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Pathways Recommended: GPCR/G Protein
Results for "

G

" in MedChemExpress (MCE) Product Catalog:

2673

Inhibitors & Agonists

16

Screening Libraries

51

Fluorescent Dye

133

Biochemical Assay Reagents

463

Peptides

7

MCE Kits

105

Inhibitory Antibodies

356

Natural
Products

398

Recombinant Proteins

112

Isotope-Labeled Compounds

94

Antibodies

55

Click Chemistry

246

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1376A
    G-Protein antagonist peptide TFA

    		mAChR Adrenergic Receptor Endocrinology
    G-Protein antagonist peptide TFA is a truncated substance P-related peptide, competes with receptor for G protein binding. G-Protein antagonist peptide TFA inhibits the activation of Gi or Go by M2 muscarinic cholinergic receptor (M2 mAChR) or of Gs by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis .
    G-Protein antagonist peptide TFA
  • HY-117082
    UTL-5g

    GBL-5g

    		 TNF Receptor Inflammation/Immunology
    UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by Cisplatin through TNF-α inhibition among other factors .
    UTL-5g
  • HY-17561
    G-418 disulfate
    30+ Cited Publications

    Geneticin sulfate; Antibiotic G-418 sulfate

    		 Bacterial Antibiotic Infection
    G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells .
    G-418 disulfate
  • HY-103450
    G36

    		Estrogen Receptor/ERR Endocrinology
    G-36 is a cell permeable non-steroidal antagonist of G-protein-coupled estrogen receptor (GPER/GPR30) which selectively inhibits estrogen-mediated activation of PI3K by GPER, but not by ERα. G-36 also inhibits estrogen-mediated calcium mobilization (IC50=112 nM) .
    G36
  • HY-P1376
    G-Protein antagonist peptide

    		mAChR Adrenergic Receptor Endocrinology
    G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.
    G-Protein antagonist peptide
  • HY-160485
    G-4'G-7S

    		Others Endocrinology
    G-4'G-7S is a endogenous metabolite of genistein (HY-14596). G-4'G-7S can be used for the research of estrogenic activity .
    G-4'G-7S
  • HY-164478
    G-631

    		PARP Cancer
    G-631 is a selective inhibitor for tankyrase. G-631 inhibits tankyrase auto-PARsylation (poly ADP ribosylation) with an IC50 of 7 nM, and inhibits Wnt signaling pathway. G-631 exhibits good pharmacokinetic characteristics in mice .
    G-631
  • HY-102036
    G-744

    		Btk Inflammation/Immunology
    G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis .
    G-744
  • HY-161672
    G-5758

    		Liposome IRE1 Cancer
    G-5758 is an orally available IRE1α inhibitor with an IC50 of 38 nM for XBP1s. G-5758 is well tolerated in multiple myeloma models (KMS-11) at oral doses up to 500 mg/kg in rats. G-5758 exhibits pharmacodynamics comparable to that of induced IRE1 knockdown .
    G-5758
  • HY-120454
    G-479

    		MEK Potassium Channel Cancer
    G-479 is the inhibitor for MEK and hERG channel (IC50=14 μM). G-479 inhibits the proliferation of HCT-116 and A375 with IC50 of 0.049 μM and 0.004 μM. G-479 exhibits good metabolic stability in liver microsomes and good pharmacokinetic characteristics in rats .
    G-479
  • HY-107216
    G-1
    20+ Cited Publications

    		 Estrogen Receptor/ERR Cancer
    G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM.
    G-1
  • HY-P2794
    G0775

    		Bacterial Infection Neurological Disease Inflammation/Immunology
    G0775 is a molecule with potent, broad-spectrum activity against Gram-negative bacteria. G0775 is active against MDR bacteria. G0775 binds the LepB protease domain .
    G0775
  • HY-108718
    G-418

    Geneticin; Antibiotic G-418

    		 Bacterial Parasite Antibiotic Infection
    G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis .
    G-418
  • HY-150927
    G12Si-2

    		Ras Cancer
    G12Si-2, an analog of G12Si-1 (HY-150926), is a negative control tool. G12Si-2 is not a covalent inhibitor of the G12S mutant of K-Ras .
    G12Si-2
  • HY-115452
    G5-7

    		JAK Apoptosis Cancer
    G5-7, an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr 1068) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. G5-7 has the potential for glioma study .
    G5-7
  • HY-P10036
    G-Subtide

    		PKG Others
    G-Subtide is a G-substrate peptide localized in Purkinje cells of the cerebellum. G-Subtide has little activity distinct from background and is a preferentially phosphorylated peptide substrate of recombinant PfPKG2 protein .
    G-Subtide
  • HY-128583
    G150
    4 Publications Verification

    		 Cyclic GMP-AMP Synthase Inflammation/Immunology
    G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory .
    G150
  • HY-W107464
    G6PDi-1
    2 Publications Verification

    		 PDI Metabolic Disease Inflammation/Immunology
    G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells .
    G6PDi-1
  • HY-153102
    G3-CNP

    		Biochemical Assay Reagents Others
    G3-CNP is an α-amylase substrate. The absorbance of G3-CNP cleavage product 2-chloro-4-nitrophenol is measured at 405 nm, which can be used to detect enzyme activity .
    G3-CNP
  • HY-124658
    G0507

    		Bacterial Infection
    G0507, a pyrrolopyrimidinedione compound, is a potent LolCDE ABC Transporter inhibitor. G0507 is a inhibitor of Escherichia coli growth and induces the extracytoplasmic σE stress response. G0507 acts as a chemical probe to dissect lipoprotein trafficking in Gram-negative bacteria .
    G0507
  • HY-19635A
    G-5555 hydrochloride
    5+ Cited Publications

    		 PAK Cancer
    G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.
    G-5555 hydrochloride
  • HY-145416
    G247

    		Bacterial Infection
    G247 is a specific MsbA inhibitor. G247 acts as a transmembrane domains (TMDs) wedge, symmetrically increasing nucleotide-binding domains (NBDs) separation and preventing conformational transition of MsbA. G247 suppresses ATPase activity by increasing inter-NBD distance .
    G247
  • HY-151263
    G4/HDAC-IN-1

    		HDAC G-quadruplex Cancer
    G4/HDAC-IN-1 (compound a6) is a G4/HDAC dual-targeting compound. G4/HDAC-IN-1 inhibits intracellular HDAC activity with an IC50 value of 1.1 μM, and induces G4 formation. G4/HDAC-IN-1 inhibits TNBC proliferation and tumor growth in TNBC xenograft model. G4/HDAC-IN-1 can be used for the research of cancer .
    G4/HDAC-IN-1
  • HY-103449
    G15
    20+ Cited Publications

    		 Estrogen Receptor/ERR Cancer
    G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM .
    G15
  • HY-N0858R
    Gomisin G (Standard)

    		HIV Infection
    Gomisin G (Standard) is the analytical standard of Gomisin G. This product is intended for research and analytical applications.
    Gomisin G (Standard)
  • HY-150926
    G12Si-1

    		Ras Cancer
    G12Si-1 is a selective K-Ras(G12S) covalent inhibitor, which can inhibit oncogenic signaling of K-Ras(G12S). G12Si-1 shows good ability to covalently engage recombinant K-Ras(G12S) at the mutant serine residue. G12Si-1 can also affect nucleotide cycling of K-Ras by blocking Sos-catalyzed exchange and decreasing the rate of EDTA promoted exchange .
    G12Si-1
  • HY-N9892
    Guttiferone G

    		Sirtuin Others
    Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla .
    Guttiferone G
  • HY-125176
    G907
    1 Publications Verification

    		 Bacterial Infection
    G907 is a selective antagonist of ATP-binding cassette (ABC) transporter MsbA with anti-microbial activity. G907 inhibits E. coli MsbA with an IC50 value of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket .
    G907
  • HY-116917
    G-9791

    		PAK Cancer
    G-9791, a poyridone side chain analogue, is a potent PAK inhibitor with Ki values of 0.95 nM and 2.0 nM for PAK1 and PAK2, respectively .
    G-9791
  • HY-N3920
    Gancaonin G

    		Bacterial Infection
    Gancaonin G is a 6-prenylated isoflavanone that can be isolated from Glycyrrhiza uralensis. Gancaonin G has antibacterial activity against Streptococcus mutants and MRSA strains .
    Gancaonin G
  • HY-117705
    G244-LM

    		PARP Cancer
    G244-LM is a potent and specific inhibitor of tankyrase 1/2 that inhibits Wnt signaling .
    G244-LM
  • HY-162749
    G9D-4

    		Histone Methyltransferase Cancer
    G9D-4 is a potent degrader of G9a, with the DC50 value of 0.1 μM in PANC-1 cells and do not directly perturb GLP protein, with the DC50 of ＞10 μM. G9D-4 plays an important role in pancreatic cancer research .
    G9D-4
  • HY-19635
    G-5555
    5+ Cited Publications

    		 PAK Cancer
    G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.
    G-5555
  • HY-17486
    Ibuproxam

    G 277; Ibudros

    		 Others Inflammation/Immunology
    Ibuproxam (G 277) is a non-steroidal anti-inflammatory agent .
    Ibuproxam
  • HY-161787
    G9a-IN-2

    		Histone Methyltransferase Others
    G9a-IN-2 (Compound 7i) is an inhibitor for histone methyltransferases G9a with IC50 of 0.024 μM. G9a-IN-2 reduces H3K9me2 levels and induces the mRNA expression of γ-globin mRNA. G9a-IN-2 shows the potential in ameliorating sickle cell disease (SCD) .
    G9a-IN-2
  • HY-44062
    G9a-IN-1

    		Histone Methyltransferase Inflammation/Immunology Cancer
    G9a-IN-1 (Compound 113) is a G9a protein inhibitor. G9A/EHMT2 is a nuclear histone lysine methyltransferase that catalyzes histone H3 lysine 9 dimethylation (H3K9me2), which is a reversible modification generally associated with transcriptional gene silencing. G9a-IN-1 can be used for the research of autoimmune disorders or cancer .
    G9a-IN-1
  • HY-121456
    Salnacedin

    G-201

    		 Others Inflammation/Immunology
    Salnacedin (G-201) has anti-inflammatory and keratolytic activity. Salnacedin can be used in the research of seborrhoeic dermatitis and acne .
    Salnacedin
  • HY-12438
    G007-LK
    5+ Cited Publications

    		 PARP Cancer
    G007-LK is a potent and selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
    G007-LK
  • HY-152229
    G0-C14

    		Liposome Cancer
    G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .
    G0-C14
  • HY-133916
    G140
    1 Publications Verification

    		 Cyclic GMP-AMP Synthase Inflammation/Immunology
    G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity .
    G140
  • HY-155716
    G43-C3-TEG

    		Bacterial Glucosylceramide Synthase (GCS) Infection
    G43-C3-TEG is a glycosyl-transferase inhibitor. G43-C3-TEG reduces the biofilm formation by decreasing the production of EPS (extracellular polysaccharides) .
    G43-C3-TEG
  • HY-B1271
    Sulfinpyrazone

    G-28315

    		 Endogenous Metabolite Inflammation/Immunology
    Sulfinpyrazone (G-28315) is an orally active and potent uricosuric agent for chronic and intermittent gouty arthritis. Sulfinpyrazone has antithrombotic and platelet inhibitory effects .
    Sulfinpyrazone
  • HY-155715
    G43

    		Glucosylceramide Synthase (GCS) Bacterial Infection
    G43 is a potent, selective glucosyltransferase inhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study .
    G43
  • HY-N5006
    Guanfu base G

    		Potassium Channel Cardiovascular Disease
    Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC50 of 17.9 μM .
    Guanfu base G
  • HY-145417
    G092

    		Bacterial Infection
    G092 is a potent inhibitor of MsbA. MsbA is an ABC transporter. Transmembrane ATP-binding cassette (ABC) transporters are crucial cellular machines that move molecules small and large across membranes. G092 has the potential for the research of antimicrobial agents .
    G092
  • HY-P1592
    G3-C12
    1 Publications Verification

    		 Galectin Cancer
    G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.
    G3-C12
  • HY-157417
    G-quadruplex ligand 1

    		DNA/RNA Synthesis Others
    G-quadruplex ligand 1, a G-quadruplex ligand, disrupts G-Quadruplex DNA structure and enhances gene expression .
    G-quadruplex ligand 1
  • HY-N2458
    Ganoderic acid G

    		Others Infection
    Ganoderic acid G is a triterpene isolated from the surface part of gills of Ganoderma lucidum .
    Ganoderic acid G
  • HY-158126
    G-quadruplex ligand 2

    		DNA/RNA Synthesis Cancer
    G-quadruplex ligand 2 (compound A3) is a triphenylamine-based ligand that targets mitochondrial DNA G4s. G-quadruplex ligand 2 activates the cGAS-STING pathway. G-quadruplex ligand 2 inhibits tumor growth and metastasis via regulation of TME .
    G-quadruplex ligand 2
  • HY-P1592A
    G3-C12 TFA
    1 Publications Verification

    		 Galectin Cancer
    G3-C12 (TFA) is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.
    G3-C12 TFA

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