Arrestin (5) Aryl Hydrocarbon Receptor (3) Atg7 (1) Atg8/LC3 (1) ATM/ATR (6) Aurora Kinase (6) AUTACs (3) Autophagy (88) Bacterial (143) Bcl-2 Family (35) Bcr-Abl (5) BCRP (4) Beta-lactamase (4) Beta-secretase (1) Biochemical Assay Reagents (170) Bombesin Receptor (4) Btk (3) c-Fms (5) c-Kit (5) c-Met/HGFR (13) c-Myc (19) Calcium Channel (18) CaMK (4) Cannabinoid Receptor (15) Carbonic Anhydrase (15) Carboxypeptidase (2) Casein Kinase (3) Caspase (37) Cathepsin (15) CCR (4) CD19 (1) CD20 (1) CD276/B7-H3 (1) CD28 (4) CD3 (12) CD47 (3) CD73 (1) CDK (54) CFTR (14) CGRP Receptor (1) Checkpoint Kinase (Chk) (5) Cholecystokinin Receptor (1) Choline Kinase (1) Cholinesterase (ChE) (19) ClpP (2) CMV (3) Complement System (10) COX (10) CRFR (1) CRM1 (1) CTLA-4 (2) Cuproptosis (1) CXCR (13) Cyclic GMP-AMP Synthase (2) Cyclin G-associated Kinase (GAK) (7) Cyclophilin (2) Cytochrome P450 (17) DAGL (1) Dengue Virus (2) Deubiquitinase (4) DGK (1) Dihydrofolate reductase (DHFR) (4) Dihydroorotate Dehydrogenase (1) Dipeptidyl Peptidase (6) DNA Alkylator/Crosslinker (5) DNA Methyltransferase (10) DNA Stain (2) DNA/RNA Synthesis (87) Dopamine Receptor (20) Drug Derivative (9) Drug Intermediate (9) Drug Isomer (2) Drug Metabolite (14) Drug-Linker Conjugates for ADC (24) DYRK (1) E-Selectin (1) E1/E2/E3 Enzyme (6) E3 Ligase Ligand-Linker Conjugates (5) EBI2/GPR183 (1) EBV (1) EGFR (63) Elastase (4) Endogenous Metabolite (169) Endothelin Receptor (4) Enteropeptidase (1) Epigenetic Reader Domain (19) Epoxide Hydrolase (1) ERK (36) Estrogen Receptor/ERR (21) Eukaryotic Initiation Factor (eIF) (5) FABP (2) Factor Xa (6) FAK (6) FAP (2) FATP (1) Fatty Acid Synthase (FASN) (3) Fc Receptor (FcR) (2) Ferroptosis (9) FGFR (9) Filovirus (1) FKBP (1) FLAP (2) Flavivirus (1) FLT3 (17) Fluorescent Dye (60) Formyl Peptide Receptor (FPR) (2) Free Fatty Acid Receptor (10) Fungal (46) FXR (5) G-quadruplex (34) G2A (GPR132) (2) GABA Receptor (8) Galectin (2) Gap Junction Protein (2) GCGR (5) GHSR (7) GLP Receptor (10) Glucocorticoid Receptor (2) Glucosylceramide Synthase (GCS) (2) GLUT (4) Glutaminase (1) Glutathione S-transferase (1) Glycosidase (12) Glycosyltransferase (1) Glyoxalase (GLO) (1) GlyT (2) GnRH Receptor (15) GPR109A (3) GSK-3 (4) Guanylate Cyclase (1) HBV (6) HCV (4) HDAC (56) Hedgehog (1) Herbicide (4) HIF/HIF Prolyl-Hydroxylase (5) Hippo (MST) (1) Histamine Receptor (2) Histone Acetyltransferase (2) Histone Demethylase (8) Histone Methyltransferase (47) HIV (37) HIV Integrase (5) HIV Protease (3) HMG-CoA Reductase (HMGCR) (5) HSP (14) HSV (10) Huntingtin (2) IAP (2) ICMT (2) IFNAR (6) IGF-1R (3) iGluR (7) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (3) Influenza Virus (13) Insecticide (2) Insulin Receptor (1) Integrin (29) Interleukin Related (21) IRAK (2) IRE1 (2) Isocitrate Dehydrogenase (IDH) (3) Isotope-Labeled Compounds (72) Itk (1) JAK (15) JNK (10) Keap1-Nrf2 (3) Kinesin (4) Kisspeptin Receptor (1) KLF (1) Lactate Dehydrogenase (2) Leukotriene Receptor (6) Ligands for E3 Ligase (7) Ligands for Target Protein for PROTAC (3) LIM Kinase (LIMK) (1) Liposome (9) Lipoxygenase (1) LPL Receptor (6) LRRK2 (18) LXR (2) mAChR (5) MAGL (1) MAP4K (1) MAPKAPK2 (MK2) (1) MARK (1) MCHR1 (GPR24) (2) MDM-2/p53 (21) MEK (5) Melatonin Receptor (1) MetAP (1) mGluR (1) MicroRNA (48) Microtubule/Tubulin (107) Mitochondrial Metabolism (10) Mitophagy (3) Mixed Lineage Kinase (1) MMP (16) MNK (3) Molecular Glues (6) Monoamine Oxidase (1) Mps1 (1) mTOR (18) Na+/K+ ATPase (2) nAChR (2) NADPH Oxidase (5) Natriuretic Peptide Receptor (NPR) (1) Necroptosis (3) NEDD8-activating Enzyme (1) NEKs (2) Neurokinin Receptor (5) Neuromedin U Receptor (NMUR) (1) Neuropeptide B/W Receptor (3) Neuropeptide FF Receptor (1) Neuropeptide Y Receptor (7) Neurotensin Receptor (4) NF-κB (17) NO Synthase (8) Notch (2) NTPDase (2) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (30) OGA (1) Opioid Receptor (19) Orexin Receptor (OX Receptor) (9) Orphan Receptor (6) Orthopoxvirus (12) Oxytocin Receptor (5) P-glycoprotein (4) P-selectin (1) P2X Receptor (4) P2Y Receptor (1) p38 MAPK (17) PACAP Receptor (1) PAI-1 (2) PAK (7) Parasite (28) PARP (26) PCSK9 (2) PD-1/PD-L1 (13) PDGFR (5) PDI (1) PDK-1 (2) PEPCK (1) Peptide-Drug Conjugates (PDCs) (1) PERK (4) Phosphatase (13) Phosphodiesterase (PDE) (7) Phospholipase (5) Photosensitizer (1) PI3K (36) PI4K (2) Pim (4) PINK1/Parkin (1) PKA (8) PKC (15) PKG (5) Platelet-activating Factor Receptor (PAFR) (2) Polo-like Kinase (PLK) (10) Potassium Channel (15) PPAR (10) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (10) PROTAC Linkers (13) PROTACs (53) Protease Activated Receptor (PAR) (8) Proteasome (8) Proton Pump (1) Protoporphyrinogen IX oxidase (4) PSMA (1) PTHR (2) Pyroptosis (3) Pyruvate Kinase (2) RABV (2) RAD51 (2) Radionuclide-Drug Conjugates (RDCs) (2) Raf (16) RAR/RXR (2) Ras (227) Reactive Oxygen Species (56) RET (10) Reverse Transcriptase (1) RGS Protein (7) Ribosomal S6 Kinase (RSK) (1) RIP kinase (2) ROCK (2) ROR (3) ROS Kinase (11) RSV (2) RXFP Receptor (1) SARS-CoV (12) Scavenger Receptor Class B type I (SR-BI） (1) Ser/Thr Kinase (4) Ser/Thr Protease (16) Serotonin Transporter (7) SHMT (1) SHP2 (3) Sigma Receptor (4) Sirtuin (8) Small Interfering RNA (siRNA) (92) SOD (1) Sodium Channel (10) SphK (2) Src (7) SRPK (1) STAT (16) Stearoyl-CoA Desaturase (SCD) (1) STING (2) Succinate Dehydrogenase (1) Succinate Receptor 1 (1) Survivin (2) TAM Receptor (3) Target Protein Ligand-Linker Conjugates (2) Tau Protein (3) Telomerase (7) TGF-beta/Smad (5) TGF-β Receptor (2) Thrombin (2) Thymidylate Synthase (1) Thyroid Hormone Receptor (1) Tie (2) TMV (4) TNF Receptor (18) Toll-like Receptor (TLR) (32) TOPK (2) Topoisomerase (54) Trace Amine-associated Receptor (TAAR) (4) Transmembrane Glycoprotein (8) Transthyretin (TTR) (3) Trk Receptor (25) TRP Channel (5) TSH Receptor (2) Tyrosinase (7) ULK (1) URAT1 (1) Urotensin Receptor (3) Vasopressin Receptor (10) VD/VDR (1) VEGFR (28) Virus Protease (3) VSV (3) WDR5 (2) Wee1 (3) Wnt (7) YAP (4) YTHDF (1) α-synuclein (1) β-catenin (7) β-glucuronidase (1)
By Research Areas:	Cancer (1696) Cardiovascular Disease (162) Endocrinology (71) Infection (304) Inflammation/Immunology (349) Metabolic Disease (193) Neurological Disease (286)
Click Chemistry:	ADC Synthesis (7) TCO (1) DBCO (7) PROTAC Synthesis (3) Azide (22) BCN (2) Tetrazine (2) Alkynes (24)
Oligonucleotides:	miRNA mimics (11) Release-retarding Agents (1) Nucleosides and their Analogs (9) miRNA antagomirs (11) Nucleoside Phosphoramidites (8) Rat Pre-designed siRNA Sets (2) Phospholipids (3) miRNA inhibitors (11) siRNA drugs (12) Antisense Oligonucleotides (38) Cap Analogs (9) siRNAs (92) Nucleotides and their Analogs (5) miRNA agomirs (11) MicroRNAs (45) Aptamers (5) CpG ODNs (34) Emulsifiers (1) Cationic Lipids (4) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (76)

3249

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

136

Biochemical Assay Reagents

479

Peptides

MCE Kits

121

Inhibitory Antibodies

372

Natural
Products

409

Recombinant Proteins

112

Isotope-Labeled Compounds

Antibodies

Click Chemistry

253

Oligonucleotides

Targets Recommended: GPR88 MyD88 Adhesion G Protein-coupled Receptors (AGPCRs) G Protein-coupled Receptor Kinase (GRK) Mas-related G-protein-coupled Receptor (MRGPR) GPR84 G protein-coupled Bile Acid Receptor 1 GPR55 GPR171 GPR35 GPR119 GPR4 GPR139 GPR6 GPR52 GPR68

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135542

NBI-27914	CRFR	Others
NBI-27914 is a potent and selective antagonist of CRFR1. The CRF receptors, CRFR1 and CRFR2, are members of the G protein-coupled receptor superfamily .

HY-N0593

Deoxycholic acid 10+ Cited Publications Cholanoic Acid; Desoxycholic acid	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite	Metabolic Disease
Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5 .

HY-N0593A

Deoxycholic acid sodium salt 10+ Cited Publications Sodium deoxycholate	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite	Metabolic Disease
Deoxycholic acid sodium salt (sodium deoxycholate), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5 .

HY-110173

TC-G 1005	G protein-coupled Bile Acid Receptor 1	Metabolic Disease
TC-G 1005 is a potent, selective and orally active agonist of the *BA receptor* Takeda G protein-coupled receptor 5 (TGR5), with EC₅₀**s of 0.72 and 6.2 nM for hTGR5 and mTGR5, respectively. TC-G 1005 can reduce glucose levels in vivo .

HY-W041308

DCOIT Kathon 930	GnRH Receptor	Endocrinology
DCOIT is a representative isothiazolinone that stimulates the gonadotropin-releasing hormone receptor (GnRHR)-mediated synthesis of follicle-stimulating hormone and luteinizing hormone in the brain. DCOIT interferes with G protein-coupled receptors, MAPK and Ca ²⁺ signaling cascades .

HY-105791

Sulazepam	GABA Receptor	Inflammation/Immunology
Sulazepam, a benzodiazepine, is a selective ovarian cancer G protein-coupled receptor (OGR1) agonist. Sulazepam has anticonvulsive action and has the potential for airway hyperresponsiveness (AHR) research .

HY-N0593B

Deoxycholic acid sodium hydrate Cholanoic Acid sodium hydrate; Desoxycholic acid sodium hydrate	Endogenous Metabolite G protein-coupled Bile Acid Receptor 1	Metabolic Disease
Deoxycholic acid (cholanoic acid) sodium hydrate, a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5 .

HY-113653

GSK2041706A GSK706	GPR119	Metabolic Disease
GSK2041706A (GSK706) is a potent *G protein-coupled* receptor 119 (GPR119)** agonist. GSK2041706A can be used for the research of type 2 diabetes .

HY-N0593R

Deoxycholic acid (Standard) Cholanoic Acid(Standard); Desoxycholic acid (Standard)	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite	Metabolic Disease
Deoxycholic acid (Standard) is the analytical standard of Deoxycholic acid. This product is intended for research and analytical applications. Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5 .

HY-143878

MRGPRX1 agonist 2	Mas-related G-protein-coupled Receptor (MRGPR)	Neurological Disease
MRGPRX1 agonist 2 (compound 1a) is a potent *Mas-related G protein-coupled* receptor X1 (MRGPRX1) positive allosteric modulator with an EC₅₀** value of 0.48 μM. MRGPRX1 agonist 2 can be used for researching neuropathic pain .

HY-148531

PF-07054894	CCR	Inflammation/Immunology
PF-07054894 is an orally active and potent C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) antagonist that blocks CCR6-mediated chemotaxis with an IC₅₀ value of 5.7 nM in vitro. PF-07054894 targets G protein-coupled receptor (GPCR). PF-07054894 can be used in research of inflammatory bowel disease .

HY-138193

Lauryl maltose neopentyl glycol 1 Publications Verification LMNG	Biochemical Assay Reagents	Others
Lauryl maltose neopentyl glycol (LMNG) is a detergent that can solubilize and stabilize membrane proteins. Lauryl maltose neopentyl glycol extracts integral membrane proteins from membranes, and improves substantially the stability of various membrane proteins, including G protein-coupled receptors and respiratory complexes .

HY-158882

FLAC6	Biochemical Assay Reagents Adenosine Receptor	Others
FLAC6 is a potent fluorinated detergent that can be used to solubilize membrane proteins (the native adenosine receptor A_2AR, a G protein-coupled receptor, and two native transporters AcrB and BmrA). FLAC6 can maintain the structural and functional integrity of different membrane proteins .

HY-143864

S1PR1 agonist 1	LPL Receptor	Inflammation/Immunology
S1PR1 agonist 1 is a potent agonist of S1PR1. Sphingosine-1-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 1 has the potential for the research of autoimmune diseases (extracted from patent WO2021175223A1, compound 22) .

HY-143865

S1PR1 agonist 2	LPL Receptor	Inflammation/Immunology
S1PR1 agonist 2 is a potent agonist of S1PR1. Sphingosine-1-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 2 has the potential for the research of autoimmune diseases (extracted from patent WO2021175225A1, compound 1) .

HY-134801

CID1231538	GPR35	Metabolic Disease Inflammation/Immunology
CID1231538, a benzothiazole analog, is a potent GPR35 antagonist with no significant activity against rodent orthologs of GPR35, which is also a G protein-coupled receptor (GPCR) .

HY-135065

3-Iodothyronamine hydrochloride	Trace Amine-associated Receptor (TAAR)	Metabolic Disease
3-Iodothyronamine (hydrochloride) is an endogenous and rapid-acting derivative of thyroid hormone. 3-Iodothyronamine potently activates an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale. 3-Iodothyronamine can be used for the research of congestive heart failure .

HY-160281

CCD-2	Others	Metabolic Disease
CCD-2 is a conventional detergent and is readily degraded. CCD-2 can efficiently solubilize and stabilize diverse G protein-coupled receptors (GPCRs). CCD-2 is amenable to the β-barrel protein research. The chemical cleavage of CCD-2 is rapid, complete and biorthogonal and should facilitate a chemical methodology for in situ detergent replacement in diverse membrane proteins (MPs) studies .

HY-109562A

CCG258208 hydrochloride GRK2-IN-1 hydrochloride	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC₅₀=30 nM) while maintaining 230-fold selectivity over GRK5 (IC₅₀=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC₅₀=87.3 μM), PKA, and ROCK1. CCG258208 hydrochloride can be used in heart failure research .

HY-109562

CCG258208 GRKs-IN-1	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
CCG258208 (GRK2-IN-1) is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC₅₀=30 nM) while maintaining 230-fold selectivity over GRK5 (IC₅₀=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC₅₀=87.3 μM), PKA, and ROCK1. CCG258208 can be used in heart failure research .

HY-P2210

BigLEN(mouse)	GPR171	Metabolic Disease
BigLEN(mouse) is a potent and selective agonist of *orphan G protein-coupled* receptor 171 (GPR171), with a K_d** of ∼0.5 nM. BigLEN(mouse) can be used to regulate responses associated with food intake and metabolism .

HY-150021

GRK5-IN-3	G Protein-coupled Receptor Kinase (GRK)	Others
GRK5-IN-3 is a covalent inhibitor of GRK5 (G Protein-Coupled Receptor Kinase 5). GRK5-IN-3 shows potent inhibitory effect to GRK5 and GRK6 with IC₅₀s of 0.22 μM and 0.41 μM, respectively .

HY-103450

G36	Estrogen Receptor/ERR	Endocrinology Cancer
G-36 is a cell-permeable nonsteroidal antagonist of the G protein-coupled estrogen receptor (GPER/GPR30), which selectively inhibits estrogen-mediated PI3K activation through GPER, rather than Erα. G-36 also inhibits estrogen-mediated calcium mobilization (IC₅₀=112 nM). G-36 is promising for research in the field of cancer .

HY-114146

CID 1375606	Orphan Receptor	Neurological Disease Metabolic Disease
CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27.

HY-123520

GSK299115A	G Protein-coupled Receptor Kinase (GRK) PKA	Cancer
GSK299115A is a *G Protein-coupled* Receptor Kinase (GRK) and PKA** inhibitor .

HY-W036034A

GRK-IN-1	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
GRK-IN-1 is a potential *G protein-coupled* receptor kinase (GRK)** inhibitor.

HY-15291

MBX-2982 10+ Cited Publications	GPR119	Metabolic Disease
MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist.

HY-172438

Setomagpran	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
Setomagpran is the antagonist for mas-related G protein-coupled receptor (MRGPR), and exhibits anti-inflammatory activity .

HY-108020

LY2881835	Free Fatty Acid Receptor	Endocrinology
LY2881835 is a potent and selective agonist of G protein-coupled receptor 40 (GPR40). LY2881835 has efficacious and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion. LY2881835 has the potential for the research of type 2 diabetes mellitus . LY2881835 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-12976

DS-1558	G Protein-coupled Receptor Kinase (GRK)	Metabolic Disease
DS-1558 is an orally active small molecule *G protein-coupled* receptor 40** agonist. DS-1558 not only increases the glucose-stimulated insulin secretion by glucagon like peptide-1 (GLP-1) but also potentiated the maximum insulinogenic effects of GLP-1 after an intravenous glucose injection in normal Sprague Dawley rats. DS-1558 is promising for research of type 2 diabetes .

HY-114165

DJ-V-159	Androgen Receptor	Metabolic Disease
DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A).

HY-101777

TC-O 9311	GPR139	Neurological Disease
TC-O 9311 is a potent *orphan G protein-coupled* receptor 139 (GPR139) agonist with an EC₅₀** of 39 nM .

HY-163531

GPR41 modulator 2	Others	Metabolic Disease
GPR41 modulator 2 (Compound 10bx) exhibits agonistic activity for G protein-coupled receptor (GPR41) .

HY-162617

PSB-KK1415	Cannabinoid Receptor	Inflammation/Immunology Cancer
PSB-KK1415 is a selective agonist for human orphan G protein-coupled receptor GPR18, with EC₅₀ of 19.1 nM .

HY-103449

G15 25+ Cited Publications	Estrogen Receptor/ERR	Cancer
G15 is a high affinity and selective *G-protein-coupled* estrogen receptor (GPER/GPR30) antagonist with a K_i** of 20 nM .

HY-111116

LY3104607	Free Fatty Acid Receptor	Metabolic Disease
LY3104607 is a potent and selective *G protein-coupled* receptor 40 (GPR40)** agonist. LY3104607 can be used in research of diabetes .

HY-149720

GRL018-21	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
GRL018-21 is a potent and highly selective G protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC₅₀ value of 10 nM .

HY-155318A

GPR3 agonist-2	Orphan Receptor	Endocrinology
GPR3 agonist-2(compound 32) is a potent full agonist of *G protein-coupled* receptor 3, with the IC₅₀**of 260 nM .

HY-12764

6-OAU 1 Publications Verification GTPL5846	GPR84 ERK Bacterial Antibiotic	Inflammation/Immunology
6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC₅₀ value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function .

HY-110285

ML382	Mas-related G-protein-coupled Receptor (MRGPR)	Neurological Disease
ML382 is a potent and selective MRGPRX1 (Mas-related G protein-coupled receptor X1, MrgX1) positive allosteric modulator, with an EC₅₀ of 190 nM .

HY-138686

GPR30 agonist-1	Estrogen Receptor/ERR	Cardiovascular Disease Endocrinology
GPR30 agonist-1 is a *G protein-coupled* receptor 30 (GPR30)** agonist. GPR30 agonist-1 exerts vasorelaxant effects .

HY-105791S

Sulazepam-d5	Isotope-Labeled Compounds GPR68	Neurological Disease
Sulazepam-d₅ is a deuterium labeled Sulazepam (HY-105791). Sulazepam is a selective ovarian cancer G protein-coupled receptor (OGR1) agonist[1].

HY-129118

Takeda103A	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
Takeda103A is a potent inhibitor of GRK2. G protein-coupled receptors (GPCRs) are central to many physiological processes. Takeda103A has the potential for the research of heart failure .

HY-10957A

L-692429 hydrochloride MK-0751 hydrochloride	GHSR	Metabolic Disease
L-692429 (MK-0751) hydrochloride is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 hydrochloride binds to G protein-coupled receptor with a K_i of 63 nM .

HY-10957

L-692429 MK-0751	GHSR	Metabolic Disease
L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 binds to G protein-coupled receptor with a K_i of 63 nM .

HY-12520B

(R)-SKF 38393 hydrochloride (±)-SKF-38393 hydrochloride; SKF-38393A hydrochloride	Dopamine Receptor Potassium Channel	Neurological Disease
(R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits *G protein-coupled* inwardly rectifying potassium (GIRK) channel** .

HY-P1944A

Apelin-13 TFA 5+ Cited Publications	Apelin Receptor (APJ)	Cardiovascular Disease Metabolic Disease
Apelin-13 TFA is an endogenous ligand for the *G-protein coupled* receptor angiotensin II protein J (APJ)*, activating this G protein-coupled* receptor with an EC₅₀ value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome .

HY-117992

BR103	Complement System	Inflammation/Immunology
BR103 is a C3aR-specific small molecule ligand. BR103 can be used to measure ligand affinity for a G protein-coupled receptor for saturation and competitive binding .

HY-P3108

Alamandine	Angiotensin Receptor Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions .

HY-N0593S1

Deoxycholic acid-d5	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite	Metabolic Disease
Deoxycholic acid-d₅ is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0593

Deoxycholic acid 10+ Cited Publications Cholanoic Acid; Desoxycholic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite
Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5 .

HY-N0593A

Deoxycholic acid sodium salt 10+ Cited Publications Sodium deoxycholate	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite
Deoxycholic acid sodium salt (sodium deoxycholate), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5 .

HY-B1811

Vasopressin 10+ Cited Publications	Structural Classification Neurological Disease Classification of Application Fields Cyclopeptides Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors .

HY-B0228

Adenosine 10+ Cited Publications Adenine riboside; D-Adenosine	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Nucleoside Antimetabolite/Analog Autophagy Apoptosis Endogenous Metabolite
Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-W014502

D-Kynurenine	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Aryl Hydrocarbon Receptor Endogenous Metabolite
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating *aryl hydrocarbon receptor* (AHR)** .

HY-141581

Lyso-PAF C-18	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Platelet-activating Factor Receptor (PAFR) Endogenous Metabolite
Lyso-PAF C-18 is an intermediate for the synthesis of C18-PAF (HY-130345). It has an easily substituted "Lyso-PAF" structure and is easy to purify and has high yield. C18-PAF is a ligand for platelet-activating factor and PAF G protein-coupled receptor (PAFR) and has renovasodilator properties and antihypertensive lipid properties .

HY-B0228R

Adenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Nucleoside Antimetabolite/Analog Autophagy Apoptosis Endogenous Metabolite
Adenosine (Standard) is the analytical standard of Adenosine. This product is intended for research and analytical applications. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-N0593R

Deoxycholic acid (Standard) Cholanoic Acid(Standard); Desoxycholic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite
Deoxycholic acid (Standard) is the analytical standard of Deoxycholic acid. This product is intended for research and analytical applications. Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5 .

HY-N10071

Poricoic acid G	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans .

HY-W014502R

D-Kynurenine (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite	Aryl Hydrocarbon Receptor Endogenous Metabolite
D-Kynurenine (Standard) is the analytical standard of D-Kynurenine. This product is intended for research and analytical applications. D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating *aryl hydrocarbon receptor* (AHR)** .

HY-113421

Linoleoyl ethanolamide Linoleic acid monoethanolamide	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Cannabinoid Receptor
Linoleoyl ethanolamide (Linoleic acid monoethanolamide) is classified as a fatty acid ethanolamide. Linoleoyl ethanolamide only weakly binds G-protein-coupled cannabinoid receptors of type-1（CB1）and CB2 receptors, and inhibits the binding of ^[3H]CP-55,940 with K_is of 10 and 25 μM, respectively. Linoleoyl ethanolamide is 4-fold less potent than anandamide at causing catalepsy in mice and it does not prolong sleep time .

HY-108496

Sphingosine-1-phosphate 5+ Cited Publications S1P	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite LPL Receptor
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors . Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids . Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration .

HY-N3248

Momordicoside G Momordicacoside G	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Momordica charantia Linn.	Endogenous Metabolite Reactive Oxygen Species Apoptosis
Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury .

HY-16950A

(E/Z)-4-Hydroxytamoxifen 1 Publications Verification Afimoxifene; 4-OHT	Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Estrogen Receptor/ERR Adhesion G Protein-coupled Receptors (AGPCRs) Drug Metabolite
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

HY-P6294

Pseudostellarin G	Structural Classification Natural Products Pseudostellaria heterophylla (Miq.) Pax Source classification Plants Caryophyllaceae	Tyrosinase
Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin .

HY-17561

G-418 disulfate 35+ Cited Publications Geneticin sulfate; Antibiotic G-418 sulfate	Structural Classification Antifungal Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Disease Research Fields	Bacterial Antibiotic
G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells .

HY-N9240

Acerogenin G	Source classification Sapindaceae Plants Acer nikoense Maxim.	Others
Acerogenin G is a synthetic diarylheptane. Acerogenin G is first isolated from Acer nikoense .

HY-N11078

Shizukaol G	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Chloranthus japonicus Sieb. Plants	Others
Shizukaol G is a dimeric sesquiterpene. Shizukaol G can be isolated from the roots of Chloranthus japonicus .

HY-130476

Satratoxin G	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Caspase Apoptosis
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase .

HY-B1463R

Penicillin G sodium salt (Standard)	Structural Classification Plant Cell Culture Microorganisms Antibiotics Source classification Animal Husbandry Mammalian Cell Culture Antibacterial Disease Research Beta-lactam Antibiotics	Beta-lactamase Bacterial Antibiotic
Penicillin G sodium salt (Standard) is the analytical standard of Penicillin G sodium salt. This product is intended for research and analytical applications. Penicillin G sodium salt is a typical β-lactam antibiotic.

HY-N8661

Fenfangjine G	Stephania tetrandra S. Moore Alkaloids Structural Classification Source classification Plants Menispermaceae	Others
Fenfangjine G is an active component in Fangji Huangqi Tang (FHT). Fenfangjine G can be used for the research of nephrotic syndrome .

HY-12372

Sanggenon G	Structural Classification Flavonoids Flavonones Source classification Morus alba L. Plants Moraceae	IAP Caspase
Sanggenon G is a cell-permeable and potent inhibitor of *X-linked inhibitor of apoptosis protein* (XIAP). Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase** activation .

HY-17591R

Penicillin G potassium (Standard)	Structural Classification Plant Cell Culture Microorganisms Antibiotics Source classification Animal Husbandry Mammalian Cell Culture Antibacterial Disease Research Other Antibiotics	Antibiotic Bacterial
Penicillin G (potassium) (Standard) is the analytical standard of Penicillin G (potassium). This product is intended for research and analytical applications. Penicillin G potassium is a fast-acting penicillin family antibiotic. Penicillin G potassium can be used for the research of bacterial infections that affect the blood, heart, lungs, joints, and genital areas .

HY-N13927

Arisugacin G	Structural Classification Natural Products Microorganisms Ketones, Aldehydes, Acids Source classification	Cholinesterase (ChE)
Arisugacin G, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin G shows no activity against AChE .

HY-P1293

Conantokin G	Structural Classification Natural Products Animals Source classification	iGluR
Conantokin G, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G inhibits NMDA-evoked currents in murine cortical neurons with an IC₅₀ of 480 nM. Conantokin G has neuroprotective properties .

HY-N7665

Prosaikogenin G	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Metabolic Disease Umbelliferae Plants Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Others
Prosaikogenin G, isolated from the roots of Bupleurum chinensis DC., exhibits significant inhibitory effects on rat mesangial cell proliferation induced by Ang II. Prosaikogenin G has protective action on the kidney . Prosaikogenin G is a derivative of Saikosaponin d in the gastrointestinal tract .

HY-N8850

Angelol G	Structural Classification Leguminosae Campylotropis hirtella (Franch.) Schindl. Source classification Coumarins Phenylpropanoids Plants	Others
Angelol G, a coumarin, can be isolated from Campylotropis hirtella. Angelol G shows inhibitory activity for prostate specific antigen (PSA)IC₅₀ value of 152.1μM. Angelol G can be used for the research of benign prostate hyperplasia (BPH) .

HY-N12395

Parishin G	Structural Classification Gastrodia elata Bl. Ketones, Aldehydes, Acids Orchidaceae Source classification Plants Saccharides Monosaccharides	Others
Parishin G is a Parishin (HY-N2031) derivative that can be isolated from Gastrodia elata. Parishin G has antioxidant activity .

HY-N11530

Kouitchenside G	Structural Classification Xanthones Source classification Gentianaceae Phenols Plants Swertia kouitchensis Franch.	Glycosidase
Kouitchenside G is a natural product that can be isolated from Swertia kouitchensis. Kouitchenside G inhibits α-Glucosidase with an IC₅₀ of 956 μM .

HY-N0858R

Gomisin G (Standard)	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	HIV
Gomisin G (Standard) is the analytical standard of Gomisin G. This product is intended for research and analytical applications.

HY-N13135

Kadsutherin G	Structural Classification Kadsura heteroclita (Roxb.) Craib Source classification Lignans Phenylpropanoids Plants Schisandraceae	Others
Kadsutherin G (compound 3) is a lignin isolated from Kadsura. Kadsutherin G inhibits adenosine diphosphate (ADP)-induced platelet aggregation by 33.1 % .

HY-N9892

Guttiferone G	Structural Classification Garcinia xanthochymus Hook. f. ex T. Anders. Source classification Guttiferae Phenols Polyphenols Plants	Sirtuin
Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC₅₀: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC₅₀: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla .

HY-113513

5-HEPE	Microorganisms Source classification	Others
5(S)-HEPE is an active metabolite of eicosapentaenoic acid. It is formed from EPA by 5-lipoxygenase (5-LO). 5(S)-HEPE is an agonist of G protein-coupled receptor 119 (GPR119). It increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 μM. 5(S)-HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 μM. Serum levels of 5(S)-HEPE are elevated in patients with hyperlipidemia.

HY-153830

LacCer (d18:1/16:0) C16 Lactosylceramide (d18:1/16:0)	Structural Classification Microorganisms Source classification Saccharides Monosaccharides	Endogenous Metabolite
LacCer (d18:1/16:0) (C16 Lactosylceramide (d18:1/16:0)) is an endogenous bioactive sphingolipid that can form membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs). The levels of LacCer (d18:1/16:0) are elevated in the plasma of insulin-resistant cattle. In a mouse model of Niemann-Pick type C1 disease (a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder), the expression of LacCer (d18:1/16:0) is also upregulated. LacCer (d18:1/16:0) can be used in research on metabolic diseases and neurodegenerative diseases .

HY-10863

Anandamide 1 Publications Verification AEA	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Cannabinoid Receptor PPAR TRP Channel GPR55 Fungal Tau Protein Endogenous Metabolite
Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .

HY-N7050

Tubulysin G	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin G is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin G can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin G displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin G inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N0817

Polyphyllin G	Structural Classification Classification of Application Fields Paris fargesii var. petiolata (Baker ex C.H.Wright) Wang et Tang Cardiacglycosides Source classification Plants Melanthiaceae Inflammation/Immunology Disease Research Fields Saccharides Monosaccharides Steroids	Apoptosis Autophagy Bacterial
Polyphyllin G is isolated from the rhizomes of Paris yunnanensis, with antimicrobial and anticancer activity. Polyphyllin G prevents the growth of both Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations (MICs) . Polyphyllin G induces apoptosis dependent on the activations of caspase-8, -3, and -9, induces autophagy .

HY-N4247R

Kuwanon G (Standard)	Structural Classification Flavonoids Flavones Source classification Phenols Polyphenols Plants Moraceae Morus alba Linn.	Bombesin Receptor Bacterial
Kuwanon G (Standard) is the analytical standard of Kuwanon G. This product is intended for research and analytical applications. Kuwanon G is a flavonoid isolated from Morus alba, acts as a bombesin receptor antagonist, with potential antimicrobial activity .

HY-N3920

Gancaonin G	Structural Classification Flavonoids Flavones Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch.	Bacterial
Gancaonin G is a 6-prenylated isoflavanone that can be isolated from Glycyrrhiza uralensis. Gancaonin G has antibacterial activity against Streptococcus mutants and MRSA strains .

HY-N3257

Millewanin G	Structural Classification Flavonoids Leguminosae Millettia pachycarpa Benth. Source classification Plants Isoflavones	Estrogen Receptor/ERR
Millewanin G is a prenylated isoflavonoid with antiestrogenic activity (IC₅₀=29 μM). Millewanin G can be isolated from the leaves of M. pachycarpa cultivated in Japan .

HY-N15292

Scutebarbolide G	Structural Classification Terpenoids Labiatae Derris robusta Source classification Diterpenoids Plants	Others
Scutebarbolide G is a neo-clerodane diterpenoid. Scutebarbolide G can be extracted from the aerial parts of Scutellaria barbata. Some neo-clerodane diterpenoids possesses brilliant phytotoxic activity .

HY-N13405

Ampelopsin G	Structural Classification Source classification Phenols Polyphenols Plants Vitaceae Ampelopsis glandulosa var. brevipedunculata (Maxim.) Momiy.	Others
Ampelopsin G is a natural product .

HY-N13377

Leachianol G	Structural Classification Source classification Phenols Plants Vitaceae Ampelopsis glandulosa var. brevipedunculata (Maxim.) Momiy.	Others
Leachianol G is a natural product .

HY-N2103

Tenacissoside G	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	P-glycoprotein
Tenacissoside G is a C21 steroid from the stems of Marsdenia tenacissima. Tenacissoside G reverses multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells .

HY-N12706

Heilaohuguosu G	Structural Classification Source classification Lignans Phenylpropanoids Kadsura coccinea (Lem.) A. C. Smith Plants Schisandraceae	Endogenous Metabolite
Heilaohuguosu G (compound 7) is a cyclolignan with hepatoprotective activity. Heilaohuguosu G against APAP toxicity with cell survival rates at 10 μM of 45.7% in HepG-2 cells .

HY-N1231R

Sophoraflavanone G (Standard)	Structural Classification Flavonoids Leguminosae Flavonones Source classification Phenols Polyphenols Sophora flavescens Aiton Plants	Apoptosis
Sophoraflavanone G (Standard) is the analytical standard of Sophoraflavanone G. This product is intended for research and analytical applications. Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways .

HY-N10302

Bipolamine G	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields	Bacterial Endogenous Metabolite
Bipolamine G is an antibacterial polyketide alkaloid .

HY-N0855

Alisol G Alisol-G; 25-Anhydroalisol A	Triterpenes Alisma plantago-aquatica Linn. Classification of Application Fields Terpenoids Source classification Other Diseases Plants Alismataceae Disease Research Fields	Others
Alisol G is a natural product extracted from Rhizoma Alismatis.

HY-N11841

Mortatarin G	Structural Classification Flavanonols Flavonoids Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	Glycosidase
Mortatarin G (compound 3) is a prenylated flavonoid, that can be isolated from mulberry leaves. Mortatarin G exhibits good α-glucosidase inhibitory activity, with an IC₅₀ of 20.4±1.4 μM .

HY-N5059

Monnieriside G	Monophenols Classification of Application Fields Carlina acaulis L. Source classification Other Diseases Phenols Plants Umbelliferae Disease Research Fields	Others
Monnieriside G is found in Cnidium monnieri fruits .

Cat. No.	Product Name	Chemical Structure

HY-N0593S

Deoxycholic acid-d4
Deoxycholic acid-d₄ is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

HY-N0593S3

Deoxycholic acid-13C
Deoxycholic acid- ¹³C is the ¹³C-labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

HY-B0228S6

Adenosine-d2
Adenosine-d₂ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio

HY-B0228S5

Adenosine-13C
Adenosine- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology,

HY-105791S

Sulazepam-d5
Sulazepam-d₅ is a deuterium labeled Sulazepam (HY-105791). Sulazepam is a selective ovarian cancer G protein-coupled receptor (OGR1) agonist[1].

HY-N0593S1

Deoxycholic acid-d5
Deoxycholic acid-d₅ is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

HY-N0593S2

Deoxycholic acid-d6
Deoxycholic acid-d₆ is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

HY-B0228S8

Adenosine-d1-2
Adenosine-d-2 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys

HY-B0228S7

Adenosine-d1-1
Adenosine-d-1 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys

HY-B0228S14

Adenosine-d9
Adenosine-d₉ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio .

HY-B0228S2

Adenosine-2′-13C
Adenosine-2′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-B0228S3

Adenosine-3′-13C
Adenosine-3′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-B0228S4

Adenosine-1′-13C
Adenosine-1′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-B1811S1

Vasopressin-d5

Vasopressin-d5 is anIsotope-labeled compound of Vasopressin. Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of the corticotropin-releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors .

HY-B0228S

Adenosine-d1
Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].

HY-B0228S1

Adenosine-13C5
Adenosine- ¹³C₅ is the ¹³C labeled Adenosine[1]. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[2][3].

HY-B0412S1

Estriol-d1
Estriol-d is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

HY-B0228S12

Adenosine-d13

Adenosine-d₁₃ (Adenine riboside-d₁₃; D-Adenosine-d₁₃) is deuterium labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

HY-B0228S13

Adenosine-13C10

Adenosine- ¹³C₁₀ (Adenine riboside- ¹³C₁₀; D-Adenosine- ¹³C₁₀) is ¹³C-labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

HY-B0412S

Estriol-d2
Estriol-d₂ is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

HY-B0412S2

Estriol-d3
Estriol-d₃ is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

HY-B0228S11

Adenosine-15N5

Adenosine- ¹⁵N₅ (Adenine riboside- ¹⁵N₅; D-Adenosine- ¹⁵N₅) is the ¹⁵N labled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-B0412S3

Estriol-13C3
Estriol- ¹³C₃ is the ¹³C-labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

HY-B1811AS1

Vasopressin-d5 TFA

Vasopressin-d5 TFA is the TFA salt form of Vasopressin-d5 (HY-B1811S1). Vasopressin-d5 TFA is an isotope-labeled compound of Vasopressin (HY-B1811). Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of the corticotropin-releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors .

HY-108496S

Sphingosine-1-phosphate-d7

Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

HY-10863S

Anandamide-d8

Anandamide-d8 is a deuterated labeled Anandamide . Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .

HY-N7139S1

Penicillin G-d7 potassium salt
Penicillin G-d₇ (potassium) is the deuterium labeled Penicillin G potassium salt[1].

HY-17591S

Penicillin G-d5 potassium
Penicillin G-d₅ (potassium) is the deuterium labeled Penicillin G potassium. Penicillin G potassium is a fast-acting antibiotic; used to treat bacterial infections that affect the blood, heart, lungs, joints, and genital areas[1][2].

HY-130547S

BS2G Crosslinker-d4 disodium
BS2G Crosslinker-d₄ (disodium) is the deuterium labeled BS2G Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-119987S

Sudan Orange G-d5
Sudan Orange G-d₅ (SOG-d₅) is the deuterated labeled Sudan Orange G (HY-119987) .

HY-166891S

Tiotropium EP Impurity G-d3(Iodide)
Tiotropium EP Impurity G-d₃(Iodide) is deuterium labeled Scopine Methiodide .

HY-13771S1

Ursodeoxycholic acid-13C

Ursodeoxycholic acid- ¹³C is the ¹³C labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].

HY-113421S

Linoleoyl ethanolamide-d4

Linoleoyl ethanolamide-d4 is a deuterated labeled Linoleoyl ethanolamide . Linoleoyl ethanolamide (Linoleic acid monoethanolamide) is classified as a fatty acid ethanolamide. Linoleoyl ethanolamide only weakly binds G-protein-coupled cannabinoid receptors of type-1（CB1）and CB2 receptors, and inhibits the binding of ^[3H]CP-55,940 with K_is of 10 and 25 μM, respectively. Linoleoyl ethanolamide is 4-fold less potent than anandamide at causing catalepsy in mice and it does not prolong sleep time .

HY-132833S

1,7-Dimethyl-1H-imidazo[4,5-g]quinoxalin-2-amine-d3
1,7-Dimethyl-1H-imidazo[4,5-g]quinoxalin-2-amine-d₃ is the deuterium labeled 1,7-Dimethyl-1H-imidazo[4,5-g]quinoxalin-2-amine[1].

HY-118634S

trans-Resveratrol-4'-O-D-Glucuronide-d4
trans-Resveratrol-4'-O-D-Glucuronide-d₄ (R-4G-d₄) is deuterium labeled trans-Resveratrol-4'-O-D-Glucuronide.

HY-113478S

Ursodeoxycholic acid-2,2,4,4-d4

Ursodeoxycholic acid-2,2,4,4-d₄ is the deuterium labeled Ursodeoxycholic acid (HY-13771). Ursodeoxycholic acid is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection[1][2][3][4][5].

HY-13948BS

Angiotensin II human-13C6,15N TFA

Angiotensin II human- ¹³C₆, ¹⁵N TFA (Ang II- ¹³C₆, ¹⁵N TFA) is ¹³C- and ¹⁵N-labeled Angiotensin II human (TFA) (HY-13948B). Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .

HY-131990S

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH-d5
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH-d₅ is deuterated labeled MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH[1].

HY-Y1250S

Fmoc-Gly-OH-15N
Fmoc-Gly-OH- ¹⁵N is the ¹⁵N labeled Fmoc-Gly-OH[1].

HY-P0014AS

Liraglutide-d8 tetraTFA
Liraglutide-d₈ tetraTFA is deuterium labeled Liraglutide (HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .

HY-P0014S2

Liraglutide-13C6,15N TFA
Liraglutide- ¹³C₆, ¹⁵N (TFA)is the ¹³C and ¹⁵N labeledLiraglutide(HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus .

HY-P0014S1

Liraglutide-13C5,15N TFA
Liraglutide- ¹³C₅, ¹⁵N (tetraTFA) is the ¹³C and ¹⁵N labeled Liraglutide (HY-P0014) . Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus .

HY-Y1250S5

Fmoc-Gly-OH-13C2
Fmoc-Gly-OH- ¹³C₂ is a ¹³C-labeled Fmoc-Gly-OH (HY-Y1250). Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds .

HY-Y1250S2

Fmoc-Gly-OH-2,2-d2
Fmoc-Gly-OH-2,2-d₂ is the deuterium labeled Fmoc-Gly-OH-2,2[1].

HY-Y1250S1

Fmoc-Gly-OH-2-13C,15N
Fmoc-Gly-OH-2- ¹³C, ¹⁵N is the ¹³C, ¹⁵N labeled Fmoc-Gly-OH-2[1].

HY-P4596S

H-Gly-Arg-OH (Arg-13C6,15N4)
H-Gly-Arg-OH (Arg- ¹³C₆, ¹⁵N₄) is the deuterium labeled H-Gly-Arg-OH (HY-P4596) .

HY-P1033S

[Pyr1]-Apelin-13, Gly(15N) TFA
Pyr1]-Apelin-13, Gly(15N) TFA is a Gly ¹⁵N labeled [Pyr1]-Apelin-13. [Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor agonist .

HY-P4596S1

H-Gly-Arg-OH (Arg-13C6,15N4) TFA
H-Gly-Arg-OH (Arg- ¹³C₆, ¹⁵N₄) TFA is the deuterium labeled H-Gly-Arg-OH (HY-P4596) .

HY-N7844S

N6-Benzyladenosine-d5
N6-Benzyladenosine-d₅ (Benzyladenosine-d₅) is deuterium labeled N6-Benzyladenosine. N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma .

HY-W032013S3

1-Octanol-d5

1-Octanol-d₅ is deuterated labeled Carvacrol (HY-N0711). Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations .

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