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Selective 2'-Hydroxyl Acylation analyzed by Primer Extension (SHAPE)

" in MedChemExpress (MCE) Product Catalog:

9969

Inhibitors & Agonists

27

Screening Libraries

296

Fluorescent Dye

114

Biochemical Assay Reagents

468

Peptides

17

MCE Kits

33

Inhibitory Antibodies

391

Natural
Products

28

Recombinant Proteins

417

Isotope-Labeled Compounds

12

Antibodies

50

Click Chemistry

31

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-164899
    2A3

    		Biochemical Assay Reagents Others
    2A3 is a highly efficient and precise SHAPE reagent with powerful biomembrane penetration capabilities, suitable for both in vivo and in vitro RNA structure detection. 2A3 can not only effectively probe most RNA loops but also better capture local nucleotide dynamics, thus enabling it to readily detect regions of ribonucleoprotein complexes that are typically inaccessible to other compounds .
    2A3
  • HY-103006
    NAI-N3
    5 Publications Verification

    		 Biochemical Assay Reagents Others
    NAI-N3 is a RNA acylation reagent that enables RNA purification. NAI-N3 is a dual-function SHAPE (selective 2-hydroxyl acylation and profiling experiment) probe (RNA structure probe and enrichment) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    NAI-N3
  • HY-N0674B
    Dehydrocorydaline (hydroxyl)
    30+ Cited Publications

    13-Methylpalmatine (Hydroxyl)

    		 Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy Infection Inflammation/Immunology Cancer
    Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
    Dehydrocorydaline (hydroxyl)
  • HY-W883690
    LacK free acid

    		Endogenous Metabolite Others
    LacK (free acid) is a lysine derivative used in lactate acylation studies .
    LacK free acid
  • HY-N9961
    2-Hydroxyl emodin-1-methyl ether

    		Others Others
    2-Hydroxyl emodin-1-methyl ether (Compound 5) is an anthraquinone that can be isolated from the seeds of Cassia obtusifolia .
    2-Hydroxyl emodin-1-methyl ether
  • HY-13247
    Setrobuvir

    ANA598

    		 DNA/RNA Synthesis HCV SARS-CoV Infection
    Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC50s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition [2].
    Setrobuvir
  • HY-B1978S
    Iprodione-d5

    		Fungal Reactive Oxygen Species Infection
    Iprodione-d5 is the deuterium labeled Iprodione[1]. Iprodione, a dicarboximide fungicide, has a highly specific action, with a capacity to cause oxidative damage through production of free oxygen radicals (ROS). Iprodione does not appear to be species selective[2].
    Iprodione-d5
  • HY-N7014
    Hydroxyl-​γ-​isosanshool

    		Others Neurological Disease
    Hydroxyl-γ-isosanshool is one of the major alkylamides in Z. bungeanum and Z. schinifolium oils. Hydroxyl-γ-isosanshoo induces a numbing sensation .
    Hydroxyl-​γ-​isosanshool
  • HY-144245S
    5-Hydroxyl ZLN005-d13

    		Isotope-Labeled Compounds Others
    5-Hydroxyl ZLN005-d13 is the deuterium labeled 5-Hydroxyl ZLN005 .
    5-Hydroxyl ZLN005-d13
  • HY-161973
    Hydroxyl-ML-210

    		Ligands for Target Protein for PROTAC Cancer
    Hydroxyl-ML-210 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Hydroxyl-ML-210 can be used for synthesis ZX782 (HY-161972) .
    Hydroxyl-ML-210
  • HY-18408
    5S rRNA modificator

    FAI

    		 Biochemical Assay Reagents Others
    5S rRNA modificator is a suitable electrophile for 2’-hydroxyl acylation on structured RNA molecules, yielding accurate structural information comparable to that obtained with existing probes; 5S rRNA RNA modification.
    5S rRNA modificator
  • HY-155869
    5-fluoro-dCTP

    5-Fluoro-2′-deoxycytidine 5′-triphosphate

    		 DNA/RNA Synthesis Others
    5-fluoro-dCTP is a fluorinated pyrimidine dNTP that can be used as a substrate for the incorporation of fluorine modification into specific DNA sequences by primer extension (PEX) catalyzed by Pwo polymerase .
    5-fluoro-dCTP
  • HY-155869A
    5-fluoro-dCTP sodium

    5-Fluoro-2′-deoxycytidine 5′-triphosphate sodium

    		 DNA/RNA Synthesis Others
    5-fluoro-dCTP sodium is a fluorinated pyrimidine dNTP that can be used as a substrate for the incorporation of fluorine modification into specific DNA sequences by primer extension (PEX) catalyzed by Pwo polymerase .
    5-fluoro-dCTP sodium
  • HY-137868
    Decanoyl coenzyme A

    Decanoyl-coa

    		 Endogenous Metabolite Endocrinology
    Decanoyl coenzyme A (Decanoyl CoA) is a primer for the fatty acid elongation system in Mycobacterium smegmat .
    Decanoyl coenzyme A
  • HY-D1720
    Cy5-dATP

    		DNA/RNA Synthesis Others
    Cy5-dATP is a Cy5 (HY-D0821)-labeled dATP (HY-136648). Cy5-dATP can be incorporated into a DNA primer [2].
    Cy5-dATP
  • HY-157131
    TRPV2-selective blocker 1

    		TRP Channel Neurological Disease
    TRPV2-selective blocker 1 (compound IV2-1) is a selective TRPV2 channel blocker with an IC50 of 6.3 μM. TRPV2-selective blocker 1 does not affect TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 also inhibits TRPV2-mediated Ca 2+ influx in macrophages, and inhibits macrophage phagocytosis .
    TRPV2-selective blocker 1
  • HY-172310
    1-(Pentan-5-ol)-2-hydroxyl-3,4-bis(TBDMS-hexane)

    		Biochemical Assay Reagents Others
    1-(Pentan-5-ol)-2-hydroxyl-3,4-bis(TBDMS-hexane) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    1-(Pentan-5-ol)-2-hydroxyl-3,4-bis(TBDMS-hexane)
  • HY-172452
    RSV L-protein-6

    		RSV Infection
    RSV L-protein-6 (Compound 19a) is a respiratory syncytial virus polymerase inhibitor, with an IC50 of 13 nM in SPA primer extensions enzymatic assay. RSV L-protein-6 can inhibit RSV replication in Hela cells .
    RSV L-protein-6
  • HY-13952
    TP-808

    		Bacterial Infection
    TP-808 is an intermediate used in tetracycline antibiotic synthesis with antimicrobial activity. TP-808 binds to the 30S ribosome subunit of the bacteria, preventing aminoacyl-trNA from entering the A site, thereby inhibiting the extension of the protein chain. TP-808 can be used in antibiotic drug development research .
    TP-808
  • HY-124089
    Eicosapentaenoyl ethanolamide

    		Cannabinoid Receptor Metabolic Disease
    Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs). Eicosapentaenoyl ethanolamide is cannabinoid CB1/CB2 receptor agonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR)-induced lifespan extension in wild type animals and suppresses lifespan extension in a TOR pathway mutant [2].
    Eicosapentaenoyl ethanolamide
  • HY-131817
    5'-GMPS

    		DNA/RNA Synthesis Others
    5'-GMPS is an analogue of 5'-GMP and a substrate, competitive inhibitor or regulator of enzymes that interact with 5'-GMP. 5'-GMPS is suitable as a primer of RNA synthesis by T7 RNA polymerase .
    5'-GMPS
  • HY-126325
    BY27

    		Epigenetic Reader Domain Cancer
    BY27 is a potent and selective BET BD2 inhibitor, shows 38, 5, 7, and 21-fold BD1/BD2 selectivity for BRD2, BRD3, BRD4, and BRDT. Anti-cancer activity .
    BY27
  • HY-149725
    proMMP-9 selective inhibitor-1

    		MMP Neurological Disease
    proMMP-9 selective inhibitor-1 (compound 33) is a highly potent and selective inhibitor of proMMP-9 activation .
    proMMP-9 selective inhibitor-1
  • HY-161021
    AC2 selective-IN-1

    		Adenylate Cyclase Others
    AC2 selective-IN-1 (compound 14) is a? potent (IC50=4.45 μM), non-toxic, and selective mAC2 inhibitor .
    AC2 selective-IN-1
  • HY-107259
    23S-Hydroxyl-11,15-dioxo-ganoderic acid DM

    23S-Hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic

    		 Others Others
    23S-Hydroxyl-11,15-dioxo-ganoderic acid DM is a compound isolated from the fruit bodies of Ganoderma lucidum .
    23S-Hydroxyl-11,15-dioxo-ganoderic acid DM
  • HY-125400
    Zaragozic acid C

    L-697350

    		 Endogenous Metabolite Cancer
    Zaragozic acid C (L-697350) is a potent sterol synthase inhibitor with potential antitumor activity. Zaragozic acid C contains multiple hydroxyl and alkyl substituents in its chemical structure, demonstrating complex functionalization capabilities. The synthesis of zaragozic acid C involves a photochemical C(sp3)-H acylation reaction, which resolves the challenging carbon substitution problem in the synthesis .
    Zaragozic acid C
  • HY-116603
    SB-236057

    		5-HT Receptor Others
    SB-236057 is an inverse agonist of the 5-HT1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis .
    SB-236057
  • HY-168473
    13-TP

    		SARS-CoV DNA/RNA Synthesis Infection
    13-TP is an inhibitor of SARS-CoV-2. 13-TP effectively inhibits the SARS-CoV-2 central replication transcription complex (C-RTC, nsp12-nsp7-nsp82) catalyzed in vitro RNA synthesis. 13-TP completely inhibits the RdRp polymerization activity. 13-TP blocks the full extension of some of the primer RNA .
    13-TP
  • HY-43520
    BODIPY-FL

    		Fluorescent Dye Others
    BODIPY-FL is a green fluorescent dye that can be used to label probes or primers. BODIPY-FL fluorescence can be quenched after interacting with uniquely positioned guanine, making it useful for quantifying specific DNA or RNA molecules. BODIPY-FL-labeled sphingolipid analogs can be used to investigate sphingolipid internalization, transport, and endocytosis in mouse embryonic stem cells. BODIPY-FL-labeled monoterpenes can quickly penetrate bacteria, mammalian, and fungal cells, allowing for the detection of characteristics of a broad spectrum of Gram-positive and Gram-negative bacteria, as well as pathogenic fungi. The maximum absorption wavelength of BODIPY-FL is 505 nm, and the maximum emission wavelength is 513 nm [2] .
    BODIPY-FL
  • HY-141570
    Lyso-PAF C-16

    		Phospholipase Others
    Lyso-PAF C-16 is a substrate of lysoplasmalogen (LysoPls)-specific phospholipase D (LysoPLD). Lyso-PAF C-16 selective acetylates with arachidonic acid [2].
    Lyso-PAF C-16
  • HY-E70283
    Recombinant endoglycoceramidase II assisted by activator II

    rEGCase II assisted by Activator II

    		 Endogenous Metabolite Others
    Recombinant endoglycoceramidase II assisted by activator II is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
    Recombinant endoglycoceramidase II assisted by activator II
  • HY-153990
    FKBP51F67V-selective antagonist Ligand2

    		FKBP Neurological Disease
    FKBP51F67V-selective antagonist Ligand2 (example 3-3) is a potent FKBP51 F67V-selective antagonist ligand. FKBP51F67V-selective antagonist Ligand2 reverses the anxiogenic phenotype induced by overexpression of FKBP51 F67V in the amygdala. FKBP51F67V-selective antagonist Ligand2 binds to FKBP51 F67V, but not to wild-type FKBP51 or FKBP52 .
    FKBP51F67V-selective antagonist Ligand2
  • HY-W020983
    Trifluoromethanesulfonic acid silver

    Triflic acid silver; Perfluoromethanesulfonic acid silver; Fluorad FC 24 silver

    		 Biochemical Assay Reagents Others
    Trifluoromethanesulfonic acid (Triflic acid) silver, a perfluoroalkanesulfonic acid, is one of the superior catalysts for C- or O-acylation .
    Trifluoromethanesulfonic acid silver
  • HY-18407
    N-Methylisatoic anhydride

    		Nucleoside Antimetabolite/Analog Others
    N-Methylisatoic anhydride is a heteronucleoside anhydride derivative conjugated with biotin and a disulfide linker for specific 2'-OH acylation of RNA. Biotin-conjugated N-Methylisatoic anhydride can selectively capture RNA from a mixture of biological RNA and DNA .
    N-Methylisatoic anhydride
  • HY-E70253
    Tridecanoyl-CoA triammonium

    		Biochemical Assay Reagents Others
    Tridecanoyl-CoA triammonium, a coenzyme, is used as a primer .
    Tridecanoyl-CoA triammonium
  • HY-D2415
    BODIPY-FL staurosporine

    		Fluorescent Dye Others
    BODIPY-FL staurosporine (Compound 8a) is a fluorescence probe based on staurosporine, exhibiting high specificity towards tyrosine kinases (TK) and tyrosine kinase-like (TKL) family kinases. BODIPY-FL staurosporine has the potential to develop binding assays for kinases that are not recommended for use with Kinase Tracer 236, such as PIM3, CDC42BPG, MAP2K7, TXK, and SIK3. BODIPY-FL staurosporine can be a powerful tool for analyzing kinase selectivity in kinase drug discovery .
    BODIPY-FL staurosporine
  • HY-126123
    NR2B-selective NMDA receptor antagonist 1

    		iGluR Potassium Channel Neurological Disease
    NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors, with IC50s of 0.05 μM, 0.73 μM, 2.4 μM to NR1/NR2B NMDA receptor, hERG, α1-AdR, respectivity. NR2B-selective NMDA receptor antagonist 1 exhibites efficient permeability across the blood–brain barrier .
    NR2B-selective NMDA receptor antagonist 1
  • HY-P10429
    RCP168

    		CXCR Infection
    RCP168 is a highly selective and affinity CXCR4 receptor antagonist (IC50=5 nM). RCP168 has a stronger ability than natural chemical factors to inhibit the entry of HIV-1 (human immunodeficiency virus type 1) into host cells via CXCR4 receptors. RCP168 inhibits HIV-1 infection by blocking viral binding sites or inducing receptor internalization. RCP168 can be used to analyze the interaction between CXCR4 receptor and other chemical factor receptors .
    RCP168
  • HY-19223
    Pumaprazole

    by-841

    		 Proton Pump Inflammation/Immunology
    Pumaprazole is a reversible proton pump antagonist.
    Pumaprazole
  • HY-120253
    Spirotetramat

    by-108330

    		 Insecticide Others
    Spirotetramat (BY-108330) is a pesticide, that can be used to control aphids on crops, without significant phytotoxicity .
    Spirotetramat
  • HY-121564
    Radermachol

    		Fluorescent Dye Others
    Radermachol is a red pigment that can be synthesized in four steps via a key ytterbium triflate-catalyzed furan cyclization and intramolecular nucleophilic acylation reaction .
    Radermachol
  • HY-N6964
    Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside

    Quercetin-3-O-[2-O-(6-O-p-Hydroxyl-E-coumaroyl)-D-glucosyl]-(1→2)-L-rhamnoside

    		 Others Metabolic Disease
    Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside (Quercetin-3-O-[2-O-(6-O-p-hydroxyl-E-coumaroyl)-D-glucosyl]-(1→2)-L-rhamnoside) is one of the major antioxidants of Ginkgo biloba leaves .
    Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside
  • HY-137868A
    Decanoyl coenzyme A triammonium

    Decanoyl-COA triammonium; 10:0 Coenzyme A

    		 Endogenous Metabolite Endocrinology
    Decanoyl coenzyme A (Decanoyl CoA) triammonium is a primer for the fatty acid elongation system in Mycobacterium smegmat .
    Decanoyl coenzyme A triammonium
  • HY-117798
    LY 806303

    		Thrombin Cardiovascular Disease
    LY 806303 is a potent and selective inhibitor of human α-thrombin. LY 806303 specifically acylates Ser-205 within the catalytic triad of α-thrombin on the heavy chain and a key site involved in the enzymatic activity of thrombin. The mechanism of action of LY 806303 as an enzyme inhibitor is through the specific acylation of this catalytic serine residue .
    LY 806303
  • HY-W012890
    Pentanehydrazide

    Valeric acid hydrazide

    		 Biochemical Assay Reagents Others
    Pentanehydrazide (Valeric acid hydrazide) is a biochemical reagent that can act as an effective alkylating agent in the copper-catalyzed oxidative cyclization of N-arylacrylamides and participate in the tandem acylation reaction .
    Pentanehydrazide
  • HY-W048838
    Acetyl-L-lysine

    		Endogenous Metabolite Metabolic Disease
    Acetyl-L-lysine is an acetylated form of the amino acid L-lysine. Acetyl-L-lysine can participate in protein acylation processes, affecting protein functions such as stability and enzyme activity .
    Acetyl-L-lysine
  • HY-W127410
    Hexanoic anhydride

    		Biochemical Assay Reagents Others
    Hexanoic anhydride is used as a reactant for the synthesis of acremomannolipin A. For the green synthesis of acyclovir dipivoxil (acyclovir proagent), for the preparation of hexanoyl-modified chitosan nanoparticles, chitosan-based polymer surfactants by N-acylation of chitosan .
    Hexanoic anhydride
  • HY-113490
    15-KETE

    		Drug Derivative Metabolic Disease
    15-KETE (15-KETE) is produced by oxidation of the 15-hydroxyl of 15-HETE.
    15-KETE
  • HY-124592
    BMT-052

    		HCV Infection
    BMT-052 is a pan-genotypic hepatitis C (HCV) NS5B polymerase primer grip inhibitor .
    BMT-052
  • HY-E70282
    Recombinant endoglycoceramidase I assisted by activator II

    rEGCase I assisted by activator II

    		 Biochemical Assay Reagents Neurological Disease
    Recombinant endoglycoceramidase I assisted by activator II (rEGCase I assisted by Activator II) is a mixture-form of EGCase I and Activator II. EGCase I is a glycolipid-specific hydrolase that well-suited to a comprehensive analysis of glycosphingolipids (GSLs). Activator II is capable of inducing activity of EGCase without any detergent reagents [2].
    Recombinant endoglycoceramidase I assisted by activator II

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