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Pathways Recommended:	Apoptosis

Results for "

Apoptosis Inducer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2701) SNIPERs (1) 5 alpha Reductase (1) 5-HT Receptor (9) Acyltransferase (3) ADC Antibody (2) ADC Cytotoxin (21) Adenosine Receptor (8) Adrenergic Receptor (16) Akt (106) Aldehyde Dehydrogenase (ALDH) (5) Aldose Reductase (1) Aminopeptidase (2) AMPK (22) Amyloid-β (12) Anaplastic lymphoma kinase (ALK) (15) Androgen Receptor (14) Angiotensin Receptor (6) Angiotensin-converting Enzyme (ACE) (4) Antibiotic (110) Antibody-Drug Conjugates (ADCs) (3) Antifolate (3) AP-1 (1) Arenavirus (3) Arginase (4) Arrestin (1) Aryl Hydrocarbon Receptor (5) ASCT (3) Atg8/LC3 (6) ATM/ATR (4) ATP Synthase (3) Aurora Kinase (11) Autophagy (347) Bacterial (170) Bcl-2 Family (130) BCL6 (3) Bcr-Abl (15) BCRP (1) Beclin1 (2) Beta-lactamase (1) Beta-secretase (3) Biochemical Assay Reagents (8) BMI1 (3) Btk (10) c-Fms (5) c-Kit (11) c-Met/HGFR (29) c-Myc (21) Calcium Channel (27) Calmodulin (1) CaMK (4) Cannabinoid Receptor (1) Carbonic Anhydrase (9) Casein Kinase (8) Caspase (172) CD47 (1) 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By Research Areas:	Cancer (2777) Cardiovascular Disease (145) Endocrinology (55) Infection (368) Inflammation/Immunology (507) Metabolic Disease (125) Neurological Disease (246)
Click Chemistry:	Azide (3) Alkynes (8)
Oligonucleotides:	Nucleosides and their Analogs (2) Nucleoside Phosphoramidites (1) CpG ODNs (3) Adjuvant (1) Phospholipids (1) Antisense Oligonucleotides (7) Cholesterol (1) Sweetening Agents (1)

3175

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

835

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101

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Apoptosis SNIPERs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-163893

Apoptosis inducer 23	Apoptosis	Cancer
Apoptosis inducer 23 (compound 6e) is an *apoptosis* inducer with antitumor activity. Apoptosis inducer 23 plays an important role in lung cancer research by inducing *apoptosis* through mitochondrial damage .

HY-161900

Apoptosis inducer 22	Apoptosis	Cancer
Apoptosis inducer 22 (QR-5) is an *apoptosis* inducer with IC₅₀ values of 63.1 and 46.5 μM for colon cancer cell lines SW480 and HT29, respectively. Apoptosis inducer 22 induces *apoptosis* by inhibiting the Wnt/β-catenin axis in colon cancer cells. Apoptosis inducer 22 can be used in anti-colon cancer research.

HY-163451

Apoptosis inducer 17	Apoptosis	Cancer
Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and *apoptosis* through activating JNK signaling pathway in lung cancer cells .

HY-146255

Apoptosis inducer 10	Apoptosis	Cancer
Apoptosis inducer 10 is a potent *apoptosis* inducer. Apoptosis inducer 10 shows antiproliferative effect. Apoptosis inducer 10 induces *apoptosis* in HeLa cancer cells via a mitochondria-dependent endogenous pathway .

HY-149222

Apoptosis inducer 12	Apoptosis	Cancer
Apoptosis inducer 12 (Compound 3z) is an *apoptosis* inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 12 can be used for the research of cancer .

HY-146029

Apoptosis inducer 3	Apoptosis	Cancer
Apoptosis inducer 3 (Compound 3) is an *apoptosis* inducer that selectively triggers apoptosis and late-apoptosis. Apoptosis inducer 3 shows cytotoxicity against cancer cells .

HY-147897

Apoptosis inducer 9	Apoptosis	Cancer
Apoptosis inducer 9 induces *apoptosis* with IC₅₀ value of 4.21 μM. Apoptosis inducer 9 induces apoptosis through the mitochondrial pathway and enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Apoptosis inducer 9 can be used the potential to develop new anti-proliferative agents .

HY-146092

Apoptosis inducer 4	Apoptosis	Cancer
Apoptosis inducer 4 (Compound 12b) is an *apoptosis* inducer with anticancer activities .

HY-149017

Apoptosis inducer 7	Apoptosis	Cancer
Apoptosis inducer 7 (Compound 5I) induces *apoptosis* in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity .

HY-149221

Apoptosis inducer 11	Apoptosis	Cancer
Apoptosis inducer 11 (compound 3u) induces *apoptosis* through the mitochondrial pathway. Apoptosis inducer 11 induces a block in G2/M, a strong decrease in S phase in non-Hodgkin lymphoma cell lines .

HY-163444

Apoptosis inducer 15	Apoptosis	Cancer
Apoptosis inducer 15 (Compound 3) induces cell *apoptosis* and cell cycle arrest at G2/M phase. Apoptosis inducer 15 is cytotoxicitic without causing DNA fragmentation .

HY-147865

Apoptosis inducer 8	Galectin Apoptosis	Cancer
Apoptosis inducer 8 (Compound 7c) is a galectin-1 (gal-1) mediated *apoptosis*-inducing agent against global major leading lung cancer burden. Apoptosis inducer 8 significantly reduced the gal-1 protein level. Apoptosis inducer 8 is also a PET imaging agent .

HY-161659

Apoptosis inducer 19	Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species	Cancer
Apoptosis inducer 19 (Compound 7g) is an *Apoptosis* inducer. Apoptosis inducer 19 elevates expression of pro-apoptotic proteins (Bax and caspase-3) and downregulates anti-apoptotic protein (Bcl-2). Apoptosis inducer 19 upregulates cellular reactive oxygen species (ROS) levels and disrupts mitochondrial membrane potential (MMP). Apoptosis inducer 19 can be used for triple-negative breast cancer (TNBC) research .

HY-155023

Apoptosis inducer 13	Apoptosis Reactive Oxygen Species	Cancer
Apoptosis inducer 13 (Compound Ru4) can induce cancer cell *apoptosis, and inhibits cancer cell migration and invasion. Apoptosis* inducer 13 converts coenzyme NADH to NAD ⁺, and increases intracellular ROS levels .

HY-169124

Apoptosis inducer 28	Apoptosis Reactive Oxygen Species Protease Activated Receptor (PAR) Bcl-2 Family	Cancer
Apoptosis Inducer 28 (Compound X1) is an apoptosis-inducing agent with anticancer activity in vitro. Apoptosis Inducer 28 can arrest the cell cycle at the G1 phase, promote cell death, and induce *apoptosis* by disrupting mitochondrial membrane potential. Apoptosis inducer 28 can also decrease the production of reactive oxygen species, downregulate the gene expression of BAX, Bcl-xL, and Bcl-2, while upregulating the gene expression of PAR-4 .

HY-168589

Apoptosis inducer 30	Apoptosis Cytochrome P450 Caspase	Cancer
Apoptosis inducer 30 (Compound 15a) is an anticancer agent. Apoptosis inducer 30 induces MCF-7 cells *apoptosis* through mitochondrial pathway. Apoptosis inducer 30 induces intracellular reactive oxygen species levels and decreases mitochondrial membrane potential, and blocks the cell cycle in the G0/G1 phase. Apoptosis inducer 30 inhibits cell growth, with an IC₅₀ value of 0.32 μM against MCF-7 cells, and inhibits tumor growth in a mouse model of breast cancer .

HY-147822

Apoptosis inducer 6	Apoptosis	Cancer
Apoptosis inducer 6 (compound 4e) is an anticancer agent with a broad-spectrum anticancer activity. Apoptosis inducer 6 triggers cell death through the induction of *apoptosis* .

HY-163924

Apoptosis inducer 25	Apoptosis	Cancer
Apoptosis inducer 25 (Compound 4H) inhibits the proliferation of cell BGC-823 with IC₅₀ of 0.37 μM. Apoptosis inducer 25 arrests cell cycle at G2/M phase, induces *apoptosis* in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 25 exhibits good pharmacokinetic properties in rats .

HY-163566

Apoptosis inducer 18	Apoptosis	Cancer
Apoptosis inducer 18, a potent inducer of apoptosis, shows significant cytotoxicity to the breast cancer cell line MCF-7 (IC₅₀=0.559 μM). Apoptosis inducer 18 inhibits cell cycle progression and promotes apoptosis by binding to DNA and causing damage, and by binding to the active site of CDK-2, interfering with its kinase activity. Apoptosis inducer 18 can be used in anti-breast cancer research .

HY-N10417

Apoptosis inducer 5	Apoptosis Autophagy	Cancer
Apoptosis inducer 5 (compound 1b) is a lignan enantiomer that can be found in Crataegus pinnatifida. Apoptosis inducer 5 exhibits cytotoxic effect via apoptosis and autophagy in Hep3B cells .

HY-162826

Apoptosis inducer 27	Apoptosis	Cancer
Apoptosis inducer 27 (compound 1c) is a potent inhibitor of MDA-MB-231 breast cancer (IC₅₀: 12.8 μM) and can induce early apoptosis in breast cancer cells. Apoptosis inducer 27 can bind to DNA molecules, Bax and Bcl-2 proteins, and induce DNA damage .

HY-163923

Apoptosis inducer 24	Apoptosis	Cancer
Apoptosis inducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with IC₅₀ of 1.2-4.8 μM. Apoptosis inducer 24 arrests cell cycle at G2/M phase, induces *apoptosis* in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 24 exhibits antitumor efficacy in mice, without significant toxicity (LD₅₀ is 91.2 mg/kg) .

HY-159096

Apoptosis inducer 21	Apoptosis	Cancer
Apoptosis inducer 21 (Compound 5h) inhibits the proliferation of lung cancer cell H69AR with an IC₅₀ of 1.58 μM. Apoptosis inducer 21 arrests the cell cycle at G0/G1 phase, induces *apoptosis* in H69AR .

HY-162819

Apoptosis inducer 26	Apoptosis	Cancer
Apoptosis inducer 26 (compound [AgCl(dap2SH)(PPh3)2]) is an autophagy inducer based on mononuclear Ag(I) ligands, with antibacterial and anticancer activities against a variety of bacterial strains and cancer cell lines. Apoptosis inducer 26 can effectively inhibit the growth of both Gram(+) and Gram(-) bacteria by causing the accumulation of Ag(I) ions in the bacterial periplasm. Apoptosis inducer 26 can intercalate between base pairs of CT DNA and induce apoptosis in A549 cells. Apoptosis inducer 26 also has the ability to scavenge free radicals, which can protect against oxidative stress .

HY-161473

Apoptosis inducer 16	Apoptosis	Cancer
Apoptosis inducer 16 (Compound 3) is a bivalent Smac mimic that can effectively bind to BIR2 and BIR3, and exhibits cancer cell (apoptosis) inducing activity .

HY-161098

Apoptosis inducer 14	Apoptosis	Cancer
Apoptosis inducer 14 (Compd 7f), a chemotherapeutic agent, induces intrinsic and extrinsic apoptotic death mediated P53. Apoptosis inducer 14 exhibits IC₅₀ values of 193.93 μg/mL, 6.76 μg/mL and 222.67 μg/mL in A549, HCT116 and HF84 cells, respectively .

HY-161814

Apoptosis inducer 20	Apoptosis	Metabolic Disease
Apoptosis inducer 20 (12) causes G2/M cell cycle arrest and induction of *apoptosis* via caspase 3/7 activation, which occurred during M arrest. Apoptosis inducer 20 is a novel indolic benzenesulfonamide with anti-proliferative effect against a broad panel of cancer cell lines, which is proming for research of new anti-mitotic agents .

HY-168122

Apoptosis inducer 29	Others	Cancer

HY-163889

*Ferroptosis/apoptosis* inducer-1**	Apoptosis Ferroptosis	Cancer
Ferroptosis/apoptosis inducer-1 (compound 4d) is a dual inducer of *apoptosis* and ferroptosis. Ferroptosis/apoptosis inducer-1 induces *apoptosis* and ferroptosis by reducing mitochondrial membrane potential and downregulating GPX4. Ferroptosis/apoptosis inducer-1 can significantly inhibit the proliferation and metastasis of triple-negative breast cancer (TNBC) both in vitro and in vivo, playing an important role in cancer research .

HY-P10057

cpm-1285	Apoptosis	Cancer
cpm-1285 induces *apoptosis* by functionally blocking intracellular Bcl-2 and related death antagonists. cpm-1285 shows strong binding potency to Bcl-2 with an IC₅₀ value of 130 nM. cpm-1285 reduces tumor burden in mice .

HY-W093067

KTX-582 intermediate-4	Others	Cancer
KTX-582 intermediate-4 (intermediate 2-1)is a synthesis IRAK4Degrading agent KTX-582 (HY-148274)of intermediates. KTX-582It is also an effective form of apoptosis (apoptosis)inducer .

HY-129407A

AAF-CMK	Ser/Thr Protease Apoptosis	Cancer
AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces *apoptosis*. AAF-CMK can be used in leukemia research .

HY-B2171

Carubicin Carminomycin; Carminomicin I	Apoptosis	Infection Cancer
Carubicin (Carminomycin) is a microbially-derived compound. Carubicin is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin also induces *apoptosis* by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin has the potential for the research of cancer diseases .

HY-121250

Fasnall	Fatty Acid Synthase (FASN) Apoptosis	Cancer
Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC₅₀ of 3.71 μM. Fasnall induces *apoptosis* in HER2 ⁺ breast cancer cell lines. Fasnall shows potent anti-tumor activities .

HY-N10354

27-Methyl withaferin A	Apoptosis	Cancer
27-Methyl withaferin A (comppund 26) is an *apoptosis* inducer with anticancer effects. 27-Methyl withaferin A shows antiproliferative effects against HeLa, A-549 and MCF-7 human tumor cell lines with IC₅₀ values of 3.2 μM, 4.2 μM and 1.4 μM, respectively .

HY-N2959

Brevilin A 4 Publications Verification	JAK STAT Apoptosis Autophagy	Cancer
Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC₅₀=?10.6 μM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce *apoptosis* and autophagy .

HY-122151

MPT0B002	Microtubule/Tubulin Apoptosis	Cancer
MPT0B002 is a potent microtubule inhibitor with anticancer activities. MPT0B002 disrupts tubulin polymerization, induces *apoptosis*, and arrests cell cycle at the G2/M phase .

HY-N10351

27-O-(tert-Butyldimethylsilyl)withaferin A	Apoptosis	Cancer
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an *apoptosis* inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .

HY-126856

HC-Toxin	HDAC Apoptosis	Cancer
HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC₅₀ of 30 nM . HC-Toxin induces tumor cell *apoptosis* and has anticancer effects .

HY-133618

Pomalidomide-C3-adavosertib	Wee1 PROTACs	Cancer
Pomalidomide-C3-adavosertib is a rapid and selective PROTAC Wee1 degrader (IC₅₀=3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces *apoptosis* .

HY-N2959R

Brevilin A (Standard)	JAK STAT Apoptosis Autophagy	Cancer
Brevilin A (Standard) is the analytical standard of Brevilin A. This product is intended for research and analytical applications. Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC₅₀= 10.6 μM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy .

HY-115928

M24	Bcl-2 Family	Cancer
M24 is a Mcl-1 selective inhibitor. M24 exhibits good binding affinity against Mcl-1 with K_i value of 0.33 μM. M24 exhibits good anti-proliferative activity and induce apoptosis in HepG2 cells .

HY-N12233

Condurango glycoside A	Apoptosis MDM-2/p53 Reactive Oxygen Species	Cancer
Condurango glycoside A is an activator of p53. Condurango glycoside A initiates ROS generation and up-regulates p53 expression. Condurango glycoside A induces *apoptosis* and pre-mature senescence associated with DNA damage in HeLa cells .

HY-W013032A

Oxamic acid sodium 5+ Cited Publications Sodium oxamate	Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce *apoptosis* .

HY-115902

FGFR4-IN-7	FGFR Apoptosis	Cancer
FGFR4-IN-7 (Compound C3) is a covalent reversible FGFR4 inhibitor with an IC₅₀ value of 0.42 μM. FGFR4-IN-7 induces *apoptosis* via the FGFR4 signaling pathway blockage. FGFR4-IN-7 can be used for the research of hepatocellular carcinoma (HCC) .

HY-137371

Lactonic sophorolipid	Bacterial Apoptosis Antibiotic	Infection Cancer
Lactonic sophorolipid is a natural antimicrobial surfactant for oral hygiene . Lactonic sophorolipid, a potential anticancer agent, induces *apoptosis* in human HepG2 cells through the caspase-3 pathway .

HY-151434

GLS1 Inhibitor-6	Glutaminase Apoptosis	Cancer
GLS1 Inhibitor-6 (Compound 24y) is an orally active, potent and selective glutaminase 1 (GLS1) inhibitor (IC₅₀=68 nM), shows 220-fold selectivity for GLS2. GLS1 Inhibitor-6 shows good anti-tumor activity, antitumor cell proliferation activity and induces *apoptosis* .

HY-158407

Anticancer agent 220	Apoptosis	Cancer
Anticancer agent 220 is a chromanone derivative with anticancer effects. Anticancer agent 220 shows highly potent activity in the colon cancer cell lines. Anticancer agent 220 induces *apoptosis* and cell cycle arrest in cells .

HY-146209

Tubulin polymerization-IN-13	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-13 (Compound 4f) is a tubulin polymerization inhibitor (IC₅₀=0.37 μM). Tubulin polymerization-IN-13 shows anti-proliferative activity against cancer cells, induces *apoptosis* and potential antivascular activity .

HY-N2460

Aloesin 1 Publications Verification Aloeresin	Tyrosinase Apoptosis	Infection Inflammation/Immunology Cancer
Aloesin (Aloeresin) is a tyrosinase inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2959

Brevilin A 4 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Euchresta horsfieldii (Lesch.) J. Benn. Source classification Plants Compositae Disease Research Fields Cancer	JAK STAT Apoptosis Autophagy
Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC₅₀=?10.6 μM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce *apoptosis* and autophagy .

HY-N12233

Condurango glycoside A	Apocynaceae Structural Classification Marsdenia cundurango Rchb.f. Polysaccharides Source classification Plants Saccharides	Apoptosis MDM-2/p53 Reactive Oxygen Species
Condurango glycoside A is an activator of p53. Condurango glycoside A initiates ROS generation and up-regulates p53 expression. Condurango glycoside A induces *apoptosis* and pre-mature senescence associated with DNA damage in HeLa cells .

HY-N2460

Aloesin 1 Publications Verification Aloeresin	Monophenols Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Aloe vera (L.) Burm. f. Plants Inflammation/Immunology Disease Research Fields	Tyrosinase Apoptosis
Aloesin (Aloeresin) is a tyrosinase inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research .

HY-N0452

Hyperoside 4 Publications Verification	Flavonols Structural Classification Flavonoids Classification of Application Fields Guttiferae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Hypericum monogynum L.	Influenza Virus Fungal NF-κB Apoptosis
Hyperoside is a NF-κB inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce *apoptosis* .

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	Classification of Application Fields Disease Research Fields Cancer	TNF Receptor
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of *TNF-like weak inducer* of apoptosis (TWEAK)*. TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces* tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-N10417

Apoptosis inducer 5	Monophenols Classification of Application Fields Source classification Lignans Rosaceae Phenols Phenylpropanoids Crataegus pinnatifida Bge. Plants Disease Research Fields Cancer	Apoptosis Autophagy
Apoptosis inducer 5 (compound 1b) is a lignan enantiomer that can be found in Crataegus pinnatifida. Apoptosis inducer 5 exhibits cytotoxic effect via apoptosis and autophagy in Hep3B cells .

HY-B2171

Carubicin Carminomycin; Carminomicin I	Infection Quinones Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Apoptosis
Carubicin (Carminomycin) is a microbially-derived compound. Carubicin is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin also induces *apoptosis* by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin has the potential for the research of cancer diseases .

HY-N10351

27-O-(tert-Butyldimethylsilyl)withaferin A	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Apoptosis
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an *apoptosis* inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .

HY-N2959R

Brevilin A (Standard)	Structural Classification Terpenoids Sesquiterpenes Euchresta horsfieldii (Lesch.) J. Benn. Source classification Plants Compositae	JAK STAT Apoptosis Autophagy
Brevilin A (Standard) is the analytical standard of Brevilin A. This product is intended for research and analytical applications. Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC₅₀= 10.6 μM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy .

HY-N0452R

Hyperoside (Standard)	Flavonols Structural Classification Flavonoids Guttiferae Source classification Phenols Polyphenols Plants Hypericum monogynum L.	Influenza Virus Fungal NF-κB Apoptosis
Hyperoside (Standard) is the analytical standard of Hyperoside. This product is intended for research and analytical applications. Hyperoside is a NF-κB inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis .

HY-N0214

Peimisine 2 Publications Verification Ebeiensine	Alkaloids Piperidine Alkaloids Structural Classification Liliaceae Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields Fritillaria cirrhosa	mAChR Angiotensin-converting Enzyme (ACE) Apoptosis
Peimisine (Ebeiensine) is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research .

HY-N0214A

Peimisine hydrochloride Ebeiensine hydrochloride	Alkaloids Piperidine Alkaloids Structural Classification Liliaceae Classification of Application Fields Source classification Fritillaria ussuriensis Maxim. Plants Inflammation/Immunology Disease Research Fields	mAChR Angiotensin-converting Enzyme (ACE) Apoptosis
Peimisine (Ebeiensine) hydrochloride is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine hydrochloride shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research .

HY-N6253

Pinoresinol (+)-Pinoresinol	Structural Classification other families Classification of Application Fields Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis
Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .

HY-N0780

Isoalantolactone 4 Publications Verification (+)-Isoalantolactone; Isohelenin	Structural Classification Classification of Application Fields Terpenoids Dalbergia velutina Benth. Sesquiterpenes Source classification Plants Compositae Endogenous metabolite Disease Research Fields Cancer	Apoptosis Autophagy Bacterial Endogenous Metabolite
Isoalantolactone is an *apoptosis* inducer, which also acts as an alkylating agent.

HY-N11067

Taccalonolide E	Structural Classification Source classification Plants Tacca chantrieri Andre Taccaceae Steroids	Apoptosis
Taccalonolide E is a microtubule stabilizer and induces cancer cell *apoptosis*.

HY-N6573

Bufarenogin	Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Apoptosis Bcl-2 Family
Bufarenogin induces intrinsic *apoptosis* via Bax and ANT cooperation .

HY-N1342

Rocaglaol	Structural Classification Natural Products Classification of Application Fields Source classification Aglaia odorata Lour. Plants Disease Research Fields Meliaceae Cancer	Apoptosis
Rocaglaol induces apoptosis and cell cycle arrest in LNCaP cells .

HY-N6253R

Pinoresinol (Standard)	Structural Classification other families Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants	Apoptosis
Pinoresinol (Standard) is the analytical standard of Pinoresinol. This product is intended for research and analytical applications. Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .

HY-W011311

Eicosapentaenoic acid methyl ester	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Balsaminaceae Other Diseases Plants Seeds of Impatiens balsamina L. Disease Research Fields Cancer	Others
Eicosapentaenoic acid methyl ester is a degradant of a monogalactosyl diacylglycerol (an anticancer compound by inducing apoptosis) .

HY-N2602

Sanggenol L	Structural Classification Flavonoids Classification of Application Fields Morus mongolica (Bur.) Schneid. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	MDM-2/p53
Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells . Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p

HY-N8659

Uzarin Uzarigenin 3-β-sophoroside	Structural Classification Polysaccharides Source classification Cucurbitaceae Plants Bolbostemma paniculatum (Maxim.) Franquet Saccharides Steroids	Others
Uzarin is a steroid glycoside. Uzarin does not inhibit cell proliferation or induce apoptosis .

HY-N4313

Eriosematin	Monophenols Classification of Application Fields Leguminosae Flemingia philippinensis Merr. et Rolfe Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Plants Disease Research Fields	Apoptosis
Eriosematin is a compound from the roots of Flemingia philippinensis with antiproliferative activity and *apoptosis*-inducing property .

HY-N0605

Ginsenoside Rh2 3 Publications Verification 20(S)-Ginsenoside Rh2; 20(S)-Rh2; Ginsenoside-Rh2	Panax ginseng C. A. Meyer Triterpenes Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	Caspase Apoptosis Endogenous Metabolite
Ginsenoside Rh2 induces the activation of caspase-8 and caspase-9. Ginsenoside Rh2 induces cancer cell *apoptosis* in a multi-path manner.

HY-N6882

Genistein 8-c-glucoside G8CG	Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	Mitochondrial Metabolism Apoptosis
Genistein 8-c-glucoside (G8CG) is a glucoside. Genistein 8-c-glucoside induces mitochondrial membrane depolarization and induces *apoptosis* .

HY-N0052C

Sanguinarine (gluconate) Sanguinarin (gluconate); Sanguinarium (gluconate); Pseudochelerythrine (gluconate)	Structural Classification Alkaloids Source classification Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Papaveraceae	Apoptosis Reactive Oxygen Species
Sanguinarine (Sanguinarin) gluconate, a benzophenanthridine alkaloid, can stimulate *apoptosis* via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB .

HY-N2184

Furanodienone 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Curcuma phaeocaulis Valeton Plants Disease Research Fields Zingiberaceae Cancer	EGFR Apoptosis
Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced *apoptosis* .

HY-N7000

Perillyl alcohol	Other Monoterpenes other families Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Perillyl alcohol, a monoterpene, is active in inducing *apoptosis* in tumor cells without affecting normal cells .

HY-N3415

Kumatakenin 1 Publications Verification	Flavonols Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Myrtaceae Plants Disease Research Fields Syzygium aromaticum Cancer	Apoptosis
Kumatakenin, a flavonoid that is isolated from cloves shows the effect of inducing *apoptosis* in ovarian cancer cells .

HY-N10449

Resistomycin	Microorganisms Source classification Phenols Polyphenols	Antibiotic Apoptosis Bacterial
Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis .

HY-N9271

Grifolin 1 Publications Verification	Structural Classification Microorganisms Source classification Phenols Polyphenols	Apoptosis
Grifolin is an antineoplastic agent can be isolated from the mushroom Albatrellus confluens and significantly induces *apoptosis* .

HY-137949

Formoxanthone A	Structural Classification Flavonoids Source classification Guttiferae Garcinia paucinervis Chun et How Plants Other Flavonoids	Apoptosis
Formoxanthone A is an *apoptosis* inducing compound that can significantly reduce the viability of HeLa cells at 25 μM .

HY-Y0152

Cinchonine 2 Publications Verification (8R,9S)-Cinchonine; LA40221	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields Cancer	Apoptosis Parasite Autophagy Caspase Calcium Channel
Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces *apoptosis* through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .

HY-N10313

Dehydrobruceine B	Structural Classification Natural Products Microorganisms Source classification	Bcl-2 Family Keap1-Nrf2 Apoptosis
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce *apoptosis* via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2 .

HY-P99934

Eftozanermin alfa ABBV-621	Classification of Application Fields Disease Research Fields Cancer	Apoptosis
Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces *apoptosis* in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .

HY-N13123

Tenacissoside C	Triterpenes Structural Classification Terpenoids Marsdenia tenacissima (Roxb.) Moon Source classification Asclepiadaceae Plants	Apoptosis
Tenacissoside C is an anti-cancer compound that inhibits angiogenesis. Tenacissoside C induces apoptosis in cancer cells by down-regulating the expression of anti-apoptotic factors and activating caspase-9 and caspase-3. Tenacissoside C also causes cell cycle arrest in cancer cells and induces apoptosis through the mitochondrial pathway.

HY-124261

Sampangine	Structural Classification Alkaloids Other Alkaloids Cananga odorata Source classification Plants Annonaceae	Apoptosis
Sampangine is an alkaloid that induces *apoptosis* by inducing cell cycle arrest in the G0/G1 phase. Sampangine can inhibit the biosynthesis of heme .

HY-130476

Satratoxin G	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Caspase Apoptosis
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase .

HY-N3268

Methyl pseudolarate A	Structural Classification Pinaceae Terpenoids Source classification Diterpenoids Pseudolarix amabilis (J. Nelson) Rehder Plants	Apoptosis
Methyl pseudolarate A is a diterpenoid compound that exerts its antitumor activity by inhibiting cell proliferation and inducing *apoptosis* .

HY-13518

Piceatannol 15+ Cited Publications Astringenin; trans-Piceatannol	Structural Classification Microorganisms Stilbenes Rheum palmatum L. Classification of Application Fields Polygonaceae Source classification Plants Disease Research Fields Cancer	Syk Autophagy Apoptosis Endogenous Metabolite
Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces *apoptosis* in DLBCL cell lines . Piceatannol induces autophagy and *apoptosis* in MOLT-4 human leukemia cells .

HY-B1971

Deltamethrin Decamethrin	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite Calcium Channel Caspase Apoptosis Bcl-2 Family NF-κB Interleukin Related
Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and *apoptosis* via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing *apoptosis*. Deltamethrin can be used extensively in pest control .

HY-N0878

Bufotalin 4 Publications Verification	Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Apoptosis Reactive Oxygen Species
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities. Bufotalin induces cancer cell *apoptosis* and also induces endoplasmic reticulum (ER) stress activation .

HY-N0052

Sanguinarine Sanguinarin; Sanguinarium; Pseudochelerythrine	Alkaloids Classification of Application Fields Source classification Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer	Apoptosis Autophagy
Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate *apoptosis* via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N0052A

Sanguinarine chloride 10+ Cited Publications Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride	Structural Classification Alkaloids Classification of Application Fields Pyridine Alkaloids Sanguinaria canadensis Plants Disease Research Fields Papaveraceae Cancer	Apoptosis Autophagy Bacterial Parasite
Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate *apoptosis* via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N0038

Alantolactone 5+ Cited Publications (+)-Alantolactone; Alant camphor; Inula camphor	Structural Classification other families Classification of Application Fields Terpenoids Dalbergia velutina Benth. Sesquiterpenes Source classification Plants Compositae Disease Research Fields Cancer	STAT Apoptosis TGF-beta/Smad
Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone induces apoptosis in cancer .

HY-113332

Myristoleic acid	Structural Classification Serenoa repens Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Animals Ketones, Aldehydes, Acids Palmae Inflammation/Immunology Disease Research Fields	Apoptosis Endogenous Metabolite
Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells .

HY-N8190

6-Hydroxykaempferol 3-O-β-D-glucoside 6-Hydroxykaempferol 3-glucoside	Flavonols Structural Classification Flavonoids Classification of Application Fields Carthamus tinctorius L. Source classification Phenols Polyphenols Plants Compositae Disease Research Fields Cancer	Apoptosis
6-Hydroxykaempferol 3-O-β-D-glucoside possesses anticancer activity and induces apoptosis .

HY-N10424

Brazilein	Structural Classification Classification of Application Fields Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Pigments Plants Inflammation/Immunology Disease Research Fields Food Research	Apoptosis
Brazilein is an important immunosuppressive component isolated from Caesalpinia sappan L. Brazilein induces *apoptosis* in mice spleen lymphocytes .

HY-N11110

Inuviscolide	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Erythrina arborescens Roxb.	Apoptosis
Inuviscolide is an *apoptosis* inducer. Inuviscolide can induce of G₂/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities .

HY-N0907

Ginsenoside Rg6	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	NF-κB Apoptosis
Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits *apoptosis*-inducing effect.

HY-N3883

Euxanthone	Structural Classification Flavonoids Garcinia oblongifolia Champ. ex Benth. Source classification Guttiferae Plants Other Flavonoids	Autophagy
Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities .

Cat. No.	Product Name	Chemical Structure

HY-N2334S

Glycochenodeoxycholic acid-d4
Glycochenodeoxycholic acid-d₄ is the deuterium labeled Glycochenodeoxycholic acid. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis[1][2].

HY-W011311S

Eicosapentaenoic acid methyl ester-d5
Eicosapentaenoic acid methyl ester-d₅ is the deuterium labeled Eicosapentaenoic acid methyl ester. Eicosapentaenoic acid methyl ester is a degradant of a monogalactosyl diacylglycerol (an anticancer compound by inducing apoptosis)[1].

HY-B0835S

Fenobucarb-d3
Fenobucarb-d₃ is the deuterium labeled Fenobucarb. Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis[1].

HY-B0849S1

Azoxystrobin-d3
Azoxystrobin-d₃ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis[1].

HY-13570S

Betamethasone-d5
Betamethasone-d₅ is the deuterium labeled Betamethasone. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].

HY-13570S1

Betamethasone-d5-1
Betamethasone-d₅-1 is deuterium labeled Betamethasone. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].

HY-N2334AS

Glycochenodeoxycholic acid-d7 sodium

Glycochenodeoxycholic acid-d₇ (sodium) is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].

HY-10999S

Trametinib-d4
Trametinib-d₄ is the deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

HY-10999S1

Trametinib-13C6
Trametinib- ¹³C₆ is the ¹³C-labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

HY-10999S2

Trametinib-13C,d3
Trametinib- ¹³C,d₃ is the ¹³C- and deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

HY-B0849S

Azoxystrobin-d4
Azoxystrobin-d₄ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

HY-B0075S2

Melatonin-d7

Melatonin-d₇ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].

HY-B0075S1

Melatonin-d3

Melatonin-d₃ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].

HY-N6746S1

Citrinin-13C13

Citrinin- ¹³C₁₃ (NSC 186- ¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-116852S

Thiocolchicine-d3

Thiocolchicine-d₃ is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis[1][2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.

HY-N1429S

Taurochenodeoxycholic acid-d9 sodium
Taurochenodeoxycholic acid-d₉ (sodium) is the deuterium labeled Taurochenodeoxycholic acid sodium. Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].

HY-N1429S1

Taurochenodeoxycholic acid-d5 sodium
Taurochenodeoxycholic acid-d₅ (sodium) is the deuterium labeled Taurochenodeoxycholic acid sodium. Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].

HY-N2027S

Taurochenodeoxycholic acid-d4 sodium
Taurochenodeoxycholic acid-d₄ (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].

HY-B0116S

Stavudine-d4
Stavudine-d₄ is the deuterium labeled Stavudine. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4].

HY-N0168AS

(Rac)-Hesperetin-d3
(Rac)-Hesperetin-d₃ is the deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N1429S2

Taurochenodeoxycholic acid-d4-1 sodium
Taurochenodeoxycholic acid-d₄-1 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].

HY-W012998S2

2,3-Pentanedione-d3
2,3-Pentanedione-d₃ is deuterated labeled Eugenol acetate (HY-W014612). Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .

HY-17371S

Oxaliplatin-d10
Oxaliplatin-d₁₀ is a deuterium labeled Oxaliplatin (HY-17371). Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research .

HY-N7364S

(E)-β-Farnesene-d6
(E)-β-Farnesene-d₆ is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-N7436S

Methyl propyl disulfide-d3
Methyl propyl disulfide-d₃ is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-15306S

Eltrombopag-13C4

1 Publications Verification

Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .}

HY-19542S

Ceramide C6-d7
Ceramide C6-d₇ is the deuterium labeled Ceramide C6. Ceramide C6, a Ceramide pathway activator, is an exogenous short-chain ceramide which can induce apoptosis of multiple cancer cells[1][2][3].

HY-B2054S

Tebufenozide-d9
Tebufenozide-d₉ is the deuterium labeled Tebufenozide[1]. Tebufenozide is a nonsteroidal ecdysone agonist used to control pest. Tebufenozide has cytotoxic and induces apoptosis in HeLa and insect Tn5B1-4 cells[2][3].

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

HY-N0168AS1

(Rac)-Hesperetin-13C,d3
(Rac)-Hesperetin- ¹³C,d₃ is the ¹³C- and deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-50936S

Trabectedin-d3

Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .

HY-13757AS1

Tamoxifen-d3

Tamoxifen-d₃ is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].

HY-131503S

13-Methyltetradecanoic acid-d6
13-Methyltetradecanoic acid-d6 is a deuterated labeled 13-Methyltetradecanoic acid . 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces *apoptosis* in many types of human cancer cells .

HY-B0114S1

Oxcarbazepine-d4-1
Oxcarbazepine-d₄-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

HY-13629S1

Etoposide-13C,d3
Etoposide- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoposide. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy[1].

HY-B0114S2

Oxcarbazepine-d8-1
Oxcarbazepine-d8-1 is a deuterium of Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Oxcarbazepine-d8-1 has anti-cancer and anticonvulsant effects .

HY-13629S

Etoposide-d3
Etoposide-d3 (VP-16-d3) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, *apoptosis* and autophagy .

HY-100490S

Rilmenidine-d4

Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].

HY-B0075S

Melatonin-d4
Melatonin-d₄ is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].

HY-10224S

Panobinostat-d4

Panobinostat-d₄ is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-10224S1

Panobinostat-d4 hydrochloride

Panobinostat-d₄ (hydrochloride) is deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-12678S

Entrectinib-d4

Entrectinib-d4 (NMS-E628-d4; RXDX-101-d4) is the deuterium labeled Entrectinib (HY-12678). Entrectinib is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC₅₀ values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice .

HY-B0114S

Oxcarbazepine-D4
Oxcarbazepine-d₄ (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

HY-10218S

Everolimus-d4
Everolimus-d₄ is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities[1][2].

HY-B0256S

Azathioprine-d3
Azathioprine-d3 (BW 57-322-d3) is the deuterium labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .

HY-B0215S

Acetylcysteine-d3

Acetylcysteine-d₃ is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-B0294S

Flubendazole-d3
Flubendazole-d₃ is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic agent, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle[1][2].

HY-B0656S

Rabeprazole-d4

Rabeprazole-d₄ is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

HY-16322S

Minodronic acid-d4
Minodronic acid-d₄ is deuterium labeled Minodronic acid. Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2].

HY-132334S

9-cis-Retinoic acid-d5
9-cis-Retinoic acid-d₅ is the deuterium labeled 9-cis-Retinoic acid. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities[1][2][3][4][5][6].

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