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Pathways Recommended: Apoptosis
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induces the apoptosis

" in MedChemExpress (MCE) Product Catalog:

3568

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3

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13

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26

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84

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20

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914

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120

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12

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21

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-173020
    W23-1006

    		Anaplastic lymphoma kinase (ALK) Apoptosis Cancer
    W23-1006 is a selective and covalent ALKBH5 inhibitor. W23-1006 binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. W23-1006 shows ~30- and 8-fold stronger inhibitory activity than that against FTO and ALKBH3, respectively. W23-1006 can be used for the study of triple-negative breast cancer (TNBC) .
    W23-1006
  • HY-146255
    Apoptosis inducer 10

    		Apoptosis Cancer
    Apoptosis inducer 10 is a potent apoptosis inducer. Apoptosis inducer 10 shows antiproliferative effect. Apoptosis inducer 10 induces apoptosis in HeLa cancer cells via a mitochondria-dependent endogenous pathway .
    Apoptosis inducer 10
  • HY-149222
    Apoptosis inducer 12

    		Apoptosis Cancer
    Apoptosis inducer 12 (Compound 3z) is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 12 can be used for the research of cancer .
    Apoptosis inducer 12
  • HY-146029
    Apoptosis inducer 3

    		Apoptosis Cancer
    Apoptosis inducer 3 (Compound 3) is an apoptosis inducer that selectively triggers apoptosis and late-apoptosis. Apoptosis inducer 3 shows cytotoxicity against cancer cells .
    Apoptosis inducer 3
  • HY-163893
    Apoptosis inducer 23

    		Apoptosis Cancer
    Apoptosis inducer 23 (compound 6e) is an apoptosis inducer with antitumor activity. Apoptosis inducer 23 plays an important role in lung cancer research by inducing apoptosis through mitochondrial damage .
    Apoptosis inducer 23
  • HY-163889
    Ferroptosis/apoptosis inducer-1

    		Apoptosis Ferroptosis Cancer
    Ferroptosis/apoptosis inducer-1 (compound 4d) is a dual inducer of apoptosis and ferroptosis. Ferroptosis/apoptosis inducer-1 induces apoptosis and ferroptosis by reducing mitochondrial membrane potential and downregulating GPX4. Ferroptosis/apoptosis inducer-1 can significantly inhibit the proliferation and metastasis of triple-negative breast cancer (TNBC) both in vitro and in vivo, playing an important role in cancer research .
    Ferroptosis/apoptosis inducer-1
  • HY-170321
    Apoptosis inducer 31

    		Apoptosis Cancer
    Apoptosis inducer 31 (compound 19) induces caspase-dependent apoptosis. Apoptosis inducer 31 plays an important role in cancer research .
    Apoptosis inducer 31
  • HY-147897
    Apoptosis inducer 9

    		Apoptosis Cancer
    Apoptosis inducer 9 induces apoptosis with IC50 value of 4.21 μM. Apoptosis inducer 9 induces apoptosis through the mitochondrial pathway and enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Apoptosis inducer 9 can be used the potential to develop new anti-proliferative agents .
    Apoptosis inducer 9
  • HY-161900
    Apoptosis inducer 22

    		Apoptosis Cancer
    Apoptosis inducer 22 (QR-5) is an apoptosis inducer with IC50 values ​​of 63.1 and 46.5 μM for colon cancer cell lines SW480 and HT29, respectively. Apoptosis inducer 22 induces apoptosis by inhibiting the Wnt/β-catenin axis in colon cancer cells. Apoptosis inducer 22 can be used in anti-colon cancer research.
    Apoptosis inducer 22
  • HY-146092
    Apoptosis inducer 4

    		Apoptosis Cancer
    Apoptosis inducer 4 (Compound 12b) is an apoptosis inducer with anticancer activities .
    Apoptosis inducer 4
  • HY-149017
    Apoptosis inducer 7

    		Apoptosis Cancer
    Apoptosis inducer 7 (Compound 5I) induces apoptosis in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity .
    Apoptosis inducer 7
  • HY-170394
    Apoptosis inducer 33

    		Bacterial Apoptosis Infection Inflammation/Immunology Cancer
    Apoptosis inducer 33 (Compound H2) is a hydrazone derivative. Apoptosis inducer 33 has antioxidant and antibacterial activity that inhibits the growth of Staphylococcus aureus, Escherichia coli and Candida albicans. Apoptosis inducer 33 inhibits tumor cells proliferation and induces apoptosis, which can be used in the study of cancer .
    Apoptosis inducer 33
  • HY-149221
    Apoptosis inducer 11

    		Apoptosis Cancer
    Apoptosis inducer 11 (compound 3u) induces apoptosis through the mitochondrial pathway. Apoptosis inducer 11 induces a block in G2/M, a strong decrease in S phase in non-Hodgkin lymphoma cell lines .
    Apoptosis inducer 11
  • HY-163444
    Apoptosis inducer 15

    		Apoptosis Cancer
    Apoptosis inducer 15 (Compound 3) induces cell apoptosis and cell cycle arrest at G2/M phase. Apoptosis inducer 15 is cytotoxicitic without causing DNA fragmentation .
    Apoptosis inducer 15
  • HY-147865
    Apoptosis inducer 8

    		Galectin Apoptosis Cancer
    Apoptosis inducer 8 (Compound 7c) is a galectin-1 (gal-1) mediated apoptosis-inducing agent against global major leading lung cancer burden. Apoptosis inducer 8 significantly reduced the gal-1 protein level. Apoptosis inducer 8 is also a PET imaging agent .
    Apoptosis inducer 8
  • HY-161659
    Apoptosis inducer 19

    		Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species Cancer
    Apoptosis inducer 19 (Compound 7g) is an Apoptosis inducer. Apoptosis inducer 19 elevates expression of pro-apoptotic proteins (Bax and caspase-3) and downregulates anti-apoptotic protein (Bcl-2). Apoptosis inducer 19 upregulates cellular reactive oxygen species (ROS) levels and disrupts mitochondrial membrane potential (MMP). Apoptosis inducer 19 can be used for triple-negative breast cancer (TNBC) research .
    Apoptosis inducer 19
  • HY-155023
    Apoptosis inducer 13

    		Apoptosis Reactive Oxygen Species Cancer
    Apoptosis inducer 13 (Compound Ru4) can induce cancer cell apoptosis, and inhibits cancer cell migration and invasion. Apoptosis inducer 13 converts coenzyme NADH to NAD +, and increases intracellular ROS levels .
    Apoptosis inducer 13
  • HY-169124
    Apoptosis inducer 28

    		Apoptosis Reactive Oxygen Species Protease Activated Receptor (PAR) Bcl-2 Family Cancer
    Apoptosis Inducer 28 (Compound X1) is an apoptosis-inducing agent with anticancer activity in vitro. Apoptosis Inducer 28 can arrest the cell cycle at the G1 phase, promote cell death, and induce apoptosis by disrupting mitochondrial membrane potential. Apoptosis inducer 28 can also decrease the production of reactive oxygen species, downregulate the gene expression of BAX, Bcl-xL, and Bcl-2, while upregulating the gene expression of PAR-4 .
    Apoptosis inducer 28
  • HY-168122
    Apoptosis inducer 29

    		Apoptosis Cancer
    Apoptosis inducer 29 (compund Y9) is an apoptosis inducer that exhibits antitumor effects in non-small cell lung cancer. Apoptosis inducer 29 selectively acidifies lysosomes and induces lysosomal dysfunction, with superior potency to Gboixn (HY-111651) in vitro and in vivo. .
    Apoptosis inducer 29
  • HY-122019
    ABD56

    		NF-κB ERK Apoptosis Others
    ABD56 is a compound that induces osteoclast apoptosis and has the activity of inhibiting osteoclast formation and inducing apoptosis. ABD56 can inhibit osteoclast formation and induce apoptosis, and its mechanism is related to the inhibition of NFκB and ERK pathways.
    ABD56
  • HY-168589
    Apoptosis inducer 30

    		Apoptosis Cytochrome P450 Caspase Reactive Oxygen Species Cancer
    Apoptosis inducer 30 (Compound 15a) is an anticancer agent. Apoptosis inducer 30 induces MCF-7 cells apoptosis through mitochondrial pathway. Apoptosis inducer 30 induces intracellular reactive oxygen species levels and decreases mitochondrial membrane potential, and blocks the cell cycle in the G0/G1 phase. Apoptosis inducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and inhibits tumor growth in a mouse model of breast cancer .
    Apoptosis inducer 30
  • HY-147822
    Apoptosis inducer 6

    		Apoptosis Cancer
    Apoptosis inducer 6 (compound 4e) is an anticancer agent with a broad-spectrum anticancer activity. Apoptosis inducer 6 triggers cell death through the induction of apoptosis .
    Apoptosis inducer 6
  • HY-163924
    Apoptosis inducer 25

    		Apoptosis Cancer
    Apoptosis inducer 25 (Compound 4H) inhibits the proliferation of cell BGC-823 with IC50 of 0.37 μM. Apoptosis inducer 25 arrests cell cycle at G2/M phase, induces apoptosis in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 25 exhibits good pharmacokinetic properties in rats .
    Apoptosis inducer 25
  • HY-163566
    Apoptosis inducer 18

    		Apoptosis Cancer
    Apoptosis inducer 18, a potent inducer of apoptosis, shows significant cytotoxicity to the breast cancer cell line MCF-7 (IC50=0.559 μM). Apoptosis inducer 18 inhibits cell cycle progression and promotes apoptosis by binding to DNA and causing damage, and by binding to the active site of CDK-2, interfering with its kinase activity. Apoptosis inducer 18 can be used in anti-breast cancer research .
    Apoptosis inducer 18
  • HY-168927
    Apoptosis inducer 36

    		Apoptosis Pyroptosis Cancer
    Apoptosis inducer 36 (Compound 42) exhibits anti-leukemic activity through reduction of leukemia stem cells (LSCs) and induction of differentiation. Apoptosis inducer 36 inhibits the proliferation of AML cells, arrests cell cycle at G1 phase, and induces PANoptosis including apoptosis, pyroptosis and necrosis. Prodrug of apoptosis inducer 36 exhibits orally active antitumor efficacy in mouse model .
    Apoptosis inducer 36
  • HY-N10417
    Apoptosis inducer 5

    		Apoptosis Autophagy Cancer
    Apoptosis inducer 5 (compound 1b) is a lignan enantiomer that can be found in Crataegus pinnatifida. Apoptosis inducer 5 exhibits cytotoxic effect via apoptosis and autophagy in Hep3B cells .
    Apoptosis inducer 5
  • HY-162826
    Apoptosis inducer 27

    		Apoptosis Cancer
    Apoptosis inducer 27 (compound 1c) is a potent inhibitor of MDA-MB-231 breast cancer (IC50: 12.8 μM) and can induce early apoptosis in breast cancer cells. Apoptosis inducer 27 can bind to DNA molecules, Bax and Bcl-2 proteins, and induce DNA damage .
    Apoptosis inducer 27
  • HY-163923
    Apoptosis inducer 24

    		Apoptosis Cancer
    Apoptosis inducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with IC50 of 1.2-4.8 μM. Apoptosis inducer 24 arrests cell cycle at G2/M phase, induces apoptosis in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 24 exhibits antitumor efficacy in mice, without significant toxicity (LD50 is 91.2 mg/kg) .
    Apoptosis inducer 24
  • HY-116692
    Apoptosis inducer 34

    		Apoptosis Caspase Mitochondrial Metabolism PARP DNA/RNA Synthesis
    Apoptosis inducer 34 (Compound 4) is a small molecule compound that induces apoptosis by directly activating the intrinsic apoptotic pathway. Apoptosis inducer 34 promotes Apaf-1 oligomerization to form mature apoptosomes, thereby activating caspase-9 and caspase-3. It significantly activates the apoptotic pathway in Jurkat cells by enhancing the cytochrome c-dependent apoptotic signaling pathway, inducing PARP cleavage and chromosomal DNA fragmentation. Furthermore, Apoptosis inducer 34 exhibits low toxicity to normal cells, demonstrating potential for selective targeting of cancer cells. Apoptosis inducer 34 is a promising candidate for studying cancer related to apoptotic pathways .
    Apoptosis inducer 34
  • HY-172110
    Apoptosis inducer 35

    		EGFR Akt p38 MAPK ERK Apoptosis Cancer
    Apoptosis inducer 35 (Compound 6) is a multi-targeted inhibitor, that reduces the expressions of EGFR, AKT, ERK and P38-MAPKα. Apoptosis inducer 35 inhibits the proliferation of cancer cell A549 and Jurkat, arrests the cell cycle at S phase, and induces apoptosis .
    Apoptosis inducer 35
  • HY-159096
    Apoptosis inducer 21

    		Apoptosis Cancer
    Apoptosis inducer 21 (Compound 5h) inhibits the proliferation of lung cancer cell H69AR with an IC50 of 1.58 μM. Apoptosis inducer 21 arrests the cell cycle at G0/G1 phase, induces apoptosis in H69AR .
    Apoptosis inducer 21
  • HY-162819
    Apoptosis inducer 26

    		Apoptosis Cancer
    Apoptosis inducer 26 (compound [AgCl(dap2SH)(PPh3)2]) is an autophagy inducer based on mononuclear Ag(I) ligands, with antibacterial and anticancer activities against a variety of bacterial strains and cancer cell lines. Apoptosis inducer 26 can effectively inhibit the growth of both Gram(+) and Gram(-) bacteria by causing the accumulation of Ag(I) ions in the bacterial periplasm. Apoptosis inducer 26 can intercalate between base pairs of CT DNA and induce apoptosis in A549 cells. Apoptosis inducer 26 also has the ability to scavenge free radicals, which can protect against oxidative stress .
    Apoptosis inducer 26
  • HY-168720
    Apoptosis inducer 32

    		Apoptosis Cancer
    Apoptosis inducer 32 (Compound 7g) is an apoptosis inducer with a KD of 42 μM, showing anti-tumor activity. Apoptosis inducer 32 caused significant cellular morphological changes in MDA-MB-231 cells, including membrane bubbling, nuclear fragmentation, and apoptotic body formation. The IC50 of Apoptosis inducer 32 in MCF-7, MDA-MB-231, and HEK cells is 4.77, 6.56 and 337.8 μM respectively .
    Apoptosis inducer 32
  • HY-161473
    Apoptosis inducer 16

    		Apoptosis Cancer
    Apoptosis inducer 16 (Compound 3) is a bivalent Smac mimic that can effectively bind to BIR2 and BIR3, and exhibits cancer cell (apoptosis) inducing activity .
    Apoptosis inducer 16
  • HY-N6253
    Pinoresinol

    (+)-Pinoresinol

    		 Apoptosis Cancer
    Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .
    Pinoresinol
  • HY-110145
    MRS 1477

    		TRP Channel Cancer
    MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis .
    MRS 1477
  • HY-123554
    Flavagline FL3

    		Apoptosis Cancer
    Flavagline FL3 is a flavagline with potent and selective cytotoxicity in cancer cells.Flavagline FL3 induces apoptosis of HL60 and Hela cells by triggering the translocation of Apoptosis Inducing Factor (AIF) and caspase-12 to the nucleus .
    Flavagline FL3
  • HY-N0780
    Isoalantolactone
    4 Publications Verification

    (+)-Isoalantolactone; Isohelenin

    		 Apoptosis Autophagy Bacterial Endogenous Metabolite Cancer
    Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.
    Isoalantolactone
  • HY-N11067
    Taccalonolide E

    		Apoptosis Cancer
    Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis.
    Taccalonolide E
  • HY-161408
    GePhos1

    		EGFR Apoptosis Cancer
    GePhos1, a EGFR-targeting PhosTAC (phosphorylation targeting chimera), induces EGFR dephosphorylation. GePhos1 induces apoptosis .
    GePhos1
  • HY-161098
    Apoptosis inducer 14

    		Apoptosis Cancer
    Apoptosis inducer 14 (Compd 7f), a chemotherapeutic agent, induces intrinsic and extrinsic apoptotic death mediated P53. Apoptosis inducer 14 exhibits IC50 values of 193.93 μg/mL, 6.76 μg/mL and 222.67 μg/mL in A549, HCT116 and HF84 cells, respectively .
    Apoptosis inducer 14
  • HY-N6573
    Bufarenogin

    		Apoptosis Bcl-2 Family Cancer
    Bufarenogin induces intrinsic apoptosis via Bax and ANT cooperation .
    Bufarenogin
  • HY-N1342
    Rocaglaol

    		Apoptosis Cancer
    Rocaglaol induces apoptosis and cell cycle arrest in LNCaP cells .
    Rocaglaol
  • HY-N6253R
    Pinoresinol (Standard)

    		Apoptosis Cancer
    Pinoresinol (Standard) is the analytical standard of Pinoresinol. This product is intended for research and analytical applications. Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .
    Pinoresinol (Standard)
  • HY-147889
    BBR-BODIPY

    		Apoptosis Caspase Bcl-2 Family Others
    BBR-BODIPY is a fluorescent probe that allows screening its interaction with the targeted cells. BBR-BODIPY induces apoptosis and changes the expression of apoptosis-related proteins .
    BBR-BODIPY
  • HY-129715
    MPI-0441138

    		Apoptosis Cancer
    MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death .
    MPI-0441138
  • HY-W011311
    Eicosapentaenoic acid methyl ester

    		Drug Metabolite Others Cancer
    Eicosapentaenoic acid methyl ester is a degradant of a monogalactosyl diacylglycerol (an anticancer compound by inducing apoptosis) .
    Eicosapentaenoic acid methyl ester
  • HY-118375
    Phenylbutyl isoselenocyanate

    ISC-4

    		 Apoptosis Cancer
    Phenylbutyl isoselenocyanate (ISC-4) is a selective apoptosis inducer that increases reactive oxygen species levels to inhibit androgen receptor (AR) and activate p53 pathway. Phenylbutyl isoselenocyanate induces apoptosis in LNCaP prostate cancer cells and has anti-prostate cancer properties.
    Phenylbutyl isoselenocyanate
  • HY-15098
    Apoptozole
    5+ Cited Publications

    apoptosis Activator VII

    		 HSP Apoptosis Cancer
    Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
    Apoptozole
  • HY-W011311S
    Eicosapentaenoic acid methyl ester-d5

    		Isotope-Labeled Compounds Apoptosis Others
    Eicosapentaenoic acid methyl ester-d5 is the deuterium labeled Eicosapentaenoic acid methyl ester. Eicosapentaenoic acid methyl ester is a degradant of a monogalactosyl diacylglycerol (an anticancer compound by inducing apoptosis)[1].
    Eicosapentaenoic acid methyl ester-d5

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