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C57Bl/6N mouse

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (8) 5 alpha Reductase (1) 5-HT Receptor (12) Acyltransferase (5) ADC Antibody (1) ADC Cytotoxin (3) ADC Linker (2) Adenosine Receptor (13) Adenylate Cyclase (2) Adiponectin Receptor (2) Adrenergic Receptor (17) Akt (11) Aldehyde Dehydrogenase (ALDH) (2) Amino Acid Derivatives (10) Aminoacyl-tRNA Synthetase (1) Aminopeptidase (2) AMPK (9) Amylin Receptor (1) Amyloid-β (11) Anaplastic lymphoma kinase (ALK) (4) Androgen Receptor (10) Angiotensin Receptor (3) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (33) AP-1 (1) Apelin Receptor (APJ) (4) Apical Sodium-Dependent Bile Acid Transporter (3) Apoptosis (155) Aquaporin (1) Arrestin (1) Aryl Hydrocarbon Receptor (4) Atg8/LC3 (5) ATP Synthase (1) ATTECs (2) Autophagy (52) Bacterial (76) Bcl-2 Family (9) BCL6 (1) Bcr-Abl (2) Beta-lactamase (2) Beta-secretase (7) Biochemical Assay Reagents (30) BMX Kinase (1) Bombesin Receptor (2) Bradykinin Receptor (4) BRK (1) Btk (10) c-Fms (5) c-Kit (1) c-Met/HGFR (8) c-Myc (3) 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EBI2/GPR183 (3) EBV (2) EGFR (17) Elastase (2) ELOVL (1) Endogenous Metabolite (89) Endothelin Receptor (4) Ephrin Receptor (1) Epigenetic Reader Domain (11) Epoxide Hydrolase (8) ERK (15) Estrogen Receptor/ERR (15) Eukaryotic Initiation Factor (eIF) (1) FAAH (4) FABP (2) Factor Xa (2) FAK (6) FAP (1) Farnesyl Transferase (1) Fat Mass and Obesity-associated Protein (FTO) (2) FATP (1) Fatty Acid Synthase (FASN) (4) Ferroptosis (13) FGFR (5) Filovirus (1) FLAP (2) Flavivirus (9) FLT3 (5) Fluorescent Dye (11) Formyl Peptide Receptor (FPR) (1) FOXO (1) Free Fatty Acid Receptor (4) Fungal (19) FXR (4) G protein-coupled Bile Acid Receptor 1 (1) G-quadruplex (1) GABA Receptor (13) Galectin (3) GCGR (3) GLP Receptor (6) Glucocorticoid Receptor (6) Glucokinase (2) Glucosidase (3) Glucosylceramide Synthase (GCS) (2) GLUT (1) Glutaminase (4) Glutathione Peroxidase (2) Glycosyltransferase (1) GlyT (2) GnRH Receptor (3) GPR109A (1) GPR119 (3) GPR139 (1) GPR171 (1) GPR52 (1) GPR84 (1) GSK-3 (10) 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Lineage Kinase (3) MMP (16) MNK (2) Molecular Glues (1) Monoamine Oxidase (14) Monoamine Transporter (1) mTOR (8) N-myristoyltransferase (1) nAChR (1) NADPH Oxidase (1) NAMPT (2) Necroptosis (4) NEKs (2) Neprilysin (3) Neurokinin Receptor (2) Neuropeptide Y Receptor (18) Neurotensin Receptor (5) NF-κB (30) NO Synthase (10) NOD-like Receptor (NLR) (19) Notch (3) Nuclear Factor of activated T Cells (NFAT) (2) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (36) Opioid Receptor (10) Orexin Receptor (OX Receptor) (12) Organoid (6) Oxytocin Receptor (3) P-glycoprotein (1) P2X Receptor (6) P2Y Receptor (5) p38 MAPK (14) p62 (3) PACAP Receptor (1) PAI-1 (1) PAK (3) Parasite (35) PARP (12) PCSK9 (3) PD-1/PD-L1 (18) PDGFR (2) PDHK (1) PDI (1) PDK-1 (1) PGE synthase (3) Phosphatase (15) Phosphodiesterase (PDE) (12) Phospholipase (3) PI3K (11) PI4K (2) Piezo Channel (1) Pim (3) PIN1 (1) PINK1/Parkin (2) PKA (3) PKC (6) PKD (2) Platelet-activating Factor Receptor (PAFR) (1) Polo-like Kinase (PLK) (2) Poly(ADP-ribose) Glycohydrolase (PARG) (1) Porcupine (1) Potassium Channel (17) PPAR (16) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (18) PROTAC Linkers (9) PROTACs (22) Protease Activated Receptor (PAR) (4) Proteasome (1) Protein Arginine Deiminase (3) PTHR (3) Pyk2 (2) Pyroptosis (4) Pyruvate Kinase (2) RABV (1) RAD51 (2) Radionuclide-Drug Conjugates (RDCs) (2) Raf (8) RANKL/RANK (1) RAR/RXR (3) Ras (12) Reactive Oxygen Species (26) RET (4) REV-ERB (1) Reverse Transcriptase (4) RGS Protein (1) Ribosomal S6 Kinase (RSK) (2) RIP kinase (6) ROCK (3) ROR (11) ROS Kinase (4) RSV (3) Salt-inducible Kinase (SIK) (1) SARS-CoV (12) Ser/Thr Protease (2) Serotonin Transporter (1) SGLT (5) SHMT (1) SHP2 (3) Sialyltransferase (1) Sigma Receptor (2) Sirtuin (7) Small Interfering RNA (siRNA) (705) Smo (5) SOD (2) Sodium Channel (8) Somatostatin Receptor (10) Src (6) SRPK (1) STAT (15) Stearoyl-CoA Desaturase (SCD) (4) Steroid Sulfatase (1) STING (11) Survivin (2) Syk (2) TAM Receptor (4) Taste Receptor (1) Tau Protein (5) Telomerase (1) TGF-beta/Smad (6) Thrombin (1) Thymidylate Synthase (1) Thyroid Hormone Receptor (4) Tie (1) Tim3 (1) TNF Receptor (24) Toll-like Receptor (TLR) (28) Topoisomerase (5) Trace Amine-associated Receptor (TAAR) (3) Trk Receptor (4) TRP Channel (12) TrxR (1) Tyrosinase (3) URAT1 (2) Urea Transporter (2) Urotensin Receptor (5) Vasopressin Receptor (4) VD/VDR (1) VDAC (1) VEGFR (7) Virus Protease (8) Wnt (14) Xanthine Oxidase (2) YAP (8) α-synuclein (4) β-catenin (8) γ-secretase (2)
By Research Areas:	Cancer (705) Cardiovascular Disease (127) Endocrinology (74) Infection (217) Inflammation/Immunology (487) Metabolic Disease (255) Neurological Disease (366)
Click Chemistry:	TCO (1) PROTAC Synthesis (3) Azide (4) Alkynes (6)
Oligonucleotides:	miRNA mimics (1) Nucleosides and their Analogs (26) Decoy ODNs (1) miRNA antagomirs (1) Nucleoside Phosphoramidites (1) mRNA (2) Phospholipids (1) miRNA inhibitors (1) Antisense Oligonucleotides (5) siRNAs (703) miRNA agomirs (1) MicroRNAs (4) Aptamers (4) Pre-designed siRNA Sets (696) CpG ODNs (1) Cationic Lipids (3)

2541

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

256

Peptides

MCE Kits

404

Inhibitory Antibodies

208

Natural
Products

2051

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

751

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117427

D5D-IN-326	Others	Metabolic Disease
D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor, with IC₅₀s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity. D5D-IN-326 reduces insulin resistance and decreases body weight in diet-induced obese C57BL/6J mice .

HY-160025

IDO antagonist-1	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO antagonist-1 (compound 163) is an antagonist of IDO . IDO antagonist-1 inhibits pancreatic adenocarcinoma cells growth in C57BL/6 mice .

HY-128435

2,4'-Dihydroxybenzophenone-1	Others	Metabolic Disease
2,4'-Dihydroxybenzophenone ((Z)-SU4312) exhibited estrogenic activities. 2,4'-Dihydroxybenzophenone has oral bioactivity that can effectively protect C57BL/6J mice from Acetaminophen (HY-66005, APAP)-induced hepatotoxicity .

HY-120958

Nisinic acid C24:6N-3	Others	Metabolic Disease
Nisinic acid (C24:6n-3) is a very long chain polyunsaturated fatty acid (VLCPUFA) that is a component of triglycerides and cholesterol esters in mouse and rat testis .

HY-157429

25N-N1-Nap	5-HT Receptor	Neurological Disease
25N-N1-Nap (compound 16) is a β-arrestin-biased 5-HT2A agonist. 25N-N1-Nap antagonizes phencyclidine induced hyperactivity in Male C57BL/6 J mice .

HY-144743

ATX inhibitor 12	Phosphodiesterase (PDE)	Others
ATX inhibitor 12 (compound 20) is an orally active and potent ATX (autotaxin) inhibitor, with an IC₅₀ of 1.72 nM. ATX inhibitor 12 effectively alleviates lung structural damage with fewer fibrotic lesions at an oral dose of 60 mg/kg in C57Bl/6J mice. ATX inhibitor 12 can be uesd for idiopathic pulmonary fibrosis (IPF) research .

HY-168081

PD-1/PD-L1-IN-52	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN-52 (Compound III-5) is an orally active PD-1/PD-L1 inhibitor that blocks the interaction between PD-1 and PD-L1, with an IC₅₀ of 109.9 nM. PD-1/PD-L1-IN-52 exhibits antitumor activity in a C57BL/6 mouse xenograft model implanted with human PD-1-expressing MC38 colon cancer cells, with a TGI of 49.6% .

HY-101930B

(R)-BMS-816336	11β-HSD	Metabolic Disease
(R)-BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor of human, *mouse* and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC₅₀s of 14.5 nM, 50.3 nM and 16 nM, respectively .

HY-146756

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin	Bacterial	Infection
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) is an antibacterial pleuromutilin derivative against Gram-positive pathogens (GPPs) and Mycoplasma pneumoniae .

HY-101930A

(Rac)-BMS-816336	11β-HSD	Metabolic Disease
(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent inhibitor of human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC₅₀s of 10 nM and 68 nM, respectively. (Rac)-BMS-816336 has good metabolic stability .

HY-155676

eIF4E-IN-5	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation .

HY-155140

BChE-IN-17	Cholinesterase (ChE)	Neurological Disease
BChE-IN-17 (compound 6n) is a potent and selective BChE inhibitor with IC₅₀s of 10.5 nM and 32.5 nM for eqBChE and hBChE, respectively. BChE-IN-17 shows over 1000-fold selectivity to BChE against AChE. BChE-IN-17 shows low neurotoxicity and moderate neuroprotective effects .

HY-147105

LRH-1 modulator-1	Others	Inflammation/Immunology
LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 shows anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces anti-inflammatory cytokine IL-10, and reduces inflammatory cytokine IL-1b and TNFa .

HY-137985

Mer-NF5003F Stachybotrydial; F 1839M; Stachybotrydial	HSV	Infection
Mer-NF5003F is a sesquiterpene originally isolated from Stachybotrys with diverse biological activities. It inhibits avian myeloblastosis virus (AMV) protease (IC₅₀=7.8 μM).1 Mer-NF5003F inhibits sialyltransferase 6N (ST6N), ST3O, and ST3N (IC₅₀s=0.61, 6.7, and 10 μg/mL, respectively), as well as fucosyltransferase (IC₅₀=11.3 μg/mL). It is active against herpes simplex virus 1 (HSV-1) in vitro (IC₅₀=4.32 μg/mL).3 Mer-NF5003F is also active against the multidrug-resistant P. falciparum strain K1 (IC₅₀=0.85 μg/mL).

HY-101984

N6,N6-Dimethyladenosine 2 Publications Verification	Nucleoside Antimetabolite/Analog	Inflammation/Immunology
N6,N6-Dimethyladenosine is a modified ribonucleoside previously found in rRNA, and also exhibits in mycobacterium bovis Bacille Calmette-Guérin tRNA .

HY-W131303

6-N-Hydroxylaminopurine	Others	Others
6-N-Hydroxylaminopurine is a base analog and has mutagenic activity .

HY-130183

Propargyl-PEG6-N3	PROTAC Linkers	Cancer
Propargyl-PEG6-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-PEG6-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W040113

6-(N-Boc)caproic acid NHS	Others	Others
6-(N-Boc)caproic acid NHS is a protein cross-linking agent.

HY-W698776

6-N-Biotinylaminohexanol	Biochemical Assay Reagents	Others
6-N-Biotinylaminohexanol is a biotinylated biochemical assay reagent that can be used as a biological material or organic compound for life science related research .

HY-W143136

6-(N-Trifluoroacetyl)caproic acid NHS TCFS	Biochemical Assay Reagents	Others
6-(N-Trifluoroacetyl)caproic acid NHS (TCFS) is a biochemical reagent.

HY-152357

N6,N6-Dimethyl-xylo-adenosine	Nucleoside Antimetabolite/Analog	Cancer
N6,N6-Dimethyl-xylo-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .

HY-N10626

*Neu5Gcα(2-6) N-Glycan*	Others	Others
Neu5Gcα(2-6) N-Glycan is an glycan. Neu5Gcα(2-6) N-Glycan can be used for the various biochemical studies .

HY-W739517

6-N-Biotinylaminohexyl hydrogenphosphonate	Biochemical Assay Reagents	Others
6-N-Biotinylaminohexyl hydrogenphosphonate is a biotinylated biochemical assay reagent that can be used as a biological material or organic compound for life science related research .

HY-148392

*Neu5Gcα(2-6) N-Glycan-Asn*	Others	Others
Neu5Gcα(2-6) N-Glycan-Asn is a glycopeptide. Neu5Gcα(2-6) N-Glycan-Asn can be used for various biochemical studies .

HY-152633

3’-Deoxy-N6,N6-dimethyladenosine	Nucleoside Antimetabolite/Analog	Cancer
3’-Deoxy-N6,N6-dimethyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-152311

2-Chloro-N6,N6-dimethyladenosine	Nucleoside Antimetabolite/Analog	Cancer
2-Chloro-N6,N6-dimethyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-152619

N6,N6-Dimethyl-4’-thio-adenosine	Nucleoside Antimetabolite/Analog	Cancer
N6,N6-Dimethyl-4’-thio-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-152490

3’-β-C-Ethynyl-N6,N6-dimethyladenosine	Nucleoside Antimetabolite/Analog	Cancer
3’-β-C-Ethynyl-N6,N6-dimethyladenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) . 3’-β-C-Ethynyl-N6,N6-dimethyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-152319

3’-Azido-3’-deoxy-N6,N6-dimethyladenosine	Nucleoside Antimetabolite/Analog	Others
3’-Azido-3’-deoxy-N6,N6-dimethyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc . 3’-Azido-3’-deoxy-N6,N6-dimethyladenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-N10628

*Neu5Acα(2-6) N-Glycan*	Others	Others
Neu5Acα(2-6) N-Glycan is a N-Glycan, and can be used for labeling and modification of proteins.

HY-152374

3’-Deoxy-3’-fluoro-N6,N6-dimethyladenosine	Nucleoside Antimetabolite/Analog	Others
3’-Deoxy-3’-fluoro-N6,N6-dimethyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-152392

2’-Fluoro-2’-deoxy-N6,N6-dimethylarabinoadenosine	Nucleoside Antimetabolite/Analog	Others
2’-Fluoro-2’-deoxy-N6,N6-dimethylarabinoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-P990110

*Lecanemab (Mouse* IGG2a)**	Amyloid-β	Neurological Disease
Lecanemab (Mouse IGG2a) is a monoclonal antibody that targets soluble β-amyloid and has the potential to reduce cognitive decline. The variable region of Lecanemab (Mouse IGG2a) is consistent with that of Lecanemab, while the constant region is of Mouse IGG2a sequence. Lecanemab (Mouse IGG2a) holds promise for research in the field of Alzheimer's disease .

HY-P10399

KGYY15 mouse KGYY15; KGYY15 peptide	TNF Receptor	Metabolic Disease
KGYY15 (Mouse KGYY15) is a CD40 targeting peptide, which weakly inhibits the CD40-CD40L interaction with IC₅₀ of more than 1mM. KGYY15 activates 33% NF-κB pathway at 100 μM .

HY-P99132

*Anti-Mouse* CTLA-4 Antibody (9D9)**	CTLA-4	Inflammation/Immunology
Anti-Mouse CTLA-4 Antibody is an anti-mouse CTLA-4 IgG2b antibody inhibitor derived from host mouse.

HY-152423

3’-Deoxy-3’-α-C-methyl-N6,N6-dimethyladenosine	Nucleoside Antimetabolite/Analog	Others
3’-Deoxy-3’-α-C-methyl-N6,N6-dimethyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-141009

N-(Mal-PEG6)-N-bis(PEG7-TCO)	PROTAC Linkers	Cancer
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-(Mal-PEG6)-N-bis(PEG7-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-152620

2-(N,N-Dimethylamino)-N6,N6-dimethyladenosine	Nucleoside Antimetabolite/Analog	Cancer
2-(N,N-Dimethylamino)-N6,N6-dimethyladenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .

HY-152365

N6,N6-Dimethyl-2’-β-C-methyladenosine	Nucleoside Antimetabolite/Analog	Others
N6,N6-Dimethyl-2’-β-C-methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .

HY-154265

2-Amino-2’-deoxy-N6,N6-dimethyl-2’-adenosine	Nucleoside Antimetabolite/Analog	Cancer
2-Amino-2’-deoxy-N6,N6-dimethyl-2’-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-P2847

Urocortin II, mouse	CRFR	Metabolic Disease Endocrinology
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca ²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow .

HY-140248

N-(Mal-PEG6)-N-bis(PEG3-amine)	PROTAC Linkers	Cancer
N-(Mal-PEG6)-N-bis(PEG3-amine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-P99133

*Anti-Mouse* Fas Ligand Antibody (MFL3)**	Fatty Acid Synthase (FASN)	Inflammation/Immunology
Anti-Mouse Fas Ligand Antibody is an anti-mouse Fas Ligand IgG antibody inhibitor derived from host Armenian Hamster.

HY-P99136

*Anti-Mouse* IFN gamma Antibody (H22)**	IFNAR	Inflammation/Immunology
Anti-Mouse IFN gamma Antibody is an anti-mouse IFN gamma IgG antibody inhibitor derived from host Armenian Hamster.

HY-P99123

*Anti-Mouse* CD28 Antibody (37.51)**	CD28	Inflammation/Immunology
Anti-Mouse CD28 Antibody is an anti-mouse CD28 IgG antibody inhibitor derived from the host Syrian Hamster.

HY-P99144

*Anti-Mouse* PD-1 Antibody (RMP1-14)** 4 Publications Verification	PD-1/PD-L1	Inflammation/Immunology
Anti-Mouse PD-1 Antibody is an anti-mouse PD-1 IgG2a antibody inhibitor.

HY-P99976

*Anti-Mouse* CD19 Antibody (1D3)**	CD19	Cancer
Anti-Mouse CD19 Antibody (1D3) is an anti-mouse CD19 IgG2a antibody inhibitor.

HY-P99999

*Anti-Mouse* CD4 Antibody (YTS 191)**	HIV	Infection
Anti-Mouse CD4 Antibody (YTS 191) is anti-mouse CD4 IgG2b antibody inhibitor derived from host Rat.

HY-152376

N6,N6-Dimethyl-3’-beta-C-methyl-adenosine	Nucleoside Antimetabolite/Analog	Others
N6,N6-Dimethyl-3’-beta-C-methyl- adenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .

HY-152750

2-Amino-N6,N6-dimethyl-2’-O-methyladenosine	Nucleoside Antimetabolite/Analog	Others
2-Amino-N6,N6-dimethyl-2’-O-methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-101984

N6,N6-Dimethyladenosine 2 Publications Verification	Microorganisms Source classification	Nucleoside Antimetabolite/Analog
N6,N6-Dimethyladenosine is a modified ribonucleoside previously found in rRNA, and also exhibits in mycobacterium bovis Bacille Calmette-Guérin tRNA .

HY-P1067

*Enterostatin(human,mouse,rat)*	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake.

HY-17563

2'-Deoxyguanosine 4 Publications Verification Deoxyguanosine; Guanine deoxyriboside	Structural Classification Natural Products Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Classification of Application Fields Source classification Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells .

HY-N7844

N6-Benzyladenosine Benzyladenosine	Natural Products Classification of Application Fields Eupatorium buniifolium Hook. & Arn. Source classification Umbelliferae Plants Phytohormone Inflammation/Immunology Disease Research Fields Cytokinin Cancer Agricultural Research	Apoptosis Adenosine Receptor
N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma ^- .

HY-N0086

N6-Methyladenosine 5 Publications Verification 6-Methyladenosine; N-Methyladenosine	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Influenza Virus Endogenous Metabolite
N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-N0160

Kinetin 5 Publications Verification 6-Furfuryladenine; N6-Furfuryladenine	Structural Classification Natural Products other families Neurological Disease Classification of Application Fields Source classification Plants Phytohormone Disease Research Fields Cytokinin Agricultural Research	SOD
Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects .

HY-141465

3-Hydroxybutyryl-CoA	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
3-Hydroxybutyryl-CoA is a metabolite which can be found in mouse or E.coli, et al. 3-Hydroxybutyryl-CoA has a 3-hydroxybutanoyl as the S-acyl component, and is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan .

HY-W587489

RL-603	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite
RL-603 is the metabolite of Anagrelide (HY-B0523). RL-603 exhibits platelet-lowering activity in mouse model .

HY-N12122

Dehydropipernonaline	Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants Piper retrofractum Vahl	Fungal
Dehydropipernonaline (Compound 24) is an amide compound. Dehydropipernonaline shows considerable cytotoxicity to L5178Y mouse lymphoma cells (IC₅₀8.9μM). Dehydropipernonaline can be used for screening antifungal and cytotoxicity .

HY-N0086R

N6-Methyladenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Influenza Virus Endogenous Metabolite
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

HY-N7922

Urolithin M5 Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Source classification Phenols Polyphenols Plants Burseraceae	Influenza Virus
Urolithin M5 is a neuraminidase inhibitor that can be isolated from Ganlanye. Urolithin M5 has antiviral activity in vitro and in vivo by inhibiting the activity of viral NA. Urolithin M5 can increase the survival rate and improve pulmonary edema in pr8-infected mouse models. Urolithin M5 can be used in anti-influenza research .

HY-114585

Sperabillin A	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Sperabillin A is an antibacterial agent against gram-positive and gram-negative bacteria. Sperabillin A shows strong inhibition of human umbilical vein endothelial (HUVE) cell proliferation. Sperabillin A also shows anti-tumor acfivity against B16 melanoma in mouse .

HY-116887

N6-Methyladenine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication .

HY-W011209

N6-Isopentenyladenosine 1 Publications Verification Riboprine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Autophagy Endogenous Metabolite
N6-Isopentenyladenosine (Riboprine), an RNA modification found in cytokinins, which regulate plant growth/differentiation, and a subset of tRNAs, where it improves the efficiency and accuracy of translation. N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with an interesting anti-melanoma activity .

HY-121152

Chiisanoside	Eleutherococcus henryi var. faberi (Harms) S. Y. Hu Triterpenes Structural Classification Terpenoids Source classification Plants Araliaceae	α-synuclein Apoptosis GABA Receptor Dopamine Receptor
Chiisanoside exhibits neuroprotective, anticancer, antidepressant, anti-inflammatory, anti-obesity and anti-platelet activities. Chiisanoside inhibits tumor growth in H22 xenograft mouse model, through immunoregulation, induction of apoptosis and inhibition of angiogenesis. Chiisanoside attenuates Parkinson’s disease through regulation of Parkin/ZNF746/PGC-1α axis, and promotion of mitochondrial biogenesis .

HY-122467

Kumbicin C	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Bacterial
Kumbicin C is a bis-indolyl benzenoid compound from an Australian soil fungus, Aspergillus kumbius. Kumbicin C inhibits the growth of mouse myeloma cells and the Gram-positive bacterium Bacillus subtilis .

HY-N0160R

Kinetin (Standard)	Structural Classification Natural Products other families Source classification Plants	SOD
Kinetin (Standard) is the analytical standard of Kinetin. This product is intended for research and analytical applications. Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects .

HY-17563R

2'-Deoxyguanosine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Source classification Disease markers Endocrine diseases Endogenous metabolite	Endogenous Metabolite
2'-Deoxyguanosine (Standard) is the analytical standard of 2'-Deoxyguanosine. This product is intended for research and analytical applications. 2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells . In Vitro: 2'-Deoxyguanosine inhibits the clonal growth of HL-60 and K562 leukemia cells with IC₅₀ values of 50 and 80 μM, respectively .

HY-N13083

PCSK9-IN-28	Structural Classification Terpenoids Source classification Diterpenoids Euphorbia esula L. Euphorbiaceae Plants	PCSK9
PCSK9-IN-28 (Compound C11) is a PCSK9 inhibitor that can be isolated from Euphorbia esula. By binding to HNF1α, PCSK9-IN-28 inhibits PCSK9 transcription by binding to HNF1α and affecting its nuclear distribution, thereby enhancing LDLR and promoting LDL uptake. PCSK9-IN-28 exhibits significant lipid-lowering activity in the high-fat diet (HFD) mouse model and can be used in the study of hyperlipidemia .

HY-P99276

Abagovomab Anti-Human CA-125 Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	Others
Abagovomab (Anti-Human CA-125 Recombinant Antibody) is a murine monoclonal anti-idiotypic antibody, against the tumor-associated antigen, CA-125. Abagovomab is generated by a mouse hybridoma, can imitate the human TAA, CA-125. Abagovomab can elicit humoral and cellular immune responses against ovarian cancer (oc) .

HY-111646

N6-Etheno 2'-deoxyadenosine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Nucleoside Antimetabolite/Analog Endogenous Metabolite
N6-Etheno 2'-deoxyadenosine is a reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced DNA oxidation product, used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues .

HY-113089

Epsilon-(gamma-glutamyl)-lysine H-Glu(H-Lys-OH)-OH; γ-Glu-ε-Lys	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative. The enzyme tissue transglutaminase (tTg) helps the formation of epsilon-(gamma-glutamyl)lysine bonds between ECM components in some disease, such as non-diabetic kidney, glaucoma filtration .

HY-P9954

Catumaxomab	Classification of Application Fields Disease Research Fields Cancer	CD3
Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers .

HY-P2792

Beauveriolide III	Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Others
Beauveriolide III is an inhibitor of lipid droplet formation in mouse macrophages .

HY-113089A

Epsilon-(gamma-glutamyl)-lysine TFA H-Glu(H-Lys-OH)-OH TFA; γ-Glu-ε-Lys TFA	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Epsilon-(gamma-glutamyl)-lysine (H-Glu(H-Lys-OH)-OH) TFA is an N(6)-acyl-L-lysine derivative. The enzyme tissue transglutaminase (tTg) helps the formation of epsilon-(gamma-glutamyl)lysine bonds between ECM components in some disease, such as non-diabetic kidney, glaucoma filtration .

HY-B1941

4-tert-Octylphenol	Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Apoptosis DNA/RNA Synthesis
4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology .

HY-N0370

Bergapten 4 Publications Verification 5-Methoxypsoralen	Structural Classification other families Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Cancer	Cytochrome P450 Autophagy
Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human CYP isoforms.

HY-N4300

4'-O-Methylochnaflavone 1 Publications Verification	Caprifoliaceae Classification of Application Fields Ginkgoaceae Lonicera japonica Thunb. Source classification Plants Ginkgo biloba Flavonoids Phenols Polyphenols Biflavones Inflammation/Immunology Disease Research Fields	Others
4'-O-Methylochnaflavone is a biflavonoid isolated from Lonicera japonica, suppresses mouse lymphocyte proliferation .

HY-N3775

Dodoviscin I	Structural Classification Flavonoids Flavones Source classification Dodonaea viscosa (L.) Jacq. Sapindaceae Plants	Others
Dodoviscin I is an adipogenesis agent that increases triglyceride content in 3T3L1 mouse fibroblasts .

HY-B1899

Taurodeoxycholic acid 2 Publications Verification	Structural Classification Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis
Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .

HY-W015061

Phenylacetylglycine 1 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Adrenergic Receptor Apoptosis Endogenous Metabolite
Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion .

HY-120843

WS009A	Structural Classification Monophenols Microorganisms Source classification Phenols	Endothelin Receptor
WS009A is an antagonist for endothelin receptor (ET Receptor) with IC₅₀ of 5.8 and 6.9 μM for ET-1 receptor and ET-2 receptor. WS009A can be used in research of cardiovascular diseases .

HY-W015061R

Phenylacetylglycine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Adrenergic Receptor Apoptosis Endogenous Metabolite
Phenylacetylglycine (Standard) is the analytical standard of Phenylacetylglycine. This product is intended for research and analytical applications. Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion .

HY-N0204

Pulchinenoside A Anemoside A3	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Ranunculaceae Other Diseases Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel	iGluR
Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice.

HY-N7935

Procyanidin B5	Structural Classification Aronia melanocarpa Source classification Rosaceae Phenols Polyphenols Plants	Reactive Oxygen Species
Procyanidin B5 is an antioxidant agent with an IC₅₀ of 0.1 mM in mouse liver homogenate lipid peroxidation assay .

HY-N7140R

Gamma-Linolenic acid (Standard) γ-Linolenic acid (Standard)	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Source classification Disease markers Metabolic Disease Espeletia schultzii Wedd. Endocrine diseases Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Gamma-Linolenic acid (Standard) is the analytical standard of Gamma-Linolenic acid. This product is intended for research and analytical applications. Gamma-linolenic acid (γ-Linolenic acid) is an omega-6 (n-6), 18 carbon (18C-) polyunsaturated fatty acid (PUFA) extracted from Perilla frutescens. Gamma-linolenic acid supplements could restore needed PUFAs and mitigate the disease .

HY-B1941R

4-tert-Octylphenol (Standard)	Monophenols Source classification Phenols Endogenous metabolite	Endogenous Metabolite Apoptosis DNA/RNA Synthesis
4-tert-Octylphenol (Standard) is the analytical standard of 4-tert-Octylphenol. This product is intended for research and analytical applications. 4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology .

HY-126813

Concanamycin C	Structural Classification Natural Products Microorganisms Source classification	Fungal
Concanamycin C inhibits proliferation of mouse splenic lymphocytes. Concanamycin C exhibits antibiotic effects against fungal and yeast .

HY-N0847

Micheliolide 4 Publications Verification	Structural Classification Other Monoterpenes other families Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields	NF-κB PI3K Akt TGF-beta/Smad
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-148614

Isocaproaldehyde 4-Methylpentanal; 4-Methylvaleraldehyde	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Others
Isocaproaldehyde is a product of side-chain cleavage of cholesterol. Isocaproaldehyde is an endogenous specific substrate of mouse vas deferens protein (MVDP) .

HY-N3595

Cleomiscosin A	Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Euphorbiaceae Phenylpropanoids Plants Macaranga adenantha Gagnep. Inflammation/Immunology Disease Research Fields	TNF Receptor
Cleomiscosin A is a coumarino-lignoid from branch of Macaranga adenantha. Cleomiscosin A is active against TNF-alpha secretion of the mouse peritoneal macrophages .

HY-N11494

Dauricumine	Structural Classification Alkaloids Source classification Plants Menispermaceae Menispermum dauricum Alkaloid Dimers	NF-κB
Dauricumine is a chlorinated alkaloid that inhibits NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts .

HY-N0648

Monotropein	Structural Classification Iridoids Classification of Application Fields Terpenoids Pyrola calliantha H. Andr. Source classification Rubiaceae Pyrolaceae Plants Morinda officinalis How Inflammation/Immunology Disease Research Fields	Others
Monotropein is an iridoid glycoside isolated Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model .

HY-121182

Chalcomycin	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Antibiotic Bacterial
Chalcomycin is a macrolide antibiotic, which exhibits antimicrobial activities against gram-positive Staphylococcus aureus and Streptococcus pyogenes. Chalcomycin protects mice from infection with a variety of staphylococci and streptococc, without significant toxicity (LD₅₀ >2500 mg/kg) .

HY-N2149A

Tomatidine hydrochloride 5 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Solanum lycopersicum L. Solanaceae Plants Disease Research Fields Steroids	NF-κB JNK Autophagy Endogenous Metabolite
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans .

HY-135743

Apovincamine cis-Apovincamine; (+)-Apovincamine	Apocynaceae Alkaloids Structural Classification Alstonia yunnanensis Diels Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Cancer	Others
Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity .

HY-N3041

Plumieride Agoniadin; NSC 609065	Apocynaceae Structural Classification Natural Products Source classification Plumeria alba L. Plants	Fungal
Plumieride is an antifungal agent. Plumieride has strong fungitoxicity against some dermatophytes. Plumieride has little cytotoxic activity against the P388 leukaemia cell line with an IC₅₀ of 85 μg/mL .

HY-117180

Diastovaricin I 30-Hydroxy-naphthomycin C	Structural Classification Macrolide Antibiotics Antibiotics Source classification Endogenous metabolite	Antibiotic
Diastovaricin I (30-Hydroxy-naphthomycin C) is an antibiotic without exhibiting antimicrobial activity. Diastovaricin I induces differentation of mouse Friend cell .

HY-P1987

Mast cell degranulating peptide (28-49)	Natural Products Animals Source classification	Others
Mast cell degranulating peptide (28-49) is a depolarizing agent from bee venom, it can raise the content of cGMP level in mouse cerebellar slices .

HY-N1403

Tigogenin	Structural Classification Classification of Application Fields Source classification Metabolic Disease Agavaceae Plants Agave sisalana Perr. ex Engelm. Disease Research Fields Steroids	Others
Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid agents. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells .

Cat. No.	Product Name	Chemical Structure

HY-N0086S

N6-Methyladenosine-d3
N6-Methyladenosine-d₃ (6-Methyladenosine-d₃; N-Methyladenosine-d₃) is a deuterium labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-W001158S

N,N-Dimethylglycine-d6 hydrochloride
N,N-Dimethylglycine-d₆ (hydrochloride) is the deuterium labeled N,N-Dimethylglycine[1].

HY-N0086S1

N6-Methyladenosine-13C
N6-Methyladenosine- ¹³C is the ¹³C labeled isotope of N6-Methyladenosine .

HY-N0086S2

N6-Methyladenosine-13C4
N6-Methyladenosine- ¹³C₄ (6-Methyladenosine- ¹³C₄; N-Methyladenosine- ¹³C₄) is ¹³C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-N0086S3

N6-Methyladenosine-13C3
N6-Methyladenosine- ¹³C₃ (6-Methyladenosine- ¹³C₃) is ¹³C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities .

HY-P1032S1

Angiotensin I-13C5,15N (human, mouse, rat)

Angiotensin I- ¹³C₅, ¹⁵N (human, mouse, rat) is the ¹³C and ¹⁵N labeled Angiotensin I (human, mouse, rat) (HY-P1032). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-P1032S

Angiotensin I-13C19,15N3 (human, mouse, rat)

Angiotensin I- ¹³C₁₉, ¹⁵N₃ (human, mouse, rat) is the ¹³C and ¹⁵N labeled Angiotensin I (human, mouse, rat) (HY-P1032). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .

HY-W010465S

N,N-Dimethylsulfamide-d6
N,N-Dimethylsulfamide-d₆ is the deuterium labeled N,N-Dimethylsulfamide[1].

HY-157247S

Dodecyl N,N-dimethylaminoacetate-d6
Dodecyl N,N-dimethylaminoacetate-d6 is the deuterium labeled Dodecyl N,N-dimethylaminoacetate .

HY-W042416S1

N,N-Dimethylacetamide-d6
N,N-Dimethylacetamide-d₆ is the deuterium labeled N,N-Dimethylacetamide[1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent[2].

HY-23149S

N,N,N-Trimethyl-1,3-propanediamine-d6
N,N,N-Trimethyl-1,3-propanediamine-d₆ is the deuterium labeled N,N,N-Trimethyl-1,3-propanediamine[1].

HY-W009512S1

N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide-d6
N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide-d₆ (N-[(2-chlorophenyl)carbamoyl]phenylalanine-d₆) is deuterium-labeled CVT-2738 (HY-W009512) .

HY-163816

Antiproliferative agent-53-d3

Antiproliferative agent-53-d3 (Compound C1) is an inhibitor for theta-mediated end joining (TMEJ) in HEK293 cell with an IC₅₀ of 0.14 µM. Antiproliferative agent-53-d3 is the inhibitor for CYP2C19 and CYP2C9 with IC₅₀ of 0.77 and 3.1 µM. Antiproliferative agent-53-d3 inhibits the proliferation of DNA repair-compromised cells, with IC₅₀ of 8.1 µM for BRCA2 ^-/- DLD-1. Antiproliferative agent-53-d3 exhibits good pharmacokinetic characteristics in CD-1 mice .

HY-B1899S

Taurodeoxycholic acid-d5

Taurodeoxycholic acid-d₅is the deuterium labeledTaurodeoxycholic acid(HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .

HY-N0370S

Bergapten-d3
Bergapten-d₃ is deuterium labeled Bergapten. Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human CYP isoforms.

HY-16582AS

Sonidegib-d4
Sonidegib-d4 is a isotope of Sonidegib. Sonidegib is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively .

HY-B0346S

Propylthiouracil-d5
Propylthiouracil-d₅ is the deuterium labeled Propylthiouracil. Propylthiouracil (6-Propyl-2-thiouracil) is a thyroperoxidase and 5'-deiodinase inhibitor.

HY-N6746S1

Citrinin-13C13

Citrinin- ¹³C₁₃ (NSC 186- ¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin shows significant antitumor effects in a mouse model of breast cancer induced by DMBA (HY-W011845). Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. In addition, Citrinin has antibacterial and neuroprotective activities .

HY-W134007S1

Hexadecanoate-13C16 potassium 2 Publications Verification
Hexadecanoate- ¹³C₁₆ (potassium) is the ¹³C-labeled Hexadecanoate sodium. Hexadecanoate potassium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-109591S

Oleoyl coenzyme A-13C18 lithium
Oleoyl coenzyme A- ¹³C₁₈ (lithium) is the ¹³C labeled Oleoyl Coenzyme A lithium[1]. Oleoyl coenzyme A (Oleoyl-CoA) is a thioester of oleic acid and coenzyme A. Oleoyl coenzyme A has a role as an Escherichia coli metabolite and a mouse metabolite[2][3].

HY-17399S

Racecadotril-d5
Racecadotril-d₅ is the deuterium labeled Racecadotril. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent[1].

HY-B0149S3

Tranexamic acid-13C2,15N
Tranexamic acid- ¹³C₂, ¹⁵N (Cyclocapron- ¹³C₂, ¹⁵N) is the ¹³C₂ and ¹⁵N labeled Tranexamic acid. Tranexamic acid is an antifibrinolytic agent that alleviates liver damage and fibrosis in mouse models of chronic bile duct injury .

HY-B0349S

Meclizine-d8
Meclizine-d₈ is a deuterium labeled Meclizine. Meclizine is a histamine H1 receptor antagonist and has the potential to treat nausea and motion sickness. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR[1][2][3].

HY-126242S

Tyk2-IN-7

Tyk2-IN-7 is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1].

HY-13956S

Pioglitazone-d4
Pioglitazone-d₄ is a deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively[1].

HY-157029S

KRASG12D-IN-1
KRASG12D-IN-1 (compound 22) is a KRAS ^G12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition .

HY-157031S

KRASG12D-IN-2
KRASG12D-IN-2 (compound 28) is a KRAS ^G12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition .

HY-13757AS1

Tamoxifen-d3

Tamoxifen-d₃ is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].

HY-114360AS1

Taurohyodeoxycholic acid-d4 sodium
Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium) . Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-17447SA

Tranylcypromine-d5 hydrochloride

Tranylcypromine-d₅ (hydrochloride) is a deuterium labeled (rel)-Tranylcypromine hydrochloride. Tranylcypromine hydrochloride is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hydrochloride is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis[1][2].

HY-N0830S18

Palmitic acid-d1
Palmitic acid-d is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S5

Palmitic acid-d3
Palmitic acid-d₃ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S2

Palmitic acid-d31
Palmitic acid-d₃₁ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830BS

Palmitic acid-13C sodium
Palmitic acid- ¹³C (sodium) is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S4

Palmitic acid-d2
Palmitic acid-d₂ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S7

Palmitic acid-d4
Palmitic acid-d₄ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S9

Palmitic acid-13C
Palmitic acid- ¹³C is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S14

Palmitic acid-d17
Palmitic acid-d₁₇ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S20

Palmitic acid-d9
Palmitic acid-d₉ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S21

Palmitic acid-d5
Palmitic acid-d₅ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-13762S

Tesmilifene-d4
Tesmilifene-d4 is the deuterium labeled Tesmilifene (HY-13762). Tesmilifene is an antihistamine agent and a chemical sensitizer. Tesmilifene targets cytochrome P450, exhibits hormonal effects on DNA synthesis in MCF-7 cells, and stimulates the tumor growth in mouse/rat models. Tesmilifene overcomes multidrug resistance .

HY-N0830S6

Palmitic acid-13C16 2 Publications Verification
Palmitic acid- ¹³C₁₆ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830BS1

Palmitic acid-13C16 sodium 2 Publications Verification
Palmitic acid- ¹³C₁₆ (sodium) is the ¹³C-labeled Palmitic acid sodium. Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S10

Palmitic acid-13C2
Palmitic acid- ¹³C₂ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S11

Palmitic acid-d2-1
Palmitic acid-d₂-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S12

Palmitic acid-d4-1
Palmitic acid-d₄-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2][3].

HY-N0830S13

Palmitic acid-d4-2
Palmitic acid-d₄-2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S15

Palmitic acid-d2-2
Palmitic acid-d₂-2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S16

Palmitic acid-d2-3
Palmitic acid-d₂-3 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S17

Palmitic acid-d2-4
Palmitic acid-d₂-4 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

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